苦白石颗粒靶动物(猪)安全性试验
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摘要
为评价苦白石颗粒对靶动物(猪)的安全性,为临床应用提供依据。将苦白石颗粒按临床推荐剂量的1、3、5、10倍剂量连续拌料给药5 d。从喂药第1天开始,连续观察14 d;测定给药前、给药后第7天和第14天试验猪的体重、血液常规指标、血液生化指标。结果表明,苦白石颗粒按临床推荐剂量1、3、5、10倍剂量应用,猪的体重、血液常规指标、血液生化指标等与对照组相比较差异均不显著(P>0.05)。表明苦白石颗粒按临床推荐剂量的1倍～10倍范围内应用,对靶动物(猪)是安全的。
In order to evaluate the safety of Kubaishi granules on target animals(swine) and provide a basis for clinical application,according to the clinically recommended dosage of Kubaishi granules,we mixed 1,3,5 and 10 times of the dosages in food of the pigs for continuous 5 days.The clinical signs were observed for 14 days beginning from the first day of feeding.The weight of swine,blood routine index and blood biochemical index were tested before treatment,the seventh day post treatment and the fourteenth day post treatment.The results showed that the body weight,blood routine index and blood biochemical index of the animals treated at doses of 1,3,5 and 10 times of clinically recommended doses of Kubaishi granules were not significantly different when compared with normal control(P>0.05).It is indicated that the application of Kubaishi granules to target animals(pigs) is safe during the range from 1 time to 10 times of the recommended dosages.
In order to evaluate the safety of Kubaishi granules on target animals(swine) and provide a basis for clinical application,according to the clinically recommended dosage of Kubaishi granules,we mixed 1,3,5 and 10 times of the dosages in food of the pigs for continuous 5 days.The clinical signs were observed for 14 days beginning from the first day of feeding.The weight of swine,blood routine index and blood biochemical index were tested before treatment,the seventh day post treatment and the fourteenth day post treatment.The results showed that the body weight,blood routine index and blood biochemical index of the animals treated at doses of 1,3,5 and 10 times of clinically recommended doses of Kubaishi granules were not significantly different when compared with normal control(P>0.05).It is indicated that the application of Kubaishi granules to target animals(pigs) is safe during the range from 1 time to 10 times of the recommended dosages.
引文
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[3] 王孝友,徐登峰,谷山林,等.荣昌猪血液生理生化指标的测定[J].黑龙江畜牧兽医,2013(5):53-56.
[4] 李艳艳,杨海峰,李勇军.蜘蛛香胶囊对靶动物犬的安全性试验[J].黑龙江畜牧兽医,2016(14):163-165.
[5] 许春燕,刘希望,孔晓军,等.银翘蓝芩口服液对鸡的安全性试验[J].动物医学进展,2017(7):62-65.
[6] 吴建华,胡庭俊,杨媚,等.胆翘注射液的安全性评价[C].中国毒理学会兽医毒理学委员会与中国畜牧兽医学会兽医食品卫生学分会联合学术研讨会暨中国毒理学会兽医毒理学委员会第5次全国会员代表大会,中国北京,2017.
[7] 胡庭俊,陈炅然,程富胜.多糖生物学研究概况[J].兽药与饲料添加剂,2005(5):29-32.
[8] 胡庭俊,程富胜,李倬,等.天然多糖免疫调节与机体自由基反应的关系研究概况[J].中兽医医药杂志,2003(4):21-23.
[9] 陈静,王彤,程奇,等.白头翁及其有效成分对仔猪免疫和抗氧化性能的影响[J].草业科学,2015(7):1164-1169.
[10] 邓淑蓉,潘宇政.肉桂主要化学成分及药理作用研究概况[J].现代中西医结合杂志,2018(4):448-451.
[11] 盛书娟.石榴皮提取物对血细胞生理特性的影响[D].山东济南:山东师范大学,2012.
[12] 魏华,彭勇,马国需,等.木香有效成分及药理作用研究进展[J].中草药,2012(3):613-620.
[13] 孟芳,牛华星,郑莉,等.卡巴匹林钙对猪的解热效果及靶动物安全性试验[J].中国兽医杂志,2017(12):102-104.
[14] 杨剑波,丁威,吴井生,等.中草药添加剂对育肥猪生产性能及生理生化指标的影响[J].安徽农业科学,2015(11):129-131.