基于文献计量的制药废水处理专利发展趋势
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摘要
为了解制药废水处理技术的实际应用情况,以与Web of Science同源的DII (Derwent Innovations Index,德温特)专利数据库为数据源,对1985—2017年的制药废水处理专利进行数据分析与挖掘.采用Excel和End Note相结合的方法,系统分析了国内外制药废水处理的研究现状,阐明了制药废水处理的主流技术及专利领先的国家和组织,讨论了该领域的研究热点及前沿方向.结果表明:制药废水处理专利数量持续增长,特别是自1998年以来增速显著;制药废水处理专利以过滤技术、非生物滤池的好氧技术、混凝技术为主,它们是制药废水处理工艺中常用和必须的单元;我国在制药废水处理领域发表的专利数量居世界第1位,并且对主流技术研究的关注度和需求很高,但专利授权数量相对较少,研究深度有待提高.研究显示,面对我国类型复杂的制药废水,建议加强技术创新,以解决我国制药废水处理的技术难题,使我国制药废水处理技术向着实用化的方向发展.
This paper analyzed the patents on pharmaceutical wastewater treatment from 1985 to 2017 in the DII Database( same data source as Web of Science) using the bibliometric analysis method in order to learn the applications of those patents. This paper combined Excel and Endnote to systematically analyze the current research on pharmaceutical wastewater treatment in China and other countries,identified the mainstream technologies and leading countries and organizations holding these patents,and discussed the hot research topics and development trend in this area. Results showed that the number of the patents on pharmaceutical wastewater treatment increased continuously,especially in recently 20 years. The mainstream technologies in the patents included filtration,aeration,and flocculation,which are commonly used in industrial applications. China ranked the first in terms of patent application in this area with a great attention to the mainstream technologies although the number of licensed patents was still low and the quality of the patents was not high. More technical innovations and more applicable technologies are still needed to solve the complicated problems due to various types of pharmaceutical wastewaters in China.
This paper analyzed the patents on pharmaceutical wastewater treatment from 1985 to 2017 in the DII Database( same data source as Web of Science) using the bibliometric analysis method in order to learn the applications of those patents. This paper combined Excel and Endnote to systematically analyze the current research on pharmaceutical wastewater treatment in China and other countries,identified the mainstream technologies and leading countries and organizations holding these patents,and discussed the hot research topics and development trend in this area. Results showed that the number of the patents on pharmaceutical wastewater treatment increased continuously,especially in recently 20 years. The mainstream technologies in the patents included filtration,aeration,and flocculation,which are commonly used in industrial applications. China ranked the first in terms of patent application in this area with a great attention to the mainstream technologies although the number of licensed patents was still low and the quality of the patents was not high. More technical innovations and more applicable technologies are still needed to solve the complicated problems due to various types of pharmaceutical wastewaters in China.
引文
[1]LI B,ZHANG T.Biodegradation and adsorption of antibiotics in the activated sludge process[J].Environmental Science&Technology,2010,44(9):3468-3473.
[2]MARTINEZ J L.Antibiotics and antibiotic resistance genes in natural environments[J].Science,2008,321(5887):365-367.
[3]KOSTICH M,LAZORCHAK J.Risks to aquatic organisms posed by human pharmaceutical use[J].Science of the Total Environment,2008,389(2/3):329-339.
[4]GOLET E M,XIFRA I,SIEGRIST H,et al.Environmental exposure assessment of fluoroquinolone antibacterial agents from sewage to soil[J].Environmental Science&Technology,2003,37(15):3243-3249.
[5]郑惠东.水环境中抗生素来源及对健康的影响[J].环境卫生学杂志,2018,8(1):73-77.ZHENG Huidong.The source of antibiotics in aquatic environment and its impact on human health[J].Journal of Environmental Hygiene,2018,8(1):73-77.
[6]冯宝佳,曾强,赵亮,等.水环境中抗生素的来源分布及对健康的影响[J].环境监测管理与技术,2013,25(1):14-17.FENG Baojia,ZENG Qiang,ZHAO Liang,et al.Source distribution of antibiotics in water environment and its impact on human health[J].The Administration and Technique of Environmental Monitoring,2013,25(1):14-17.
