粮油加工副产物在微生物群导向型食品研发中的应用潜力
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摘要
人体肠道上皮附着着数以亿计的菌群,它们是人体健康和生理功能实现的参与者,也是大健康概念所涵盖的一个重要靶点。到目前为止,补充益生元仍是调节肠道菌群和促进有益菌群生长的有效手段之一。粮油加工副产物产量大,种类丰富,且其中很多成分可被寄居人体的肠道菌群利用,是优质益生元的来源之一,亦是"微生物群导向型食品"开发中重要的物质基础与原料来源。
Hundreds of millions of bacteria adhere to human intestinal epithelium, which are the participants of human health and physiological functions, and also an important target covered by the concept of comprehensive health. So far, the supplementation of prebiotics remainsare still one of the effective means to regulate intestinal microbiota and promote the growth of beneficial microbes. The by-productsof grain and oil processing are abundant in variety and yield, and many of them can be utilized by human intestinal microbiota, which are one of the sources of high-quality prebiotics, and also the important material basis and raw material source in the development of "microbial-oriented food".
Hundreds of millions of bacteria adhere to human intestinal epithelium, which are the participants of human health and physiological functions, and also an important target covered by the concept of comprehensive health. So far, the supplementation of prebiotics remainsare still one of the effective means to regulate intestinal microbiota and promote the growth of beneficial microbes. The by-productsof grain and oil processing are abundant in variety and yield, and many of them can be utilized by human intestinal microbiota, which are one of the sources of high-quality prebiotics, and also the important material basis and raw material source in the development of "microbial-oriented food".
引文
[1]刘晓庚,杨国峰,陶进华,等.我国主要粮食副产物功能性成分及其利用研究进展[J].粮食与油脂,2014(4):10-13.
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[4]孟海波,毛春季,刘湘新,等.米糠甾醇对大鼠免疫功能的影响[J].营养学报,2015(1):37-40.
[5]李莹.富γ-氨基丁酸麦麸干预高脂饮食诱发代谢紊乱的研究[D].天津科技大学,2017.
[6]段元霄.麦麸阿魏酰聚糖对大鼠抗氧化功能的影响及其作用机制[D].内蒙古农业大学,2018.
[7]KAWAMURA S,NARASAKI T.Study on carbohydrate of soy bean:Component sugars of fractionated polysaccharides,especially identification of fucose in some hemicelluloses[J].Agricultural Biological Chemistry,1961,25:527-531.
[8]PAN K,CHEN H Q,BEAK S J,et al.nanoparticles polysaccharide soybean Self-assembledcurcumin-soluble:in Physicochemical properties and anti-proliferation activity against cancer cells vitro[J].Food Chemistry,2018,246:82-89.
[9]黄高霞,张莉,汪东风,等.大豆胰蛋白酶抑制剂对饮食肥胖小鼠的减肥作用[J].大豆科学,2012(2):284-287.
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[12]BELKAID Y and HAND T W.Role of the microbiota in immunity and inflammation[J].Cell,2014,157:121-141.
[13]BRESTOFF J R,ARTIS D.Commensal bacteria at the interface of host metabolism and the immune system[J].Nature Immunology,2013,14:676-684.
[14]毕玉晶,杨瑞馥.人体肠道微生物群,营养与健康[J].科学通报,2018,64(3):260-271.
[15]JANNEKE P O,WILLEM M D,CLARA B.Glycobiome:Bacteria and mucus at the epithelial interface[J].Best Practice&Research Clinical Gastroenterology,2013,27:25-38.
[16]YE J X.Intestinal bacteria associated with colitis and inflammatory bowel disease[D].University of Californiariverside,2009.
[17]CAROLINE L J K,JENNY?,XU J,et al.The microbiota of the gut in preschool Children with normal and excessive body weight[J].Pediatric Obesity,2012(11):2257-2261.
[18]WANG L V,CLAUS T C,MICHAEL J S,et al.Low relative abundances of the mucolytic bacterium Akkermansia muciniphila and Bifidobacterium spp.in faces of children with autism[J].Applied and Environmental Microbiology,2011,77(18):6718-6721.
[19]CANI P D,GEURTS L,MATAMOROS S,et al.Glucose metabolism:Focus on gut microbiota,the endocannabinoid system and beyond[J].Diabetes&Metabolism,2014,40:246-257.
