巨噬细胞在骨组织修复中的研究进展
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摘要
免疫系统是人体的一道重要防线,参与其中的细胞包括B细胞、T细胞、DC细胞、巨噬细胞等,其中的巨噬细胞在组织损伤、肿瘤、骨改建等过程中起到尤为重要的作用,随着时间的推移,对于巨噬细胞的了解更为深入,但巨噬细胞与生物材料之间的应答仍有很多机理尚未明了。因此本综述主要探讨生物材料与巨噬细胞之间的应答,展望其潜在应用,为基础及临床研究提供新思路。
The immune system is an important barrier for defense in the human body.This system includes B cells,T cells,dendritic cells(DC),and macrophages,which play a pivotal role in tissue injury,tumor,and bone remodeling.The understanding of macrophages has improved in the past years,but numerous mechanisms between macrophages and biomaterials remain largely unknown.Thus,the present study discusses the response between macrophages and biomaterials and predicts their potential application to provide new ideas for basic and clinical research.
The immune system is an important barrier for defense in the human body.This system includes B cells,T cells,dendritic cells(DC),and macrophages,which play a pivotal role in tissue injury,tumor,and bone remodeling.The understanding of macrophages has improved in the past years,but numerous mechanisms between macrophages and biomaterials remain largely unknown.Thus,the present study discusses the response between macrophages and biomaterials and predicts their potential application to provide new ideas for basic and clinical research.
引文
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[11]Chang MK,Raggatt LJ,Alexander KA,et al.Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo[J].J Immunol,2008,181(2):1232-1244.
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[16]Rifas L.T-cell cytokine induction of BMP-2 regulates human mesenchymal stromal cell differentiation and mineralization[J].J Cell Biochem,2006,98(4):706-714.
[17]Sridharan R,Cameron AR,Kelly DJ,et al.Biomaterial based modulation of macrophage polarization:a review and suggested design principles[J].Mater Today(Kidlington),2015,18(6):313-325.
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[22]Kigerl KA,Gensel JC,Ankeny DP,et al.Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord[J].J Neurosci,2009,29(43):13435-13444.
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[24]Shi M,Wang C,Wang Y,et al.Deproteinized bovine bone matrix induces osteoblast differentiation via macrophage polarization[J].J Biomed Mater Res A,2018,106(5):1236-1246.
[25]Chen Z,Klein T,Murray RZ,et al.Osteoimmunomodulation for the development of advanced bone biomaterials[J].Mater Today(Kidlington),2016,19(6):304-321.
[26]Chu C,Deng J,Sun X,et al.Collagen membrane and immune response in guided bone regeneration:recent progress and perspectives[J].Tissue Eng Part B Rev,2017,23(5):421-435.
[27]Batoon L,Millard SM,Raggatt LJ,et al.Osteomacs and bone regeneration[J].Curr Osteoporos Rep,2017,15(4):385-395.
[28]Parfitt AM.The bone remodeling compartment:a circulatory function for bone lining cells[J].J Bone Miner Res,2001,16(9):1583-1585.
[29]Henson PM,Hume DA.Apoptotic cell removal in development and tissue homeostasis[J].Trends Immunol,2006,27(5):244-250.
[30]Sadtler K,Estrellas K,Allen BW,et al.Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells[J].Science,2016,352(6283):366-370.
[31]Sicari BM,Rubin JP,Dearth CL,et al.An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss[J].Sci Transl Med,2014,6(234):234-258.
[32]Chen Z,Bachhuka A,Han S,et al.Tuning chemistry and topography of nanoengineered surfaces to manipulate immune response for bone regeneration applications[J].ACS Nano,2017,11(5):4494-4506.
[33]Elgali I,Turri A,Xia W,et al.Guided bone regeneration using resorbable membrane and different bone substitutes:early histological and molecular events[J].Acta Biomater,2016,29:409-423.
[34]Spiller KL,Nassiri S,Witherel CE,et al.Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds[J].Biomaterials,2015,37:194-207.
[35]Mathew A,Vaquette C,Hashimi S,et al.Antimicrobial and immunomodulatory surface-functionalized electrospun membranes for bone regeneration[J].Adv Healthc Mater,2017,6(10).doi:10.1002/adhm.201601345.
[2]Trindade R,Albrektsson T,Tengvall P,et al.Foreign body reaction to biomaterials:on mechanisms for buildup and breakdown of osseointegration[J].Clin Implant Dent Relat Res,2016,18(1):192-203.
[3]Sheikh Z,Brooks PJ,Barzilay O,et al.Macrophages,foreign body giant cells and their response to implantable biomaterials[J].Materials(Basel),2015,8(9):5671-5701.
[4]Klopfleisch R,Jung F.The pathology of the foreign body reaction against biomaterials[J].J Biomed Mater Res A,2017,105(3):927-940.
[5]Schmidt-Bleek K,Petersen A,Dienelt A,et al.Initiation and early control of tissue regeneration—bone healing as a model system for tissue regeneration[J].Expert Opin Biol Ther,2014,14(2):247-259.
[6]Ai-Aql ZS,Alagl AS,Graves DT,et al.Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis[J].J Dent Res,2008,87(2):107-118.
