天麻中巴利森苷类化合物的结构解析研究进展
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摘要
天麻是传统名贵中药,收载于《中国药典》(2015年版一部),临床多用于治疗头痛目眩,肢体麻木等症,具有保护神经、镇静催眠、增强免疫力等药理学作用。巴利森苷(parishin)是天麻的主要活性成分之一,不仅含量高,且衍生产物多样,并具有改善记忆、抗抑郁等药理作用。本文从化学结构命名与结构解析方面对巴利森苷的研究进展进行综述,为天麻中新的巴利森苷类化合物的发现及规范命名提供借鉴。
The rhizomes of Gastrodia elata Blume,used under the name of Tianma,have long been used as a traditional Chinese medicine. This drug is prescribed for the treatment of headaches,dizziness and convulsion. It is said to have beneficial properties for expelling all kinds of toxins,enhancing strength,and improving the circulation and the memory. Previous phytochemical investigations found that parishins and gastrodin were the major constituents of this plant. Some papers have reported the research progresses on gastrodin,however papers on parishin were few. Recent studies on Tianma found that parishins is a class of active ingredients and the content is high. Its pharmacological activity was mainly focused on memory improvement and anti-depression. In this paper,we reviewed the progress on structure analysis based on NMR and MS technology. A more systematic atom nomenclature for parishins is proposed for the description of the structure. The proposed nomenclature was aimed to provide references for further discovery and nomenclature of parishins.
The rhizomes of Gastrodia elata Blume,used under the name of Tianma,have long been used as a traditional Chinese medicine. This drug is prescribed for the treatment of headaches,dizziness and convulsion. It is said to have beneficial properties for expelling all kinds of toxins,enhancing strength,and improving the circulation and the memory. Previous phytochemical investigations found that parishins and gastrodin were the major constituents of this plant. Some papers have reported the research progresses on gastrodin,however papers on parishin were few. Recent studies on Tianma found that parishins is a class of active ingredients and the content is high. Its pharmacological activity was mainly focused on memory improvement and anti-depression. In this paper,we reviewed the progress on structure analysis based on NMR and MS technology. A more systematic atom nomenclature for parishins is proposed for the description of the structure. The proposed nomenclature was aimed to provide references for further discovery and nomenclature of parishins.
引文
[1]中国药典[S].一部.2015.
[2]南京中医药大学,中药大词典,上册[S].上海:上海科学技术出版社,2006:429-432.
[3]周碧乾,齐路明,马云桐,等.天麻初加工方法对主要成分含量的影响及加工方法的化学模式识别[J].天然产物研究与开发,2018,30(5):736-743+869.
[4]王庆,李丹丹,潘芸芸,等.西南地区三种天麻变型巴利森苷类成分含量比较[J].天然产物研究与开发,2018:1-9.
[5]王信,王徽,曹广尚,等.天麻清蒸过程中7种化学成分变化规律研究及分析[J].中国医院药学杂志,2018(6):1-5.
[6]康传志,蒋靖怡,杨婉珍,等.不同贮藏时间硫熏天麻化学成分及二氧化硫变化规律研究[J].中国中药杂志,2018,43(2):261-266.
[7]吴仲珍,刘丽丹,陈旭东,等.壳寡糖处理对天麻贮藏品质的影响[J].保鲜与加工,2014,14(2):21-24+29.
[8]秦俊哲,张洁,周涵.不同炮制方法对天麻素含量的影响[J].中药材,2006,(12):1285-1288.
[9]李运曼,陈芳萍,刘国卿.天麻素抗谷氨酸和氧自由基诱导的PC12细胞损伤的研究[J].中国药科大学学报,2003,(5):70-74.
[10]Dahmén,JK Leander,The structure of parishin,a glucoside from Vanda parishii[J].Phytochemistry,1976.15(12):1986-1987.
[11]Taguchi,H,I Yosioka,K Yamasaki,I Kim,Studies on the Constituents of Gastrodia elata BLUME[J].Chemical&Pharmaceutical Bulletin,1981.29(1):55-62.
