乳腺癌超声征象与病理组织学类型的相关性
|
摘要
目的探讨乳腺癌超声征象与病理组织学类型的相关性。方法研究时间为2016年2月到2018年5月,采用回顾性总结研究方法,选择79例乳腺癌患者作为研究对象。所有患者都给予常规超声诊断与超声造影分析,记录患者的病理组织学类型并进行相关性分析。结果 79例患者超声显示边界缘毛刺67例,后方回声衰减70例,内部微钙化76例,形态不规则67例。ER与PR阳性分别43例和45例,阳性率为54. 4%和57. 0%。超声造影评分为(3. 54±0. 14)分,其中1分0例、2分6例、3分44例、4分29例。直线相关分析显示超声征象特征(边界缘毛刺、内部微钙化、后方回声衰减、形态不规则)与ER阳性、PR阳性、临床分期、分化类型、淋巴结转移都有显著正相关性(P <0. 05)。超声造影评分在不同分化类型、临床分期、淋巴结转移患者中的对比差异有统计学意义(P <0. 05),Spearman相关性分析显示患者的分化类型、临床分期、淋巴结转移与超声造影评分有显著相关性(P <0. 05)。结论乳腺癌常规超声征象、超声造影评分与病理组织学类型有显著相关性,对判定患者病情与预测预后有很好的价值。
Objective To explore the correlation between ultrasonographic features and histopathology of breast cancer.Methods 79 patients of breast cancer patients were selected,All patients were given routine ultrasound diagnosis and ultrasound contrast analysis,recorded the patients' histopathology and were given the correlation analysis. Results In the 79 patients,there were 67 patients were border burrs,70 patients were posterior echo attenuation,76 patients were internal microcalcification,67 patients were irregular morphology. The positive rates of ER and PR were 43 patients and 45 patients respectively,the positive rate were 54. 4% and 57. 0% respectively. The score of contrast enhanced ultrasound were 3. 54 ± 0. 14 points that included 1 points of 0 patients,2 points of 6 patients,3 points of 44 patients,4 points of 29 patients. The linear correlation analysis showed that the characteristics of ultrasonic signs( boundary margin burr,internal microcalcification,posterior echo attenuation,irregular shape)were significant positive correlation with ER positive,PR positive,clinical stage,differentiation type and lymph node metastasis( P< 0. 05). Contrast-enhanced ultrasound scores in different types of differentiation,clinical stage and lymph node metastasis were statistically significant difference( P < 0. 05). Spearman correlation analysis showed that the type of differentiation,clinical stage and lymph node metastasis were significantly correlated with the contrast-enhanced ultrasound score( P < 0. 05). Conclusion There are significant correlation ultrasonographic features and histopathology of breast cancer,which are great value in determining the patient's condition and predicting the prognosis.
Objective To explore the correlation between ultrasonographic features and histopathology of breast cancer.Methods 79 patients of breast cancer patients were selected,All patients were given routine ultrasound diagnosis and ultrasound contrast analysis,recorded the patients' histopathology and were given the correlation analysis. Results In the 79 patients,there were 67 patients were border burrs,70 patients were posterior echo attenuation,76 patients were internal microcalcification,67 patients were irregular morphology. The positive rates of ER and PR were 43 patients and 45 patients respectively,the positive rate were 54. 4% and 57. 0% respectively. The score of contrast enhanced ultrasound were 3. 54 ± 0. 14 points that included 1 points of 0 patients,2 points of 6 patients,3 points of 44 patients,4 points of 29 patients. The linear correlation analysis showed that the characteristics of ultrasonic signs( boundary margin burr,internal microcalcification,posterior echo attenuation,irregular shape)were significant positive correlation with ER positive,PR positive,clinical stage,differentiation type and lymph node metastasis( P< 0. 05). Contrast-enhanced ultrasound scores in different types of differentiation,clinical stage and lymph node metastasis were statistically significant difference( P < 0. 05). Spearman correlation analysis showed that the type of differentiation,clinical stage and lymph node metastasis were significantly correlated with the contrast-enhanced ultrasound score( P < 0. 05). Conclusion There are significant correlation ultrasonographic features and histopathology of breast cancer,which are great value in determining the patient's condition and predicting the prognosis.
