饮食疗法对癌症病人血液中微量元素水平的影响
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摘要
目的分析饮食疗法对癌症病人血液中微量元素水平的影响。方法收集2013年5月至2015年6月我院收治的180例恶性肿瘤患者,将其随机分为研究组与对照组,研究组(n=96)患者由专业营养师根据饮食调查与各项检查结果给予饮食治疗,而对照组(n=84)患者则根据饮食指导自行控制饮食。同期收集40例于我院体检的健康人群作为健康对照组,对比治疗前、后癌症患者血清中铁(Fe)、铜(Cu)、硒(Se)、锌(Zn)等微量元素水平变化情况。结果癌症组患者的Cu、Zn元素浓度明显高于健康对照组,而Fe、Se明显低于健康对照组(P<0.05)。肝癌患者的Cu与Zn高于健康对照组,而Se则低于健康对照组(P<0.05);胃癌患者的Fe低于健康对照组;结直肠癌患者的Fe和Cu均高于健康对照组,而Zn低于健康对照组(P<0.05);乳腺癌患者与肺癌患者的Fe、Se均低于健康对照组,而Cu则高于健康对照组,此外,乳腺癌患者中Zn水平也显著低于健康对照组(P<0.05)的。治疗前,2组不同癌症患者的Fe、Cu、Se、Zn浓度经比较无明显差异(P>0.05),但在治疗后,肝癌研究组患者的Cu与Zn低于对照组,而Se则高于对照组(P<0.05);胃癌研究组患者的Fe高于对照组(P<0.05);结直肠癌研究组患者的Fe和Cu均低于对照组,而Zn高于对照组(P<0.05);乳腺癌研究组患者的Fe、Se、Zn均高于对照组,而Cu低于对照组(P<0.05);肺癌研究组患者的Fe、Se均高于对照组,而Se低于对照组(P<0.05)。结论与健康对照组相比,癌症患者血液中铁、铜、硒、锌等微量元素水平发生明显改变,饮食疗法能有效改善癌症患者血液中相关微量元素水平。
Objective To analyze the effect of dietary therapy on the levels of trace elements in the blood of cancer patients. Methods 180 patients with malignant tumors admitted to our hospital from May 2013 to June 2015 were randomly divided into study group and control group. The study group(n=96) was given diet therapy by a professional dietitian based on dietary surveys and various test results, while the patients of control group(n=84) underwent self-controlled diet according to dietary guidelines. In the same period, 40 healthy people in our hospital were collected as healthy controls. The levels of trace elements such as iron(Fe), copper(Cu), selenium(Se) and zinc(Zn) in serum of patients with cancer before and after treatment were compared. Results The concentrations of Cu and Zn in the cancer group were significantly higher than those in the healthy control group, while Fe and Se were significantly lower than those in the healthy control group(P<0.05). Cu and Zn in patients with liver cancer were higher than those in healthy controls, while Se was lower than healthy controls( P<0.05); The patients with gastric cancer was lower than that of the healthy control group; Fe and Cu in patients with colorectal cancer were higher than those in healthy controls, while Zn was lower than healthy controls(P<0.05). Fe and Se in breast cancer patients and lung cancer patients were lower than those in healthy controls, while Cu was higher than healthy controls, in addition, the Zn level in breast cancer patients was also significantly lower than that in the healthy control group(P<0.05). Before treatment, the concentrations of Fe, Cu, Se and Zn in the two groups of cancer patients were not significantly different(P>0.05). However, after treatment, the Cu and Zn of the liver cancer research group were lower than the control group, while the Se was higher than the control group(P<0.05). The Fe of patients in the gastric cancer study group was higher than that of the control group(P<0.05); The Fe and Cu of the colorectal cancer study group were lower than the control group, while the Zn was higher than the control group(P<0.05). Fe, Se, and Zn in the breast cancer study group were higher than those in the control group, while Cu was lower than the control group(P<0.05). The Fe and Se of the lung cancer research group were higher than the control group, while the Se was lower than the control group(P<0.05). Conclusion Compared with the healthy control group, the levels of trace elements such as iron, copper, selenium and zinc in the blood of cancer patients changed significantly. Dietary therapy can effectively interfere with the levels of related trace elements in the blood of cancer patients.
