五味子保肝作用的研究进展
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摘要
五味子是常用的传统滋补类中药,具有宁心安神的功效,主治心神失养之虚烦心悸,失眠多梦等症状。近年来,国内外关于五味子在保肝方面的药理作用进行了大量的研究,本文对五味子在此方面的研究进行了总结阐述,为临床研究开发保肝新药提供了理论参考。
Schisandra chinensis is a commonly used traditional nourishing Chinese medicine.It possesses the effects of calming the heart and tranquilizing the mind and is mainly used for treatment of dysphoria and palpitation,insomnia and dreamful sleep due to the lack of spirit preservation.In recent years,a great deal of domestic and international research had been carried out on the hepatoprotective effects of Schisandra chinensis.In this paper,the hepatoprotective effects of Schisandra chinensis were summarized and elaborated to provide a theoretical reference for the clinical research and development of hepatoprotective drugs.
Schisandra chinensis is a commonly used traditional nourishing Chinese medicine.It possesses the effects of calming the heart and tranquilizing the mind and is mainly used for treatment of dysphoria and palpitation,insomnia and dreamful sleep due to the lack of spirit preservation.In recent years,a great deal of domestic and international research had been carried out on the hepatoprotective effects of Schisandra chinensis.In this paper,the hepatoprotective effects of Schisandra chinensis were summarized and elaborated to provide a theoretical reference for the clinical research and development of hepatoprotective drugs.
引文
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[8] 金银萍,李珊珊,郑颖,等.五味子抗糖尿病和抗氧化作用研究进展[J].特产研究,2017,39(1):64-68.
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[10] JANG M K,NAM J S,KIM J H,et al.Schisandra chinensis extract ameliorates nonalcoholic fatty liver via inhibition of endoplasmic reticulum stress[J].J Ethnopharmacol,2016(185):96-104.
[11] 邱炳勋,刘珂,邹利,等.五味子诱导的CYPs和Nrf2活化对对乙酰氨基酚急性肝损伤的影响[J].中国中药杂志,2018,43(24):4908-4915.
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[15] 睢大筼,高普军,吕忠智,等.北五味子粗多糖保肝作用的药理研究[J].吉林中医药,1995(1):37.
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[17] WANG C M,YUAN R S,ZHUANG W Y,et al.Schisandra polysaccharide inhibits hepatic lipid accumulation by downregulating expression of SREBPs in NAFLD mice[J].Lipids Health Dis,2016,15(1):195.
[18] YUAN R S,TAO X,LIANG S,et al.Protective effect of acidic polysaccharide from Schisandra chinensis on acute ethanol-induced liver injury through reducing CYP2E1-dependent oxidative stress[J].Biomed Pharmacother,2018(99):537-542.
[19] 潘炎,陶雪,梁爽,等.五味子酸性多糖分级产物对小鼠急性酒精性肝损伤的改善作用[J].食品工业科技,2018,39(14):297-300,305.
[20] 苑荣爽,李贺,孙靖辉,等.北五味子多糖对高脂诱导非酒精性脂肪性肝病大鼠的降血脂作用及其抗氧化活性[J].吉林大学学报(医学版),2017,43(6):1103-1108,13.
[21] JANG M K,YUN Y R,KIM J H,et al.Protective effect of Gomisin N against endoplasmic reticulum stress-induced hepatic steatosis[J].Biol Pharm Bull,2016,39(5):832-838.
[22] LI B,LI B N,WANG Y H,et al.Schisantherin A alleviated alcohol-induced liver injury by the regulation of alcohol metabolism and NF-κB pathway[J].Exp Anim,2018,67(4):451-461.
[23] ZENG H,JIANG Y M,CHEN P,et al.Schisandrol B protects against cholestatic liver injury through pregnane X receptors[J].Br J Pharmacol,2017,174(8):672-688.
[24] JIANG Y M,WANG Y,TAN H S,et al.Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway[J].Acta Pharmacol Sin,2016,37(3):382-389.
[25] CHEN Q S,ZHANG H,CAO Y,et al.Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TgF-β/smad signaling pathways[J].Drug Des Devel Ther,2017(11):2179-2191.
[26] 白慧媛,俸珊.五味子乙素对氯氮平致小鼠肝损伤的保护作用[J].药学学报,2017,52(3):390-396.
[27] 王菊平,李小芹,李永春.五味子甲素对急性肝内胆汁淤积大鼠肝功能的保护作用研究[J].亚太传统医药,2018,14(6):32-33.
[28] 曹媛,夏延哲,陈杰,等.五味子甲素在人肝星状细胞中的抗纤维化作用[J].中国临床药理学与治疗学,2016,21(8):878-883.
[2] RUSH B,WALLEY K R,CELI L A,et al.Palliative care access for hospitalized patients with end stage liver disease across the United States[J].Hepatology,2017,66(5):1585-1591.
[3] 李妍,吕士杰,张巍.五味子生物活性成分及其药理作用的研究进展[J].吉林医药学院学报,2013,34(6):454-456.
