不同基原肾精子药效的比较研究
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摘要
目的:初步对不同基原肾精子治疗前列腺增生症的疗效进行比较。方法:采用皮下注射丙酸睾酮复制前列腺增生动物模型的方法,以前列腺湿重、脏器指数及脏器病理变化的程度为指标,比较两种基原肾精子的药效作用。结果:两种基原肾精子给药组与模型组比较,前列腺脏器指数减小,差异有统计学意义(P<0.05)。肾精子各给药组之间比较,前列腺体积、前列腺湿重、前列腺脏器指数比较差异无统计学意义(P>0.05)。结论:不同基原肾精子均可抑制前列腺增生,疗效比较差异无统计学意义。
Objective:To compare the curative effect of Shenjingzi from different origins on prostatic hyperplasia. Methods:Subcutaneous injection of testosterone propionate was used to replicate the animal models of prostatic hyperplasia. After administration,prostate tissue of rats were removed and weighed,ant their morphological changes were observed. Results:Compared with the model group,there was a decrease in the prostate organ index(P<0.05)and the difference was statistically significant. There was no statistical significance in volume,wet weight and organ index of prostate(P>0.05)among the four administration groups of Shenjingzi. Conclusion:Shenjingzi from different origins could inhibit the prostatic hyperplasia and have no statistical significance in curative effect.
Objective:To compare the curative effect of Shenjingzi from different origins on prostatic hyperplasia. Methods:Subcutaneous injection of testosterone propionate was used to replicate the animal models of prostatic hyperplasia. After administration,prostate tissue of rats were removed and weighed,ant their morphological changes were observed. Results:Compared with the model group,there was a decrease in the prostate organ index(P<0.05)and the difference was statistically significant. There was no statistical significance in volume,wet weight and organ index of prostate(P>0.05)among the four administration groups of Shenjingzi. Conclusion:Shenjingzi from different origins could inhibit the prostatic hyperplasia and have no statistical significance in curative effect.
引文
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[4]刘馨,赵思俊,王春芳,等.中药肾精子对大鼠前列腺增生模型的影响研究[J].山西中医,2018,34(6):53-55,62.
[5]中华中医药学会中药实验药理专业委员会.前列腺增生动物模型制备规范(草案)[J].中国实验方剂学杂志,2018,24(19):15-19.
[6]郭琳,苗明三.基于前列腺增生症临床病症特点的动物模型分析[J].中华中医药杂志,2016,31(1):261-264.
[7]孙汀,缪云萍,程敏,等.葛陈胶囊对大鼠前列腺增生的防治作用[J].浙江实用医学,2017,22(1):1-4.
[8]邹莹,张连富.玛咖水提物抗小鼠前列腺增生作用[J].食品与生物技术学报,2017,36(4):371-375.
[9]徐薇,庄田畋,刘杨,等.黄芪抗大鼠前列腺增生的实验研究[J].贵阳中医学院学报,2018,40(1):18-22.
[10]Jonler M,Riehmann M,Brinkmann R,et al.Benign prostatic hyperplasia[J].Endocrinol Metab Clin North Am,1994(23):795-807.
[11]Nicholson TM,Ricke WA.Androgens and estrogens in benign prostatic hyperplasia:past,present and future[J].Differentiation,2011(82):184-199.
[12]Safarinejad MR.Prevalence of benign prostatic hyperplasia in a population-based study in Iranian men 40 years old or older[J].Int Urol Nephrol,2008,40(4):921-931.
[13]Thiruchelvam N.Benign prostatic hyperplasia[J].Surgery,2014,83(6):314-322.
[14]李小滨,曾柯,刘跃江,等.经尿道等离子前列腺解剖性剜除术与经尿道前列腺电切术治疗良性前列腺增生的疗效比较[J].中国医学创新,2018,15(5):30-33.
[15]张玲,谢辉,聂钰松,等.中药治疗前列腺增生症的动物实验研究进展[J].中成药,2018,40(1):162-166.
[2]北京市药材公司,北京市药品检验所.中药材手册拾遗[M].北京:北京市药品检验所,1973:176
[3]郑锦章,刘学文,宋鉴蓉.肾精子利尿作用好[J].中药通报,1981(1):41.
[4]刘馨,赵思俊,王春芳,等.中药肾精子对大鼠前列腺增生模型的影响研究[J].山西中医,2018,34(6):53-55,62.
[5]中华中医药学会中药实验药理专业委员会.前列腺增生动物模型制备规范(草案)[J].中国实验方剂学杂志,2018,24(19):15-19.
[6]郭琳,苗明三.基于前列腺增生症临床病症特点的动物模型分析[J].中华中医药杂志,2016,31(1):261-264.
[7]孙汀,缪云萍,程敏,等.葛陈胶囊对大鼠前列腺增生的防治作用[J].浙江实用医学,2017,22(1):1-4.
[8]邹莹,张连富.玛咖水提物抗小鼠前列腺增生作用[J].食品与生物技术学报,2017,36(4):371-375.
[9]徐薇,庄田畋,刘杨,等.黄芪抗大鼠前列腺增生的实验研究[J].贵阳中医学院学报,2018,40(1):18-22.
[10]Jonler M,Riehmann M,Brinkmann R,et al.Benign prostatic hyperplasia[J].Endocrinol Metab Clin North Am,1994(23):795-807.
[11]Nicholson TM,Ricke WA.Androgens and estrogens in benign prostatic hyperplasia:past,present and future[J].Differentiation,2011(82):184-199.
[12]Safarinejad MR.Prevalence of benign prostatic hyperplasia in a population-based study in Iranian men 40 years old or older[J].Int Urol Nephrol,2008,40(4):921-931.
[13]Thiruchelvam N.Benign prostatic hyperplasia[J].Surgery,2014,83(6):314-322.
[14]李小滨,曾柯,刘跃江,等.经尿道等离子前列腺解剖性剜除术与经尿道前列腺电切术治疗良性前列腺增生的疗效比较[J].中国医学创新,2018,15(5):30-33.
[15]张玲,谢辉,聂钰松,等.中药治疗前列腺增生症的动物实验研究进展[J].中成药,2018,40(1):162-166.