肝脏巨噬细胞极化在肝脏缺血再灌注损伤中的作用及机制研究进展
摘要
<正>缺血再灌注损伤(ischemia-reperfusion injury,IRI)是失血性休克、复苏、肝脏切除术、肝移植术等过程中伴随的病理生理过程,是影响肝脏功能,导致肝脏功能障碍甚至肝脏功能衰竭的关键因素[1]。肝脏IRI也是肝移植术后发生急、慢性免疫排斥反应的不利因素之一,尤其是边缘供肝对IRI高度敏感,会进一步加重器官短缺。目前,已有大量的研究深入阐明肝脏
引文
[1] NASTOS C,KALIMERIS K,PAPOUTSIDAKIS N,et al.Global consequences of liver ischemia/reperfusion injury[J].Oxid Med Cell Longev,2014.DOI:10.1155/2014/906965.
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[10] MIHM S.Danger-Associated Molecular Patterns (DAMPs):Molecular Triggers for Sterile Inflammation in the Liver[J].Int J Mol Sci,2018,19(10).DOI:10.3390/ijms19103104.
[11] BRAUN H,AFONINA I S,MUELLER C,et al.Dichotomous function of IL-33 in health and disease:From biology to clinical implications[J].Biochem Pharmacol,2018,148:238-252.
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[13] ELLETT J D,ATKINSON C,EVANS Z P,et al.Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10[J].J Immunol,2010,184(10):5849-5858.
[14] KATO A,OKAYA T,LENTSCH A B.Endogenous IL-13 protects hepatocytes and vascular endothelial cells during ischemia/reperfusion injury[J].Hepatology,2003,37(2):304-312.
[15] OLIVEIRA T H C,MARQUES P E,PROOST P,et al.Neutrophils:a cornerstone of liver ischemia and reperfusion injury[J].Lab Invest,2018,98(1):51-62.
[16] SADATOMO A,INOUE Y,ITO H,et al.Interaction of Neutrophils with Macrophages Promotes IL-1beta Maturation and Contributes to Hepatic Ischemia-Reperfusion Injury[J].J Immunol,2017,199(9):3306-3315.
[17] JAESCHKE H.Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning[J].Am J Physiol Gastrointest Liver Physiol,2003,284(1):G15-G26.
[18] YUE S,ZHOU H,WANG X,et al.Prolonged Ischemia Triggers Necrotic Depletion of Tissue-Resident Macrophages To Facilitate Inflammatory Immune Activation in Liver Ischemia Reperfusion Injury[J].J Immunol,2017,198(9):3588-3595.
[19] LIU Z J,YAN L N,LI S W,et al.Glycine blunts transplantative liver ischemia-reperfusion injury by downregulating interleukin 1 receptor associated kinase-4[J].Acta Pharmacol Sin,2006,27(11):1479-1486.
[20] KE B,SHEN X D,TSUCHIHASHI S,et al.Viral interleukin-10 gene transfer prevents liver ischemia-reperfusion injury:Toll-like receptor-4 and heme oxygenase-1 signaling in innate and adaptive immunity[J].Hum Gene Ther,2007,18(4):355-366.
[21] NAITO Y,TAKAGI T,HIGASHIMURA Y.Heme oxygenase-1 and anti-inflammatory M2 macrophages[J].Arch Biochem Biophys,2014,564:83-88.
[22] LIU B,QIAN J M.Cytoprotective role of heme oxygenase-1 in liver ischemia reperfusion injury[J].Int J Clin Exp Med,2015,8(11):19867-19873.
[23] NAKAMURA K,ZHANG M,KAGEYAMA S,et al.Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury[J].J Hepatol,2017,67(6):1232-1242.
[24] ZHANG M,NAKAMURA K,KAGEYAMA S,et al.Myeloid HO-1 modulates macrophage polarization and protects against ischemia-reperfusion injury[J].JCI Insight,2018,3(19).DOI:10.1172/jci.insight.120596.
[25] SHEN X D,KE B,UCHIDA Y,et al.Native macrophages genetically modified to express heme oxygenase 1 protect rat liver transplants from ischemia/reperfusion injury[J].Liver Transpl,2011,17(2):201-210.