[12]Jer-Huei,L,L Yi-Chu,H Jiing-Ping,W Kuo-Ching,Parishins B and C from rhizomes of Gastrodia elata[J].Phytochemistry,1996.42(2):549-551.
[13]Yang,X-D,J Zhu,R Yang,J-P Liu,L Li,H-BZhang,Phenolic constituents from the rhizomes of Gastrodia elata[J].Natural Product Research,2007.21(2):180-186.
[14]Wang,L,H-B Xiao,L Yang,Z-T Wang,Two new phenolic glycosides from the rhizome of Gastrodia elata[J].Journal of Asian Natural Products Research,2012.14(5):457-462.
[15]Li,Z,Y Wang,H Ouyang,Y Lu,Y Qiu,Y Feng,H Jiang,X Zhou,S Yang,A novel dereplication strategy for the identification of two new trace compounds in the extract of Gastrodia elata using UHPLC/Q-TOF-MS/MS[J].Journal of Chromatography B,2015.988:45-52.
[16]肖红斌,王莉,彭杰.同时制备parishin、parishin B、parishin C化学对照品的方法[P].2011.
[17]赵静.三七中皂苷类成分的裂解规律探究及其化学特征的道地性研究[D].北京:北京中医药大学,2015.
[18]Ma,F-W,B Xia,S-H Luo,S-H Li,Y Zhou,Analysis of the lithiated leucosceptroids from Leucosceptrum canum to facilitate their identification and differentiation by electrospray ionization tandem mass spectrometry[J].Rapid Communications in Mass Spectrometry,2016.30:100-110.
[19]Wang,L,H Xiao,X Liang,L Wei,Identification of phenolics and nucleoside derivatives in Gastrodia elata by HPLC-UV-MS[J].Journal of Separation Science,2007.30(10):1488-1495.
[20]尹珉,毛克臣,陈志峰,等.不同炮制方法对天麻中天麻素含量的影响[J].中国中医药信息杂志,2010,17(7):49-50.
[21]王莉.天麻化学物质基础及质量控制方法研究[D].大连:中国科学院研究生院(大连化学物理研究所),2007.
[22]康传志,吕朝耕,杨健,等.基于UPLC-MS/MS的不同主产区天麻药材质量评价研究[J].中华中医药杂志,2017,32(5):2010-2015.
[23]肖佳佳,黄红,雷有成,等.天麻HPLC指纹图谱建立及判别分析[J].中国中药杂志,2017,42(13):2524-2531.
[24]段小花,王维丽,吴霜,等.HPLC测定天麻成分对甲氧基苄醇在大鼠血液中的药代动力学参数[J].中国中医药信息杂志,2015,22(6):99-102.
[25]彭正午.天麻素的神经保护作用及其分子机制研究[D].北京:第四军医大学,2016.
[26]邢静静.高效液相色谱和近红外光谱结合化学计量学的天麻产地的识别[D].武汉:华中师范大学,2015.
[27]王信,王徽,杨飞,等.天麻中6种天麻素类成分一测多评分析法的建立[J].中草药,2018,49(3):694-699.
[2]南京中医药大学,中药大词典,上册[S].上海:上海科学技术出版社,2006:429-432.
[3]周碧乾,齐路明,马云桐,等.天麻初加工方法对主要成分含量的影响及加工方法的化学模式识别[J].天然产物研究与开发,2018,30(5):736-743+869.
[4]王庆,李丹丹,潘芸芸,等.西南地区三种天麻变型巴利森苷类成分含量比较[J].天然产物研究与开发,2018:1-9.
[5]王信,王徽,曹广尚,等.天麻清蒸过程中7种化学成分变化规律研究及分析[J].中国医院药学杂志,2018(6):1-5.
[6]康传志,蒋靖怡,杨婉珍,等.不同贮藏时间硫熏天麻化学成分及二氧化硫变化规律研究[J].中国中药杂志,2018,43(2):261-266.