[20]AMANDINE E,CLARA B,LUCIE G,et al.Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity[J].PNAS,2013,110(22):9066-9071.
[21]SERGEY S S,NATASHA G,BRYAN S,et al.NLRP6 protects Il10-/-mice from colitis by limiting colonization of Akkermansia muciniphila[J].Cell Report,2017,19:733-745.
[22]AUDREY M N,USUNE E,BERNARD T,et al.Rhubarb extract prevents hepatic inflammation induced by acute alcohol intake,an effect related to the modulation of the gut microbiota[J].Molecular Nutrition&Food Research,2017,61(1):1500899.
[23]EVERARD A,BELZER C,GEURTS L,et al.Akkermansia muciniphila communiquéavec l’épithélium intestinal pour contr?ler le développement de l’obésitéet du diabète de type 2[J].Diabetes&Metabolism,2013,39:A1-A20.
[24]HILL C,GUARNER F,REID G,et al.The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic[J].Nature Reviews Gastroenterology&Herpetology,2014,11:506-514.
[25]IANIRO G,RIZZATTI G,PLOMER M,et al.Bacillus clausii for the Treatment of Acute Diarrhea in Children:A Systematic Review and Meta-Analysis of Randomized Controlled Trials[J].Nutrients,2018,10(1074):1-15.
[26]GIRI S S,YUN S,JUN J W,et al.The rapeutic effect of intestinal autochthonous Lactobacillus reuteri P16 against Waterborne lead Toxicity in Cyprinus carpio[J].Frontiers in Immunology,2018,9(1824):1-13.
[27]MAJEED M,NAGABHUSHANAM K,ARUMUGAM S,et al.Bacillus coagulans MTCC 5856 for the management of major depression with irritable bowel syndrome:a randomized,doubleblind,placebo controlled,multi-centre,pilot clinical study[J].Food&Nutrition Research,2018,62(1218):1-15.
[28]PEDRET A,VALLS R M,CALDERóN-PéREZ L,et al.Effects of daily consumption of the probiotic Bifidobacterium animalis subsp.lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects:a randomized controlled trial[J].International Journal of Obesity,2018,Published online:1-6.
[29]ARTHUR C O,CAI D L,XU W J,et al.Probiotics reduce symptoms of antibiotic use in a hospital setting:A randomized dose response study[J].Vaccine,2014,32:458-463.
[30]WANG J J,TANG H,ZHANG C H,et al.Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice[J].International Society for Microbial Ecology,2015,9:1-15.
[31]PIEWNGAM P,ZHENG Y,NGUYEN T H,et al.Pathogen elimination by probiotic Bacillus via signalling interference[J].Nature,2018,562:532-537.
[32]TAKEDA R,KANESUGI N,KANESUGI M,et al.Effects of Saccharomyces cerevisiae NK-1 on stool frequency and volume in healthy individuals with infrequent bowel movements:a randomized,placebo,placebo controlled,double-blind study[J].Functional Foods in Health and Disease,2018,8(9):462-471.
[33]H?RTEL C,PAGEL J,SPIEGLER J,et al.Lactobacillus acidophilus/Bifdobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics[J].Scientific Reports,2017,7(5633):1-11.
[34]SCHRETTER C,VIELMETTER J,BARTOS I,et al.A gut microbial factor modulates locomotor behaviour in drosophila[J].Nature,2018,563:402-406.
[35]STEWART C J,AJAMI N J,O’BRIEN J L,et al.Temporal development of the gut microbiome in early childhood from the TEDDY study[J].Nature,2018,562:583-600.
[36]VATANEN T,FRANZOSA E A,SCHWAGER R,et al.The human gut microbiome in early-onset type 1 diabetes from the TEDDY study[J].Nature,2018,562:589-607.
[37]KAWAI K,KAMOCHI R,OIKI S,et al.Robiotics in human gut microbiota can degrade host glycosaminoglycans[J].Scientific Reports,2018,8(10674):1-13.
[38]ROMAN P,ESTEVEZ A F,MIRAS A,et al.A pilot randomized controlled trial to explore cognitive and emotional effects of probiotics in fibromyalgia[J].Scientific Reports,2018,8(10965):1-9.