[7]王俊峰,尹尧,加春生,等.抗生素制药工业废水污染及处理技术研究[J].生物技术世界,2014,83(10):9.WANG Junfeng,YIN Yao,JIA Chunsheng,et al.Study on pollution and treatment technology of antibiotic pharmaceutical industry wastewater[J].Biotech World,2014,83(10):9.
[8]刘姗姗.中国制药产业发展现状分析[J].民营科技,2017(11):18.
[9]中华人民共和国国家统计局.中国统计年鉴[M].北京:中国统计出版社,2017:88-91.
[10]李晓红.制药废水有毒有害物的控制技术评估[D].青岛:山东科技大学,2015:6-7.
[11]MOLINOS S M,REIF R,GARRIDO B M,et al.Economic valuation of environmental benefits of removing pharmaceutical and personal care products from WWTP effluents by ozonation[J].Science of the Total Environment,2013,461/462:409-415.
[12]NADDEO V,BELGIORNO V,RICCO D,et al.Degradation of diclofenac during sonolysis,ozonation and their simultaneous application[J].Ultrasonics Sonochemistry,2009,16(6):790-794.
[13]MARTNEZ F,LPEZ M M J,AGUADO J,et al.Coupling membrane separation and photocatalytic oxidation processes for the degradation of pharmaceutical pollutants[J].Water Research,2013,47(15):345-355.
[14]HAN W Q,WANG L J,SUN X Y,et al.Treatment of bactericide wastewater by combined process chemical coagulation,electrochemical oxidation and membrane bioreactor[J].Journal of Hazardous Materials,2008,151(2/3):306-315.
[15]MESTR A S,PIRES J,NOGUEIRA J M F,et al.Waste-derived activated carbons for removal of ibuprofen from solution:role of surface chemistry and pore structure[J].Bioresource Technology,2009,100(5):1720-1726.
[16]ROSSNER A,SNYDER S A,KNAPPE D R U.Removal of emerging contaminants of concern by alternative adsorbents[J].Water Research,2009,43(15):3787-3796.
[17]SINGH K P,MALIK A,SINHA S,et al.Liquid-phase adsorption of phenols using activated carbons derived from agricultural waste material[J].Journal of Hazardous Materials,2008,150(3):626-641.
[18]NYDER S,ADHAM A S,REDDING A M,et al.Role of membranes and activated carbon in the removal of endocrine disruptors and pharmaceuticals[J].Desalination,2007,202(1/2/3):156-181.
[19]BATT A L,KIM S,AGA D S.Enhanced biodegradation of iopromide and trimethoprim in nitrifying activated sludge[J].Environmental Science&Technology,2006,40(23):7367-7373.
[20]JOSS A S,ZABCZYNSKI A G,HOFFMANN B,et al.Biological degradation of pharmaceuticals in municipal wastewater treatment,proposing a classification scheme[J].Water Research,2006,40(8):1686-1696.
[21]TAMBOSI J L,DE SENA R F,FAVIER M,et al.Removal of pharmaceutical compounds in membrane bioreactors(MBR)applying submerged membranes[J].Desalination,2010,261(1/2):148-156.
[22]GONZALEZ O,ESPLUGAS M,SANS C,et al.Performance of a sequencing batch biofilm reactor for the treatment of pre-oxidized sulfamethoxazole solutions[J].Water Research,2009,43(8):2149-2158.
[23]MOHAN S V,PRAKASHAM R S,SATYAVATHI B,et al.Biotreatability studies of pharmaceutical wastewater using an anaerobic suspended film contact reactor[J].Water Science and Technology,2001,43(2):271-276.
[24]ENRIGHT A M,MCHUGH S,COLLINS G,et al.Low temperature anaerobic biological treatment of solvent-containing pharmaceutical wastewater[J].Water Research,2005,39(19):4587-4596.
[25]SREEKANTH D,SIVARAMAKRISHNA D,HIMABINDU V,et al.Thermophilic treatment of bulk drug pharmaceutical industrial wastewaters by using hybrid up flow anaerobic sludge blanket reactor[J].Bioresource Technology,2009,100(9):2534-2539.
