肥胖症与抑郁症相关性的研究进展
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摘要
<正>肥胖症和抑郁症都是当今世界主要的健康问题之一。随着社会迅速发展、人民生活水平不断提高、社会竞争日益加剧、生活和工作节奏加快,人们所承受的压力和挑战(应激)也越来越大,这种情况下抑郁症、肥胖症等疾病的多发引起人民的广泛关注。肥胖症是一种由多因素引起的慢性代谢性疾病,它是
引文
[1]Arroyo-Johnson C,Mincey K D.Obesity Epidemiology Worldwide[J].Gastroenterology Clinics of North America,2016,45(4):571-579.
[2]Allison DB,Newcomer JW,Dunn AL,et al.Obesity Among Those with Mental Disorders[J].American Journal of Preventive Medicine,2009,36(4):341-350.
[3]Scully T.Public health:Society at large[J].Nature,2014,508(7496):S50-S51.
[4]施慎逊,陈致宇,张斌,等.全球抑郁症研究最新进展[J].中国医师杂志,2015(z2):229-232.
[5]Preiss K,Brennan L,Clarke D.A systematic review of variables associated with the relationship between obesity and depression[J].Obes Rev,2013,14(11):906-918.
[6]Castanon N,Luheshi G,Laye S.Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity[J].Front Neurosci,2015,9:229.
[7]Sharma S,Fulton S.Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry[J].Int J Obes(Lond),2013,37(3):382-389.
[8]van Reedt DA,Giltay EJ,van Veen T,et al.Metabolic syndrome abnormalities are associated with severity of anxiety and depression and with tricyclic antidepressant use[J].Acta Psychiatr Scand,2010,122(1):30-39.
[9]Sanchez-Villegas A,Martinez-Gonzalez MA.Diet,a new target to prevent depression?[J].BMC Med,2013,11:3.
[10]Valladolid-Acebes I,Merino B,Principato A,et al.High-fat diets induce changes in hippocampal glutamate metabolism and neurotransmission[J].Am J Physiol Endocrinol Metab,2012,302(4):E396-E402.
[11]Larrieu T,Hilal ML,Fourrier C,et al.Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depressionrelated behaviour through corticosterone secretion[J].Transl Psychiatry,2014,4:e437.
[12]Strekalova T,Evans M,Costa-Nunes J,et al.Tlr4 upregulation in the brain accompanies depression-and anxiety-like behaviors induced by a high-cholesterol diet[J].Brain Behav Immun,2015,48:42-47.
[13]Sun S,Yang S,Mao Y,et al.Reduced cholesterol is associated with the depressive-like behavior in rats through modulation of the brain5-HT1A receptor[J].Lipids Health Dis,2015,14:22.
[14]Marazziti D,Rutigliano G,Baroni S,et al.Metabolic syndrome and major depression[J].CNS Spectr,2014,19(4):293-304.
[15]Stieg MR,Sievers C,Farr O,et al.Leptin:A hormone linking activation of neuroendocrine axes with neuropathology[J].Psychoneuroendocrinology,2015,51:47-57.
[16]Diwan AG,Kuvalekar AA,Dharamsi S,et al.Correlation of Serum Adiponectin and Leptin levels in Obesity and Type 2 Diabetes Mellitus[J].Indian J Endocrinol Metab,2018,22(1):93-99.
[17]Yamada N,Katsuura G,Ochi Y,et al.Impaired CNS leptin action is implicated in depression associated with obesity[J].Endocrinology,2011,152(7):2634-2643.
[18]Guo M,Lu Y,Garza JC,et al.Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression[J].Transl Psychiatry,2012,2:e83.
[19]Liu J,Guo M,Zhang D,et al.Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity[J].Proc Natl Acad Sci U S A,2012,109(30):12248-12253.
[20]Yau SY,Li A,Hoo RL,et al.Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin[J].Proc Natl Acad Sci U S A,2014,111(44):15810-15815.
[21]Wilhelm CJ,Choi D,Huckans M,et al.Adipocytokine signaling is altered in Flinders sensitive line rats,and adiponectin correlates in humans with some symptoms of depression[J].Pharmacol Biochem Behav,2013,103(3):643-651.
[22]Gorelick PB.Role of inflammation in cognitive impairment:results of observational epidemiological studies and clinical trials[J].Ann N YAcad Sci,2010,1207:155-162.
[23]Walker AK,Kavelaars A,Heijnen CJ,et al.Neuroinflammation and comorbidity of pain and depression[J].Pharmacol Rev,2014,66(1):80-101.
[24]Wu TY,Liu L,Zhang W,et al.High-mobility group box-1 was released actively and involved in LPS induced depressive-like behavior[J].J Psychiatr Res,2015,64:99-106.
[25]van Heesch F,Prins J,Konsman JP,et al.Lipopolysaccharide increases degradation of central monoamines:an in vivo microdialysis study in the nucleus accumbens and medial prefrontal cortex of mice[J].Eur J Pharmacol,2014,725:55-63.