引文
[1]Liu H,Tao M,Ding H,et al.Ultrasonographic manifestations of a rare granular cell tumor of the accessory breast:Acase report[J].Medicine(Baltimore),2018,97(1):e9462.
[2]Khanduri S,Chaudhary M,Sabharwal T,et al.A low-cost,low-skill model for efficient breast cancer screening in low resource rural settings of a developing country[J].Cureus,2017,9(8):e1571.
[3]高杰.B超判断乳腺癌腋窝淋巴结转移状态的临床研究[J].影像研究与医学应用,2018,2(1):138-139.
[4]Inoue M,Ohta T,Shioya H,et al.Inflammatory myofibroblastic tumors of the breast with simultaneous intracranial,lung,and pancreas involvement:ultrasonographic findings and a review of the literature[J].J Med Ultrason(2001),2018,45(2):331-335.
[5]冷晓玲,黄国福,马富成.乳腺癌病灶大小与超声造影表现的相关性[J].中华超声影像学杂志,2015,24(4):324-327.
[6]张梅,袁安鹏.超声弹性成像、常规超声、钼靶X线技术在乳腺癌诊断中的应用[J].影像研究与医学应用,2018,2(2):116-117.
[7]Akissue C,Teixeira P,Chala LF,et al.Axillary lymph node sonographic features and breast tumor characteristics as predictors of malignancy:A nomogram to predict risk[J].Ultrasound Med Biol,2017,43(9):1837-1845.
[8]Chen Q,Wei T,Wang XL,et al.The total number of prelaryngeal and pretracheal lymph node metastases:is it a reliable predictor of contralateral central lymph node metastasis in papillary thyroid carcinoma?[J].J Surg Res,2017,15(214):162-167.
[9]吴积新,刘江泽.超声诊断在乳腺肿瘤中的应用进展[J].医学综述,2015,21(4):680-682.
[10]Jahan AB,Ahmed MU,Begum M,et al.Ultrasonographic evaluation of palpable breast mass and correlation with histopathology[J].Mymensingh Med J,2017,26(2):223-229.
[11]苏爱江,罗扬,毛爱琴.超声引导下穿刺活检对早期乳腺癌的诊断价值[J].实用癌症杂志,2018,33(3):377-379.
[12]Tadros AB,Yang WT,Krishnamurthy S,et al.Identification of patients with documented pathologic complete response in the breast after neoadjuvant chemotherapy for omission of axillary surgery[J].JAMA Surg,2017,152(7):665-670.
[13]Chesebro AL,Chikarmane SA,Ritner JA,et al.Troubleshooting to overcome technical challenges in image-guided breast biopsy[J].Radiographics,2017,37(3):705-718.
[14]陆艺红,严优江,叶迅.彩色多普勒超声在乳腺良恶性占位性病变鉴别诊断中的应用价值[J].中国实用医刊,2018,45(3):62-64.
[15]Chen YL,Chen JJ,Chang C,et al.Sclerosing adenosis:Ultrasonographic and mammographic findings and correlation with histopathology[J].Mol Clin Oncol,2017,6(2):157-162.
[16]Faustino-Rocha AI,Gama A,Oliveira PA,et al.Modulation of mammary tumor vascularization by mast cells:Ultrasonographic and histopathological approaches[J].Life Sci,2017,1(176):35-41.
[17]王璐,史鹏丽,郑继慧,等.青年女性乳腺癌患者临床病理及超声影像学特征分析[J].肿瘤研究与临床,2018,30(3):169-172.
[18]Ueda A,Yamamoto D,Tsubota Y,et al.Serous carcinoma of the peritoneum with metastases to the breast and axillary lymph nodes[J].Gan To Kagaku Ryoho,2016,43(12):2252-2254.
[19]黄泽君,杨正春,李芳,等.超声弹性成像与磁共振对T1~2N1~2M0乳腺癌新辅助化疗疗效评估的对比研究[J].重庆医学,2018,47(7):899-901.
