n-HA添加对聚磷酸钙水凝胶结构与性能的影响
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摘要
采用共混法制备纳米羟基磷灰石/聚磷酸钙(n-HA/CPP)复合水凝胶,探究了n-HA的添加对CPP水凝胶的结构形貌、热稳定性、溶胀降解性能和力学性能的影响。结果表明:通过控制n-HA的添加量可以改变CPP水凝胶的链长进而改变其性能,n-HA的加入提高了CPP水凝胶的热稳定性。随着n-HA添加量的增加,n-HA/CPP复合水凝胶的溶胀率和降解率均呈现先减小后增大再减小的趋势,溶胀后内部孔洞大小也呈现先减后增再减的变化规律。添加量为1wt%时,n-HA/CPP复合水凝胶的抗压强度达到最大值(5. 06±0. 60) MPa,与纯CPP水凝胶相比提高了22%。
The nano-hydroxyapatite/calcium polyphosphate( n-HA/CPP) composite hydrogels were prepared by blending method. The influence of n-HA addition on the structure,morphology,thermal stability,swelling properties and mechanical properties of the CPP hydrogel was investigated. The results show that by controlling the amount of n-HA,the chain length of CPP hydrogel can be adjusted and the properties can be further changed. The addition of n-HA improves the thermal stability of CPP hydrogel.With the increase of n-HA addition,the swelling ratio and degradation ratio of n-HA/CPP composite hydrogels initially decreases,then increases and finally decreases,as well as the size of internal pores after swelling varied following a similar way. At the amount of addition is 1 wt%,n-HA/CPP composite hydrogel reaches the maximum compressive strength( 5. 06 ± 0. 60) MPa,22% higher than that of the pure CPP hydrogel.
The nano-hydroxyapatite/calcium polyphosphate( n-HA/CPP) composite hydrogels were prepared by blending method. The influence of n-HA addition on the structure,morphology,thermal stability,swelling properties and mechanical properties of the CPP hydrogel was investigated. The results show that by controlling the amount of n-HA,the chain length of CPP hydrogel can be adjusted and the properties can be further changed. The addition of n-HA improves the thermal stability of CPP hydrogel.With the increase of n-HA addition,the swelling ratio and degradation ratio of n-HA/CPP composite hydrogels initially decreases,then increases and finally decreases,as well as the size of internal pores after swelling varied following a similar way. At the amount of addition is 1 wt%,n-HA/CPP composite hydrogel reaches the maximum compressive strength( 5. 06 ± 0. 60) MPa,22% higher than that of the pure CPP hydrogel.
引文
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[17]李思晴,王剑辉,宋岩.PLLA/n-HA复合材料降解中降解过程中pH值变化[J].吉林化工学院学报,2013,30(9):50-52.
[2]Dion A,Berno B,Hall G,et al.The effect of processing on the structural characteristics of vancomycin-loaded amorphous calcium phosphate matrices[J].Biomaterials,2005,26(21):4486-4494.
[3]Kasuga T,Wakita T,Nogami M,et al.Hydrogelation of calcium metaphosphate glass[J].Chemistry Letters,2001,30(8):820-821.
[4]Song W,Seta J,Kast R E,et al.Influence of particle size and soaking conditions on rheology and microstructure of amorphous calcium polyphosphate hydrogel[J].Journal of the American Ceramic Society,2015,98(12):3758-3769.
[5]Zhou Z,Seta J,Markel D C,et al.Release of vancomycin and tobramycin from polymethylmethacrylate cements impregnated with calcium polyphosphate hydrogel[J].Journal of Biomedical Materials Research Part B:Applied Biomaterials,2018,106(8):2827-2840.
[6]Ren W,Song W,Yurgelevic S,et al.Setting mechanism of a new injectable Dicalcium Phosphate Dihydrate(DCPD)forming cement[J].Journal of the Mechanical Behavior of Biomedical Materials,2018,79(12):226-234.
[7]张敏东,金高军,黄梅.纳米复合水凝胶的研究进展[J].高分子通报,2010(6):41-46.
[8]殷雅婷,安燕,顾雪梅.陈化和煅烧条件对纳米HAP影响的研究[J].贵州大学学报:自然科学版,2011,28(4):48-50.
[9]Brow R K,Kirkpatrick R J,Turner G L.The short range structure of sodium phosphate glasses I.MAS NMR studies[J].Journal of NonCrystalline Solids,1990,116(1):39-45.
[10]Kopp W,Barud H S,Paz M F,et al.Calcium polyphosphate coacervates:effects of thermal treatment[J].Journal of Sol-Gel Science and Technology,2012,63(2):219-223.
[11]邓迟,陈清宇,姚宁,等.聚乙二醇对不同粒度羟基磷灰石的表面修饰[J].硅酸盐学报,2007,35(6):9-12.
[12]崔亦华,崔英德,郭建维,等.NVP共聚物水凝胶中吸附水的性能研究[J].高分子材料科学与工程,2007,23(4):152-154.
[13]Rudzinski W E,Dave A M,Vaishnav U H,et al.Hydrogels as controlled release devices in agriculture[J].Designed Monomers and Polymers,2002,5(1):39-65.
[14]Zhang J,Wang Q,Wang A.In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug-controlled release matrices[J].Acta Biomaterialia,2010,6(2):445-454.
[15]Ma Y,Bai T,Wang F.The physical and chemical properties of the polyvinylalcohol/polyvinylpyrrolidone/hydroxyapatite composite hydrogel[J].Materials Science and Engineering:C,2016,59:948-957.
[16]Huang J,Xiong J,Liu J,et al.Investigation of the in vitro degradation of a novel polylactide/nanohydroxyapatite composite for artificial bone[J].Journal of Nanomaterials,2013,2013(2):7758-7765.
[17]李思晴,王剑辉,宋岩.PLLA/n-HA复合材料降解中降解过程中pH值变化[J].吉林化工学院学报,2013,30(9):50-52.
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