Objective To analyze the effect of dietary therapy on the levels of trace elements in the blood of cancer patients. Methods 180 patients with malignant tumors admitted to our hospital from May 2013 to June 2015 were randomly divided into study group and control group. The study group(n=96) was given diet therapy by a professional dietitian based on dietary surveys and various test results, while the patients of control group(n=84) underwent self-controlled diet according to dietary guidelines. In the same period, 40 healthy people in our hospital were collected as healthy controls. The levels of trace elements such as iron(Fe), copper(Cu), selenium(Se) and zinc(Zn) in serum of patients with cancer before and after treatment were compared. Results The concentrations of Cu and Zn in the cancer group were significantly higher than those in the healthy control group, while Fe and Se were significantly lower than those in the healthy control group(P<0.05). Cu and Zn in patients with liver cancer were higher than those in healthy controls, while Se was lower than healthy controls( P<0.05); The patients with gastric cancer was lower than that of the healthy control group; Fe and Cu in patients with colorectal cancer were higher than those in healthy controls, while Zn was lower than healthy controls(P<0.05). Fe and Se in breast cancer patients and lung cancer patients were lower than those in healthy controls, while Cu was higher than healthy controls, in addition, the Zn level in breast cancer patients was also significantly lower than that in the healthy control group(P<0.05). Before treatment, the concentrations of Fe, Cu, Se and Zn in the two groups of cancer patients were not significantly different(P>0.05). However, after treatment, the Cu and Zn of the liver cancer research group were lower than the control group, while the Se was higher than the control group(P<0.05). The Fe of patients in the gastric cancer study group was higher than that of the control group(P<0.05); The Fe and Cu of the colorectal cancer study group were lower than the control group, while the Zn was higher than the control group(P<0.05). Fe, Se, and Zn in the breast cancer study group were higher than those in the control group, while Cu was lower than the control group(P<0.05). The Fe and Se of the lung cancer research group were higher than the control group, while the Se was lower than the control group(P<0.05). Conclusion Compared with the healthy control group, the levels of trace elements such as iron, copper, selenium and zinc in the blood of cancer patients changed significantly. Dietary therapy can effectively interfere with the levels of related trace elements in the blood of cancer patients.
引文
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[11]吴丹丹,杨磊,傅庆洪,等.石墨消解-火焰原子吸收分光光度法测定苹果中五种微量元素[J].应用化工,2016,45(2):367-380.Wu DD,Yang L,Fu QH,et al.Determination of five trace elements in apple by graphite digestion-flame atomic absorption spectrophotometry[J].J Appl Chem,2016,45(2):367-380.
[12]杨茹,薛雷喜,唐梅,等.类风湿关节炎患者药物治疗前后血清硒、铜、锌含量的变化分析[J].中国地方病防治杂志,2016,31(4):431-432,435.Yang R,Xue LX,Tang M,et al.Changes of serum selenium,copper and zinc contents in patients with rheumatoid arthritis before and after drug treatment[J].Chin J Contr Endem Disenec,2016,31(4):431-432,435.
[13]唐小宇.锌、铜、硒、锰抗氧化机制的研究进展[J].国际皮肤性病学杂志,2016,42(1):54-56.Tang XY.Research progress in antioxidant mechanism of zinc,copper,selenium and manganese[J].Int J Dermatol Venereol,2016,42(1):54-56.
[14]刘志辉,杨伟萍,韦长元,等.微量元素锌、铜、锰与硒在原发性肝癌组织和血清中的含量及相关性研究[J].广西医科大学学报,2016,33(1):66-70.Liu ZH,Yang WP,Wei CY,et al.Content and correlation of trace elements zinc,copper,manganese and selenium in primary liver cancer tissues and serum[J].J Guangxi Med Univ,2016,33(1):66-70.
[15]朱徐慧,丁钢强,章荣华,等.铁、锌、铜、硒、锰与代谢综合征的研究进展[J].中国老年学杂志,2016,36(1):197-200.Zhu XH,Ding GQ,Zhang RH,et al.Research progress of iron,zinc,copper,selenium,manganese and metabolic syndrome[J].Chin J Gerontol,2016,36(1):197-200.
[16]邱凌,徐蓉,汪思阳,等.2型糖尿病患者血清微量元素水平及糖代谢指标的相关性[J].中华老年多器官疾病杂志,2015,14(6):440-443.Qiu L,Xu R,Wang SY,et al.Correlation of serum levels of trace elements with glycometabolic parameters in patients with type 2 diabetes[J].Chin JMult Organ Dis Eld,2015,14(6):440-443.
[2]刘军.微量元素铜和锌在实验性肝癌中的变化及意义[J].医药前沿,2017,7(33):165-166.Liu J.Changes and significance of trace elements copper and zinc in experimental liver cancer[J].J Med Front,2017,7(33):165-166.
[3]李居武,饶晓明.微量元素及免疫指标与复发性口腔溃疡的关系研究[J].海南医学院学报,2016,22(7):719-721.Li JW,Rao XM.Relationship between trace elements and immune indexes and recurrent oral ulcers[J].J Hainan Med Univ,2016,22(7):719-721.
