SPB-C/A(18)基因多态性与中国新生儿支气管肺发育不良关系的荟萃分析
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摘要
目的探讨肺表面活性物质相关蛋白B(surfactant protein B,SPB)-C/A(18)基因多态性与中国新生儿支气管肺发育不良(broncho-pulmonary dysplasia,BPD)发病风险的相关性。方法利用中国知网、维普、万方、PubMed、Medline、Web of Science等数据库检索有关SPB-C/A(18)基因多态性与BPD相关性的病例对照研究,时限为1998年1月至2018年4月。根据纳入和排除标准选择文献,评估文献质量,并提取相关研究数据,采用Revman 5.3软件进行荟萃分析。结果共纳入5篇文献,观察组患儿332例,对照组患儿409例。荟萃分析显示:SPB-C/A(18)基因多态性与中国新生儿BPD发病风险无明显相关性(AA+AC与AA+AC+CC:OR=1.65,95%CI:0.90～3.03,P=0.10;A与A+C:OR=1.35,95%CI:0.72～2.53,P=0.34)。结论 SPB-C/A(18)基因多态性与中国新生儿BPD发病风险可能无明显相关性,但仍需大量高质量的研究进一步证实。
Objective To investigate the association between pulmonary surfactant protein B(SPB)-C/A(18) gene polymorphism and the risk of broncho-pulmonary dysplasia(BPD) in Chinese newborn. Method CNKI, VIP, Wanfang, Pub Med, Medline, Web of Science and other databases were used to search for case-control studies on the association between SPB-C/A(18) gene polymorphism and BPD. The time limit was January 1998 to April 2018. The literature was selected according to inclusion and exclusion criteria, the quality of the literature was assessed, and relevant research data was extracted and meta-analyzed using Revman 5.3 software. Result A total of 5 articles were included, 332 cases in observation group and 409 cases in control group. Meta-analysis showed that there was no significant correlation between the SPB-C/A(18) gene polymorphism and the risk of BPD in Chinese newborn(AA + AC and AA + AC + CC: OR = 1.65, 95%CI: 0.90 ～ 3.03, P = 0.10; A and A + C: OR = 1.35, 95%CI: 0.72 ～ 2.53, P = 0.34). Conclusion SPB-C/A(18) gene polymorphism may not be associated with the risk of BPD in Chinese newborn, but it still needs a lot of high-quality studies to further confirm.
Objective To investigate the association between pulmonary surfactant protein B(SPB)-C/A(18) gene polymorphism and the risk of broncho-pulmonary dysplasia(BPD) in Chinese newborn. Method CNKI, VIP, Wanfang, Pub Med, Medline, Web of Science and other databases were used to search for case-control studies on the association between SPB-C/A(18) gene polymorphism and BPD. The time limit was January 1998 to April 2018. The literature was selected according to inclusion and exclusion criteria, the quality of the literature was assessed, and relevant research data was extracted and meta-analyzed using Revman 5.3 software. Result A total of 5 articles were included, 332 cases in observation group and 409 cases in control group. Meta-analysis showed that there was no significant correlation between the SPB-C/A(18) gene polymorphism and the risk of BPD in Chinese newborn(AA + AC and AA + AC + CC: OR = 1.65, 95%CI: 0.90 ～ 3.03, P = 0.10; A and A + C: OR = 1.35, 95%CI: 0.72 ～ 2.53, P = 0.34). Conclusion SPB-C/A(18) gene polymorphism may not be associated with the risk of BPD in Chinese newborn, but it still needs a lot of high-quality studies to further confirm.
引文
[1]Hadchouel A,Durrmeyer X,Bouzigon E,et al.Identification of SPOCK2 as a susceptibility gene for bronchopulmonary dysplasia[J].Am J Respir Crit Care Med,2011,184(10):1164-1170.
[2]王颖.支气管肺发育不良(新生儿慢性肺疾病)的诊断与治疗[J].实用医学杂志,2005,21(17):1859-1860.
[3]刘洋.咖啡因对早产儿支气管肺发育不良的预防作用[J].中国当代儿科杂志,2018,20(7):598-602,封3.
[4]早产儿支气管肺发育不良调查协作组.早产儿支气管肺发育不良发生率及高危因素的多中心回顾调查分析[J].中华儿科杂志,2011,49(9):655-662.
[5]Mailaparambil B,Krueger M,Heizmann U,et al.Genetic and epidemiological risk factors in the development of bronchopulmonary dysplasia[J].Dis Markers,2010,29(1):1-9.
[6]王敏婕,陈超.干细胞治疗支气管肺发育不良的研究进展[J].中华儿科杂志,2015,53(11):876-879.
[7]曾凌空,李文斌,潘睿,等.肺泡表面活性物质蛋白B基因多态性与支气管肺发育不良易感性的关系[J].实用儿科临床杂志,2011,26(2):132-134.
[8]卢维城,向伟,郑旭,等.肺表面活性物质蛋白B基因多态性与早产儿支气管肺发育不良的相关性[J].中华实用儿科临床杂志,2013,28(2):118-121.
[9]Zhang S,Zhang X,Li Q,et al.Surfactant protein B gene polymorphisms is associated with risk of bronchopulmonary dysplasia in Chinese Han population[J].Int J Clin Exp Pathol,2015,8(3):2971-2978.
[10]程红斌.肺表面活性蛋白B基因多态性与新生儿肺支气管发育不良的危险相关性[J].临床和实验医学杂志,2015,14(10):800-802.
[11]赵堃.汉族早产儿支气管肺发育不良临床危险因素及易感基因筛查[D].汕头:汕头大学,2015.
[12]卢冬梅,李南方,姚晓光.肺表面活性物质气道分布及功能研究进展[J].中国临床研究,2016,29(10):1409-1413.
