四川省2000～2017年麻风病流行病学特征分析
|
摘要
目的调查2000~2017年四川省新发麻风病病例的流行病学特征,为麻风病防治决策提供参考。方法搜集2000~2017年四川省所有新发麻风病患者的资料,采用SPSS 19.0软件对其流行病学特征进行统计分析。结果 2000~2017年全省新发麻风病例3 082例,其中男性2 197例(71.28%),女性885例(28.72%);儿童病例(≤14岁)82例(2.66%);2级畸残者614例(19.92%)。男性麻风病患者平均年龄大于女性(41.64±14.26 vs.38.89±15.12岁,P<0.05)。男性麻风病患者2级畸残率高于女性(20.94%vs. 17.40%,P<0.05)。麻风病发现方式以自报为最多,而接触者检查组的男女比例显著低于皮肤科就诊组、自报组、线索检查组和报病组(男女比例分别为:1.57、2.38、2.88、2.48、2.37,P<0.05)。结论四川省2000~2017年麻风病发病率呈现逐年下降趋势,高流行地区、男性新发病例下降更为显著。女性麻风病患者初诊年龄更年轻,畸残情况更少。发现方式以自报为最多,女性发现方式更为被动。
Objectives To analyze epidemiological characteristics of leprosy in Sichuan province from 2000 to 2017. Methods Case data of all new leprosy patients in Sichuan province from 2000 to 2017 were collected. A retrospective analysis of its epidemiological characteristics was performed by using SPSS 19.0 software. Results A total of 3 208 cases of leprosy were detected during 2000 to 2017, of whom 2 197(71.28%) were male, 885(28.72%) were female.The younger cases whose ages were less than 14 were 82(2.66%), and the cases with grade 2 disabilities were 614(19.92%).The mean age of male was older than female(41.64±14.26 vs. 38.89±15.12 years, P<0.05). The grade 2 disability rate ofmale was significantly higher than that of female(20.94% vs. 17.40%, P<0.05). Self-report was the most common method of discovery. But the ratio of male who were detected through contact examination was significantly lower than that detected through dermatological clinic, self-report, clues check and report(the ratio of male to female was 1.57, 2.38, 2.88,2.48, 2.37, respectively, P<0.05). Conclusions The case detection of leprosy declines annually in Sichuan province from2000 to 2017, especially in high-endemic area and male patients. Female patients are younger than male patients when they are detected. The grade 2 disability situation of male patients is significantly more serious than that of female patients.Self-report is the most common way of discovery, while women are more passive.
Objectives To analyze epidemiological characteristics of leprosy in Sichuan province from 2000 to 2017. Methods Case data of all new leprosy patients in Sichuan province from 2000 to 2017 were collected. A retrospective analysis of its epidemiological characteristics was performed by using SPSS 19.0 software. Results A total of 3 208 cases of leprosy were detected during 2000 to 2017, of whom 2 197(71.28%) were male, 885(28.72%) were female.The younger cases whose ages were less than 14 were 82(2.66%), and the cases with grade 2 disabilities were 614(19.92%).The mean age of male was older than female(41.64±14.26 vs. 38.89±15.12 years, P<0.05). The grade 2 disability rate ofmale was significantly higher than that of female(20.94% vs. 17.40%, P<0.05). Self-report was the most common method of discovery. But the ratio of male who were detected through contact examination was significantly lower than that detected through dermatological clinic, self-report, clues check and report(the ratio of male to female was 1.57, 2.38, 2.88,2.48, 2.37, respectively, P<0.05). Conclusions The case detection of leprosy declines annually in Sichuan province from2000 to 2017, especially in high-endemic area and male patients. Female patients are younger than male patients when they are detected. The grade 2 disability situation of male patients is significantly more serious than that of female patients.Self-report is the most common way of discovery, while women are more passive.
引文
1 WHO. Enhanced global strategy for further reducing the disease burden due to leprosy. New Delhi:WHO Regional Office for South-East Asia, 2009:22-24.
2 WHO. Global leprosy update, 2013:reducing disease burden. Wkly Epidemiol Rec,2014, 89(36):389-400.
3 WHO. Global leprosy update, 2014:need for early case detection.Wkly Epidemiol Rec, 2015, 90(36):461-474.
4 WHO. Global leprosy update, 2015:time for action, accountability and inclusion. Wkly Epidemiol Rec, 2015, 91(35):405-420.
5刘杨英,宁湧,王皓,等.2000-2014年四川省麻风病流行特征分析.中国皮肤病性病杂志,2016, 35(4):362-365.
6余美文,张过程,严良斌,等.2001-2011年中国麻风病流行病学特征分析.中华皮肤科杂志,2012,45(6):381-383.
7 van Veen NH, Meima A, Richardus JH. The relationship between detection delay and impairment in leprosy control:a comparison of patient cohorts from Bangladesh and Ethiopia. Lepr Rev, 2006,77(4):356-365.
8 Varkevisser CM, Lever P, Alubo O, et al. Gender and leprosy:case studies in Indonesia, Nigeria, Nepal and Brazil. Lepr Rev, 2009,80(1):65-76.