[26]CHELLIAPAN S,WILBY T,SALLIS P J.Performance of an up-flow anaerobic stage reactor(UASR)in the treatment of pharmaceutical wastewater containing macrolide antibiotics[J].Water Research,2006,40(3):507-516.
[27]LINDBERG R H,OLOFSSON U,RENDAHL P,et al.Behavior of fluoroquinolones and trimethoprim during mechanical,chemical,and active sludge treatment of sewage water and digestion of sludge[J].Environmental Science&Technology,2006,40(3):1042-1048.
[28]BADAWY M I,WAHAA R A,EL K A S.Fenton-biological treatment processes for the removal of some pharmaceuticals from industrial wastewater[J].Journal of Hazardous Materials,2009,167(1/2/3):567-574.
[29]SIRTORI C,ZAPATA A,OLLER I,et al.Solar photo-fenton as finishing step for biological treatment of a pharmaceutical wastewater[J].Environmental Science&Technology,2009,43(4):1185-1191.
[30]SIPMA J,OSUNA B,COLLADO N,et al.Comparison of removal of pharmaceuticals in MBR and activated sludge systems[J].Desalination,2010,250(2):653-659.
[31]ENICK V,MOORE M M.Assessing the assessments,pharmaceuticals in the environment[J].Environmental Impact Assessment Review,2007,27(8):707-729.
[32]BOXALL A B A,KOLPIN D W,HALLING S B,et al.Are veterinary medicines causing environmental risks?[J].Environmental Science&Technology,2003,37:286-294.
[33]OZ A N,INCE O,INCE K B,et al.Microbial population dynamics in an anaerobic CSTR treating chemical synthesis based pharmaceutical wastewater[J].Journal of Environmental Science and Health,2002,38(10):2029-2042.
[34]INCE K B,SELCUK A,INCE O.Effect of a chemical synthesis based pharmaceutical wastewater performance,acetoclastic methanogenic activity and microbial population in an upflow anaerobic filter[J].Journal of Chemical Technology Biotechnology,2002,77(6):711-719.
[35]唐霞,张志强,王金平,等.基于文献计量的国际河流水资源研究发展态势[J].水资源与水工程学报,2013,24(2):124-128.TANG Xia,ZHANG Zhiqiang,WANG Jinping,et al.Development trend of research on water resources in international rivers based on bibliometric[J].Journal of Water Resources and Water Engineering,2013,24(2):124-128.
[36]宋永会,魏健,马印臣,等.络合萃取法处理金刚烷胺制药废水[J].环境科学研究,2014,27(12):1513-1518.SONG Yonghui,WEI Jian,MA Yinchen,et al.Treatment of amantadine pharmaceutical wastewater by complexation extraction[J].Research of Environmental Sciences,2014,27(12):1513-1518.
[37]张国芳,肖书虎,肖宏康,等.黄连素制药废水的电化学预处理试验[J].环境科学研究,2011,24(1):79-84.ZHANG Guofang,XIAO Shuhu,XIAO Hongkang,et al.Pretreatment of berberine pharmaceutical wastewater using electrochemical process[J].Research of Environmental Sciences,2011,24(1):79-84.
[38]任美洁,宋永会,曾萍,等.脉冲电絮凝法处理黄连素制药废水[J].环境科学研究,2010,23(7):892-896.REN Meijie,SONG Yonghui,ZENG Ping,et al.Treatment of berberine hydrochloride pharmaceutical wastewater by pulse electro-coagulation[J].Research of Environmental Sciences,2010,23(7):892-896.
[2]MARTINEZ J L.Antibiotics and antibiotic resistance genes in natural environments[J].Science,2008,321(5887):365-367.
[3]KOSTICH M,LAZORCHAK J.Risks to aquatic organisms posed by human pharmaceutical use[J].Science of the Total Environment,2008,389(2/3):329-339.
[4]GOLET E M,XIFRA I,SIEGRIST H,et al.Environmental exposure assessment of fluoroquinolone antibacterial agents from sewage to soil[J].Environmental Science&Technology,2003,37(15):3243-3249.
