基于中药饮片质量常数等级评价方法的大川芎方优质优效研究
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摘要
质量常数评价方法是一种基于传统特征与质控指标有机结合的中药饮片等级评价方法。该方法已成功应用于甘草等多种中药饮片的等级评价,在行业内产生了积极的影响。该文以大川芎方为范例,在饮片等级评价的基础上,将不同等级的川芎、天麻饮片组成优质、中等、合格3个不同"等级"的大川芎方,并采用药效学方法评价其药效强弱。结果显示:3个"等级"大川芎方的最大血管舒张率分别为(80. 3±5. 2)%,(67. 0±6. 1)%,(60. 3±6. 5)%,其药效强弱与其组成饮片川芎、天麻的等级优劣成正相关。该文首次以复方的形式揭示了中药饮片质量常数等级评价方法在客观可量化的划分饮片等级的同时,对由这些饮片所组成的中药复方药效强弱亦有重要的关联和提示作用,这对推动中药饮片行业的分级管理,实行优质优价,明确优质优效具有重要意义。
Quality constant is a kind of grading evaluation method of traditional Chinese medicine pieces based on the combination of traditional knowledge and modern quality control. This method has been successfully applied in the grading evaluation of Glycyrrizae Radix et Rhizome pieces and traditional Chinese medicine pieces,and with a positive influence in the industry. With Dachuanxiong Formula for example,different grades of Ligusticum chuanxiong and Gastrodia elata pieces formed high-quality,moderate and qualified Dachuanxiong Formula on the basis of the grading evaluation of the pieces,and the pharmacodynamics method was used to evaluate its efficacy. The results showed that the maximum vascular diastolic rates of Dachuanxiong Formula in the three grades were( 80. 3±5. 2) %,( 67. 0±6. 1) %and( 60. 3±6. 5) %,and the strength of pharmacodynamics was positively correlated with the grade of L. chuanxiong and G. elata pieces.The quality constant technique can objectively and quantitatively classify single decoctions,and has important correlations and prompts for the efficacy of traditional Chinese medicine prescriptions composed of these pieces,with important significance in promoting hierarchical management of the industry,implementing better price for high quality and defining high quality and superior effect.
Quality constant is a kind of grading evaluation method of traditional Chinese medicine pieces based on the combination of traditional knowledge and modern quality control. This method has been successfully applied in the grading evaluation of Glycyrrizae Radix et Rhizome pieces and traditional Chinese medicine pieces,and with a positive influence in the industry. With Dachuanxiong Formula for example,different grades of Ligusticum chuanxiong and Gastrodia elata pieces formed high-quality,moderate and qualified Dachuanxiong Formula on the basis of the grading evaluation of the pieces,and the pharmacodynamics method was used to evaluate its efficacy. The results showed that the maximum vascular diastolic rates of Dachuanxiong Formula in the three grades were( 80. 3±5. 2) %,( 67. 0±6. 1) %and( 60. 3±6. 5) %,and the strength of pharmacodynamics was positively correlated with the grade of L. chuanxiong and G. elata pieces.The quality constant technique can objectively and quantitatively classify single decoctions,and has important correlations and prompts for the efficacy of traditional Chinese medicine prescriptions composed of these pieces,with important significance in promoting hierarchical management of the industry,implementing better price for high quality and defining high quality and superior effect.
引文
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[22]曹雪,蔡广知,赵凌,等.基于复合质量常数的北柴胡饮片等级评价[J].中国实验方剂学杂志,2018,24(18):36.
[2]邓哲,焦梦姣,章军,等.相对质量常数用于甘草饮片等级评价研究[J].中国中药杂志,2017,42(13):2492.
[3]邓哲,章军,焦梦姣,等.以质量常数为核心的黄芩饮片等级评价研究[J].中国中药杂志,2017,42(9):1673.
[4]邓哲,焦梦姣,章军,等.基于质量常数评价方法划分黄柏饮片等级研究[J].中国中药杂志,2017,42(17):3356.
[5]夏成凯,胡云飞,陈思宇,等.基于中药质量常数的牡丹皮饮片等级划分[J].中国中药杂志,2018,43(3):647.
[6]赵华叶,闫沛沛,杨文华,等.浅议中药材商品规格等级标准研究方法[J].中国中药杂志,2015,40(4):765.
[7]杨光,曾燕,郭兰萍,等.中药材商品规格等级标准研究现状及几个关键问题的商榷[J].中国中药杂志,2014,39(9):1734.
[8]汤劐菱,杨芳炬,王正荣,等.大川芎方提取物对犬脑血管张力的影响[J].四川生理科学杂志,2004,26(1):32.
[9]毛伦林,毛晓薇,顾桢茂,等.天舒胶囊对大鼠局灶性脑缺血再灌注损伤的保护作用[J].中国实验方剂学杂志,2012,18(15):144.
[10]陈士林,刘安,李琦,等.中药饮片标准汤剂研究策略[J].中国中药杂志,2016,41(8):1368.
[11]穆二廷,赵宜欢,闫攀,等.探索建立中药饮片规格等级标准[J].时珍国医国药,2018,29(3):714.
[12]翁德会,刘先琼,许腊英,等.不同等级厚朴饮片质量评价指标的系统聚类分析[J].中国实验方剂学杂志,2016,22(23):6.
[13]万军,周霞,李晓倩.天麻饮片等级研究[J].中国实验方剂学杂志,2013,19(1):342.
[14]Li C M,Guo Y Q,Dong X L,et al. Ethanolic extract of rhizome of Ligusticum chuanxiong Hort.(chuanxiong)enhances endothelium-dependent vascular reactivity in ovariectomized rats fed with high-fat diet[J].Food Funct,2014,5(10):2475.
[15]Feng L,Manavalan A,Mishra M,et al. Tianma modulates 25blood vessel tonicity[J].Op Bio,2012,6(1):56.
[16]Dai R,Wang T,Si X,et al. Vasodilatory effects and underlying mechanisms of the ethyl acetate extracts from Gastrodia elata Blume[J].Can J Physiol Pharml,2016,95(5):564.
[17]Chen C,Chen J X,Wu H W,et al.Identification of key constituents in volatile oil of Ligusticum chuanxiong based on data mining approaches[J].Pharm Biol,2011,49(5):445.
[18]Suzuki A,Yamamoto M,Jokura H,et al. Ferulic acid restores endothelium-dependent vasodilation in aortas of spontaneously hypertensive[J].Am J Hyp,2007,20(5):508.
[19]Chan S S,Cheng T Y,Lin G.Relaxation effects of ligustilide and senkyunolide A,two main constituents of Ligusticum chuanxiong,in rat isolated aorta[J].J Ethnopharmacol,2007,111(3):677.
[20]Shih C H,Lin Y J,Chen C M,et al.Butylidenephthalide antagonizes cromakalim-induced systolic pressure reduction in conscious normotensive rats[J].Bmc Com Alter Med,2015,15(1):344.
[21]李鹏英,王海洋,李健,等.中药材商品规格等级的形成和演变[J].中国中药杂志,2016,41(5):764.
[22]曹雪,蔡广知,赵凌,等.基于复合质量常数的北柴胡饮片等级评价[J].中国实验方剂学杂志,2018,24(18):36.