[7]Matsuno T,Nakamura T,Kuremoto K,et al.Development of beta-tricalcium phosphate/collagen sponge composite for bone regeneration[J].Dent Mater J,2006,25(1):138-144.
[8]Geiger M,Li RH,Friess W.Collagen sponges for bone regeneration with rh BMP-2[J].Adv Drug Deliv Rev,2003,55(12):1613-1629.
[9]Chu C,Deng J,Xiang L,et al.Evaluation of epigallocatechin-3-gallate(EGCG)cross-linked collagen membranes and concerns on osteoblasts[J].Mater Sci Eng C Mater Biol Appl,2016,67:386-394.
[10]Chu C,Deng J,Man Y,et al.Evaluation of nanohydroxyapaptite(nano-HA)coated epigallocatechin-3-gallate(EGCG)cross-linked collagen membranes[J].Mater Sci Eng C Mater Biol Appl,2017,78:258-264.
[11]Chang MK,Raggatt LJ,Alexander KA,et al.Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo[J].J Immunol,2008,181(2):1232-1244.
[12]Dimitriou R,Jones E,Mc Gonagle D,et al.Bone regeneration:current concepts and future directions[J].BMC Med,2011,9:66.
[13]Xing Z,Lu C,Hu D,et al.Multiple roles for CCR2during fracture healing[J].Dis Model Mech,2010,3(7/8):451-458.
[14]Claes L,Recknagel S,Ignatius A.Fracture healing under healthy and inflammatory conditions[J].Nat Rev Rheumatol,2012,8(3):133-143.
[15]Einhorn TA.The cell and molecular biology of fracture healing[J].Clin Orthop Relat Res,1998(355Suppl):S7-S21.
[16]Rifas L.T-cell cytokine induction of BMP-2 regulates human mesenchymal stromal cell differentiation and mineralization[J].J Cell Biochem,2006,98(4):706-714.
[17]Sridharan R,Cameron AR,Kelly DJ,et al.Biomaterial based modulation of macrophage polarization:a review and suggested design principles[J].Mater Today(Kidlington),2015,18(6):313-325.
[18]Das A,Sinha M,Datta S,et al.Monocyte and macrophage plasticity in tissue repair and regeneration[J].Am J Pathol,2015,185(10):2596-2606.
[19]Miron RJ,Bosshardt DD.Osteo Macs:key players around bone biomaterials[J].Biomaterials,2016,82:1-19.
[20]Martinez FO,Sica A,Mantovani A,et al.Macrophage activation and polarization[J].Front Biosci,2008,13:453-461.
[21]Godwin JW,Pinto AR,Rosenthal NA.Macrophages are required for adult salamander limb regeneration[J].Proc Natl Acad Sci USA,2013,110(23):9415-9420.
[22]Kigerl KA,Gensel JC,Ankeny DP,et al.Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord[J].J Neurosci,2009,29(43):13435-13444.
[23]Sinder BP,Pettit AR,Mc Cauley LK.Macrophages:their emerging roles in bone[J].J Bone Miner Res,2015,30(12):2140-2149.
[24]Shi M,Wang C,Wang Y,et al.Deproteinized bovine bone matrix induces osteoblast differentiation via macrophage polarization[J].J Biomed Mater Res A,2018,106(5):1236-1246.
[25]Chen Z,Klein T,Murray RZ,et al.Osteoimmunomodulation for the development of advanced bone biomaterials[J].Mater Today(Kidlington),2016,19(6):304-321.
[26]Chu C,Deng J,Sun X,et al.Collagen membrane and immune response in guided bone regeneration:recent progress and perspectives[J].Tissue Eng Part B Rev,2017,23(5):421-435.
[27]Batoon L,Millard SM,Raggatt LJ,et al.Osteomacs and bone regeneration[J].Curr Osteoporos Rep,2017,15(4):385-395.
[28]Parfitt AM.The bone remodeling compartment:a circulatory function for bone lining cells[J].J Bone Miner Res,2001,16(9):1583-1585.
[29]Henson PM,Hume DA.Apoptotic cell removal in development and tissue homeostasis[J].Trends Immunol,2006,27(5):244-250.
[30]Sadtler K,Estrellas K,Allen BW,et al.Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells[J].Science,2016,352(6283):366-370.
[31]Sicari BM,Rubin JP,Dearth CL,et al.An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss[J].Sci Transl Med,2014,6(234):234-258.
[32]Chen Z,Bachhuka A,Han S,et al.Tuning chemistry and topography of nanoengineered surfaces to manipulate immune response for bone regeneration applications[J].ACS Nano,2017,11(5):4494-4506.
[33]Elgali I,Turri A,Xia W,et al.Guided bone regeneration using resorbable membrane and different bone substitutes:early histological and molecular events[J].Acta Biomater,2016,29:409-423.
[34]Spiller KL,Nassiri S,Witherel CE,et al.Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds[J].Biomaterials,2015,37:194-207.
[35]Mathew A,Vaquette C,Hashimi S,et al.Antimicrobial and immunomodulatory surface-functionalized electrospun membranes for bone regeneration[J].Adv Healthc Mater,2017,6(10).doi:10.1002/adhm.201601345.