[39]CARVALHO R,VAZ A,PEREIRA F L,et al.Gut microbiome modulation during treatment of mucositis with the dairy bacterium Lactococcus lactis and recombinant strain secreting human antimicrobial PAP[J].Scientific Reports,2018,8(15072):1-10.
[40]SAARELA M H.Safety aspects of next generation probiotics[J].Current Opinion in Food Science,2019,30:8-13.
[41]国家卫生和计划生育委员会.《食品安全国家标准食品用菌种》(征求意见稿)[DB/OL].http://down.foodmate.net/wap/index.php?itemid=52399&moduleid=24.
[42]农业部公告(第2045号).《饲料添加剂品种目录(2013)》[DB/OL].https://baike.so.com/doc/6789413-7006022.html.
[43]BARRATT M J,LEBRILLA C,SHAPIRO H Y,et al.The gut microbiota,food science,and human nutrition:a timely marriage[J].Cell Host&Microbe,2017,22:134-141.
[44]ZHAO L P,ZHANG F,DING X Y,et al.Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes[J].Science,2018,359(6380):1151-1156.
[45]PAUL H A,BOMHOF M R,VOGEL H J,et al.Diet-induced changes in maternal gut microbiota and metabolomic profles influence programming of offspring obesity risk in rats[J].Science Report,2016,6(20683):1-14.
[46]PIETER V D A,PHILIPPE G,SYLVIE R,et al.Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin-degradation in humanized rats[J].Environmental Microbiology,2011,13(10):2667-2680.
[47]TAN S,CAPARROS-MARTIN J A,MATTHEWS V B,et al.Isoquercetin and inulin synergistically modulate the gut microbiome to prevent development of the metabolic syndrome in mice fed a high fat diet[J].Science Report,2018,8(10100):1-13.
[48]MISTRY R H,GU F J,SCHOLS H A,et al.Effect of the prebiotic fiber inulin on cholesterol metabolism in wild type mice[J].Science Report,2018,8(13238):1-8.
[49]王鑫,朱婧,刘静,等.低聚木糖润肠通便及调节肠道菌群功能的研究[J].食品工业科技,2015,36(14):359-362.
[50]POEKER S A,GEIRNAERT A,BERCHTOLD L,et al.Understanding the prebiotic potential of diferent dietary fbers using an in vitro continuous adult fermentation model(PolyFermS)[J].Science Report,2018,8(4318):1-12.
[51]杨华,叶发银,赵国华.膳食多酚与肠道微生物相互作用研究进展[J].食品科学,2015,36(3):223-227.
[2]郑立友,石爱民,刘红芝,等.粮油加工副产物损失及利用现状与对策建议[J].农产品加工,2016,401(2):60-64.
[3]VERSCHOYLE R D,GREAVES P,CAI H,et al.Evaluation of the cancer chemo preventive efficacy of rice bran in genetic mouse models of breast,prostate and intestinal carcinogenesis[J].British Journal of Cancer,2007,96:248-254.
[4]孟海波,毛春季,刘湘新,等.米糠甾醇对大鼠免疫功能的影响[J].营养学报,2015(1):37-40.
[5]李莹.富γ-氨基丁酸麦麸干预高脂饮食诱发代谢紊乱的研究[D].天津科技大学,2017.
[6]段元霄.麦麸阿魏酰聚糖对大鼠抗氧化功能的影响及其作用机制[D].内蒙古农业大学,2018.
[7]KAWAMURA S,NARASAKI T.Study on carbohydrate of soy bean:Component sugars of fractionated polysaccharides,especially identification of fucose in some hemicelluloses[J].Agricultural Biological Chemistry,1961,25:527-531.
[8]PAN K,CHEN H Q,BEAK S J,et al.nanoparticles polysaccharide soybean Self-assembledcurcumin-soluble:in Physicochemical properties and anti-proliferation activity against cancer cells vitro[J].Food Chemistry,2018,246:82-89.
[9]黄高霞,张莉,汪东风,等.大豆胰蛋白酶抑制剂对饮食肥胖小鼠的减肥作用[J].大豆科学,2012(2):284-287.
