咪唑啉I2受体生物学功能研究进展
摘要
本综述总结归纳了咪唑啉I2受体生物学功能研究的最新进展。咪唑啉I2受体配体是探讨与I2受体有关的药理作用的一种非常有价值的研究工具,大量证据提示咪唑啉I2受体配体本身具有抗伤害感受性作用,并且与镇痛药的联合使用不仅增强镇痛药的抗伤害性感受性作用,还可以减轻长期使用镇痛药产生的耐受性和依赖性等副作用。咪唑啉I2受体配体的另一作用是具有确切的神经保护作用,但其具体机制需要进一步探索及研究。此外,一些研究表明咪唑啉I2受体具有改善阿尔兹海默病、抗抑郁、调节体温等作用。
引文
[1]COUPRY I,PODEVIN R A,DAUSSE J P,et al.Evidence for imidazoline binding sites in basolateral membranes from rabbit kidney[J].Biochemical&Biophysical Research Communications,1987,147(3):1055-1060.
[2]LI G,REGUNATHAN S,BARROW C J,et al.Agmatine:an endogenous clonidine-displacing substance in the brain[J].Science,1994,263(5149):966-969.
[3]PILETZ J E,ARICIOGLU F,CHENG J T,et al.Agmatine:clinical applications after 100 years in translation[J].Drug Discovery Today,2013,18(17-18):880-893.
[4]UZBAY T,GOKTALAY G,KAYIR H,et al.Increased plasma agmatine levels in patients with schizophrenia[J].Journal of Psychiatric Research,2013,47(8):1054-1060.
[5]TAKSANDE B G,FALDU D S,DIXIT M P,et al.Agmatine attenuates chronic unpredictable mild stress induced behavioral alteration in mice[J].European Journal of Pharmacology,2013,720(1-3):115-120.
[6]GULATI A,BHALLA S,MATWYSHYN G,et al.Determination of adrenergic and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by clonidine and BMS182874[J].Pharmacology,2009,83(1):45-58.
[7]ABAS S,ERDOZAIN A M,KELLER B,et al.Neuroprotective effects of a structurally new family of high affinity imidazoline i2 receptor ligands[J].Acs Chemical Neuroscience,2017,8(4):737-742.
[8]LANZA M,FERRARI F,MENGHETTI I,et al.Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats[J].British Journal of Pharmacology,2014,171(15):3693-3701.
[9]THORN D A,QIU Y,ZHANG Y,et al.Antinociceptive effects of imidazoline I2 receptor agonists in the formalin test in rats[J].Behavioural Pharmacology,2016,27(4):377-383.
[10]HUNSKAAR S,HOLE K.The formalin test in mice:dissociation between inflammatory and non-inflammatory pain[J].Pain,1987,30(1):103-114.
[11]THORN D A,SIEMIAN J N,ZHANG Y,et al.Anti-hyperalgesic effects of imidazoline I2 receptor ligands in a rat model of inflammatory pain:interactions with oxycodone[J].Psychopharmacology,2015,232(18):3309-3318.
[12]THORN D A,ZHANG Y,LI J X.Tolerance and cross-tolerance to the antinociceptive effects of oxycodone and the imidazoline I 2,receptor agonist phenyzoline in adult male rats[J].Psychopharmacology,2017,234(12):1871-1880.
[13]THORN D A,ZHANG Y,LI J X.Effects of the imidazoline I2receptor agonist 2-BFI on the development of tolerance to and behavioural/physical dependence on morphine in rats[J].Br J Pharmacol,2016,173(8):1363-1372.
[14]SIEMIAN J N,OBENG S,ZHANG Y,et al.Antinociceptive interactions between the imidazoline I2 receptor agonist 2-BFI and opioids in rats:role of efficacy at theμopioid receptor[J].Journal of Pharmacology&Experimental Therapeutics,2016,357(3):509-519.
[15]SIEMIAN J N,LI J,ZHANG Y,et al.Interactions between imidazoline I2 receptor ligands and acetaminophen in adult male rats:antinociception and schedule-controlled responding[J].Psychopharmacology,2016,233(5):873-882.
[16]CUI H,LEE J H,KIM J Y,et al.The neuroprotective effect of agmatine after focal cerebral ischemia in diabetic rats[J].JNeurosurg Anesthesiol,2012,24(1):39-50.
[17]HAN Z,CHENG Z H,LIU S,et al.Neurovascular protection conferred by 2-BFI treatment during rat cerebral ischemia[J].Biochemical&Biophysical Research Communications,2012,424(3):544-548.
