脑心通胶囊联合阿司匹林与氯吡格雷治疗急性缺血性中风的效果观察
|
摘要
目的探讨脑心通胶囊联合阿司匹林与氯吡格雷治疗急性缺血性中风的效果。方法选取96例急性缺血性中风患者进行研究,以随机数字表法将其分为对照组与观察组各48例,对照组采用阿司匹林与氯吡格雷治疗,观察组在对照组基础上加用脑心通胶囊治疗,对2组患者的治疗效果、血尿酸(UA)、B细胞淋巴瘤-2基因(Bcl-2)、Bcl-2相关X蛋白(BAX)水平、神经功能评分进行观察。结果观察组、对照组的治疗总有效率分别为95. 83%、81. 25%,组间差异显著(P <0. 05);治疗前,2组的UA、BAX、Bcl-2水平无显著差异(P> 0. 05),治疗后2组均显著改善,且观察组较对照组改善更显著(P <0. 05);治疗后,观察组的改良Rankin量表(mRS)、美国国立卫生院神经功能缺损评分量表(NIHSS)评分与对照组比较有显著差异(P <0. 05)。结论脑心通胶囊联合阿司匹林与氯吡格雷治疗急性缺血性中风效果满意,能改善患者神经功能,调节UA、BAX、Bcl-2蛋白水平。
Objective To explore the effect of Naoxintong Capsule combined with aspirin and clopidogrel in the treatment of acute ischemic stroke. Methods A total of 96 patients with acute ischemic stroke who were admitted in our hospital were selected as subjects. According to the random number table method,they were divided into control group( n = 48) and observation group( n = 48).The control group was treated with aspirin and clopidogrel,while the observation group was treated with Naoxintong Capsule on the basis of the control group. The treatment efficacy,blood uric acid( UA),B cell lymphoma-2 gene( Bcl-2),X protein related to Bcl-2( BAX),neurological function score of the two groups were observed. Results The total effective rate of the observation group and the control group was 95. 83% and 81. 25%,respectively,and the difference was significant( P <0. 05). There were no significant differences in the levels of UA,BAX and BCL-2 between the two groups before treatment( P > 0. 05),the above indicators were significantly improved after treatment,and the observation group was better than the control group( P < 0. 05). The modified Rankin Scale score( mRS) and National Institutes of Health Neurologic Impairment Scale( NIHSS) scores of the observation group showed significant between group differences( P < 0. 05). Conclusion Naoxintong Capsule combined with aspirin and clopidogrel are effective in treating acute ischemic stroke,which can improve neurological function and regulate UA,BAX and BCL-2 protein levels.
Objective To explore the effect of Naoxintong Capsule combined with aspirin and clopidogrel in the treatment of acute ischemic stroke. Methods A total of 96 patients with acute ischemic stroke who were admitted in our hospital were selected as subjects. According to the random number table method,they were divided into control group( n = 48) and observation group( n = 48).The control group was treated with aspirin and clopidogrel,while the observation group was treated with Naoxintong Capsule on the basis of the control group. The treatment efficacy,blood uric acid( UA),B cell lymphoma-2 gene( Bcl-2),X protein related to Bcl-2( BAX),neurological function score of the two groups were observed. Results The total effective rate of the observation group and the control group was 95. 83% and 81. 25%,respectively,and the difference was significant( P <0. 05). There were no significant differences in the levels of UA,BAX and BCL-2 between the two groups before treatment( P > 0. 05),the above indicators were significantly improved after treatment,and the observation group was better than the control group( P < 0. 05). The modified Rankin Scale score( mRS) and National Institutes of Health Neurologic Impairment Scale( NIHSS) scores of the observation group showed significant between group differences( P < 0. 05). Conclusion Naoxintong Capsule combined with aspirin and clopidogrel are effective in treating acute ischemic stroke,which can improve neurological function and regulate UA,BAX and BCL-2 protein levels.
引文
[1]覃怡贞.中西医结合治疗急性缺血性中风疗效观察[J].实用中医药杂志,2016,32(7):691-692.
[2]李瑞荣.脑心通胶囊治疗急性缺血性脑中风的临床分析[J].医药前沿,2018,8(33):150-151.
[3]吴丽霜.丹参川芎嗪注射液联合康复训练治疗急性缺血性中风的临床观察[J].中国中医急症,2016,25(2):311-313.
[4]徐月华,徐建华.自拟通腑祛痰方联合依达拉奉治疗急性缺血性中风的临床观察[J].中国中医急症,2017,26(2):300-302.
[5]李军.阿司匹林联合氯吡格雷治疗急性缺血性脑卒中的临床疗效及其对血清同型半胱氨酸水平的影响[J].实用心脑肺血管病杂志,2018,26(4):124-125.
[6]刘志君,黄汉烽.氯吡格雷联合阿司匹林对进展性缺血性脑卒中患者神经功能及生活能力的影响[J].中国药物经济学,2016,11(5):41-43.
[7]林彬武,吴明怀,林智强,等.阿司匹林联合氯吡格雷治疗进展型缺血性卒中的疗效分析[J].中国校医,2017,31(1):8-9.