[20]Yao JP,Hao YZ,Chang Q,et al.Value of ultrasonographic features for assessing malignant potential of complex cystic breast lesions[J].J Ultrasound Med,2017,36(4):699-704.
[2]Khanduri S,Chaudhary M,Sabharwal T,et al.A low-cost,low-skill model for efficient breast cancer screening in low resource rural settings of a developing country[J].Cureus,2017,9(8):e1571.
[3]高杰.B超判断乳腺癌腋窝淋巴结转移状态的临床研究[J].影像研究与医学应用,2018,2(1):138-139.
[4]Inoue M,Ohta T,Shioya H,et al.Inflammatory myofibroblastic tumors of the breast with simultaneous intracranial,lung,and pancreas involvement:ultrasonographic findings and a review of the literature[J].J Med Ultrason(2001),2018,45(2):331-335.
[5]冷晓玲,黄国福,马富成.乳腺癌病灶大小与超声造影表现的相关性[J].中华超声影像学杂志,2015,24(4):324-327.
[6]张梅,袁安鹏.超声弹性成像、常规超声、钼靶X线技术在乳腺癌诊断中的应用[J].影像研究与医学应用,2018,2(2):116-117.
[7]Akissue C,Teixeira P,Chala LF,et al.Axillary lymph node sonographic features and breast tumor characteristics as predictors of malignancy:A nomogram to predict risk[J].Ultrasound Med Biol,2017,43(9):1837-1845.
[8]Chen Q,Wei T,Wang XL,et al.The total number of prelaryngeal and pretracheal lymph node metastases:is it a reliable predictor of contralateral central lymph node metastasis in papillary thyroid carcinoma?[J].J Surg Res,2017,15(214):162-167.
[9]吴积新,刘江泽.超声诊断在乳腺肿瘤中的应用进展[J].医学综述,2015,21(4):680-682.
[10]Jahan AB,Ahmed MU,Begum M,et al.Ultrasonographic evaluation of palpable breast mass and correlation with histopathology[J].Mymensingh Med J,2017,26(2):223-229.
[11]苏爱江,罗扬,毛爱琴.超声引导下穿刺活检对早期乳腺癌的诊断价值[J].实用癌症杂志,2018,33(3):377-379.
[12]Tadros AB,Yang WT,Krishnamurthy S,et al.Identification of patients with documented pathologic complete response in the breast after neoadjuvant chemotherapy for omission of axillary surgery[J].JAMA Surg,2017,152(7):665-670.
[13]Chesebro AL,Chikarmane SA,Ritner JA,et al.Troubleshooting to overcome technical challenges in image-guided breast biopsy[J].Radiographics,2017,37(3):705-718.
[14]陆艺红,严优江,叶迅.彩色多普勒超声在乳腺良恶性占位性病变鉴别诊断中的应用价值[J].中国实用医刊,2018,45(3):62-64.
[15]Chen YL,Chen JJ,Chang C,et al.Sclerosing adenosis:Ultrasonographic and mammographic findings and correlation with histopathology[J].Mol Clin Oncol,2017,6(2):157-162.
[16]Faustino-Rocha AI,Gama A,Oliveira PA,et al.Modulation of mammary tumor vascularization by mast cells:Ultrasonographic and histopathological approaches[J].Life Sci,2017,1(176):35-41.
[17]王璐,史鹏丽,郑继慧,等.青年女性乳腺癌患者临床病理及超声影像学特征分析[J].肿瘤研究与临床,2018,30(3):169-172.
[18]Ueda A,Yamamoto D,Tsubota Y,et al.Serous carcinoma of the peritoneum with metastases to the breast and axillary lymph nodes[J].Gan To Kagaku Ryoho,2016,43(12):2252-2254.
[19]黄泽君,杨正春,李芳,等.超声弹性成像与磁共振对T1~2N1~2M0乳腺癌新辅助化疗疗效评估的对比研究[J].重庆医学,2018,47(7):899-901.
[20]Yao JP,Hao YZ,Chang Q,et al.Value of ultrasonographic features for assessing malignant potential of complex cystic breast lesions[J].J Ultrasound Med,2017,36(4):699-704.