丁苯酞联合抗氧化治疗对脑梗死合并糖尿病周围神经病变患者神经营养状态及细胞氧化损伤的影响
|
摘要
目的:研究丁苯酞联合抗氧化治疗对脑梗死合并糖尿病周围神经病变患者神经营养状态及细胞氧化损伤的影响。方法:选择我院收治的脑梗死合并糖尿病周围神经病变患者,随机分为接受常规治疗的对照组、接受丁苯酞联合抗氧化治疗的观察组。治疗前及治疗后4周,测定血清中细胞因子及氧化损伤标志物的含量。结果:两组治疗后的血清脑源性神经营养因子(BDNF)、胰岛素样生长因子-I(IGFI)、血管内皮生长因子(VEGF)、血管内皮细胞生长因子(PD-ECGF)、总抗氧化力(T-AOC)含量均明显升高,巨噬细胞移动抑制因子(MIF)、肿瘤坏死因子-α(TNF-α)、趋化因子配体16(CXCL16)、活化白细胞细胞黏附分子(ALCAM)、血小板内皮细胞黏附分子-1(PECAM-1)、丙二醛(MDA)、8-异前列腺素F2α(8-iso-PGF2α)、8-羟基脱氧鸟苷酸(8-OHdG)含量均明显降低且观察组治疗后的血清BDNF、IGFI、VEGF、PD-ECGF、T-AOC含量明显高于对照组,MIF、TNF-α、CXCL16、ALCAM、PECAM-1、MDA、8-iso-PGF2α、8-OHdG含量明显低于对照组。结论:丁苯酞联合抗氧化治疗脑梗死合并糖尿病周围神经病变能够改善神经营养状态、减轻细胞氧化损伤。
Objective:To study the effects of butyphthalide combined with antioxidant therapy on neurotrophic status and cellular oxidative damage in patients with cerebral infarction complicated by diabetic peripheral neuropathy.Methods:The patients with cerebral infarction complicated by diabetic peripheral neuropathy admitted to our hospital between January 2017 and December 2017 were selected and randomly divided into the control group receiving conventional therapy and the observation group receiving butyphthalide combined with antioxidant therapy.The contents of cytokines and oxidative damage markers in serum were measured before treatment and 4 weeks after treatment.Results:Serum brain-derived neurotrophic factor(BDNF),insulin-like growth factor-I(IGF-I),vascular endothelial growth factor(VEGF),platelet-derived endothelial cell growth factor(PD-ECGF)and total antioxidant capacity(T-AOC)levels of both groups significantly increased whereas macrophage migration inhibitory factor(MIF),tumor necrosis factor-α(TNF-α),chemokine ligand 16(CXCL16),activated leukocyte cell adhesion molecule(ALCAM),platelet endothelial cell adhesion molecule-1(PECAM-1),malondialdehyde(MDA),8-isoprostaglandin F2α(8-iso-PGF2α)and 8-hydroxy-2-deoxyguanosine(8-OHdG)levels significantly decreased after treatment.Besides,serum BDNF,IGF-I,VEGF,PD-ECGF and T-AOC levels of the observation group after treatment were significantly higher than those of the control group whereas MIF,TNF-α,CXCL16,ALCAM,PECAM-1,MDA,8-iso-PGF2αand 8-OHdG levels were significantly lower than those of the control group.Conclusion:Butyphthalide combined with antioxidant therapy in treatment of cerebral infarction complicated by diabetic peripheral neuropathy can improve the neurotrophic status and alleviate the cellular oxidative damage.
Objective:To study the effects of butyphthalide combined with antioxidant therapy on neurotrophic status and cellular oxidative damage in patients with cerebral infarction complicated by diabetic peripheral neuropathy.Methods:The patients with cerebral infarction complicated by diabetic peripheral neuropathy admitted to our hospital between January 2017 and December 2017 were selected and randomly divided into the control group receiving conventional therapy and the observation group receiving butyphthalide combined with antioxidant therapy.The contents of cytokines and oxidative damage markers in serum were measured before treatment and 4 weeks after treatment.Results:Serum brain-derived neurotrophic factor(BDNF),insulin-like growth factor-I(IGF-I),vascular endothelial growth factor(VEGF),platelet-derived endothelial cell growth factor(PD-ECGF)and total antioxidant capacity(T-AOC)levels of both groups significantly increased whereas macrophage migration inhibitory factor(MIF),tumor necrosis factor-α(TNF-α),chemokine ligand 16(CXCL16),activated leukocyte cell adhesion molecule(ALCAM),platelet endothelial cell adhesion molecule-1(PECAM-1),malondialdehyde(MDA),8-isoprostaglandin F2α(8-iso-PGF2α)and 8-hydroxy-2-deoxyguanosine(8-OHdG)levels significantly decreased after treatment.Besides,serum BDNF,IGF-I,VEGF,PD-ECGF and T-AOC levels of the observation group after treatment were significantly higher than those of the control group whereas MIF,TNF-α,CXCL16,ALCAM,PECAM-1,MDA,8-iso-PGF2αand 8-OHdG levels were significantly lower than those of the control group.Conclusion:Butyphthalide combined with antioxidant therapy in treatment of cerebral infarction complicated by diabetic peripheral neuropathy can improve the neurotrophic status and alleviate the cellular oxidative damage.
引文
1 Chen YY,Yen YF,Lin JX,et al.Risk of ischemic stroke,hemorrhagic stroke,and all-cause mortality in retinal vein occlusion:a nationwide population-based cohort study[J].J Ophthalmol,2018,9(2018):8629429.
2 Sarfo FS,Mobula LM,Plange-Rhule J,et al.Incident stroke among Ghanaians with hypertension and diabetes:A multicenter,prospective cohort study[J].J Neurol Sci,2018,13(395):17-24.
