细胞免疫功能改变与鼻咽癌患者疗效及预后的关系
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摘要
目的:探究细胞免疫功能改变与鼻咽癌患者疗效及预后的关系。方法:选取2014年2月-2015年9月本院收治的100例鼻咽癌患者为研究对象,分别于放疗前、放疗中、放疗后即刻、放疗后3个月及1年进行细胞免疫功能指标检测,并统计3年生存率,比较其不同疗效及预后者的细胞免疫指标及生存率,并以多因素分析法分析细胞免疫指标与预后的关系。结果:100例鼻咽癌患者中CR、P及SD和PD者分别为20、59、21例,不同疗效及预后者放疗前、放疗中、放疗后即刻、放疗后3个月及1年的细胞免疫指标及生存率比较,差异均有统计学意义(P<0.05),多因素分析法显示,细胞免疫指标CD4~+、CD4~+/CD8~+、CD8~+及NK是与预后密切相关的方面。结论:鼻咽癌患者的细胞免疫功能状态较差,免疫功能较正常低下,这可能是发病原因之一,且细胞免疫功能状态对鼻咽癌患者疗效及预后具有较高的反应价值。
Objective:To investigate the relationship between the changes of cellular immune function and curative effect and prognosis of patients with nasopharyngeal carcinoma.Method:A total of 100 patients with nasopharyngeal carcinoma from February 2014 to September 2015 were chosen for the study,then the cellular immune function indexes of all the patients before radiotherapy,during radiotherapy,at once,the third month and the first year after the radiotherapy were detected,and the three year survival rate was analyzed,and the cellular immune function indexes and survival rates of patients with different curative effect and prognosis were compared,then the relationship between the cellular immune function indexes and prognosis were analyzed with multifactor analysis methods.Result:The CR,PR,SD and PD of 100 patients with nasopharyngeal carcinoma were respectively 20,59 and 21 cases,the cellular immune function indexes before radiotherapy,during radiotherapy,at once,third month and first year after the radiotherapy and survival rates of patients with different curative effect and prognosis were compared,the differences were all statistically significant(P<0.05),the multifactor analysis showed the cellular immune function indexes CD4~+,CD4~+/CD8~+,CD8~+ and NK were closely related to the prognosis.Conclusion:The cellular immune function state of patients with nasopharyngeal carcinoma are worse,and they have higher reaction value for the curative effect and prognosis of patients with nasopharyngeal carcinoma.
Objective:To investigate the relationship between the changes of cellular immune function and curative effect and prognosis of patients with nasopharyngeal carcinoma.Method:A total of 100 patients with nasopharyngeal carcinoma from February 2014 to September 2015 were chosen for the study,then the cellular immune function indexes of all the patients before radiotherapy,during radiotherapy,at once,the third month and the first year after the radiotherapy were detected,and the three year survival rate was analyzed,and the cellular immune function indexes and survival rates of patients with different curative effect and prognosis were compared,then the relationship between the cellular immune function indexes and prognosis were analyzed with multifactor analysis methods.Result:The CR,PR,SD and PD of 100 patients with nasopharyngeal carcinoma were respectively 20,59 and 21 cases,the cellular immune function indexes before radiotherapy,during radiotherapy,at once,third month and first year after the radiotherapy and survival rates of patients with different curative effect and prognosis were compared,the differences were all statistically significant(P<0.05),the multifactor analysis showed the cellular immune function indexes CD4~+,CD4~+/CD8~+,CD8~+ and NK were closely related to the prognosis.Conclusion:The cellular immune function state of patients with nasopharyngeal carcinoma are worse,and they have higher reaction value for the curative effect and prognosis of patients with nasopharyngeal carcinoma.
引文
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[17]Meng-Xia Zhang,Yi-Jun Hua,Hai-Yun Wang,et al.Longterm prognostic implications and therapeutic target role of hexokinaseⅡin patients with nasopharyngeal carcinoma[J].Oncotarget,2016,7(16):21287-21297.
[18]贺琴,吴府容,邱大,等.81例复发鼻咽癌的临床特征及预后因素分析[J].重庆医学,2016,45(24):3402-3404.
