甘草浓煎治疗附子中毒致心律失常的回顾性临床研究
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摘要
目的:探讨甘草浓煎口服对附子中毒导致心律失常救治中的治疗作用。方法:采用回顾性分析2014年1月至2016年12月浙江省中医院急诊科收治的附子中毒患者11例。根据治疗不同,分为甘草组5例和对照组6例。记录患者入院时的相关资料,临床症状、心电图、心律失常时间和住院时间。结果:甘草组心电图转律时间、住院时间较对照组显著降低(P<0.05)。结论:甘草浓煎口服可以有效缩短改善附子中毒引起的心律失常的时间,降低住院天数。
Objective: To investigate the therapeutic effect of Licorice Decoction on arrhythmia caused by aconite poisoning. Methods: Retrospective analysis was conducted to select patients with Aconite poisoning admitted to the emergency department of Zhejiang Traditional Chinese Medicine Hospital from January 2014 to December 2016. According to different treatments, they were divided into 5 cases in licorice group and 6 cases in control group. Relevant information, clinical symptoms, electrocardiogram, arrhythmia time and hospitalization time were recorded. Results: The time of correcting arrhythmia and hospitalization in the glycyrrhiza group were significantly lower than those in the control group(P<0.05). Conclusion: Glycyrrhiza Decoction can effectively shorten the time of improving arrhythmia caused by aconite poisoning and reduce the days of hospitalization.
Objective: To investigate the therapeutic effect of Licorice Decoction on arrhythmia caused by aconite poisoning. Methods: Retrospective analysis was conducted to select patients with Aconite poisoning admitted to the emergency department of Zhejiang Traditional Chinese Medicine Hospital from January 2014 to December 2016. According to different treatments, they were divided into 5 cases in licorice group and 6 cases in control group. Relevant information, clinical symptoms, electrocardiogram, arrhythmia time and hospitalization time were recorded. Results: The time of correcting arrhythmia and hospitalization in the glycyrrhiza group were significantly lower than those in the control group(P<0.05). Conclusion: Glycyrrhiza Decoction can effectively shorten the time of improving arrhythmia caused by aconite poisoning and reduce the days of hospitalization.
引文
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[2]Chan T Y.Aconitum alkaloid content and the high toxicity of aconite tincture.Forensic Sci Int,2012,222(1-3):1-3
[3]Suzuki K,Matsumoto A,Nishida H,et al.Termination of aconitineinduced atrial fibrillation by the KACh-channel blocker tertiapin:underlying electrophy siological mechanism.J Pharmacol Sci,2014,125(4):406-414
[4]V Niels,A T Issam,H Jordi,et al.Constitutive activity of the acetylcholine-activated potassium current IK,ACh in cardiomyocytes.Advances in Pharmacology,2014,70(70):393-409
[5]Ono T,Hayashida M,Tezuka A,et al.Antagonistic effects of tetrodotoxin on aconitine-induced cardiac toxicity.J Nippon Med Sch,2013,80(5):350-361
[6]Z Zhenying,Y Yongqiang,W Hong,et al.Arctigenin,a potential anti-arrhythmic agent,inhibits aconitine-induced arrhythmia by regulating multi-ion channels.Cellular Physiology&Biochemistry International Journal of Experimental Cellular Physiology Biochemistry&Pharmacology,2013,32(5):1342-1353
[7]Lei Chen,Kevin J Sampson,Robert S Kass.Cardiac delayed rectifier potassium channels in health and disease.Cardiac Electrophysiology Clinics,2016,8(2):307-322
[8]M Fu,R X Li,L Fan,et al.Sarcoplasmic reticulum Ca2+release channel ryanodine receptor(RyR2)plays a crucial role in aconitineinduced arrhythmias.Biochem Pharmacol,2008,75(11):2147-2156
[9]M Yi,W Peng,X Chen,et al.Effect of hypaconitine combined with liquiritin on the expression of calmodulin and connexin43 in rat cardiac muscle in vivo.J Pharm Pharmacol,2012,64(11):1654-1658
[10]周天梅,杨洁红,万海同,等.附子甘草主要成分配伍对乌头碱致大鼠传代心肌细胞损伤的保护作用.北京中医药大学学报,2014,37(1):22-26
[11]张雪,赵炳祥,宋玉琴,等.乌头碱配伍人参皂苷Rb1对原代培养心肌细胞能量代谢的影响.世界科学技术-中医药现代化,2015,9(9):1785-1789
[12]J Nie,F Wang,T Ji,et al.Assessment of in vitro cardiotoxicity of extract fractions and diterpene alkaloids from Aconitum leucostomum Worosch:A short communication.Journal of Pharmaceutical and Biomedical Analysis,2017,137:84-89
[13]陈建萍,谭炳炎,吴伟康,等.四逆汤中附子甘草配伍规律研究.中国实验方剂学杂志,2001,7(3):16-17
[14]杨明,刘小彬,黄庆德.附子甘草配伍减毒增效机理探析.时珍国医国药,2003,14(4):197-198
[15]陈长勋,徐姗珺.甘草、干姜与附子配伍减毒的物质基础与作用环节研究进展.中药新药与临床药理,2006,17(6):472-476