3 邵淋淋,陈良富,方跃屏,等.丁苯酞注射液对急性脑梗死患者疗效及侧支代偿血管建立的影响[J].浙江临床医学,2018,20(4):616-618.
4 范勤毅,干静,王晓蓉,等.抗氧化药物添加治疗急性脑梗死合并2型糖尿病的疗效观察[J].中风与神经疾病杂志,2018,35(2):131-135.
5 中华医学会神经病学分会?偊b中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
6 Stanne TM,berg ND,Nilsson S,et al.Low circulating acute brain-derived neurotrophic factor levels are associated with poor long-term functional outcome after ischemic stroke[J].Stroke,2016,47(7):1943-1945.
7 berg ND,berg D,Jood K,et al.Altered levels of circulating insulin-like growth factor I(IGF-I)following ischemic stroke are associated with outcome-aprospective observational study[J].BMC Neurol,2018,18(1):106.
8 钱淑霞,沈宇斐,张晓玲,等.2型糖尿病对脑梗死患者血小板衍生内皮细胞生长因子和血管内皮细胞生长因子的影响[J].中国临床药理学杂志,2018,34(7):783-785,792.
9 Horváth E,Huanu A,Chiriac L,et al.Ischemic damage and early inflammatory infiltration are different in the core and penumbra lesions of rat brain after transient focal cerebral ischemia[J].J Neuroimmunol,2018,15(324):35-42.
10 Xu T,Pu S,Ni Y,et al.Elevated plasma macrophage migration inhibitor factor as a risk factor for the development of post-stroke depression in ischemic stroke[J].J Neuroimmunol,2018,15(320):58-63.
11 贾二娟.血清Hcy、hs-CRP、IL-6和TNF-α水平与急性脑梗死严重程度的关系[J].实验与检验医学,2017,35(3):382-384.
12 Jin G.The relationship between serum CXCL16level and carotid vulnerable plaque in patients with ischemic stroke[J].Eur Rev Med Pharmacol Sci,2017,21(17):3911-3915.
13 谭志勇.急性脑卒中患者血清炎症细胞因子水平变化及临床意义[J].西南国防医药,2016,26(10):1107-1110.
14 卫静,吴巍,杨璐,等.2型糖尿病合并急性脑梗死患者血糖波动对体内氧化应激及炎症因子水平的影响及意义[J].现代生物医学进展,2018,18(6):1081-1084,116.
15 张同庆.急性脑梗死患者颈动脉粥样硬化与血清HCY、MDA、SOD的关系[J].医学检验与临床,2018,29(2):37-39.
16 Marks KJ,Hartman TJ,Judd SE,et al.Dietary oxidative balance scores and biomarkers of inflammation among individuals with and without chronic kidney disease[J].Nephron Extra,2018,8(2):11-23.
2 Sarfo FS,Mobula LM,Plange-Rhule J,et al.Incident stroke among Ghanaians with hypertension and diabetes:A multicenter,prospective cohort study[J].J Neurol Sci,2018,13(395):17-24.
3 邵淋淋,陈良富,方跃屏,等.丁苯酞注射液对急性脑梗死患者疗效及侧支代偿血管建立的影响[J].浙江临床医学,2018,20(4):616-618.
4 范勤毅,干静,王晓蓉,等.抗氧化药物添加治疗急性脑梗死合并2型糖尿病的疗效观察[J].中风与神经疾病杂志,2018,35(2):131-135.
5 中华医学会神经病学分会?偊b中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
6 Stanne TM,berg ND,Nilsson S,et al.Low circulating acute brain-derived neurotrophic factor levels are associated with poor long-term functional outcome after ischemic stroke[J].Stroke,2016,47(7):1943-1945.
7 berg ND,berg D,Jood K,et al.Altered levels of circulating insulin-like growth factor I(IGF-I)following ischemic stroke are associated with outcome-aprospective observational study[J].BMC Neurol,2018,18(1):106.
8 钱淑霞,沈宇斐,张晓玲,等.2型糖尿病对脑梗死患者血小板衍生内皮细胞生长因子和血管内皮细胞生长因子的影响[J].中国临床药理学杂志,2018,34(7):783-785,792.
9 Horváth E,Huanu A,Chiriac L,et al.Ischemic damage and early inflammatory infiltration are different in the core and penumbra lesions of rat brain after transient focal cerebral ischemia[J].J Neuroimmunol,2018,15(324):35-42.
10 Xu T,Pu S,Ni Y,et al.Elevated plasma macrophage migration inhibitor factor as a risk factor for the development of post-stroke depression in ischemic stroke[J].J Neuroimmunol,2018,15(320):58-63.
11 贾二娟.血清Hcy、hs-CRP、IL-6和TNF-α水平与急性脑梗死严重程度的关系[J].实验与检验医学,2017,35(3):382-384.
12 Jin G.The relationship between serum CXCL16level and carotid vulnerable plaque in patients with ischemic stroke[J].Eur Rev Med Pharmacol Sci,2017,21(17):3911-3915.
13 谭志勇.急性脑卒中患者血清炎症细胞因子水平变化及临床意义[J].西南国防医药,2016,26(10):1107-1110.
14 卫静,吴巍,杨璐,等.2型糖尿病合并急性脑梗死患者血糖波动对体内氧化应激及炎症因子水平的影响及意义[J].现代生物医学进展,2018,18(6):1081-1084,116.
15 张同庆.急性脑梗死患者颈动脉粥样硬化与血清HCY、MDA、SOD的关系[J].医学检验与临床,2018,29(2):37-39.
16 Marks KJ,Hartman TJ,Judd SE,et al.Dietary oxidative balance scores and biomarkers of inflammation among individuals with and without chronic kidney disease[J].Nephron Extra,2018,8(2):11-23.