[18]何丹,杨势赫,金志成,等.碱性成纤维细胞生长因子预处理对大鼠脑缺血/再灌注损伤的神经保护作用[J].东南大学学报(医学版),2015,34(5):714-720.
[19]ZHU Y,XIA N,ZHANG Y,et al.Brain protection conferred by long-term administration of 2-(2-benzofuranyl)-2-imidazoline against experimental autoimmune encephalomyelitis[J].Neurochemical Research,2015,40(3):572-578.
[20]HAN Z,YANG J L,JIANG S X,et al.Fast,non-competitive and reversible inhibition of NMDA-activated currents by 2-BFI confers neuroprotection[J].PLo S One,2013,8(5):1-10.
[21]KELLER B,GARCIASEYILLA J A.Inhibitory effects of imidazoline receptor ligands on basal and kainic acid-induced neurotoxic signalling in mice[J].Journal of Psychopharmacology,2016,30(9):875-886.
[22]GARAU C,MIRALLES A,GARCIA-SEVILLA J A.Chronic treatment with selective I2-imidazoline receptor ligands decreases the content of pro-apoptotic markers in rat brain[J].J Psychopharmacol(Oxford),2013,27(2):123-134.
[23]LI F,ZHANG Z X,LIU Y F,et al.2-BFI ameliorates EAE-induced mouse spinal cord damage:Effective therapeutic time window and possible mechanisms[J].Brain Research,2012,1483(45):13-19.
[24]WANG X,CHEN Y X,ZHU Z,et al.Idazoxan attenuates spinal cord injury by enhanced astrocytic activation and reduced microglial activation in rat experimental autoimmune encephalomyelitis[J].Brain Research,2009,1253:198-209.
[25]MIN J W,PENG B W,HE X,et al.Gender difference in epileptogenic effects of 2-BFI and BU224 in mice[J].European Journal of Pharmacology,2013,718(3):81-86.
[26]TIAN J S,ZHAI Q J,ZHAO Y,et al.2-(2-benzofuranyl)-2-imidazoline(2-BFI)improved the impairments in AD rat models by inhibiting oxidative stress,inflammation and apoptosis[J].Journal of Integrative Neuroscience,2017,16(4):1-16.
[27]TONELLO R,VILLARINHO J G,DA S S G,et al.The potential antidepressant-like effect of imidazoline I2 ligand 2-BFIin mice[J].Progress in Neuro-Psychopharmacology&Biological Psychiatry,2012,37(1):15-21.
[28]THORN D A,AN X F,ZHANG Y,et al.Characterization of the hypothermic effects of imidazoline I receptor agonists in rats[J].British Journal of Pharmacology,2012,166(6):1936-1945.
[2]LI G,REGUNATHAN S,BARROW C J,et al.Agmatine:an endogenous clonidine-displacing substance in the brain[J].Science,1994,263(5149):966-969.
[3]PILETZ J E,ARICIOGLU F,CHENG J T,et al.Agmatine:clinical applications after 100 years in translation[J].Drug Discovery Today,2013,18(17-18):880-893.
[4]UZBAY T,GOKTALAY G,KAYIR H,et al.Increased plasma agmatine levels in patients with schizophrenia[J].Journal of Psychiatric Research,2013,47(8):1054-1060.
[5]TAKSANDE B G,FALDU D S,DIXIT M P,et al.Agmatine attenuates chronic unpredictable mild stress induced behavioral alteration in mice[J].European Journal of Pharmacology,2013,720(1-3):115-120.
[6]GULATI A,BHALLA S,MATWYSHYN G,et al.Determination of adrenergic and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by clonidine and BMS182874[J].Pharmacology,2009,83(1):45-58.
[7]ABAS S,ERDOZAIN A M,KELLER B,et al.Neuroprotective effects of a structurally new family of high affinity imidazoline i2 receptor ligands[J].Acs Chemical Neuroscience,2017,8(4):737-742.
[8]LANZA M,FERRARI F,MENGHETTI I,et al.Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats[J].British Journal of Pharmacology,2014,171(15):3693-3701.
[9]THORN D A,QIU Y,ZHANG Y,et al.Antinociceptive effects of imidazoline I2 receptor agonists in the formalin test in rats[J].Behavioural Pharmacology,2016,27(4):377-383.
[10]HUNSKAAR S,HOLE K.The formalin test in mice:dissociation between inflammatory and non-inflammatory pain[J].Pain,1987,30(1):103-114.