[26] XU X,WANG M,LI J Z,et al.Tauroursodeoxycholic acid alleviates hepatic ischemia reperfusion injury by suppressing the function of Kupffer cells in mice[J].Biomed Pharmacother,2018,106:1271-1281.
[27] LI X,WANG J,SONG X,et al.Ketamine ameliorates ischemia-reperfusion injury after liver autotransplantation by suppressing activation of Kupffer cells in rats[J].Can J Physiol Pharmacol,2018,96(9):886-892.
[28] LI X,WU Y,ZHANG W,et al.Pre-conditioning with tanshinone ⅡA attenuates the ischemia/reperfusion injury caused by liver grafts via regulation of HMGB1 in rat Kupffer cells[J].Biomed Pharmacother,2017,89:1392-1400.
[29] LIU Y,ZHANG W,CHENG Y,et al.Activation of PPARγ by Curcumin protects mice from ischemia/reperfusion injury induced by orthotopic liver transplantation via modulating polarization of Kupffer cells[J].Int Immunopharmacol,2018,62:270-276.
[30] XIE Y,ZHAO D,DONG P,et al.Macrophage-targeting Fasudil treatment protects liver from the ischemia/reperfusion injury by promoting M2 macrophage polarization[J].Biosci Rep,2018.DOI:10.1042/BSR20171734.
[31] KANG J W,LEE S M.Resolvin D1 protects the liver from ischemia/reperfusion injury by enhancing M2 macrophage polarization and efferocytosis[J].Biochim Biophys Acta,2016,1861(9 Pt A):1025-1035.
[2] SONG P,ZHANG J,ZHANG Y,et al.Hepatic recruitment of CD11b+Ly6C+ inflammatory monocytes promotes hepatic ischemia/reperfusion injury[J].Int J Mol Med,2018,41(2):935-945.
[3] DAL-SECCO D,WANG J,ZENG Z,et al.A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury[J].J Exp Med,2015,212(4):447-456.
[4] LU T F,YANG T H,ZHONG C P,et al.Dual Effect of Hepatic Macrophages on Liver Ischemia and Reperfusion Injury during Liver Transplantation[J].Immune Netw,2018,18(3):e24.
[5] KRENKEL O,TACKE F.Liver macrophages in tissue homeostasis and disease[J].Nat Rev Immunol,2017,17(5):306-321.
[6] SARADNA A,DO D C,KUMAR S,et al.Macrophage polarization and allergic asthma[J].Transl Res,2018,191:1-14.
[7] SHAPOURI-MOGHADDAM A,MOHAMMADIAN S,VAZINI H,et al.Macrophage plasticity,polarization,and function in health and disease[J].J Cell Physiol,2018,233(9):6425-6440.
[8] TAN H Y,WANG N,LI S,et al.The Reactive Oxygen Species in Macrophage Polarization:Reflecting Its Dual Role in Progression and Treatment of Human Diseases[J].Oxid Med Cell Longev,2016.DOI:10.1155/2016/2795090.
[9] CHISTIAKOV D A,MYASOEDOVA V A,REVIN V V,et al.The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2[J].Immunobiology,2018,223(1):101-111.
[10] MIHM S.Danger-Associated Molecular Patterns (DAMPs):Molecular Triggers for Sterile Inflammation in the Liver[J].Int J Mol Sci,2018,19(10).DOI:10.3390/ijms19103104.
[11] BRAUN H,AFONINA I S,MUELLER C,et al.Dichotomous function of IL-33 in health and disease:From biology to clinical implications[J].Biochem Pharmacol,2018,148:238-252.
[12] KATO A,YOSHIDOME H,EDWARDS M J,et al.Reduced hepatic ischemia/reperfusion injury by IL-4:potential anti-inflammatory role of STAT6[J].Inflamm Res,2000,49(6):275-279.
[13] ELLETT J D,ATKINSON C,EVANS Z P,et al.Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10[J].J Immunol,2010,184(10):5849-5858.
[14] KATO A,OKAYA T,LENTSCH A B.Endogenous IL-13 protects hepatocytes and vascular endothelial cells during ischemia/reperfusion injury[J].Hepatology,2003,37(2):304-312.
