多组分一锅法合成N-取代-4-羟基-2-吡啶酮
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摘要
以3-氧代戊二酸二酯、N,N-二甲基甲酰胺二甲基缩醛(DMF-DMA)、伯胺为原料,L-脯氨酸为催化剂,多组分一步构建了以4-羟基-2-吡啶酮为母核的一系列化合物,并通过核磁、高分辨质谱等确证了其结构.该方法操作简便,无需中间体的分离,为4-羟基-2-吡啶酮类化合物的合成提供了便捷的方法,且溶剂参与反应,从而丰富了母体5位取代基的多样性.
A series of 4-hydroxyl-2-pyridone derivatives were synthesized via a one-pot and multicomponent reaction of dimethyl 3-oxopentanedioate, N,N-dimethylformamide dimethyl acetal(DMF-DMA) and primary amine in aliphatic alcohol by using L-proline as catalyst. The structures of these compounds were confirmed by NMR and HRMS. This work provides a convenient method for construction of pyridones with the advantages of operation simplicity, free of isolating intermediates etc. Moreover, the participation of solvent in the reaction enriched the diversity of 5-substitution in the pyridone backbone.
A series of 4-hydroxyl-2-pyridone derivatives were synthesized via a one-pot and multicomponent reaction of dimethyl 3-oxopentanedioate, N,N-dimethylformamide dimethyl acetal(DMF-DMA) and primary amine in aliphatic alcohol by using L-proline as catalyst. The structures of these compounds were confirmed by NMR and HRMS. This work provides a convenient method for construction of pyridones with the advantages of operation simplicity, free of isolating intermediates etc. Moreover, the participation of solvent in the reaction enriched the diversity of 5-substitution in the pyridone backbone.
引文
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