[4] 王飞.五味子保肝作用物质基础[J].人人健康,2018(8):223.
[5] HONG M,ZHANG Y S,LI S,et al.A Network Pharmacology-Based Study on the Hepatoprotective Effect of Fructus Schisandrae[J].Molecules,2017,22(10):1-11.
[6] 宋群.五味子在肝病治疗中的应用[J].上海中医药杂志,2014,48(2):66-67.
[7] 吴伦,陈晓宇,于浩然,等.五味子醇甲的抗炎免疫作用研究[J].现代中药研究与实践,2017,31(5):18-21.
[8] 金银萍,李珊珊,郑颖,等.五味子抗糖尿病和抗氧化作用研究进展[J].特产研究,2017,39(1):64-68.
[9] JANG H I,DO G M,LEE H M,et al.Schisandra Chinensis Baillon regulates the gene expression of phase II antioxidant/detoxifying enzymes in hepatic damage induced rats[J].Nutr Res Pract,2014,8(3):272-277.
[10] JANG M K,NAM J S,KIM J H,et al.Schisandra chinensis extract ameliorates nonalcoholic fatty liver via inhibition of endoplasmic reticulum stress[J].J Ethnopharmacol,2016(185):96-104.
[11] 邱炳勋,刘珂,邹利,等.五味子诱导的CYPs和Nrf2活化对对乙酰氨基酚急性肝损伤的影响[J].中国中药杂志,2018,43(24):4908-4915.
[12] PU H J,CAO Y F,HE RR,et al.Correlation between antistress and hepatoprotective effects of Schisandra lignans was related with its antioxidative actions in liver cells[J].Evid Based Complement Alternat Med,2012(2012):161062.
[13] CHEN Q S,ZHAN Q,LI Y,et al.Schisandra lignan extract protects against carbon tetrachloride-induced liver injury in mice by inhibiting oxidative stress and regulating the NF-κB and JNK Signaling Pathways[J].Evid Based Complement Alternat Med,2017(2017):5140297.
[14] 王小宁,郝晶,刘子晨,等.五味子油超声辅助提取工艺优化及其护肝作用[J].食品与机械,2018,34(1):135-139,172.
[15] 睢大筼,高普军,吕忠智,等.北五味子粗多糖保肝作用的药理研究[J].吉林中医药,1995(1):37.
[16] 高普军,朴云峰,郭晓林,等.北五味子粗多糖保肝作用的机理[J].白求恩医科大学学报,1996(1):23-24.
[17] WANG C M,YUAN R S,ZHUANG W Y,et al.Schisandra polysaccharide inhibits hepatic lipid accumulation by downregulating expression of SREBPs in NAFLD mice[J].Lipids Health Dis,2016,15(1):195.
[18] YUAN R S,TAO X,LIANG S,et al.Protective effect of acidic polysaccharide from Schisandra chinensis on acute ethanol-induced liver injury through reducing CYP2E1-dependent oxidative stress[J].Biomed Pharmacother,2018(99):537-542.
[19] 潘炎,陶雪,梁爽,等.五味子酸性多糖分级产物对小鼠急性酒精性肝损伤的改善作用[J].食品工业科技,2018,39(14):297-300,305.
[20] 苑荣爽,李贺,孙靖辉,等.北五味子多糖对高脂诱导非酒精性脂肪性肝病大鼠的降血脂作用及其抗氧化活性[J].吉林大学学报(医学版),2017,43(6):1103-1108,13.
[21] JANG M K,YUN Y R,KIM J H,et al.Protective effect of Gomisin N against endoplasmic reticulum stress-induced hepatic steatosis[J].Biol Pharm Bull,2016,39(5):832-838.
[22] LI B,LI B N,WANG Y H,et al.Schisantherin A alleviated alcohol-induced liver injury by the regulation of alcohol metabolism and NF-κB pathway[J].Exp Anim,2018,67(4):451-461.
[23] ZENG H,JIANG Y M,CHEN P,et al.Schisandrol B protects against cholestatic liver injury through pregnane X receptors[J].Br J Pharmacol,2017,174(8):672-688.
[24] JIANG Y M,WANG Y,TAN H S,et al.Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway[J].Acta Pharmacol Sin,2016,37(3):382-389.
[25] CHEN Q S,ZHANG H,CAO Y,et al.Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TgF-β/smad signaling pathways[J].Drug Des Devel Ther,2017(11):2179-2191.
[26] 白慧媛,俸珊.五味子乙素对氯氮平致小鼠肝损伤的保护作用[J].药学学报,2017,52(3):390-396.
[27] 王菊平,李小芹,李永春.五味子甲素对急性肝内胆汁淤积大鼠肝功能的保护作用研究[J].亚太传统医药,2018,14(6):32-33.
[28] 曹媛,夏延哲,陈杰,等.五味子甲素在人肝星状细胞中的抗纤维化作用[J].中国临床药理学与治疗学,2016,21(8):878-883.