[7]吴仲珍,刘丽丹,陈旭东,等.壳寡糖处理对天麻贮藏品质的影响[J].保鲜与加工,2014,14(2):21-24+29.
[8]秦俊哲,张洁,周涵.不同炮制方法对天麻素含量的影响[J].中药材,2006,(12):1285-1288.
[9]李运曼,陈芳萍,刘国卿.天麻素抗谷氨酸和氧自由基诱导的PC12细胞损伤的研究[J].中国药科大学学报,2003,(5):70-74.
[10]Dahmén,JK Leander,The structure of parishin,a glucoside from Vanda parishii[J].Phytochemistry,1976.15(12):1986-1987.
[11]Taguchi,H,I Yosioka,K Yamasaki,I Kim,Studies on the Constituents of Gastrodia elata BLUME[J].Chemical&Pharmaceutical Bulletin,1981.29(1):55-62.
[12]Jer-Huei,L,L Yi-Chu,H Jiing-Ping,W Kuo-Ching,Parishins B and C from rhizomes of Gastrodia elata[J].Phytochemistry,1996.42(2):549-551.
[13]Yang,X-D,J Zhu,R Yang,J-P Liu,L Li,H-BZhang,Phenolic constituents from the rhizomes of Gastrodia elata[J].Natural Product Research,2007.21(2):180-186.
[14]Wang,L,H-B Xiao,L Yang,Z-T Wang,Two new phenolic glycosides from the rhizome of Gastrodia elata[J].Journal of Asian Natural Products Research,2012.14(5):457-462.
[15]Li,Z,Y Wang,H Ouyang,Y Lu,Y Qiu,Y Feng,H Jiang,X Zhou,S Yang,A novel dereplication strategy for the identification of two new trace compounds in the extract of Gastrodia elata using UHPLC/Q-TOF-MS/MS[J].Journal of Chromatography B,2015.988:45-52.
[16]肖红斌,王莉,彭杰.同时制备parishin、parishin B、parishin C化学对照品的方法[P].2011.
[17]赵静.三七中皂苷类成分的裂解规律探究及其化学特征的道地性研究[D].北京:北京中医药大学,2015.
[18]Ma,F-W,B Xia,S-H Luo,S-H Li,Y Zhou,Analysis of the lithiated leucosceptroids from Leucosceptrum canum to facilitate their identification and differentiation by electrospray ionization tandem mass spectrometry[J].Rapid Communications in Mass Spectrometry,2016.30:100-110.
[19]Wang,L,H Xiao,X Liang,L Wei,Identification of phenolics and nucleoside derivatives in Gastrodia elata by HPLC-UV-MS[J].Journal of Separation Science,2007.30(10):1488-1495.
[20]尹珉,毛克臣,陈志峰,等.不同炮制方法对天麻中天麻素含量的影响[J].中国中医药信息杂志,2010,17(7):49-50.
[21]王莉.天麻化学物质基础及质量控制方法研究[D].大连:中国科学院研究生院(大连化学物理研究所),2007.
[22]康传志,吕朝耕,杨健,等.基于UPLC-MS/MS的不同主产区天麻药材质量评价研究[J].中华中医药杂志,2017,32(5):2010-2015.
[23]肖佳佳,黄红,雷有成,等.天麻HPLC指纹图谱建立及判别分析[J].中国中药杂志,2017,42(13):2524-2531.
[24]段小花,王维丽,吴霜,等.HPLC测定天麻成分对甲氧基苄醇在大鼠血液中的药代动力学参数[J].中国中医药信息杂志,2015,22(6):99-102.
[25]彭正午.天麻素的神经保护作用及其分子机制研究[D].北京:第四军医大学,2016.
[26]邢静静.高效液相色谱和近红外光谱结合化学计量学的天麻产地的识别[D].武汉:华中师范大学,2015.
[27]王信,王徽,杨飞,等.天麻中6种天麻素类成分一测多评分析法的建立[J].中草药,2018,49(3):694-699.