[5]郑惠东.水环境中抗生素来源及对健康的影响[J].环境卫生学杂志,2018,8(1):73-77.ZHENG Huidong.The source of antibiotics in aquatic environment and its impact on human health[J].Journal of Environmental Hygiene,2018,8(1):73-77.
[6]冯宝佳,曾强,赵亮,等.水环境中抗生素的来源分布及对健康的影响[J].环境监测管理与技术,2013,25(1):14-17.FENG Baojia,ZENG Qiang,ZHAO Liang,et al.Source distribution of antibiotics in water environment and its impact on human health[J].The Administration and Technique of Environmental Monitoring,2013,25(1):14-17.
[7]王俊峰,尹尧,加春生,等.抗生素制药工业废水污染及处理技术研究[J].生物技术世界,2014,83(10):9.WANG Junfeng,YIN Yao,JIA Chunsheng,et al.Study on pollution and treatment technology of antibiotic pharmaceutical industry wastewater[J].Biotech World,2014,83(10):9.
[8]刘姗姗.中国制药产业发展现状分析[J].民营科技,2017(11):18.
[9]中华人民共和国国家统计局.中国统计年鉴[M].北京:中国统计出版社,2017:88-91.
[10]李晓红.制药废水有毒有害物的控制技术评估[D].青岛:山东科技大学,2015:6-7.
[11]MOLINOS S M,REIF R,GARRIDO B M,et al.Economic valuation of environmental benefits of removing pharmaceutical and personal care products from WWTP effluents by ozonation[J].Science of the Total Environment,2013,461/462:409-415.
[12]NADDEO V,BELGIORNO V,RICCO D,et al.Degradation of diclofenac during sonolysis,ozonation and their simultaneous application[J].Ultrasonics Sonochemistry,2009,16(6):790-794.
[13]MARTNEZ F,LPEZ M M J,AGUADO J,et al.Coupling membrane separation and photocatalytic oxidation processes for the degradation of pharmaceutical pollutants[J].Water Research,2013,47(15):345-355.
[14]HAN W Q,WANG L J,SUN X Y,et al.Treatment of bactericide wastewater by combined process chemical coagulation,electrochemical oxidation and membrane bioreactor[J].Journal of Hazardous Materials,2008,151(2/3):306-315.
[15]MESTR A S,PIRES J,NOGUEIRA J M F,et al.Waste-derived activated carbons for removal of ibuprofen from solution:role of surface chemistry and pore structure[J].Bioresource Technology,2009,100(5):1720-1726.
[16]ROSSNER A,SNYDER S A,KNAPPE D R U.Removal of emerging contaminants of concern by alternative adsorbents[J].Water Research,2009,43(15):3787-3796.
[17]SINGH K P,MALIK A,SINHA S,et al.Liquid-phase adsorption of phenols using activated carbons derived from agricultural waste material[J].Journal of Hazardous Materials,2008,150(3):626-641.
[18]NYDER S,ADHAM A S,REDDING A M,et al.Role of membranes and activated carbon in the removal of endocrine disruptors and pharmaceuticals[J].Desalination,2007,202(1/2/3):156-181.
[19]BATT A L,KIM S,AGA D S.Enhanced biodegradation of iopromide and trimethoprim in nitrifying activated sludge[J].Environmental Science&Technology,2006,40(23):7367-7373.
[20]JOSS A S,ZABCZYNSKI A G,HOFFMANN B,et al.Biological degradation of pharmaceuticals in municipal wastewater treatment,proposing a classification scheme[J].Water Research,2006,40(8):1686-1696.
[21]TAMBOSI J L,DE SENA R F,FAVIER M,et al.Removal of pharmaceutical compounds in membrane bioreactors(MBR)applying submerged membranes[J].Desalination,2010,261(1/2):148-156.
[22]GONZALEZ O,ESPLUGAS M,SANS C,et al.Performance of a sequencing batch biofilm reactor for the treatment of pre-oxidized sulfamethoxazole solutions[J].Water Research,2009,43(8):2149-2158.
[23]MOHAN S V,PRAKASHAM R S,SATYAVATHI B,et al.Biotreatability studies of pharmaceutical wastewater using an anaerobic suspended film contact reactor[J].Water Science and Technology,2001,43(2):271-276.
