基于藏药药性理论的藏药复方制剂安全性评价研究思考
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摘要
本研究主要通过分析藏医方剂基本规律,结合现代中药毒性研究的方法和成果,提出基于藏药药性理论的含毒性药材藏药复方制剂安全性的研究思路。在藏医药文献、临床数据及藏药药性理论的基础上,开展藏药复方制剂的安全性研究,有助于完善对藏药复方制剂的认识,并有助于科学地阐释藏药复方制剂本质,正确评价和客观对待藏药的不良反应和毒副作用。
This study was aimed to investigate study thoughts on the safety of Tibetan medicine compound preparation contained toxin herbs based on theory of medicine property in Tibetan medicine through the analysis of the basic rules of Tibetan medicine prescriptions in combination with the methods and results of modern Chinese medicine toxicity research.Based on Tibetan medicine literatures,clinical data and theory of medicine property in Tibetan medicine,the study on safety of Tibetan medicine compound preparation was carried on.This study contributed to the understanding of Tibetan medicine compound preparation and the scientific interpretation of the intrinsic quality of Tibetan medicine compound preparation,as well as the correct evaluation and objective attitude towards the adverse reactions,toxic and side effects of Tibetan medicine.
This study was aimed to investigate study thoughts on the safety of Tibetan medicine compound preparation contained toxin herbs based on theory of medicine property in Tibetan medicine through the analysis of the basic rules of Tibetan medicine prescriptions in combination with the methods and results of modern Chinese medicine toxicity research.Based on Tibetan medicine literatures,clinical data and theory of medicine property in Tibetan medicine,the study on safety of Tibetan medicine compound preparation was carried on.This study contributed to the understanding of Tibetan medicine compound preparation and the scientific interpretation of the intrinsic quality of Tibetan medicine compound preparation,as well as the correct evaluation and objective attitude towards the adverse reactions,toxic and side effects of Tibetan medicine.
引文
1拉毛才让,华尖本.藏药方剂的发展现状浅析.中国民族医药杂志,2014(10):40—41.
2任小巧,毛萌,郭慧娟.藏药矿物药的认识及研究思路.中华中医药杂志,2016,31(1):21-24.
3卢海儒,刘志勤.二十五味松石丸引起严重肾功能损害.药物不良反应杂志,2003(6):413.
4端智才让.藏药25味松石丸治疗淤胆型肝炎20例疗效观察.中国民族民间医药杂志,2000(2):83.
5张增珠,李刚,吴地尧,等.六味安消胶囊致临床不良反应2例.中国药师,2009(10):1456。
6孙红娟.五味麝香丸急性中毒103例报告.西藏医药杂志,2002(5):26—27.
7董燕飞,王聿成,王璞.《中国药典》藏药成方制剂的不良反应文献分析.云南中医学院学报,2012,35(4):14-17.
8叶祖光,张广平.中药安全性评价的发展、现状及其对策.中国实验方剂学杂志,2014,20(16):1-6.
9赵红玉,周春祥.基于药、毒效成分辨证关系探讨有毒中药研究思路.中草药,2008,39(11):1601—1604.
10王伽伯,高月,肖小河.从何首乌肝损害论符合中药安全用药需求的毒性评控方法(摘要).中华中医药学会2014第七次临床中药学术研讨会论文集,2014.
11格桑次仁.藏药不良反应初探.中国民族医药杂志,2007(4):27—28.
12任小巧,毛萌,郭慧娟,等.藏药药性理论及其对现代藏药药性理论研究的启示.世界科学技术-中医药现代化,2015,17(9):1911—1916.
13杨畅,李飞,侯跃飞,等.诃子草乌配伍与诃子制草乌水煎液中生物碱含量的比较-诃子制草乌炮制原理探讨Ⅱ.中国实验方剂学杂志,2013,19(4):130.
14李发美,熊志立,鹿秀梅,等.中药质量控制和评价模式的发展及系统生物学对其的作用.世界科学技术-中医药现代化,2009,11(1):120-126.
