鼠神经生长因子与甲钴胺治疗紫衫醇引起周围神经病变的疗效观察
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摘要
目的探讨鼠神经生长因子及甲钴胺应用于紫衫醇引起周围神经病变的治疗效果。方法选择82例单用紫衫醇化疗引起周围神经病变的恶性肿瘤患者,随机分为A组与B组,每组各41例,其中A组采用鼠神经生长因子治疗,B组采用甲钴胺治疗,疗程均为半月,比较两组治疗前后的神经运动传导速度(MNCV)、神经感觉传导速度(SNCV)、肢体疼痛、肢体麻木、乏力的改善情况。结果两组治疗后MNCV、SNCV、肢体疼痛、肢体麻木、乏力临床症状较治疗前均有改善,差异均有统计学意义(P<0.05);A组的改善情况优于B组,差异有统计学意义(P<0.05)。结论鼠神经生长因子应用于紫杉醇引起的周围神经病变,能明显改善患者的神经运动传导速度(MNCV)和神经感觉传导速度(SNCV),可使患者的肢体疼痛、肢体麻木、乏力等症状明显改善,无严重不良反应发生,可在临床推广使用。
Objective To analyze the effect of mouse nerve growth factor and mecobalamine on the peripheral neuropathy caused by the paclitaxel injection.Methods 82 patients with malignant neoplasm were chosen because they suffered peripheral neuropathy caused by paclitaxel treatment.They were randomly divided into Group A and Group B.Group A included 41 patients with mouse nerve growth factor therapy.Group B included 41 patients with mecobalamine treatment.The course of treatment was half a month.The motor nerve conduction velocity(MNCV),sensory nerve conduction velocity(SNCV),physical pain,numbness and weakness were compared between the two groups.Results The clinical symptoms of MNCV,SNCV,physical pain,numbness and weakness were improved after treatment,and the difference was statistically significant(P<0.05).The improvement of treatment group was significantly better than the control group,and the difference was statistically significant(P< 0.05).Conclusion The mouse nerve growth factor can significantly improve patients' MNCV and SNCV.The symptoms of physical pain,numbness and weakness were also improved without severe adverse reaction.
Objective To analyze the effect of mouse nerve growth factor and mecobalamine on the peripheral neuropathy caused by the paclitaxel injection.Methods 82 patients with malignant neoplasm were chosen because they suffered peripheral neuropathy caused by paclitaxel treatment.They were randomly divided into Group A and Group B.Group A included 41 patients with mouse nerve growth factor therapy.Group B included 41 patients with mecobalamine treatment.The course of treatment was half a month.The motor nerve conduction velocity(MNCV),sensory nerve conduction velocity(SNCV),physical pain,numbness and weakness were compared between the two groups.Results The clinical symptoms of MNCV,SNCV,physical pain,numbness and weakness were improved after treatment,and the difference was statistically significant(P<0.05).The improvement of treatment group was significantly better than the control group,and the difference was statistically significant(P< 0.05).Conclusion The mouse nerve growth factor can significantly improve patients' MNCV and SNCV.The symptoms of physical pain,numbness and weakness were also improved without severe adverse reaction.
引文
[1]罗光华,郭莉莉,刘利华.紫衫醇与肿瘤的免疫研究进展[J].中国肿瘤生物治疗杂志,2013,(02):251-254.
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[8] Effects of ramipril on cardiovascular and microvascular outcomesin people with diabetes mellitus:results of the HOPE study andMICRO-HOPE substudy[J].Heat Outcomes PreVentio Evalua-tion Study Investigators,2000,355(9200):253-259.
[9]吴波,李力.单唾液酸四己糖神经节苷脂钠治疗糖尿病周围神经病变80例疗效分析[J].中国老年学杂志,2011,31(5):885-886.
[10] Xu F,Zhao LH,Su JB.The relationship between glycemic varia-bility and diabetic peripheral in type 2diabetes with well-con-trolled HbA1c[J].Diabetol Metab Syndr,2014,6(1):130.
[11]王宏涛,张会欣,赵韶华,等.糖尿病周围神经病变小鼠神经生长因子及其受体的变化及周络通胶囊的干预作用[J].时珍国医国药,2013,24(3):547-549.
[12]管常荣,朱英标,丁莉,等.鼠神经生长因子联合a-硫辛酸治疗糖尿病周围神经病变的临床观察[J].中国临床药理学杂志,2014,30(10):892-894,900.
[13]王世昌,陈朝.活血通痹方联合甲钴胺注射液治疗胃肠肿瘤化疗引起致周围神经病变的疗效观察[J].中国实用神经疾病杂志,2014,17(7):96-97.
[14] Kuwabara S,Nakazawa R,Azuma N,et al.Intravenous methyl-cobalamin treament for uremic and diabetic neuropathy in chron-ic hemodialysis patients[J].Internal Medicine,1999,38(6):472-475.
[15]胡德荣.鼠神经生长因子联合甲钴胺治疗糖尿病周围神经病变的临床观察[J].海南医学院学报,2016:1086-1088,1092.
