火龙灸配合药物对肾阳虚IVF-ET反复移植失败患者子宫内膜厚度影响
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摘要
目的观察火龙灸配合药物对肾阳虚体外受精-胚胎移植(IVF-ET)反复移植失败患者子宫内膜厚度及临床妊娠率的影响。方法将72例肾阳虚IVF-ET反复移植失败患者随机分为治疗组和对照组,每组36例。治疗组予以火龙灸疗法配合口服戊酸雌二醇片治疗,对照组予口服戊酸雌二醇片治疗。治疗后统计IVF-ET移植妊娠结局,并比较患者治疗前后子宫内膜厚度。结果两组治疗后子宫内膜厚度较同组治疗前增加(P<0.05),且治疗组治疗后子宫内膜厚度与对照组比较,差异有统计学意义(P<0.05)。治疗组临床妊娠率高于对照组,差异有统计学意义(P<0.05)。结论火龙灸疗法能改善子宫内膜厚度,促进子宫内膜的生长,有利于胚胎着床,提高临床妊娠率。
Objective To observe the effect of fiery dragon moxibustion plus medicine on endometrial thickness and clinical pregnancy rate in kidney yang deficiency patients with repeated implantation failure following in vitro fertilization and embryo transfer (IVF-ET). Method Seventy-two yang deficiency patients with repeated implantation failure following IVF-ET were randomized to treatment and control groups, with 36 cases in each group. The treatment group received fiery dragon moxibustion plus oral administration of estradiol valerate tablets and the control group, oral administration of estradiol valerate tablets. The pregnancy outcome following IVF-ET was calculated after treatment. Pre-treatment and post-treatment endometrial thicknesses were compared in the patients. Result Endometrial thickness increased in both groups after treatment compare with before (P<0.05). After treatment, there was a statistically significant difference in endometrial thickness between the treatment and control groups (P<0.05). The clinical pregnancy rate was higher in the treatment group than in the control group with a statistically significant difference (P<0.05). Conclusion Fiery dragon moxibustion can increase endometrial thickness, promote its growth, help embryo implantation and raise clinical pregnancy rate.
Objective To observe the effect of fiery dragon moxibustion plus medicine on endometrial thickness and clinical pregnancy rate in kidney yang deficiency patients with repeated implantation failure following in vitro fertilization and embryo transfer (IVF-ET). Method Seventy-two yang deficiency patients with repeated implantation failure following IVF-ET were randomized to treatment and control groups, with 36 cases in each group. The treatment group received fiery dragon moxibustion plus oral administration of estradiol valerate tablets and the control group, oral administration of estradiol valerate tablets. The pregnancy outcome following IVF-ET was calculated after treatment. Pre-treatment and post-treatment endometrial thicknesses were compared in the patients. Result Endometrial thickness increased in both groups after treatment compare with before (P<0.05). After treatment, there was a statistically significant difference in endometrial thickness between the treatment and control groups (P<0.05). The clinical pregnancy rate was higher in the treatment group than in the control group with a statistically significant difference (P<0.05). Conclusion Fiery dragon moxibustion can increase endometrial thickness, promote its growth, help embryo implantation and raise clinical pregnancy rate.
引文
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[15]赵俐黎,王庆波,陈利,等.火龙灸对亚健康阳虚体质的干预效果观察[J].时珍国医国药,2015,26(4):920-922.
[16]王薇,李菊莲,宋志靖,等.火龙灸联合针刺治疗寒湿型腰椎间盘突出症48例[J].中医研宄,2014,27(5):52-53.
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[19]张吉玲,宋春青,毛忠南.芒针透刺加电针结合火龙灸治疗腰椎间盘突出症临床研究[J].新中医,2016,48(3):113-114.
[20]洪磊.火龙灸起源及应用简析[J].浙江中西医结合杂志,2017,27(7):624-625,636.
[21]覃含麦.论妇科癥瘕之病因病机和辩证施治[J].中国保健营养(上旬刊),2013,23(6):3346-3347.
[22]章婷婷,王念宏,何天有.铺灸治疗痛经经验[J].中国中医药现代远程教育,2007,5(4):22-23.