[10]沙如意,崔艳丽,王少林,等.植酸/植酸钠在食品工业上的应用研究进展[J].现代食品科技,2018(6):293-309.
[11]SENDER R,FUCHS S,MILO R.Are we really vastly outnumbered Revisiting the ratio of bacterial to host cells in humans[J].Cell,2016,164:337-340.
[12]BELKAID Y and HAND T W.Role of the microbiota in immunity and inflammation[J].Cell,2014,157:121-141.
[13]BRESTOFF J R,ARTIS D.Commensal bacteria at the interface of host metabolism and the immune system[J].Nature Immunology,2013,14:676-684.
[14]毕玉晶,杨瑞馥.人体肠道微生物群,营养与健康[J].科学通报,2018,64(3):260-271.
[15]JANNEKE P O,WILLEM M D,CLARA B.Glycobiome:Bacteria and mucus at the epithelial interface[J].Best Practice&Research Clinical Gastroenterology,2013,27:25-38.
[16]YE J X.Intestinal bacteria associated with colitis and inflammatory bowel disease[D].University of Californiariverside,2009.
[17]CAROLINE L J K,JENNY?,XU J,et al.The microbiota of the gut in preschool Children with normal and excessive body weight[J].Pediatric Obesity,2012(11):2257-2261.
[18]WANG L V,CLAUS T C,MICHAEL J S,et al.Low relative abundances of the mucolytic bacterium Akkermansia muciniphila and Bifidobacterium spp.in faces of children with autism[J].Applied and Environmental Microbiology,2011,77(18):6718-6721.
[19]CANI P D,GEURTS L,MATAMOROS S,et al.Glucose metabolism:Focus on gut microbiota,the endocannabinoid system and beyond[J].Diabetes&Metabolism,2014,40:246-257.
[20]AMANDINE E,CLARA B,LUCIE G,et al.Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity[J].PNAS,2013,110(22):9066-9071.
[21]SERGEY S S,NATASHA G,BRYAN S,et al.NLRP6 protects Il10-/-mice from colitis by limiting colonization of Akkermansia muciniphila[J].Cell Report,2017,19:733-745.
[22]AUDREY M N,USUNE E,BERNARD T,et al.Rhubarb extract prevents hepatic inflammation induced by acute alcohol intake,an effect related to the modulation of the gut microbiota[J].Molecular Nutrition&Food Research,2017,61(1):1500899.
[23]EVERARD A,BELZER C,GEURTS L,et al.Akkermansia muciniphila communiquéavec l’épithélium intestinal pour contr?ler le développement de l’obésitéet du diabète de type 2[J].Diabetes&Metabolism,2013,39:A1-A20.
[24]HILL C,GUARNER F,REID G,et al.The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic[J].Nature Reviews Gastroenterology&Herpetology,2014,11:506-514.
[25]IANIRO G,RIZZATTI G,PLOMER M,et al.Bacillus clausii for the Treatment of Acute Diarrhea in Children:A Systematic Review and Meta-Analysis of Randomized Controlled Trials[J].Nutrients,2018,10(1074):1-15.
[26]GIRI S S,YUN S,JUN J W,et al.The rapeutic effect of intestinal autochthonous Lactobacillus reuteri P16 against Waterborne lead Toxicity in Cyprinus carpio[J].Frontiers in Immunology,2018,9(1824):1-13.
[27]MAJEED M,NAGABHUSHANAM K,ARUMUGAM S,et al.Bacillus coagulans MTCC 5856 for the management of major depression with irritable bowel syndrome:a randomized,doubleblind,placebo controlled,multi-centre,pilot clinical study[J].Food&Nutrition Research,2018,62(1218):1-15.
[28]PEDRET A,VALLS R M,CALDERóN-PéREZ L,et al.Effects of daily consumption of the probiotic Bifidobacterium animalis subsp.lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects:a randomized controlled trial[J].International Journal of Obesity,2018,Published online:1-6.
[29]ARTHUR C O,CAI D L,XU W J,et al.Probiotics reduce symptoms of antibiotic use in a hospital setting:A randomized dose response study[J].Vaccine,2014,32:458-463.
[30]WANG J J,TANG H,ZHANG C H,et al.Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice[J].International Society for Microbial Ecology,2015,9:1-15.
