青龙衣萘醌类化学成分及其抗癌活性研究进展
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摘要
青龙衣为胡桃楸Juglansmandshurica未成熟果实的外果皮,作为中国传统中药应用已经有千余年的历史,主要用于清热解毒、抗菌消炎、止痛止痢、抗疟疾等。近年来,其抗癌活性引起了国内外学者的广泛关注。现代药理学研究表明,萘醌类化合物是青龙衣的主要抗癌活性成分。对青龙衣中提取分离到的萘醌类化学成分进行梳理,并对其中部分化合物的抗癌活性进行综述,为阐明青龙衣抗癌作用的药效物质基础提供重要的科学依据。
Green walnut husks of Juglans mandshurica is the exocarp of the immature fruit of Juglans mandshurica. It has been used for thousands of years as a traditional Chinese herbal medicine. It is mainly used for antipyretic and detoxification, antibacterial and anti-inflammatory, analgesic and anti-malarial, and so on. In recent years, its anticancer activity has attracted widespread attention from domestic and foreign scientists. Modern pharmacological studies have shown that naphthoquinones are the main anticancer active ingredients of green walnut husks of J. mandshurica. In this review, we combed the naphthoquinone chemical components extracted from green walnut husks of J. mandshurica and described the chemical constituents of naphthoquinones with strong anticancer activity. It provides an important scientific basis for clarifying the pharmacodynamic basis of the anti-cancer effect of Chinese medicine green walnut husks of J. mandshurica.
Green walnut husks of Juglans mandshurica is the exocarp of the immature fruit of Juglans mandshurica. It has been used for thousands of years as a traditional Chinese herbal medicine. It is mainly used for antipyretic and detoxification, antibacterial and anti-inflammatory, analgesic and anti-malarial, and so on. In recent years, its anticancer activity has attracted widespread attention from domestic and foreign scientists. Modern pharmacological studies have shown that naphthoquinones are the main anticancer active ingredients of green walnut husks of J. mandshurica. In this review, we combed the naphthoquinone chemical components extracted from green walnut husks of J. mandshurica and described the chemical constituents of naphthoquinones with strong anticancer activity. It provides an important scientific basis for clarifying the pharmacodynamic basis of the anti-cancer effect of Chinese medicine green walnut husks of J. mandshurica.
引文
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[27]孙墨珑,宋湛谦,方桂珍.核桃楸叶乙醇提取物的抑菌活性及活性成分分析[J].林产化学与工业,2007,27(增刊):81-84.
[28]Zhou Y Y,Yang B Y,Jiang Y Q,et al.Studies on cytotoxic activity against Hep G-2 cells of naphthoquinones from green walnut husks of Juglans mandshurica Maxim.[J].Molecules,2015,doi:10.3390/molecules200915572.
[29]吴德玲,陈仕云,刘劲松.山核桃外蒲壳化学成分及抗肿瘤活性研究[J].中药材,2011,34(7):1055-1057.
[30]黄成刚,阎新佳,邹晓祺.青龙衣的化学成分及抗肿瘤活性研究[J].哈尔滨商业大学学报,2014,34(5):517-541.
[2]王艳秋.北青龙衣抗氧化活性谱效关系的研究[D].哈尔滨:黑龙江大学,2013.
[3]许绍惠,唐婉屏,韩忠环.胡桃楸毒性成分研究[J].沈阳农业大学学报,1986,17(2):34-39.
[4]李海洋.胡桃青皮有效化学成分及抑菌性研究[D].咸阳:西北农林科技大学,2012.
[5]黄柳舒.山胡桃果皮活性成分的研究[D].杭州:浙江工商大学,2011.
[6]董梅,袁日,齐凤琴,等.青龙衣中细胞毒活性成分的研究[J].天然产物研究与开发,2011,23(5):805-808.
[7]曲中原.青龙衣抗肿瘤活性成分及其作用机制研究[D].北京:北京中医药大学,2010.