[23]朱现民,苏红利,张蕊.督脉铺灸法在内脏虚寒病证中的应用[J].中国老年保健医学,2013,11(3):77-78.
[24]丰培学.铺灸治疗慢传输型便秘35例临床观察[J].针灸临床杂志,2008,24(4):34-35,59.
[25]李晓杰,刘晓燕,杜镭.督灸治疗干扰素不良反应66例[J].中国中西医结合消化杂志,2011,19(3):188-189.
[26]沈克艰,吴梅珍.伏天铺灸对慢性盆腔炎患者近期补体的影响[J].针灸临床杂志,2005,21(9):50-51.
[27]张娜.穴位注射合火龙灸法治疗产后身痛40例[J].中医研究,2015,28(7):46-48.
[28]管钰琴.火龙灸法治疗类风湿性关节炎的疗效观察[J].当代医学,2013,19(36):143-144.
[29]陈雄杰,来明,袁兴,等.改良火龙灸疗法对气虚质亚健康人群调节作用的临床观察[J].针灸临床杂志,2017,33(12):49-52.
[30]杜晓宁.火龙液外用结合按摩对运动性疲劳及血睾酮和血乳酸的影响[J].江苏中医药,2008,(9):60-62.
[31]林启有,戴伟春,欧阳东亮,等.温阳补肾法合并艾灸及西药治疗虚寒型痛风性关节炎的临床研究[J].世界中西医结合杂志,2018,13(11):1553-1555.
[32]勾志静,王淑洁,李兰英.补肾强督治偻汤结合督灸治疗强直性脊柱炎临床观察[J].实用中医药杂志,2018,34(10):1167-1168.
[33]欧阳颀.火龙灸治疗产后风湿病的思路与方法[J].针灸临床杂志,2013,29(8):44-46.
[34]梁修朗,刘朝业,苏坤莲,等.火龙灸治疗特发性膜性肾病脾肾阳虚证32例临床观察[J].湖南中医杂志,2018,34(5):103-105.
[35]顾敏洁.火龙灸治疗寒湿犯腰型强直性脊柱炎20例观察[J].浙江中医杂志,2018,53(1):42-43.
[36]张韬,雷雪飞.火龙灸对急性腰扭伤患者细胞免疫功能的影响[J].针灸临床杂志,2017,33(11):47-50.
[37]阮丽萍,梁成名,张金山.补肾强督汤合火龙灸治疗肾虚督寒型强直性脊柱炎的临床研究[J].中医药临床杂志,2017,29(10):1737-1740.
[2]徐蔚华,杨兰馥.人类辅助生殖技术的伦理问题及其监管[J].中国妇幼保健,2012,27(32):5031-5033.
[3]陈芊,郝翠芳.针灸对IVF-ET反复种植失败患者子宫内膜血流及胞饮突表达的影响[J].生殖与避孕,2015,35(3):159-165.
[4]Lessey BA,Palomino WA,Apparao KB,et al.Estrogen receptor-alpha(ER-alpha)and defects in uterine receptivity in women[J].Reprod Biol Endocrinol,2006,4 Suppl 1:S9.
[5]汪宏波,占海英,李红发.黄体功能不全患者着床期子宫内膜雌孕激素受体的表达及超微结构改变[J].中国妇幼保健,2004,19(6):44-46.
[6]郑筱萸.中药新药临床研究指导原则[S].北京:人民卫生出版社,2002:385-388.
[7]张玉珍.中医妇科学[M].北京:中国中医药出版社,2002:121-124.
[8]邓铁涛.中医证候规范[M].北京:人民卫生出版社,2001:201-250.
[9]何晓辉,陈建章.中医150证候辨证论治辑要[M].北京:学苑出版社,2003:2-184.
[10]徐迪华,徐剑秋.中医量化诊断[M].南京:江苏科学技术出版社,1997:35-51.
[11]王燕.火龙灸联合穴位贴敷辅助治疗肾病脾肾阳虚型水肿的临床观察[J].中国中医药现代远程教育,2018,16(17):135-137.
[12]孙琰,王雷.隔姜灸治疗膝关节炎的临床观察及护理[J].内蒙古中医药,2014,33(23):64-65.