[13]Melton KR,Nesslein LL,Ikegami M,et al.SP-B deficiency causes respiratory failure in adult mice[J].Am J Physiol Lung Cell Mol Physiol,2003,285(3):L543-L549.
[14]Steagall WK,Lin JP,Moss J.The C/A(-18)polymorphism in the surfactant protein B gene influences transcription and protein levels of surfactant protein B[J].Am J Physiol Lung Cell Mol Physiol,2007,292(2):448-453.
[15]王晓磊,梅花.肺表面活性蛋白-B、三磷酸腺苷结合盒转运子A3基因变异与新生儿呼吸窘迫综合征的研究进展[J].中华围产医学杂志,2016,19(2):157-160.
[16]Tibboel J,Reiss I,de Jongste JC,et al.Sphingolipids in lung growth and repair[J].Chest,2014,145(1):120-128.
[17]Dahmer MK,O'Cain P,Patwari PP,et al.The influence of genetic variation in surfactant protein B on severe lung injury in African American children[J].Crit Care Med,2011,39(5):1138-1144.
[18]王晶,梅花.肺表面活性蛋白B、C与新生儿肺疾病关系的研究进展[J].中国新生儿科杂志,2015,30(5):387-389.
[19]陈冲,封志纯.支气管肺发育不良分子遗传学研究进展[J].实用儿科临床杂志,2012,27(16):1282-1284.
[20]Keller RL,Merrill JD,Black DM,et al.Late administration of surfactant replacement therapy increases surfactant protein-Bcontent:a randomized pilot study[J].Pediatr Res,2012,72(6):613-619.
[21]Liu W,Bentley CM,Joanna F.Study of human SP-A,SP-Band SP-D loci:allele frequencies,linkage disequilibrium and heterozygosity in different races and ethnic groups[J].BMCGenet,2003,4(1):13.
[2]王颖.支气管肺发育不良(新生儿慢性肺疾病)的诊断与治疗[J].实用医学杂志,2005,21(17):1859-1860.
[3]刘洋.咖啡因对早产儿支气管肺发育不良的预防作用[J].中国当代儿科杂志,2018,20(7):598-602,封3.
[4]早产儿支气管肺发育不良调查协作组.早产儿支气管肺发育不良发生率及高危因素的多中心回顾调查分析[J].中华儿科杂志,2011,49(9):655-662.
[5]Mailaparambil B,Krueger M,Heizmann U,et al.Genetic and epidemiological risk factors in the development of bronchopulmonary dysplasia[J].Dis Markers,2010,29(1):1-9.
[6]王敏婕,陈超.干细胞治疗支气管肺发育不良的研究进展[J].中华儿科杂志,2015,53(11):876-879.
[7]曾凌空,李文斌,潘睿,等.肺泡表面活性物质蛋白B基因多态性与支气管肺发育不良易感性的关系[J].实用儿科临床杂志,2011,26(2):132-134.
[8]卢维城,向伟,郑旭,等.肺表面活性物质蛋白B基因多态性与早产儿支气管肺发育不良的相关性[J].中华实用儿科临床杂志,2013,28(2):118-121.
[9]Zhang S,Zhang X,Li Q,et al.Surfactant protein B gene polymorphisms is associated with risk of bronchopulmonary dysplasia in Chinese Han population[J].Int J Clin Exp Pathol,2015,8(3):2971-2978.
[10]程红斌.肺表面活性蛋白B基因多态性与新生儿肺支气管发育不良的危险相关性[J].临床和实验医学杂志,2015,14(10):800-802.
[11]赵堃.汉族早产儿支气管肺发育不良临床危险因素及易感基因筛查[D].汕头:汕头大学,2015.
[12]卢冬梅,李南方,姚晓光.肺表面活性物质气道分布及功能研究进展[J].中国临床研究,2016,29(10):1409-1413.
[13]Melton KR,Nesslein LL,Ikegami M,et al.SP-B deficiency causes respiratory failure in adult mice[J].Am J Physiol Lung Cell Mol Physiol,2003,285(3):L543-L549.
[14]Steagall WK,Lin JP,Moss J.The C/A(-18)polymorphism in the surfactant protein B gene influences transcription and protein levels of surfactant protein B[J].Am J Physiol Lung Cell Mol Physiol,2007,292(2):448-453.
[15]王晓磊,梅花.肺表面活性蛋白-B、三磷酸腺苷结合盒转运子A3基因变异与新生儿呼吸窘迫综合征的研究进展[J].中华围产医学杂志,2016,19(2):157-160.
[16]Tibboel J,Reiss I,de Jongste JC,et al.Sphingolipids in lung growth and repair[J].Chest,2014,145(1):120-128.
[17]Dahmer MK,O'Cain P,Patwari PP,et al.The influence of genetic variation in surfactant protein B on severe lung injury in African American children[J].Crit Care Med,2011,39(5):1138-1144.
[18]王晶,梅花.肺表面活性蛋白B、C与新生儿肺疾病关系的研究进展[J].中国新生儿科杂志,2015,30(5):387-389.
[19]陈冲,封志纯.支气管肺发育不良分子遗传学研究进展[J].实用儿科临床杂志,2012,27(16):1282-1284.
[20]Keller RL,Merrill JD,Black DM,et al.Late administration of surfactant replacement therapy increases surfactant protein-Bcontent:a randomized pilot study[J].Pediatr Res,2012,72(6):613-619.
[21]Liu W,Bentley CM,Joanna F.Study of human SP-A,SP-Band SP-D loci:allele frequencies,linkage disequilibrium and heterozygosity in different races and ethnic groups[J].BMCGenet,2003,4(1):13.