[24]ENRIGHT A M,MCHUGH S,COLLINS G,et al.Low temperature anaerobic biological treatment of solvent-containing pharmaceutical wastewater[J].Water Research,2005,39(19):4587-4596.
[25]SREEKANTH D,SIVARAMAKRISHNA D,HIMABINDU V,et al.Thermophilic treatment of bulk drug pharmaceutical industrial wastewaters by using hybrid up flow anaerobic sludge blanket reactor[J].Bioresource Technology,2009,100(9):2534-2539.
[26]CHELLIAPAN S,WILBY T,SALLIS P J.Performance of an up-flow anaerobic stage reactor(UASR)in the treatment of pharmaceutical wastewater containing macrolide antibiotics[J].Water Research,2006,40(3):507-516.
[27]LINDBERG R H,OLOFSSON U,RENDAHL P,et al.Behavior of fluoroquinolones and trimethoprim during mechanical,chemical,and active sludge treatment of sewage water and digestion of sludge[J].Environmental Science&Technology,2006,40(3):1042-1048.
[28]BADAWY M I,WAHAA R A,EL K A S.Fenton-biological treatment processes for the removal of some pharmaceuticals from industrial wastewater[J].Journal of Hazardous Materials,2009,167(1/2/3):567-574.
[29]SIRTORI C,ZAPATA A,OLLER I,et al.Solar photo-fenton as finishing step for biological treatment of a pharmaceutical wastewater[J].Environmental Science&Technology,2009,43(4):1185-1191.
[30]SIPMA J,OSUNA B,COLLADO N,et al.Comparison of removal of pharmaceuticals in MBR and activated sludge systems[J].Desalination,2010,250(2):653-659.
[31]ENICK V,MOORE M M.Assessing the assessments,pharmaceuticals in the environment[J].Environmental Impact Assessment Review,2007,27(8):707-729.
[32]BOXALL A B A,KOLPIN D W,HALLING S B,et al.Are veterinary medicines causing environmental risks?[J].Environmental Science&Technology,2003,37:286-294.
[33]OZ A N,INCE O,INCE K B,et al.Microbial population dynamics in an anaerobic CSTR treating chemical synthesis based pharmaceutical wastewater[J].Journal of Environmental Science and Health,2002,38(10):2029-2042.
[34]INCE K B,SELCUK A,INCE O.Effect of a chemical synthesis based pharmaceutical wastewater performance,acetoclastic methanogenic activity and microbial population in an upflow anaerobic filter[J].Journal of Chemical Technology Biotechnology,2002,77(6):711-719.
[35]唐霞,张志强,王金平,等.基于文献计量的国际河流水资源研究发展态势[J].水资源与水工程学报,2013,24(2):124-128.TANG Xia,ZHANG Zhiqiang,WANG Jinping,et al.Development trend of research on water resources in international rivers based on bibliometric[J].Journal of Water Resources and Water Engineering,2013,24(2):124-128.
[36]宋永会,魏健,马印臣,等.络合萃取法处理金刚烷胺制药废水[J].环境科学研究,2014,27(12):1513-1518.SONG Yonghui,WEI Jian,MA Yinchen,et al.Treatment of amantadine pharmaceutical wastewater by complexation extraction[J].Research of Environmental Sciences,2014,27(12):1513-1518.
[37]张国芳,肖书虎,肖宏康,等.黄连素制药废水的电化学预处理试验[J].环境科学研究,2011,24(1):79-84.ZHANG Guofang,XIAO Shuhu,XIAO Hongkang,et al.Pretreatment of berberine pharmaceutical wastewater using electrochemical process[J].Research of Environmental Sciences,2011,24(1):79-84.
[38]任美洁,宋永会,曾萍,等.脉冲电絮凝法处理黄连素制药废水[J].环境科学研究,2010,23(7):892-896.REN Meijie,SONG Yonghui,ZENG Ping,et al.Treatment of berberine hydrochloride pharmaceutical wastewater by pulse electro-coagulation[J].Research of Environmental Sciences,2010,23(7):892-896.