营养膳食与生命早期发育的表观遗传的认识进展
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摘要
生命早期1 000天的发育是密切伴随着表观遗传的动态编程与调控,这一过程与儿童的早期膳食平衡密切相关,其体现了体内环境与遗传的交互作用。因此,就生命前沿的表观遗传学进展,本文介绍了将基因组比喻为"计算机硬件系统"和"软件操作系统"的不同功能形象,同时也介绍了"饭碗中的遗传学"(genetics in our food)这一营养表观遗传学的基本概念,强调了从机体膳食营养摄入到细胞内三大生化基本代谢乃至到基因组化学修饰三者密切关联,因此为日常专业的儿童膳食营养均衡指导工作提供更为科学的遗传学和表观遗传学依据。
The development in the first thousand days of a child is closely accompanied by epigenetic dynamic programming and regulation. This process is closely related to the early dietary balance of children,which reflects the interaction between body environment and genetics. This paper introduces the functional genome compared to the computer′s hardware system and software operating system,as well as the concept of ′genetics in our food′. Furthermore,the close correlation among body′s dietary nutrition intake,the three biochemical basic metabolism in cells and genomic chemical modification is emphasized in this paper,thereby providing more scientific genetic and epigenetic basis for daily professional guidance on children′s nutrition balance.
The development in the first thousand days of a child is closely accompanied by epigenetic dynamic programming and regulation. This process is closely related to the early dietary balance of children,which reflects the interaction between body environment and genetics. This paper introduces the functional genome compared to the computer′s hardware system and software operating system,as well as the concept of ′genetics in our food′. Furthermore,the close correlation among body′s dietary nutrition intake,the three biochemical basic metabolism in cells and genomic chemical modification is emphasized in this paper,thereby providing more scientific genetic and epigenetic basis for daily professional guidance on children′s nutrition balance.
引文
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[27] 王玉英,陈春明,王福珍,等.营养强化辅助食品补充物对甘肃贫困农村婴幼儿体格生长的影响[J].卫生研究,2007,36(1):78-81.
[2] Dor Y,Cedar H.Principles of DNA methylation and their implications for biology and medicine[J].Lancet,2018,392(10149):777-786.
[3] Ichi S,Costa FF,Bischof JM,et al.Folic acid remodels chromatin on Hes1 and Neurog2 promoters during caudal neural tube development[J].J Biol Chem,2010,285(47):3692 2-36932.
[4] Wu J,Xu J,Liu B,et al.Chromatin analysis in human early development reveals epigenetic transition during ZGA[J].Nature,2018,557(7704):256-260.
[5] Ho L,Ronan JL,Wu J,et al.An embryonic stem cell chromatin remodeling complex,esBAF,is an essential component of the core pluripotency[J].Proc Natl Acad Sci USA,2009,106(13):5181-5186.
[6] Iqbal K,Jin SG,Pfeifer GP,et al.Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine[J].Proc Natl Acad Sci U S A,2011,108(9):3642-3647.
[7] Wang L,Shangguan S,Xin Y,et al.Folate deficiency disturbs hsa-let-7 g level through methylation regulation in neural tube defects[J].J Cell Mol Med,2017,21(12):3244-3253.
[8] Kim W,Kim R,Park G,et al.Deficiency of H3K79 histone methyltransferase Dot1-like protein (DOT1L) inhibits cell proliferation[J].J Biol Chem,2012,287(8):5588-5599.
[9] Hoeller D,Hecker CM,Dikic I.Ubiquitin and ubiquitin-like proteins in cancer pathogenesis[J].Nat Rev Cancer,2006,6(10):776-788.
[10] Nijman SM,Luna-Vargas MP,Velds A,et al.A genomic and functional inventory of deubiquitinating enzymes[J].Cell,2005,123(5):773-786.
[11] Alberts B,Johnson A,Lewis J,et al.Molecular biology of the cell[M].4th edition.New York:Garland Science,2002.
[12] Goldberg AD,Allis CD,Bernstein E.Epigenetics:a landscape takes shape[J].Cell,2007,128(4):635-638.
[13] Zhang BJ,Zheng H,Huang B,et al.Allelic reprogramming of the histone modification H3K4me3 in early mammalian development[J].Nature,2016,537(7621):553-557.
[14] Yao TP,Oh SP,Fuchs M,et al.Gene dosage-dependent emb ryonic development and proliferation defects in mice lacking the transcriptional integrator p300[J].Cell,1998,93(3):361-372.
[15] Selak MA,Armour SM,MacKenzie ED,et al.Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase[J].Cancer Cell,2005,7(1):77-85.
[16] Braverman NE,Moser AB.Functions of plasmalogen lipids in health and disease[J].Biochim Biophys Acta,2012,1822(9):1442-1452.
[17] 17Brown KK,Spinelli JB,Asara JM,et al.Adaptive reprogramming of de novo pyrimidine synthesis is a metabolic vulnerability in triple-negative breast cancer[J].Cancer Discov,2017,7(4):391-399.
[18] Xie Q,Li C,Song X,et al.Folate deficiency facilitates recruitment of upstream binding factor to hot spots of DNA double-strand breaks of rRNA genes and promotes its transcription[J].Nucleic Acids Res,2017,45(5):2472-2489.
[19] Ingrosso D,Cimmino A,Perna AF,et al.Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia[J].Lancet,2003,361(9370):1693-1699.
[20] Chang H,Zhang T,Zhang Z,et al.Tissue-specific distribution of aberrant DNA methylation associated with maternal low-folate status in human neural tube defects[J].J Nutr Biochem,2011,22(12):1172-1177.
[21] Ono K,Yamada M.Vitamin A and Alzheimer's disease[J].Geriatr Gerontol Int,2012,12(2):180-188.
[22] Semba RD.The role of vitamin A and related retinoids in immune function[J].Nutr Rev,1998,56(1 Pt 2):S38- S48.
[23] Xue JH,Chen GD,Hao F,et al.A vitamin-C-derived DNA modification catalysed by an algal TET homologue[J].Nature,2019,569(7757):581-585.
[24] Borel P,Moussa M,Reboul E,et al.Human plasma levels of vitamin E and carotenoids are associated with genetic polymorphisms in genes involved in lipid metabolism[J].J Nutr,2007,137(12):2653-2659.
[25] 中国发展研究基金会.贫困地区儿童早期发展项目青海试点中期评估报告[R].2011
[26] 王丽娟,霍军生,孙静,等.营养包对汶川地震后四川省理县6～23月龄婴幼儿干预效果研究[J].卫生研究,2011,40(1):61-64.
[27] 王玉英,陈春明,王福珍,等.营养强化辅助食品补充物对甘肃贫困农村婴幼儿体格生长的影响[J].卫生研究,2007,36(1):78-81.