母羊多胎性候选基因GDF9的研究进展
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摘要
生长分化因子9(GDF9)是转化生长因子β超家族的一个新成员。近年来研究发现,GDF9基因的多态性与哺乳动物的繁殖性状相关。综述了GDF9基因的结构和多态性、生理效应及GDF9基因多态性与母羊产羔性能的相关性研究进展,并对母羊繁殖性能相关功能基因的研究进行了展望,以期为相关领域的研究提供参考。
Growth differentiation factor 9(GDF9) is described as a new member of transforming growth factor β superfamily. In recent years, the polymorphism of GDF9 gene is found to be associated with reproductive traits of mammalian. The structure,polymorphism and physiological effects of GDF9 gene as well as the association of GDF9 polymorphism and lambing performance of ewes were reviewed. Furthermore, the research on functional genes associated with ewes reproductive traits was prospected, so as to provide references for the studies in related fields.
Growth differentiation factor 9(GDF9) is described as a new member of transforming growth factor β superfamily. In recent years, the polymorphism of GDF9 gene is found to be associated with reproductive traits of mammalian. The structure,polymorphism and physiological effects of GDF9 gene as well as the association of GDF9 polymorphism and lambing performance of ewes were reviewed. Furthermore, the research on functional genes associated with ewes reproductive traits was prospected, so as to provide references for the studies in related fields.
引文
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[17]DONG J,ALBERTINI D F,NISHIMORI K,et al.Growth differentiation factor-9 is required during early ovarian folliculogenesis[J].Nature,1996,383(6600):531-535.
[18]王百川,张钦恺,徐君君,等.3个山羊品种GDF9基因外显子2多态性检测[J].中国草食动物科学,2014(S1):132-136.
[19]储明星.绵羊高繁殖力主效基因的研究及应用[J].农业生物技术学报,2008,16(1):1-9.
[20]程箫,任春环,张子军,等.安徽白山羊、波尔山羊GDF9和BMP15基因的RFLP分析[J].安徽农业大学学报,2012,39(3):352-355.
[21]周泽晓,王嘉福,冉雪琴.贵州白山羊GDF9和BMP15基因多态性与产羔数的相关性研究[J].中国畜牧杂志,2012,28(21):9-11.
[22]CHUMX,LIBX,WANG J Y,et al.Association between PCR-SSCP of growth differentiation factor 9 gene and high prolificacy in Small Tail Han sheep[J].Anim Biotechnol,2004,15(2):111-120.
[23]SOUZA C J,MACDOUGALL C,CAMPBELL B K,et al.The Booroola(FecB)phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B(BMPRIB)gene[J].J Endocrinol,2001,169(2):1-6.
[24]于佐卿,杨博辉,郭健,等.两种绵羊杂种GDF9基因和FecB基因的多态性及其与产羔数和体重关系的研究[J].中国草食动物,2008,28(2):5-8.
[25]朱广琴,王庆林,康永刚,等.GnRHR、GDF9、KISS1基因多态性与黄淮山羊产羔性状相关性的研究[J].黑龙江畜牧兽医,2013(6):58-61.
[2]CRAWFORD J L,MCNATTY K P.The ratio of growth differentiation factor 9:bone morphogenetic protein 15 mRNA expression is tightly co-regulated and differs between species over a wide range of ovulation rates[J].Mol Cell Endocrinol,2012,348(1):339-343.
[3]HOSOE M,KANEYAMA K,USHIZAWA K,et al.Quantitative analysis of bone morphogenetic protein 15(BMP15)and growth differentiation factor 9(GDF9)gene expression in calf and adult bovine ovaries[J].Reprod Biol Endocrinol,2011(9):33.
[4]吴泽辉,储明星,李学伟,等.山羊生长分化因子9基因外显子2的PCR-SSCP分析[J].中国农业科学,2006,39(4):802-808.
[5]HOU J X,AN X P,WANG J G,et al.New genetic polymorphisms of KISS-1 gene and their association with litter size in goats[J].Small Ruminant Res,2011,96(2/3):106-110.