[31]PIEWNGAM P,ZHENG Y,NGUYEN T H,et al.Pathogen elimination by probiotic Bacillus via signalling interference[J].Nature,2018,562:532-537.
[32]TAKEDA R,KANESUGI N,KANESUGI M,et al.Effects of Saccharomyces cerevisiae NK-1 on stool frequency and volume in healthy individuals with infrequent bowel movements:a randomized,placebo,placebo controlled,double-blind study[J].Functional Foods in Health and Disease,2018,8(9):462-471.
[33]H?RTEL C,PAGEL J,SPIEGLER J,et al.Lactobacillus acidophilus/Bifdobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics[J].Scientific Reports,2017,7(5633):1-11.
[34]SCHRETTER C,VIELMETTER J,BARTOS I,et al.A gut microbial factor modulates locomotor behaviour in drosophila[J].Nature,2018,563:402-406.
[35]STEWART C J,AJAMI N J,O’BRIEN J L,et al.Temporal development of the gut microbiome in early childhood from the TEDDY study[J].Nature,2018,562:583-600.
[36]VATANEN T,FRANZOSA E A,SCHWAGER R,et al.The human gut microbiome in early-onset type 1 diabetes from the TEDDY study[J].Nature,2018,562:589-607.
[37]KAWAI K,KAMOCHI R,OIKI S,et al.Robiotics in human gut microbiota can degrade host glycosaminoglycans[J].Scientific Reports,2018,8(10674):1-13.
[38]ROMAN P,ESTEVEZ A F,MIRAS A,et al.A pilot randomized controlled trial to explore cognitive and emotional effects of probiotics in fibromyalgia[J].Scientific Reports,2018,8(10965):1-9.
[39]CARVALHO R,VAZ A,PEREIRA F L,et al.Gut microbiome modulation during treatment of mucositis with the dairy bacterium Lactococcus lactis and recombinant strain secreting human antimicrobial PAP[J].Scientific Reports,2018,8(15072):1-10.
[40]SAARELA M H.Safety aspects of next generation probiotics[J].Current Opinion in Food Science,2019,30:8-13.
[41]国家卫生和计划生育委员会.《食品安全国家标准食品用菌种》(征求意见稿)[DB/OL].http://down.foodmate.net/wap/index.php?itemid=52399&moduleid=24.
[42]农业部公告(第2045号).《饲料添加剂品种目录(2013)》[DB/OL].https://baike.so.com/doc/6789413-7006022.html.
[43]BARRATT M J,LEBRILLA C,SHAPIRO H Y,et al.The gut microbiota,food science,and human nutrition:a timely marriage[J].Cell Host&Microbe,2017,22:134-141.
[44]ZHAO L P,ZHANG F,DING X Y,et al.Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes[J].Science,2018,359(6380):1151-1156.
[45]PAUL H A,BOMHOF M R,VOGEL H J,et al.Diet-induced changes in maternal gut microbiota and metabolomic profles influence programming of offspring obesity risk in rats[J].Science Report,2016,6(20683):1-14.
[46]PIETER V D A,PHILIPPE G,SYLVIE R,et al.Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin-degradation in humanized rats[J].Environmental Microbiology,2011,13(10):2667-2680.
[47]TAN S,CAPARROS-MARTIN J A,MATTHEWS V B,et al.Isoquercetin and inulin synergistically modulate the gut microbiome to prevent development of the metabolic syndrome in mice fed a high fat diet[J].Science Report,2018,8(10100):1-13.
[48]MISTRY R H,GU F J,SCHOLS H A,et al.Effect of the prebiotic fiber inulin on cholesterol metabolism in wild type mice[J].Science Report,2018,8(13238):1-8.
[49]王鑫,朱婧,刘静,等.低聚木糖润肠通便及调节肠道菌群功能的研究[J].食品工业科技,2015,36(14):359-362.
[50]POEKER S A,GEIRNAERT A,BERCHTOLD L,et al.Understanding the prebiotic potential of diferent dietary fbers using an in vitro continuous adult fermentation model(PolyFermS)[J].Science Report,2018,8(4318):1-12.
[51]杨华,叶发银,赵国华.膳食多酚与肠道微生物相互作用研究进展[J].食品科学,2015,36(3):223-227.