[15] OLIVEIRA T H C,MARQUES P E,PROOST P,et al.Neutrophils:a cornerstone of liver ischemia and reperfusion injury[J].Lab Invest,2018,98(1):51-62.
[16] SADATOMO A,INOUE Y,ITO H,et al.Interaction of Neutrophils with Macrophages Promotes IL-1beta Maturation and Contributes to Hepatic Ischemia-Reperfusion Injury[J].J Immunol,2017,199(9):3306-3315.
[17] JAESCHKE H.Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning[J].Am J Physiol Gastrointest Liver Physiol,2003,284(1):G15-G26.
[18] YUE S,ZHOU H,WANG X,et al.Prolonged Ischemia Triggers Necrotic Depletion of Tissue-Resident Macrophages To Facilitate Inflammatory Immune Activation in Liver Ischemia Reperfusion Injury[J].J Immunol,2017,198(9):3588-3595.
[19] LIU Z J,YAN L N,LI S W,et al.Glycine blunts transplantative liver ischemia-reperfusion injury by downregulating interleukin 1 receptor associated kinase-4[J].Acta Pharmacol Sin,2006,27(11):1479-1486.
[20] KE B,SHEN X D,TSUCHIHASHI S,et al.Viral interleukin-10 gene transfer prevents liver ischemia-reperfusion injury:Toll-like receptor-4 and heme oxygenase-1 signaling in innate and adaptive immunity[J].Hum Gene Ther,2007,18(4):355-366.
[21] NAITO Y,TAKAGI T,HIGASHIMURA Y.Heme oxygenase-1 and anti-inflammatory M2 macrophages[J].Arch Biochem Biophys,2014,564:83-88.
[22] LIU B,QIAN J M.Cytoprotective role of heme oxygenase-1 in liver ischemia reperfusion injury[J].Int J Clin Exp Med,2015,8(11):19867-19873.
[23] NAKAMURA K,ZHANG M,KAGEYAMA S,et al.Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury[J].J Hepatol,2017,67(6):1232-1242.
[24] ZHANG M,NAKAMURA K,KAGEYAMA S,et al.Myeloid HO-1 modulates macrophage polarization and protects against ischemia-reperfusion injury[J].JCI Insight,2018,3(19).DOI:10.1172/jci.insight.120596.
[25] SHEN X D,KE B,UCHIDA Y,et al.Native macrophages genetically modified to express heme oxygenase 1 protect rat liver transplants from ischemia/reperfusion injury[J].Liver Transpl,2011,17(2):201-210.
[26] XU X,WANG M,LI J Z,et al.Tauroursodeoxycholic acid alleviates hepatic ischemia reperfusion injury by suppressing the function of Kupffer cells in mice[J].Biomed Pharmacother,2018,106:1271-1281.
[27] LI X,WANG J,SONG X,et al.Ketamine ameliorates ischemia-reperfusion injury after liver autotransplantation by suppressing activation of Kupffer cells in rats[J].Can J Physiol Pharmacol,2018,96(9):886-892.
[28] LI X,WU Y,ZHANG W,et al.Pre-conditioning with tanshinone ⅡA attenuates the ischemia/reperfusion injury caused by liver grafts via regulation of HMGB1 in rat Kupffer cells[J].Biomed Pharmacother,2017,89:1392-1400.
[29] LIU Y,ZHANG W,CHENG Y,et al.Activation of PPARγ by Curcumin protects mice from ischemia/reperfusion injury induced by orthotopic liver transplantation via modulating polarization of Kupffer cells[J].Int Immunopharmacol,2018,62:270-276.
[30] XIE Y,ZHAO D,DONG P,et al.Macrophage-targeting Fasudil treatment protects liver from the ischemia/reperfusion injury by promoting M2 macrophage polarization[J].Biosci Rep,2018.DOI:10.1042/BSR20171734.
[31] KANG J W,LEE S M.Resolvin D1 protects the liver from ischemia/reperfusion injury by enhancing M2 macrophage polarization and efferocytosis[J].Biochim Biophys Acta,2016,1861(9 Pt A):1025-1035.