9 Arora M, Katoch K, Natrajan M, et al. Changing profile of disease in leprosy patients diagnosed in a tertiary care centre during years1995-2000. Indian J Lepr, 2008, 80(3):257-265.
10 Peters ES, Eshiet AL. Male-female(sex)differences in leprosy patients in south eastern Nigeria:females present late for diagnosis and treatment and have higher rates of deformity. Lepr Rev, 2002,73(3):262-267.
11 Arora M, Katoch K, Natrajan M, et al. Changing profile of disease in leprosy patients diagnosed in a tertiary care centre during years1995-2000. Indian J Lepr, 2008, 80(3):257-265.
12 Lockwood DN,Sinha HH. Pregnancy and leprosy:a comprehensive literature review. Int J Lepr Other Mycobact Dis,1999, 67(1):6-12.
13 Sarkar R, Pradhan S. Leprosy and women. Int J Womens Dermatol,2016,2(4):117-121.
14 Kumar RB, Singhasivanon P, Sherchand JB, et al. Gender differences in epidemiological factors associated with treatment completion status of leprosy patients in the most hyperendemic district of Nepal. Southeast Asian J Trop Med Public Health, 2004,35(2):334-339.
15 Guerrero MI, Muvdi S, Leon CI. Delay in leprosy diagnosis as a predictor of disability in a cohort of patients in Colombia, 2000-2010. Rev Panam Salud Publica, 2013, 33(2):137-143.
16 Tiendrebeogo A, Coulibalv I, Sarr AM, et al. Nature and sensitivity of bacteria super infecting plantar ulcers caused by leprosy at the marchoux institute, Bamako, Mali. Acta Leprol, 1999, 11(2):153-159.
17 Kunst H. Predisposing factors for recurrent skin ulcers in leprosy.Lepr Rev, 2000, 71(3):363-368.
18 Britton WJ, Lockwood DN. Leprosy. Lancet, 2004, 363(9416):1209-1219.
2 WHO. Global leprosy update, 2013:reducing disease burden. Wkly Epidemiol Rec,2014, 89(36):389-400.
3 WHO. Global leprosy update, 2014:need for early case detection.Wkly Epidemiol Rec, 2015, 90(36):461-474.
4 WHO. Global leprosy update, 2015:time for action, accountability and inclusion. Wkly Epidemiol Rec, 2015, 91(35):405-420.
5刘杨英,宁湧,王皓,等.2000-2014年四川省麻风病流行特征分析.中国皮肤病性病杂志,2016, 35(4):362-365.
6余美文,张过程,严良斌,等.2001-2011年中国麻风病流行病学特征分析.中华皮肤科杂志,2012,45(6):381-383.
7 van Veen NH, Meima A, Richardus JH. The relationship between detection delay and impairment in leprosy control:a comparison of patient cohorts from Bangladesh and Ethiopia. Lepr Rev, 2006,77(4):356-365.
8 Varkevisser CM, Lever P, Alubo O, et al. Gender and leprosy:case studies in Indonesia, Nigeria, Nepal and Brazil. Lepr Rev, 2009,80(1):65-76.
9 Arora M, Katoch K, Natrajan M, et al. Changing profile of disease in leprosy patients diagnosed in a tertiary care centre during years1995-2000. Indian J Lepr, 2008, 80(3):257-265.
10 Peters ES, Eshiet AL. Male-female(sex)differences in leprosy patients in south eastern Nigeria:females present late for diagnosis and treatment and have higher rates of deformity. Lepr Rev, 2002,73(3):262-267.
11 Arora M, Katoch K, Natrajan M, et al. Changing profile of disease in leprosy patients diagnosed in a tertiary care centre during years1995-2000. Indian J Lepr, 2008, 80(3):257-265.
12 Lockwood DN,Sinha HH. Pregnancy and leprosy:a comprehensive literature review. Int J Lepr Other Mycobact Dis,1999, 67(1):6-12.
13 Sarkar R, Pradhan S. Leprosy and women. Int J Womens Dermatol,2016,2(4):117-121.
14 Kumar RB, Singhasivanon P, Sherchand JB, et al. Gender differences in epidemiological factors associated with treatment completion status of leprosy patients in the most hyperendemic district of Nepal. Southeast Asian J Trop Med Public Health, 2004,35(2):334-339.
15 Guerrero MI, Muvdi S, Leon CI. Delay in leprosy diagnosis as a predictor of disability in a cohort of patients in Colombia, 2000-2010. Rev Panam Salud Publica, 2013, 33(2):137-143.
16 Tiendrebeogo A, Coulibalv I, Sarr AM, et al. Nature and sensitivity of bacteria super infecting plantar ulcers caused by leprosy at the marchoux institute, Bamako, Mali. Acta Leprol, 1999, 11(2):153-159.
17 Kunst H. Predisposing factors for recurrent skin ulcers in leprosy.Lepr Rev, 2000, 71(3):363-368.
18 Britton WJ, Lockwood DN. Leprosy. Lancet, 2004, 363(9416):1209-1219.