[4]胡明月,张萍,李晨,等.轻度认知障碍患者体内微量元素Cu和Zn含量的Meta分析[J].现代预防医学,2017,44(6):1097-1101,1127.Hu MY,Zhang P,Li C,et al.Meta-analysis of trace elements Cu and Zn in patients with mild cognitive impairment[J].Mod Prev Med,2017,44(6):1097-1101,1127.
[5]余晓燕,王烈宏.青海地区女性微量元素与宫颈疾病发病的关系及宫颈癌发病相关因素[J].中国老年学杂志,2016,36(15):3774-3775.Yu XY,Wang LH.Relationship between trace elements in women and cervical diseases in Qinghai and factors related to cervical cancer[J].Chin J Gerontol,2016,36(15):3774-3775.
[6]Janbabai G,Alipour A,Ehteshami S,et al.Investigation of trace elements in the hair and nail of patients with stomach cancer[J].Indian J Clin Biochem,2018,33(4):450-455.
[7]何钰卿.日常传统饮食对乳腺癌风险影响的研究现状[J].护理研究,2016,30(11):4107-4109.He YQ.Research status of the influence of daily traditional diet on breast cancer risk[J].J Nur Res,2016,30(11):4107-4109.
[8]朱雪梅.饮食护理干预对胃癌根治术患者术后营养指标及免疫功能的影响[J].实用临床医药杂志,2016,20(18):73-75.Zhu XM.Effects of dietary nursing intervention on postoperative nutritional status and immune function in patients undergoing radical gastrectomy[J].J Clin Med Pract,2016,20(18):73-75.
[9]王东艳,鲁延红.对进行化疗的食道癌患者实施饮食护理对其营养状况的影响观察[J].中国医疗设备,2017,32(S2):111.Wang DY,Lu YH.Observation on the effect of dietary nursing on nutritional status of patients with esophageal cancer undergoing chemotherapy[J].China Med Dev,2017,32(S2):111.
[10]赵聪,黄浩,陈贵堂.缺铁性贫血与补铁剂研究概况[J].食品安全质量检测学报,2016,7(9):3216-3221.Zhao C,Huang H,Chen GT.overview of iron deficiency anemia and iron supplement[J].J Food Saf Qual,2016,7(9):3216-3221.
[11]吴丹丹,杨磊,傅庆洪,等.石墨消解-火焰原子吸收分光光度法测定苹果中五种微量元素[J].应用化工,2016,45(2):367-380.Wu DD,Yang L,Fu QH,et al.Determination of five trace elements in apple by graphite digestion-flame atomic absorption spectrophotometry[J].J Appl Chem,2016,45(2):367-380.
[12]杨茹,薛雷喜,唐梅,等.类风湿关节炎患者药物治疗前后血清硒、铜、锌含量的变化分析[J].中国地方病防治杂志,2016,31(4):431-432,435.Yang R,Xue LX,Tang M,et al.Changes of serum selenium,copper and zinc contents in patients with rheumatoid arthritis before and after drug treatment[J].Chin J Contr Endem Disenec,2016,31(4):431-432,435.
[13]唐小宇.锌、铜、硒、锰抗氧化机制的研究进展[J].国际皮肤性病学杂志,2016,42(1):54-56.Tang XY.Research progress in antioxidant mechanism of zinc,copper,selenium and manganese[J].Int J Dermatol Venereol,2016,42(1):54-56.
[14]刘志辉,杨伟萍,韦长元,等.微量元素锌、铜、锰与硒在原发性肝癌组织和血清中的含量及相关性研究[J].广西医科大学学报,2016,33(1):66-70.Liu ZH,Yang WP,Wei CY,et al.Content and correlation of trace elements zinc,copper,manganese and selenium in primary liver cancer tissues and serum[J].J Guangxi Med Univ,2016,33(1):66-70.
[15]朱徐慧,丁钢强,章荣华,等.铁、锌、铜、硒、锰与代谢综合征的研究进展[J].中国老年学杂志,2016,36(1):197-200.Zhu XH,Ding GQ,Zhang RH,et al.Research progress of iron,zinc,copper,selenium,manganese and metabolic syndrome[J].Chin J Gerontol,2016,36(1):197-200.
[16]邱凌,徐蓉,汪思阳,等.2型糖尿病患者血清微量元素水平及糖代谢指标的相关性[J].中华老年多器官疾病杂志,2015,14(6):440-443.Qiu L,Xu R,Wang SY,et al.Correlation of serum levels of trace elements with glycometabolic parameters in patients with type 2 diabetes[J].Chin JMult Organ Dis Eld,2015,14(6):440-443.