[11]THORN D A,SIEMIAN J N,ZHANG Y,et al.Anti-hyperalgesic effects of imidazoline I2 receptor ligands in a rat model of inflammatory pain:interactions with oxycodone[J].Psychopharmacology,2015,232(18):3309-3318.
[12]THORN D A,ZHANG Y,LI J X.Tolerance and cross-tolerance to the antinociceptive effects of oxycodone and the imidazoline I 2,receptor agonist phenyzoline in adult male rats[J].Psychopharmacology,2017,234(12):1871-1880.
[13]THORN D A,ZHANG Y,LI J X.Effects of the imidazoline I2receptor agonist 2-BFI on the development of tolerance to and behavioural/physical dependence on morphine in rats[J].Br J Pharmacol,2016,173(8):1363-1372.
[14]SIEMIAN J N,OBENG S,ZHANG Y,et al.Antinociceptive interactions between the imidazoline I2 receptor agonist 2-BFI and opioids in rats:role of efficacy at theμopioid receptor[J].Journal of Pharmacology&Experimental Therapeutics,2016,357(3):509-519.
[15]SIEMIAN J N,LI J,ZHANG Y,et al.Interactions between imidazoline I2 receptor ligands and acetaminophen in adult male rats:antinociception and schedule-controlled responding[J].Psychopharmacology,2016,233(5):873-882.
[16]CUI H,LEE J H,KIM J Y,et al.The neuroprotective effect of agmatine after focal cerebral ischemia in diabetic rats[J].JNeurosurg Anesthesiol,2012,24(1):39-50.
[17]HAN Z,CHENG Z H,LIU S,et al.Neurovascular protection conferred by 2-BFI treatment during rat cerebral ischemia[J].Biochemical&Biophysical Research Communications,2012,424(3):544-548.
[18]何丹,杨势赫,金志成,等.碱性成纤维细胞生长因子预处理对大鼠脑缺血/再灌注损伤的神经保护作用[J].东南大学学报(医学版),2015,34(5):714-720.
[19]ZHU Y,XIA N,ZHANG Y,et al.Brain protection conferred by long-term administration of 2-(2-benzofuranyl)-2-imidazoline against experimental autoimmune encephalomyelitis[J].Neurochemical Research,2015,40(3):572-578.
[20]HAN Z,YANG J L,JIANG S X,et al.Fast,non-competitive and reversible inhibition of NMDA-activated currents by 2-BFI confers neuroprotection[J].PLo S One,2013,8(5):1-10.
[21]KELLER B,GARCIASEYILLA J A.Inhibitory effects of imidazoline receptor ligands on basal and kainic acid-induced neurotoxic signalling in mice[J].Journal of Psychopharmacology,2016,30(9):875-886.
[22]GARAU C,MIRALLES A,GARCIA-SEVILLA J A.Chronic treatment with selective I2-imidazoline receptor ligands decreases the content of pro-apoptotic markers in rat brain[J].J Psychopharmacol(Oxford),2013,27(2):123-134.
[23]LI F,ZHANG Z X,LIU Y F,et al.2-BFI ameliorates EAE-induced mouse spinal cord damage:Effective therapeutic time window and possible mechanisms[J].Brain Research,2012,1483(45):13-19.
[24]WANG X,CHEN Y X,ZHU Z,et al.Idazoxan attenuates spinal cord injury by enhanced astrocytic activation and reduced microglial activation in rat experimental autoimmune encephalomyelitis[J].Brain Research,2009,1253:198-209.
[25]MIN J W,PENG B W,HE X,et al.Gender difference in epileptogenic effects of 2-BFI and BU224 in mice[J].European Journal of Pharmacology,2013,718(3):81-86.
[26]TIAN J S,ZHAI Q J,ZHAO Y,et al.2-(2-benzofuranyl)-2-imidazoline(2-BFI)improved the impairments in AD rat models by inhibiting oxidative stress,inflammation and apoptosis[J].Journal of Integrative Neuroscience,2017,16(4):1-16.
[27]TONELLO R,VILLARINHO J G,DA S S G,et al.The potential antidepressant-like effect of imidazoline I2 ligand 2-BFIin mice[J].Progress in Neuro-Psychopharmacology&Biological Psychiatry,2012,37(1):15-21.
[28]THORN D A,AN X F,ZHANG Y,et al.Characterization of the hypothermic effects of imidazoline I receptor agonists in rats[J].British Journal of Pharmacology,2012,166(6):1936-1945.