[6]AN X P,HAN D,HOU J X,et al.GnRHR gene polymorphisms and their effects on reproductive performance in Chinese goats[J].Small Ruminant Res,2009,85(2):130-134.
[7]MULLEN M P,HANRAHAN J P,HOWARD D J,et al.Investigation of prolific sheep from UK and Ireland for evidence on origin of the mutations in BMP15(FecXG,FecXB)and GDF9(FecG~H)in Belclare and Cambridge sheep[J].PLoS One,2013,8(1):e53172.
[8]MOTTERSHEAD D G,RITTER L J,GILCHRIST R B.Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15[J].Mol Hum Report,2012,18(3):121-128.
[9]PRAMOD R K,SHARMA S K,SINGHI A,et al.Differential ovarian morphometry and follicular expression of BMP15,GDF9 and BMPR1B influence the prolificacy in goat[J].Repord Domest Anim,2013,48(5):803-809.
[10]SADIGHI M,BODENSTEINER K J,BEATTIE A E,et al.Genetic mapping of ovine growth differentiation factor 9(GDF9)to sheep chromosome 5[J].Anim Genet,2002,33(3):244-245.
[11]HANRAHAN J P,GREGAN S M,MULSANT P,et al.Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep(Ovis aries)[J].Biol Reprod,2004,70(4):900-909.
[12]李碧侠,储明星,王金玉.生长分化因子9基因的研究进展[J].中国畜牧兽医,2002,29(6):33-36.
[13]孟丽娜,张英杰,刘月琴.山羊基因及其多态性分析研究进展[J].中国草食动物科学,2012(S1):54-57.
[14]董传河,杜立新.山羊GDF9基因多态性与产羔数关联分析研究[J].山东农业大学学报:自然科学版,2011,42(2):227-237.
[15]陶萨茹拉,王峰,刘永斌.生长分化因子GDF9基因的研究进展[J].畜牧与饲料科学,2009,30(1):54-55.
[16]SHI F T,CHEUNG A P,HUANG H F,et al.Growth differentiation factor 9(GDF9)suppresses follistatin and follistatin-like 3 production in human granulosa-lutein cells[J]PLoS One,2011,6(8):e22866.
[17]DONG J,ALBERTINI D F,NISHIMORI K,et al.Growth differentiation factor-9 is required during early ovarian folliculogenesis[J].Nature,1996,383(6600):531-535.
[18]王百川,张钦恺,徐君君,等.3个山羊品种GDF9基因外显子2多态性检测[J].中国草食动物科学,2014(S1):132-136.
[19]储明星.绵羊高繁殖力主效基因的研究及应用[J].农业生物技术学报,2008,16(1):1-9.
[20]程箫,任春环,张子军,等.安徽白山羊、波尔山羊GDF9和BMP15基因的RFLP分析[J].安徽农业大学学报,2012,39(3):352-355.
[21]周泽晓,王嘉福,冉雪琴.贵州白山羊GDF9和BMP15基因多态性与产羔数的相关性研究[J].中国畜牧杂志,2012,28(21):9-11.
[22]CHUMX,LIBX,WANG J Y,et al.Association between PCR-SSCP of growth differentiation factor 9 gene and high prolificacy in Small Tail Han sheep[J].Anim Biotechnol,2004,15(2):111-120.
[23]SOUZA C J,MACDOUGALL C,CAMPBELL B K,et al.The Booroola(FecB)phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B(BMPRIB)gene[J].J Endocrinol,2001,169(2):1-6.
[24]于佐卿,杨博辉,郭健,等.两种绵羊杂种GDF9基因和FecB基因的多态性及其与产羔数和体重关系的研究[J].中国草食动物,2008,28(2):5-8.
[25]朱广琴,王庆林,康永刚,等.GnRHR、GDF9、KISS1基因多态性与黄淮山羊产羔性状相关性的研究[J].黑龙江畜牧兽医,2013(6):58-61.