[19]盖秀娟,魏玉梅,李宝生.鼻咽癌预后相关因素研究进展[J].中华肿瘤防治杂志,2016,24(20):1398-1402.
[20]周方正,陈洁,王小聪,等.鼻咽癌初治患者实施调强放疗的远期疗效及预后影响因素[J].中国临床研究,2018,31(1):81-84.
[2]吴伟.102例多位鼻咽癌患者细胞免疫功能状态与预后的关系[J].上海医药,2017,38(11):51-53.
[3]陈洪志,罗花南,权博源,等.人参皂苷Rg3对鼻咽癌放疗患者CD 80/86表达及细胞免疫功能的影响[J].吉林中医药,2017,37(12):1211-1214.
[4]张娜,胡春宏.EB病毒与宿主免疫在鼻咽癌发病中的作用及相关免疫治疗的研究进展[J].临床肿瘤学杂志,2017,22(2):184-188.
[5]Lu Zhang,Huai Liu,Lin-Quan Tang,et al.Prognostic effect of pregnancy on young female patients with nasopharyngeal carcinoma:results from a matched cohort analysis[J].Oncotarget,2016,7(16):21913-21921.
[6]Chang-Juan Tao,Yuan-Yuan Chen,Feng Jiang,et al.Aprognostic model combining CD4/CD8 ratio and N stage predicts the risk of distant metastasis for patients with nasopharyngeal carcinoma treated by intensity modulated radiotherapy[J].Oncotarget,2016,7(29):46653-46661.
[7]胡晓菲,汪俊,王钢胜.TPF方案诱导时间调节化疗对局部晚期鼻咽癌的近期疗效、毒副反应和患者免疫功能的影响[J].河北医药,2016,38(23):3541-3544.
[8]张小明,唐忠敏,韦夏,等.局部晚期鼻咽癌同期放化疗患者营养状况与免疫功能的相关性研究[J].微创医学,2015,10(6):740-742.
[9]毕佩,王洁,鲁娟,等.鼻咽癌免疫逃逸中EB病毒募集Treg细胞相关性分析[J].中华耳鼻咽喉头颈外科杂志,2017,52(9):692-697.
[10]林伟明.白细胞介素-2对鼻咽癌化疗患者机体免疫功能的影响分析[J].海峡药学,2015,27(7):151-152.
[11]吴伟.鼻咽癌患者T淋巴细胞免疫功能状态与其预后的关系[J].实用癌症杂志,2015,30(12):1803-1805.
[12]穆光锐.益气解毒方联合同期放化疗对局部晚期鼻咽癌患者T淋巴细胞亚群及生存率的影响[J].现代中西医结合杂志,2016,25(24):2701-2703.
[13]沈川,陈玲玲.老年鼻咽癌患者预后及相关影响因素[J].中国老年学杂志,2017,37(16):4143-4144.
[14]杨健筌,郭文,文世民,等.新辅助化疗联合同步放化疗对局部晚期鼻咽癌预后影响的Meta分析[J].肿瘤预防与治疗,2017,30(3):174-181.
[15]朱平.120例鼻咽癌综合治疗疗效及预后影响因素分析[J].吉林医学,2016,37(8):2027-2029.
[16]Shaina Chor Mei Huang,Sai Wah Tsao,Chi Man Tsang.Interplay of Viral Infection,Host Cell Factors and Tumor Microenvironment in the Pathogenesis of of Nasopharyngeal Carcinoma[J].Cancers(Basel),2018,10(4):106.
[17]Meng-Xia Zhang,Yi-Jun Hua,Hai-Yun Wang,et al.Longterm prognostic implications and therapeutic target role of hexokinaseⅡin patients with nasopharyngeal carcinoma[J].Oncotarget,2016,7(16):21287-21297.
[18]贺琴,吴府容,邱大,等.81例复发鼻咽癌的临床特征及预后因素分析[J].重庆医学,2016,45(24):3402-3404.
[19]盖秀娟,魏玉梅,李宝生.鼻咽癌预后相关因素研究进展[J].中华肿瘤防治杂志,2016,24(20):1398-1402.
[20]周方正,陈洁,王小聪,等.鼻咽癌初治患者实施调强放疗的远期疗效及预后影响因素[J].中国临床研究,2018,31(1):81-84.