离子液体中醛与2-(2-苯并咪唑)乙腈的Knoevenagel缩合反应
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摘要
以离子液体作为绿色反应介质,醛和2-(2-苯并咪唑)乙腈为原料,80℃发生Knoevenagel缩合反应,选择性合成了一系列的(E)-2-(2-苯并咪唑)-3-芳基丙烯腈衍生物.和其他方法相比,该方法具有反应条件温和、产率高(86%～95%)和环境友好等优点.产物的结构均通过熔点、红外、氢谱和高分辨质谱加以确证.
A series of (E)-2-(1 H-benzo[d]imidazol-2-yl)-3-arylacrylonitrile derivatives are synthesized by a Knoevenagel condensation of 2-(1 H-benzo[d]imidazol-2-yl)acetonitrile and aromatic aldehyde at 80 ℃ in ionic liquids.Compared to the other methods,this method has the advantages of milder reaction conditions,high yields(86%～95%)and environmental benignity.The structures of the products are characterized by melting points,IR,1 HNMR and HRMS.
A series of (E)-2-(1 H-benzo[d]imidazol-2-yl)-3-arylacrylonitrile derivatives are synthesized by a Knoevenagel condensation of 2-(1 H-benzo[d]imidazol-2-yl)acetonitrile and aromatic aldehyde at 80 ℃ in ionic liquids.Compared to the other methods,this method has the advantages of milder reaction conditions,high yields(86%～95%)and environmental benignity.The structures of the products are characterized by melting points,IR,1 HNMR and HRMS.
引文
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