[13]程宁,陈艳,余晓云,等.改良隔姜灸治疗风寒湿型冻结肩疗效观察及护理[J].中医临床研究,2015,7(6):130-133.
[14]田雪秋,牟开今.循经火疗配合中药外敷治疗带状疱疹后遗神经痛60例[J].中医药临床杂志,2009,21(3):235.
[15]赵俐黎,王庆波,陈利,等.火龙灸对亚健康阳虚体质的干预效果观察[J].时珍国医国药,2015,26(4):920-922.
[16]王薇,李菊莲,宋志靖,等.火龙灸联合针刺治疗寒湿型腰椎间盘突出症48例[J].中医研宄,2014,27(5):52-53.
[17]王越.火龙罐艾灸为主治疗强直性脊柱炎的临床效果观察[J].内蒙古中医药,2014,33(24):47,116.
[18]王世友.针刺配合火龙灸治疗腰背肌筋膜炎60例[J].中国中医药现代远程教育,2011,9(3):52-53.
[19]张吉玲,宋春青,毛忠南.芒针透刺加电针结合火龙灸治疗腰椎间盘突出症临床研究[J].新中医,2016,48(3):113-114.
[20]洪磊.火龙灸起源及应用简析[J].浙江中西医结合杂志,2017,27(7):624-625,636.
[21]覃含麦.论妇科癥瘕之病因病机和辩证施治[J].中国保健营养(上旬刊),2013,23(6):3346-3347.
[22]章婷婷,王念宏,何天有.铺灸治疗痛经经验[J].中国中医药现代远程教育,2007,5(4):22-23.
[23]朱现民,苏红利,张蕊.督脉铺灸法在内脏虚寒病证中的应用[J].中国老年保健医学,2013,11(3):77-78.
[24]丰培学.铺灸治疗慢传输型便秘35例临床观察[J].针灸临床杂志,2008,24(4):34-35,59.
[25]李晓杰,刘晓燕,杜镭.督灸治疗干扰素不良反应66例[J].中国中西医结合消化杂志,2011,19(3):188-189.
[26]沈克艰,吴梅珍.伏天铺灸对慢性盆腔炎患者近期补体的影响[J].针灸临床杂志,2005,21(9):50-51.
[27]张娜.穴位注射合火龙灸法治疗产后身痛40例[J].中医研究,2015,28(7):46-48.
[28]管钰琴.火龙灸法治疗类风湿性关节炎的疗效观察[J].当代医学,2013,19(36):143-144.
[29]陈雄杰,来明,袁兴,等.改良火龙灸疗法对气虚质亚健康人群调节作用的临床观察[J].针灸临床杂志,2017,33(12):49-52.
[30]杜晓宁.火龙液外用结合按摩对运动性疲劳及血睾酮和血乳酸的影响[J].江苏中医药,2008,(9):60-62.
[31]林启有,戴伟春,欧阳东亮,等.温阳补肾法合并艾灸及西药治疗虚寒型痛风性关节炎的临床研究[J].世界中西医结合杂志,2018,13(11):1553-1555.
[32]勾志静,王淑洁,李兰英.补肾强督治偻汤结合督灸治疗强直性脊柱炎临床观察[J].实用中医药杂志,2018,34(10):1167-1168.
[33]欧阳颀.火龙灸治疗产后风湿病的思路与方法[J].针灸临床杂志,2013,29(8):44-46.
[34]梁修朗,刘朝业,苏坤莲,等.火龙灸治疗特发性膜性肾病脾肾阳虚证32例临床观察[J].湖南中医杂志,2018,34(5):103-105.
[35]顾敏洁.火龙灸治疗寒湿犯腰型强直性脊柱炎20例观察[J].浙江中医杂志,2018,53(1):42-43.
[36]张韬,雷雪飞.火龙灸对急性腰扭伤患者细胞免疫功能的影响[J].针灸临床杂志,2017,33(11):47-50.
[37]阮丽萍,梁成名,张金山.补肾强督汤合火龙灸治疗肾虚督寒型强直性脊柱炎的临床研究[J].中医药临床杂志,2017,29(10):1737-1740.