15 Hopkins A L.Network pharmacology:the next paradigmin drug discovery.Nat Chew,Biol,2008,4(11):682-690.
16 Nicholson J K,Connelly J,Lindon J C,et al.Metabonomics:a platform for studying drug toxicity and gene function.Nat Rev Drug Discov,2002,1(2):153-161.
17范刚,周林,赖先荣,等.基于代谢组学的中药质量控制研究思路探讨.世界科学技术-中医药现代化,2010,12(6):870-875.
18 Li L,Sun B,Zhang Q,et al.Metabonomic study on thetoxicity of HeiShun-Pian,the processed lateral root of Aconitum carmichael Debx.(Ranunculaceae).J Ethnopharmacol,2008,116(3):561-568.
19邝婷婷,张海伟,陈一龙,等.藏药三果汤散干预高原红细胞增多症模型大鼠的代谢组学研究.世界科学技术-中医药现代化,2014,16(1):171-176.
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2任小巧,毛萌,郭慧娟.藏药矿物药的认识及研究思路.中华中医药杂志,2016,31(1):21-24.
3卢海儒,刘志勤.二十五味松石丸引起严重肾功能损害.药物不良反应杂志,2003(6):413.
4端智才让.藏药25味松石丸治疗淤胆型肝炎20例疗效观察.中国民族民间医药杂志,2000(2):83.
5张增珠,李刚,吴地尧,等.六味安消胶囊致临床不良反应2例.中国药师,2009(10):1456。
6孙红娟.五味麝香丸急性中毒103例报告.西藏医药杂志,2002(5):26—27.
7董燕飞,王聿成,王璞.《中国药典》藏药成方制剂的不良反应文献分析.云南中医学院学报,2012,35(4):14-17.
8叶祖光,张广平.中药安全性评价的发展、现状及其对策.中国实验方剂学杂志,2014,20(16):1-6.
9赵红玉,周春祥.基于药、毒效成分辨证关系探讨有毒中药研究思路.中草药,2008,39(11):1601—1604.
10王伽伯,高月,肖小河.从何首乌肝损害论符合中药安全用药需求的毒性评控方法(摘要).中华中医药学会2014第七次临床中药学术研讨会论文集,2014.
11格桑次仁.藏药不良反应初探.中国民族医药杂志,2007(4):27—28.
12任小巧,毛萌,郭慧娟,等.藏药药性理论及其对现代藏药药性理论研究的启示.世界科学技术-中医药现代化,2015,17(9):1911—1916.
13杨畅,李飞,侯跃飞,等.诃子草乌配伍与诃子制草乌水煎液中生物碱含量的比较-诃子制草乌炮制原理探讨Ⅱ.中国实验方剂学杂志,2013,19(4):130.
14李发美,熊志立,鹿秀梅,等.中药质量控制和评价模式的发展及系统生物学对其的作用.世界科学技术-中医药现代化,2009,11(1):120-126.
15 Hopkins A L.Network pharmacology:the next paradigmin drug discovery.Nat Chew,Biol,2008,4(11):682-690.
16 Nicholson J K,Connelly J,Lindon J C,et al.Metabonomics:a platform for studying drug toxicity and gene function.Nat Rev Drug Discov,2002,1(2):153-161.
17范刚,周林,赖先荣,等.基于代谢组学的中药质量控制研究思路探讨.世界科学技术-中医药现代化,2010,12(6):870-875.
18 Li L,Sun B,Zhang Q,et al.Metabonomic study on thetoxicity of HeiShun-Pian,the processed lateral root of Aconitum carmichael Debx.(Ranunculaceae).J Ethnopharmacol,2008,116(3):561-568.
19邝婷婷,张海伟,陈一龙,等.藏药三果汤散干预高原红细胞增多症模型大鼠的代谢组学研究.世界科学技术-中医药现代化,2014,16(1):171-176.
http://news.xinhuanet.com