[26]Thaler JP,Yi CX,Schur EA,et al.Obesity is associated with hypothalamic injury in rodents and humans[J].J Clin Invest,2012,122(1):153-162.
[27]van Reedt DA,Vreeburg SA,Giltay EJ,et al.The impact of stress systems and lifestyle on dyslipidemia and obesity in anxiety and depression[J].Psychoneuroendocrinology,2013,38(2):209-218.
[28]Guo M,Lu Y,Garza JC,et al.Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression[J].Transl Psychiatry,2012,2:e83.
[29]Carney RM,Freedland KE,Veith RC.Depression,the autonomic nervous system,and coronary heart disease[J].Psychosom Med,2005,67 Suppl 1:S29-S33.
[30]Marazziti D,Rutigliano G,Baroni S,et al.Metabolic syndrome and major depression[J].CNS Spectr,2014,19(4):293-304.
[31]Carnethon MR,Golden SH,Folsom AR,et al.Prospective investigation of autonomic nervous system function and the development of type 2 diabetes:the Atherosclerosis Risk In Communities study,1987-1998[J].Circulation,2003,107(17):2190-2195.
[32]Kreier F,Yilmaz A,Kalsbeek A,et al.Hypothesis:shifting the equilibrium from activity to food leads to autonomic unbalance and the metabolic syndrome[J].Diabetes,2003,52(11):2652-2656.
[33]Martin KA,Mani MV,Mani A.New targets to treat obesity and the metabolic syndrome[J].Eur J Pharmacol,2015,763(Pt A):64-74.
[34]Zheng P,Wang Y,Chen L,et al.Identification and validation of urinary metabolite biomarkers for major depressive disorder[J].Mol Cell Proteomics,2013,12(1):207-214.
[35]Lozupone CA,Stombaugh JI,Gordon JI,et al.Diversity,stability and resilience of the human gut microbiota[J].Nature,2012,489(7415):220-230.
[36]Backhed F,Ding H,Wang T,et al.The gut microbiota as an environmental factor that regulates fat storage[J].Proc Natl Acad Sci U S A,2004,101(44):15718-15723.
[37]Le Chatelier E,Nielsen T,Qin J,et al.Richness of human gut microbiome correlates with metabolic markers[J].Nature,2013,500(7464):541-546.
[38]Backhed F,Manchester JK,Semenkovich CF,et al.Mechanisms underlying the resistance to diet-induced obesity in germ-free mice[J].Proc Natl Acad Sci U S A,2007,104(3):979-984.
[39]Turnbaugh PJ,Ley RE,Mahowald MA,et al.An obesity-associated gut microbiome with increased capacity for energy harvest[J].Nature,2006,444(7122):1027-1031.
[40]Kelly JR,Borre Y,O'B C,et al.Transferring the blues:Depressionassociated gut microbiota induces neurobehavioural changes in the rat[J].J Psychiatr Res,2016,82:109-118.
[2]Allison DB,Newcomer JW,Dunn AL,et al.Obesity Among Those with Mental Disorders[J].American Journal of Preventive Medicine,2009,36(4):341-350.
[3]Scully T.Public health:Society at large[J].Nature,2014,508(7496):S50-S51.
[4]施慎逊,陈致宇,张斌,等.全球抑郁症研究最新进展[J].中国医师杂志,2015(z2):229-232.
[5]Preiss K,Brennan L,Clarke D.A systematic review of variables associated with the relationship between obesity and depression[J].Obes Rev,2013,14(11):906-918.
[6]Castanon N,Luheshi G,Laye S.Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity[J].Front Neurosci,2015,9:229.
[7]Sharma S,Fulton S.Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry[J].Int J Obes(Lond),2013,37(3):382-389.
[8]van Reedt DA,Giltay EJ,van Veen T,et al.Metabolic syndrome abnormalities are associated with severity of anxiety and depression and with tricyclic antidepressant use[J].Acta Psychiatr Scand,2010,122(1):30-39.
[9]Sanchez-Villegas A,Martinez-Gonzalez MA.Diet,a new target to prevent depression?[J].BMC Med,2013,11:3.
[10]Valladolid-Acebes I,Merino B,Principato A,et al.High-fat diets induce changes in hippocampal glutamate metabolism and neurotransmission[J].Am J Physiol Endocrinol Metab,2012,302(4):E396-E402.
[11]Larrieu T,Hilal ML,Fourrier C,et al.Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depressionrelated behaviour through corticosterone secretion[J].Transl Psychiatry,2014,4:e437.
[12]Strekalova T,Evans M,Costa-Nunes J,et al.Tlr4 upregulation in the brain accompanies depression-and anxiety-like behaviors induced by a high-cholesterol diet[J].Brain Behav Immun,2015,48:42-47.
[13]Sun S,Yang S,Mao Y,et al.Reduced cholesterol is associated with the depressive-like behavior in rats through modulation of the brain5-HT1A receptor[J].Lipids Health Dis,2015,14:22.
[14]Marazziti D,Rutigliano G,Baroni S,et al.Metabolic syndrome and major depression[J].CNS Spectr,2014,19(4):293-304.
