纳米金属有机框架材料在药物递送领域的应用
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摘要
金属有机框架材料(Metal-Organic Frameworks, MOFs)是一类由金属离子及有机配体自组装而成的多孔材料,具有孔隙率高、比表面积大和结构多样化等独特优点,广泛应用于气体储存、物质分离和催化等领域。纳米尺寸金属有机框架材料(Nanoscale Metal-Organic Frameworks, NMOFs)既保持了传统MOFs的规整性,也具有纳米颗粒的特殊性质,在生物医药领域中是绝佳的药物载体。相比于传统纳米药物载体,NMOFs与药物的结合方式丰富,展现了多种药物装载模式,可以满足不同药物的制备需求,也可引入不同功能分子优化性能。最近,有越来越多的研究报道了多功能化NMOFs应用于药物递送领域,并实现刺激响应性的可控释放。本文将着重对NMOFs材料作为药物载体负载抗癌药物、光敏剂和核酸的应用进展进行综述。
Metal-organic frameworks(MOFs), a class of self-assembled porous materials with metal ions and organic ligands, have attracted increasing research attention owing to their high porosity, tunable pore size, large surface area and multiple structures. In recent years, MOFs have been extensively investigated in gas storage, separation, catalysis and other fields. When the size of these hybrid materials drops down to nanosized scale, the regular morphology and unique properties make NMOFs become promising candidates for drug delivery. Compared to other nanocarriers, NMOFs provide multiple binding sites for a variety of small-molecule drugs and biomacromolecule via inclusion or surface conjugation. These chemical modifications do not affect NMOFs′ intrinsic physicochemical properties. Moreover, the facile synthesis and mild preparation conditions endow NMOFs with advantages in biomedicine. Nowadays, NMOFs have been demonstrated with multifunctionalities and stimuli-responsive controlled release in vivo. Therefore, a detailed review of the application of NMOFs in controlled drug delivery of anticancer drugs, photosensitizer and nucleic acids is provided here.
Metal-organic frameworks(MOFs), a class of self-assembled porous materials with metal ions and organic ligands, have attracted increasing research attention owing to their high porosity, tunable pore size, large surface area and multiple structures. In recent years, MOFs have been extensively investigated in gas storage, separation, catalysis and other fields. When the size of these hybrid materials drops down to nanosized scale, the regular morphology and unique properties make NMOFs become promising candidates for drug delivery. Compared to other nanocarriers, NMOFs provide multiple binding sites for a variety of small-molecule drugs and biomacromolecule via inclusion or surface conjugation. These chemical modifications do not affect NMOFs′ intrinsic physicochemical properties. Moreover, the facile synthesis and mild preparation conditions endow NMOFs with advantages in biomedicine. Nowadays, NMOFs have been demonstrated with multifunctionalities and stimuli-responsive controlled release in vivo. Therefore, a detailed review of the application of NMOFs in controlled drug delivery of anticancer drugs, photosensitizer and nucleic acids is provided here.
引文
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