[16]张东讯,胡艳云,尹超.鼠神经生长因子配合甲钴胺对糖尿病周围神经病变患者血清维生素B12水平及神经传导速度的影响[J].现代中西医结合杂志,2016,25(16):1799-1801.
[17]刘凤兰,兰林.鼠神经因子联合丹红对2型糖尿病周围神经病变临床症状及神经传导速度的影响[J].四川医学,2016,22(2):204-207.
[18]张蓓,李怀苏.鼠神经生长因子治疗糖尿病周围神经病变的疗效观察[J].医学临床研究,2015,32(4):658-660,664.
[19]郑志高,陈毅德,洪东花,等.α-硫辛酸联合甲钴胺治疗化疗引起周围神经病变的疗效观察[J].中国医院用药评价与分析,2015,15(6):730-732.
[20]区梅,叶冬梅.甲钴胺治疗化疗后周围神经病变的疗效观察[J].中国临床新医学,2009,2(8):846-847.
[2]王佳妮,李青.紫衫醇化疗致周围神经病变的诊治进展[J].癌症进展,2016,14(4):300-303,307.
[3]王军飞,张伟,丁宁,等.紫衫醇类前药的研究进展[J].中国药物化学杂志,2010,(05):394-402.
[4] Singh S,Dash AK.Paclitaxel in cancer treatment:perspetivs andprospects of its delivery challengs[J].Crit Rev Ther Drug Syst,2009,26(4):333-372.
[5] Sucheston LE,Zhao H,Yao S,et al.Genetic predictors of tax-ane-induced neurotoxicity in a SWOG phase III intergroup adju-vant berast cancer treatment trial(S0221)[J].Breast Cancer resTerat,2011,130(3):993-1002.
[6] Von Delius S,Eckel F,Wagenpfil S.Cabamazepine for perven-tiong of oxaliplatin-relaed neurotoxicity in patients with ad-vanced colorectal cancer:final results of randomised controlled,multicentre phase II study[J].Invest New Drugs,2007,25(2):173-180.
[7] RaoRD,Michalak JC,Sloan JA,et al.Eficacy of gahapentin inthe managementchemotherapy-induced peripheralneuropathyaphase 3randomized,double-blind,placebo-controlled,crossovertrial[J].Cancer,2007,110(9),2110-2118.
[8] Effects of ramipril on cardiovascular and microvascular outcomesin people with diabetes mellitus:results of the HOPE study andMICRO-HOPE substudy[J].Heat Outcomes PreVentio Evalua-tion Study Investigators,2000,355(9200):253-259.
[9]吴波,李力.单唾液酸四己糖神经节苷脂钠治疗糖尿病周围神经病变80例疗效分析[J].中国老年学杂志,2011,31(5):885-886.
[10] Xu F,Zhao LH,Su JB.The relationship between glycemic varia-bility and diabetic peripheral in type 2diabetes with well-con-trolled HbA1c[J].Diabetol Metab Syndr,2014,6(1):130.
[11]王宏涛,张会欣,赵韶华,等.糖尿病周围神经病变小鼠神经生长因子及其受体的变化及周络通胶囊的干预作用[J].时珍国医国药,2013,24(3):547-549.
[12]管常荣,朱英标,丁莉,等.鼠神经生长因子联合a-硫辛酸治疗糖尿病周围神经病变的临床观察[J].中国临床药理学杂志,2014,30(10):892-894,900.
[13]王世昌,陈朝.活血通痹方联合甲钴胺注射液治疗胃肠肿瘤化疗引起致周围神经病变的疗效观察[J].中国实用神经疾病杂志,2014,17(7):96-97.
[14] Kuwabara S,Nakazawa R,Azuma N,et al.Intravenous methyl-cobalamin treament for uremic and diabetic neuropathy in chron-ic hemodialysis patients[J].Internal Medicine,1999,38(6):472-475.
[15]胡德荣.鼠神经生长因子联合甲钴胺治疗糖尿病周围神经病变的临床观察[J].海南医学院学报,2016:1086-1088,1092.
[16]张东讯,胡艳云,尹超.鼠神经生长因子配合甲钴胺对糖尿病周围神经病变患者血清维生素B12水平及神经传导速度的影响[J].现代中西医结合杂志,2016,25(16):1799-1801.
[17]刘凤兰,兰林.鼠神经因子联合丹红对2型糖尿病周围神经病变临床症状及神经传导速度的影响[J].四川医学,2016,22(2):204-207.
[18]张蓓,李怀苏.鼠神经生长因子治疗糖尿病周围神经病变的疗效观察[J].医学临床研究,2015,32(4):658-660,664.
[19]郑志高,陈毅德,洪东花,等.α-硫辛酸联合甲钴胺治疗化疗引起周围神经病变的疗效观察[J].中国医院用药评价与分析,2015,15(6):730-732.
[20]区梅,叶冬梅.甲钴胺治疗化疗后周围神经病变的疗效观察[J].中国临床新医学,2009,2(8):846-847.
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