难治性抑郁症与首发抑郁症患者认知功能比较
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摘要
目的探讨难治性抑郁症与首发抑郁症患者认知功能的差异。方法选择2008年1月～2018年3月在我院诊断治疗的难治性抑郁症患者25例为难治组,首发抑郁症患者30例为首发组,另选择健康志愿者30例为对照组。采用HAMD-17量表对两组患者临床严重程度进行评价。采用WAIS(韦氏成人智力量表)、WMS(韦氏记忆量表)对三组认知功能进行评价。结果难治组焦虑/躯体化评分显著高于首发组,差异有统计学意义(P<0.05)。难治组WAIS总分、言语智商总分、图形拼凑评分显著低于首发组与对照组,差异有统计学意义(P<0.05);难治组与首发组数字符号、图片排列、操作智商总分显著低于对照组,差异有统计学意义(P<0.05)。难治组与首发组记忆商数、累加评分、图片回忆、触觉显著低于对照组,差异有统计学意义(P<0.05);难治组时空定向、视觉再生显著低于首发组与对照组,差异有统计学意义(P<0.05)。结论难治性抑郁症患者在时空定向、视觉再生、图形拼凑等方面与首发患者存在显著差异。
Objective To investigate the difference of cognitive function between patients with refractory depression and first-episode depressive disorder. Methods 25 cases of refractory depression diagnosed and treated in our hospital from January 2008 to March 2018 were selected as refractory group, 30 cases of first episode depressive patients as the primary group, and 30 health volunteers were selected as control group. HAMD-17 scale was used to evaluate the clinical severity of the two groups. The cognitive function of the three groups was evaluated by WAIS(Wechsler Adult Intelligence Scale) and WMS(Wechsler memory scale). Results The anxiety/somatization score of the refractory group was significantly higher than that of the primary group(P<0.05). The total score of WAIS, Language IQ score and graphics score in the refractory group were significantly lower than those in the primary group and the control group(P<0.05);The total number of digit symbols, picture arrangement and operation IQ in the refractory group and the primary group were significantly lower than those in the control group(P<0.05). The memory quotient, cumulative score, picture recall and touch in the refractory group and the primary group were significantly lower than those in the control group(P<0.05).The time and space orientation score and visual regeneration in the refractory group were significantly lower than those in the primary group and the control group(P<0.05). Conclusion There are significant differences between refractory depression patients with first episode depression patients in terms of temporal and spatial orientation, visual regeneration, and graphic patchwork.
Objective To investigate the difference of cognitive function between patients with refractory depression and first-episode depressive disorder. Methods 25 cases of refractory depression diagnosed and treated in our hospital from January 2008 to March 2018 were selected as refractory group, 30 cases of first episode depressive patients as the primary group, and 30 health volunteers were selected as control group. HAMD-17 scale was used to evaluate the clinical severity of the two groups. The cognitive function of the three groups was evaluated by WAIS(Wechsler Adult Intelligence Scale) and WMS(Wechsler memory scale). Results The anxiety/somatization score of the refractory group was significantly higher than that of the primary group(P<0.05). The total score of WAIS, Language IQ score and graphics score in the refractory group were significantly lower than those in the primary group and the control group(P<0.05);The total number of digit symbols, picture arrangement and operation IQ in the refractory group and the primary group were significantly lower than those in the control group(P<0.05). The memory quotient, cumulative score, picture recall and touch in the refractory group and the primary group were significantly lower than those in the control group(P<0.05).The time and space orientation score and visual regeneration in the refractory group were significantly lower than those in the primary group and the control group(P<0.05). Conclusion There are significant differences between refractory depression patients with first episode depression patients in terms of temporal and spatial orientation, visual regeneration, and graphic patchwork.
引文
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[11]郭晓杰,田峰.抑郁症患者认知功能及相关影响因素研究进展[J].中国药物与临床,2016,16(3):368-370.
[12]郭琳.首发老年抑郁症的临床特点研究[J].中华老年多器官疾病杂志,2013,12(5):371-374.
[13]李宁,叶兰仙.伴与不伴躯体化症状中青年首发抑郁症患者认知功能的对照研究[J].中华行为医学与脑科学杂志,2012,21(8):722-724.
[14]谢新凤,邓书禄,李德波,等.抑郁症的认知功能损害[J].中国健康心理学杂志,2018,26(2):311-316.
[15]刘露,刘健.精神分裂症和抑郁症患者自我反思与洞察力水平及特征研究[J].中华行为医学与脑科学杂志,2018,27(1):31-34.
[2]姜小琴,杨开仁,郑利锋,等.首发老年抑郁症临床特征分析[J].浙江临床医学,2015,17(11):1904-1905.
[3]王彦芳,杜巧荣,赵晋霞,等.难治性抑郁症患者认知功能损害特点及临床治疗效果[J].中华行为医学与脑科学杂志,2014,23(7):594-597.
[4]Nagayama H,Kubo S,Hatano T,et al.Validity and reliability assessment of a Japanese version of the SnaithHamilton pleasure scale[J].Intern Med,2012,51(8):865-869.
[5]崔界峰,王健,范宏振,等.中文版韦氏成人智力量表第四版的常模制订[J].中国心理卫生杂志,2017,31(8):635-641.
[6]王健,邹义壮,崔界峰,等.韦克斯勒记忆量表第四版中文版(成人版)的修订[J].中国心理卫生杂志,2015,29(1):53-59.
[7]任力杰.抑郁症及其认知功能的事件相关电位、脑形态学及功能影像学的时空模式研究[D].南方医科大学,2010.
[8]任会鹏,王岚,崔卫华,等.抑郁症共病2型糖尿病患者的认知功能及神经内分泌指标[J].中国心理卫生杂志,2012,26(7):500-504.
[9]喻妍,杨栋,赵靖平,等.难治性抑郁症认知功能的研究[J].中国临床心理学杂志,2015,23(1):101-103.
[10]陈俊,吴志国,王勇,等.难治性抑郁症与首发抑郁症认知功能对照研究[J].上海交通大学学报:医学版,2010,30(6):631-635.
[11]郭晓杰,田峰.抑郁症患者认知功能及相关影响因素研究进展[J].中国药物与临床,2016,16(3):368-370.
[12]郭琳.首发老年抑郁症的临床特点研究[J].中华老年多器官疾病杂志,2013,12(5):371-374.
[13]李宁,叶兰仙.伴与不伴躯体化症状中青年首发抑郁症患者认知功能的对照研究[J].中华行为医学与脑科学杂志,2012,21(8):722-724.
[14]谢新凤,邓书禄,李德波,等.抑郁症的认知功能损害[J].中国健康心理学杂志,2018,26(2):311-316.
[15]刘露,刘健.精神分裂症和抑郁症患者自我反思与洞察力水平及特征研究[J].中华行为医学与脑科学杂志,2018,27(1):31-34.