[8]伍瑚,李超强.氯吡格雷联合阿司匹林对非心源性缺血性卒中患者的预防效果及安全性[J].临床医学工程,2018,25(8):1027-1028.
[9]赵米珠.脑心通胶囊对缺血性中风患者神经功能缺损的改善临床观察[J].光明中医,2017,32(12):1740-1741.
[10]熊维,常飞.脑心通胶囊联合丹红注射液治疗急性脑梗死的临床疗效及其机制探讨[J].华中科技大学学报:医学版,2016,45(1):74-77.
[11]沈卫东,张云峰.脑心通胶囊联合注射用血塞通治疗脑梗死临床效果观察[J].临床军医杂志,2017,45(12):1279-1281.
[12]张婷,安琪.脑心通胶囊联合穴位埋线治疗缺血性脑中风痰热腑实证疗效及对血液流变性影响的研究[J].陕西中医,2018,39(12):1684-1686,1690.
[13]周梁国,乐永平.脑心通、辛伐他汀及阿司匹林治疗脑梗死的临床效果[J].交通医学,2018,32(6):578-579.
[14]邓子宁,赵霞霞,祝美珍.脑心通胶囊联合注射用灯盏花素治疗缺血性中风临床观察[J].广西中医药,2017,40(4):9-11.
[15]任岩红,刘娜娜,马文慧.脑心通联合脉络宁治疗脑梗死的临床效果分析[J].当代医学,2018,24(18):122-124.
[16]蔡松泉,蔡宇.脑心通和脉络宁在脑梗死治疗中的应用价值[J].中国药物经济学,2017,12(10):43-45.
[17]孔利环,付娇阳.丹参川芎注射液联合针刺治疗对急性缺血性脑卒中病人神经功能及UA、BCL-2、BAX水平的影响[J].中西医结合心脑血管病杂志,2018,16(5):627-630.
[18]刘勇,王洪,赵军,等.针刺介入时机对缺血性中风大鼠神经功能评分和Bcl-2、Bax表达的影响[J].环球中医药,2014,7(8):581-586.
[2]李瑞荣.脑心通胶囊治疗急性缺血性脑中风的临床分析[J].医药前沿,2018,8(33):150-151.
[3]吴丽霜.丹参川芎嗪注射液联合康复训练治疗急性缺血性中风的临床观察[J].中国中医急症,2016,25(2):311-313.
[4]徐月华,徐建华.自拟通腑祛痰方联合依达拉奉治疗急性缺血性中风的临床观察[J].中国中医急症,2017,26(2):300-302.
[5]李军.阿司匹林联合氯吡格雷治疗急性缺血性脑卒中的临床疗效及其对血清同型半胱氨酸水平的影响[J].实用心脑肺血管病杂志,2018,26(4):124-125.
[6]刘志君,黄汉烽.氯吡格雷联合阿司匹林对进展性缺血性脑卒中患者神经功能及生活能力的影响[J].中国药物经济学,2016,11(5):41-43.
[7]林彬武,吴明怀,林智强,等.阿司匹林联合氯吡格雷治疗进展型缺血性卒中的疗效分析[J].中国校医,2017,31(1):8-9.
[8]伍瑚,李超强.氯吡格雷联合阿司匹林对非心源性缺血性卒中患者的预防效果及安全性[J].临床医学工程,2018,25(8):1027-1028.
[9]赵米珠.脑心通胶囊对缺血性中风患者神经功能缺损的改善临床观察[J].光明中医,2017,32(12):1740-1741.
[10]熊维,常飞.脑心通胶囊联合丹红注射液治疗急性脑梗死的临床疗效及其机制探讨[J].华中科技大学学报:医学版,2016,45(1):74-77.
[11]沈卫东,张云峰.脑心通胶囊联合注射用血塞通治疗脑梗死临床效果观察[J].临床军医杂志,2017,45(12):1279-1281.
[12]张婷,安琪.脑心通胶囊联合穴位埋线治疗缺血性脑中风痰热腑实证疗效及对血液流变性影响的研究[J].陕西中医,2018,39(12):1684-1686,1690.
[13]周梁国,乐永平.脑心通、辛伐他汀及阿司匹林治疗脑梗死的临床效果[J].交通医学,2018,32(6):578-579.
[14]邓子宁,赵霞霞,祝美珍.脑心通胶囊联合注射用灯盏花素治疗缺血性中风临床观察[J].广西中医药,2017,40(4):9-11.
[15]任岩红,刘娜娜,马文慧.脑心通联合脉络宁治疗脑梗死的临床效果分析[J].当代医学,2018,24(18):122-124.
[16]蔡松泉,蔡宇.脑心通和脉络宁在脑梗死治疗中的应用价值[J].中国药物经济学,2017,12(10):43-45.
[17]孔利环,付娇阳.丹参川芎注射液联合针刺治疗对急性缺血性脑卒中病人神经功能及UA、BCL-2、BAX水平的影响[J].中西医结合心脑血管病杂志,2018,16(5):627-630.
[18]刘勇,王洪,赵军,等.针刺介入时机对缺血性中风大鼠神经功能评分和Bcl-2、Bax表达的影响[J].环球中医药,2014,7(8):581-586.