[15]Stieg MR,Sievers C,Farr O,et al.Leptin:A hormone linking activation of neuroendocrine axes with neuropathology[J].Psychoneuroendocrinology,2015,51:47-57.
[16]Diwan AG,Kuvalekar AA,Dharamsi S,et al.Correlation of Serum Adiponectin and Leptin levels in Obesity and Type 2 Diabetes Mellitus[J].Indian J Endocrinol Metab,2018,22(1):93-99.
[17]Yamada N,Katsuura G,Ochi Y,et al.Impaired CNS leptin action is implicated in depression associated with obesity[J].Endocrinology,2011,152(7):2634-2643.
[18]Guo M,Lu Y,Garza JC,et al.Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression[J].Transl Psychiatry,2012,2:e83.
[19]Liu J,Guo M,Zhang D,et al.Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity[J].Proc Natl Acad Sci U S A,2012,109(30):12248-12253.
[20]Yau SY,Li A,Hoo RL,et al.Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin[J].Proc Natl Acad Sci U S A,2014,111(44):15810-15815.
[21]Wilhelm CJ,Choi D,Huckans M,et al.Adipocytokine signaling is altered in Flinders sensitive line rats,and adiponectin correlates in humans with some symptoms of depression[J].Pharmacol Biochem Behav,2013,103(3):643-651.
[22]Gorelick PB.Role of inflammation in cognitive impairment:results of observational epidemiological studies and clinical trials[J].Ann N YAcad Sci,2010,1207:155-162.
[23]Walker AK,Kavelaars A,Heijnen CJ,et al.Neuroinflammation and comorbidity of pain and depression[J].Pharmacol Rev,2014,66(1):80-101.
[24]Wu TY,Liu L,Zhang W,et al.High-mobility group box-1 was released actively and involved in LPS induced depressive-like behavior[J].J Psychiatr Res,2015,64:99-106.
[25]van Heesch F,Prins J,Konsman JP,et al.Lipopolysaccharide increases degradation of central monoamines:an in vivo microdialysis study in the nucleus accumbens and medial prefrontal cortex of mice[J].Eur J Pharmacol,2014,725:55-63.
[26]Thaler JP,Yi CX,Schur EA,et al.Obesity is associated with hypothalamic injury in rodents and humans[J].J Clin Invest,2012,122(1):153-162.
[27]van Reedt DA,Vreeburg SA,Giltay EJ,et al.The impact of stress systems and lifestyle on dyslipidemia and obesity in anxiety and depression[J].Psychoneuroendocrinology,2013,38(2):209-218.
[28]Guo M,Lu Y,Garza JC,et al.Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression[J].Transl Psychiatry,2012,2:e83.
[29]Carney RM,Freedland KE,Veith RC.Depression,the autonomic nervous system,and coronary heart disease[J].Psychosom Med,2005,67 Suppl 1:S29-S33.
[30]Marazziti D,Rutigliano G,Baroni S,et al.Metabolic syndrome and major depression[J].CNS Spectr,2014,19(4):293-304.
[31]Carnethon MR,Golden SH,Folsom AR,et al.Prospective investigation of autonomic nervous system function and the development of type 2 diabetes:the Atherosclerosis Risk In Communities study,1987-1998[J].Circulation,2003,107(17):2190-2195.
[32]Kreier F,Yilmaz A,Kalsbeek A,et al.Hypothesis:shifting the equilibrium from activity to food leads to autonomic unbalance and the metabolic syndrome[J].Diabetes,2003,52(11):2652-2656.
[33]Martin KA,Mani MV,Mani A.New targets to treat obesity and the metabolic syndrome[J].Eur J Pharmacol,2015,763(Pt A):64-74.
[34]Zheng P,Wang Y,Chen L,et al.Identification and validation of urinary metabolite biomarkers for major depressive disorder[J].Mol Cell Proteomics,2013,12(1):207-214.
[35]Lozupone CA,Stombaugh JI,Gordon JI,et al.Diversity,stability and resilience of the human gut microbiota[J].Nature,2012,489(7415):220-230.
[36]Backhed F,Ding H,Wang T,et al.The gut microbiota as an environmental factor that regulates fat storage[J].Proc Natl Acad Sci U S A,2004,101(44):15718-15723.
[37]Le Chatelier E,Nielsen T,Qin J,et al.Richness of human gut microbiome correlates with metabolic markers[J].Nature,2013,500(7464):541-546.
[38]Backhed F,Manchester JK,Semenkovich CF,et al.Mechanisms underlying the resistance to diet-induced obesity in germ-free mice[J].Proc Natl Acad Sci U S A,2007,104(3):979-984.
[39]Turnbaugh PJ,Ley RE,Mahowald MA,et al.An obesity-associated gut microbiome with increased capacity for energy harvest[J].Nature,2006,444(7122):1027-1031.
[40]Kelly JR,Borre Y,O'B C,et al.Transferring the blues:Depressionassociated gut microbiota induces neurobehavioural changes in the rat[J].J Psychiatr Res,2016,82:109-118.