[8]Machida K,Matsuoka E,Kasabara T,et al.Studies on the constituents of Juglans species I.Structural determination of(4S)-and(4R)-4-hydroxy-α-tetralone derivatives from the fruit of Juglans mandshurica Maxim.var.sieboldiana Makino[J].Chem Pharm Bull,2005,53(8):934-937.
[9]王红萍,尹江燕.胡桃青皮的有效成分及综合利用[J].安徽农业科学,2013,41(24):10129-10131.
[10]Zhou Y Y,Yang B Y,Liu Z X,et al.Cytotoxicity of triterpenes from green walnut husks of Juglans mandshurica Maxim in HepG-2 cancer cells[J].Molecules,2015,20(10):19252-19262.
[11]Hirakawa K,Ogiue E,Motoyoshiya J,et al.Naphthoquinones from Juglandaeae[J].Phytochemistry,1986,25(6):1494-1495.
[12]王海香,申照静,杜艳丽,等.胡桃属植物青皮的化学成分及作用机理研究进展[J].生物质化学工程,2008,24(1):47-52.
[13]周媛媛,刘兆熙,孟颖.青龙衣有效部位化学成分研究[J].中草药,2014,45(16):2303-2306.
[14]王宏歌.胡桃楸外果皮活性成分的研究[D].哈尔滨:东北林业大学,2013.
[15]周媛媛,刘雨新,蒋艳秋.青龙衣抗肿瘤有效部位的化学成分研究[J].中草药,2016,47(17):2879-2983.
[16]张建斌.甘肃青龙衣核桃青皮化学成分的研究[D].兰州:西北师范大学,2009.
[17]Binder R G,Benson M E,Flash R A,et al.Eight1,4-naphthoquinones from Juglans[J].Phytochemistry,1989,28(10):2799-2801.
[18]Liu L J,Li W,Koike K,et al.Newα-tetralonyl glucosides from the fruit of Juglans mandshurica[J].Chem Pharm Bull,2004,52(5):566-569.
[19]高小宁,孙晓飞,黄国兴.核桃楸青皮中的一个新四氢萘酮化合物[J].中成药,2013,35(7):1487-1489.
[20]王艳梅.胡桃楸青果皮生物活性及活性成分研究[D].哈尔滨:东北林业大学,2008.
[21]Chen G,Pi X M,Yu C Y.A new naphthalenone isolated from the green walnut husks of Juglans mandshurica Maxim.[J].Nat Prod Res,2015,29(2):174-179.
[22]戚雅君,翁琳,王增.山胡桃的化学成分及药理活性研究进展[J].中国医院药学杂志,2010,30(19):18-20.
[23]张建斌,柳军玺,查飞,等.青龙衣的化学成分研究[J].中草药,2009,40(6):847-849.
[24]刘丽娟,齐凤琴,龚显峰北青龙衣中萘醌类衍生物细胞毒活性研究[J].中国现代应用药学,2010,27(7):574-577.
[25]张野平,杨志博,景永奎.胡桃醌对肿瘤细胞的增殖抑制作用和抗菌作用[J].沈阳药学院学报,1993,10(4):271-274.
[26]Yang Q,Yao Q S,Kuang Y,et al.Antimicrobial and cytotoxic juglones from the immature exocarps of Juglans mandshurica[J].Nat Prod Res,2018,doi:10.1080/14786419.2018.1468326.
[27]孙墨珑,宋湛谦,方桂珍.核桃楸叶乙醇提取物的抑菌活性及活性成分分析[J].林产化学与工业,2007,27(增刊):81-84.
[28]Zhou Y Y,Yang B Y,Jiang Y Q,et al.Studies on cytotoxic activity against Hep G-2 cells of naphthoquinones from green walnut husks of Juglans mandshurica Maxim.[J].Molecules,2015,doi:10.3390/molecules200915572.
[29]吴德玲,陈仕云,刘劲松.山核桃外蒲壳化学成分及抗肿瘤活性研究[J].中药材,2011,34(7):1055-1057.
[30]黄成刚,阎新佳,邹晓祺.青龙衣的化学成分及抗肿瘤活性研究[J].哈尔滨商业大学学报,2014,34(5):517-541.