TWIK相关性酸敏感钾离子通道与疾病研究进展
摘要
TASK-1和TASK-3是广泛表达于全身各组织,产生外向钾离子电流,受细胞外酸浓度抑制而不受经典钾离子阻滞剂影响的TWIK相关性酸敏感钾离子通道。TASK-1和TASK-3参与中枢神经系统、呼吸系统、心房颤动、肾上腺皮质激素、炎症免疫及肿瘤的发生等一系列生理病理过程,有望为相关疾病药物治疗研究提供靶点。
引文
1 田真,蔡鑫,唐碧.双孔钾通道TASK-1与缺氧性肺血管收缩的研究进展[J].国际心血管病杂志,2013,40(4):236-239
2 Shinoda K,Luijten IH,Hasegawa Y,et al.Genetic and functional characterization of clonally derived adult human brown adipocytes[J].Nat Med,2015,21(4):389-394
3 Buckler KJ.TASK channels in arterial chemoreceptors and their role in oxygen and acid sensing[J].Pflugers Arch,2015,467(5):1013-1025
4 Ma L,Roman-Campos D,Austin ED,et al.A novel channelopathy in pulmonary arterial hypertension[J].N Engl J Med,2013,369(4):351-361
5 Liang B,Soka M,Christensen AH,et al.Genetic variation in the two-pore domain potassium channel,TASK-1,may contribute to an atrial substrate for arrhythmogenesis[J].J Mol Cell Cardiol,2014,67:69-76
6 Graham JM Jr,Zadeh N,Kelley M,et al.KCNK9 imprinting syndrome-further delineation of a possible treatable disorder[J].Am J Med Genet A,2016,170 (10):2632-2637
7 Meuth SG,Kleinschnitz C,Broicher T,et al.The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice[J].Neurobiol Dis,2009,33(1):1-11
8 Ehling P,Bittner S,Bobak N,et al.Two pore domain potassium channels in cerebral ischemia:a focus on K2P9.1 (TASK3,KCNK9)[J].Exp Transl Stroke Med,2013,5(1):3
9 Na B,Zhang H,Wang G,et al.The effect of mechanical ventilation on TASK-1 expression in the brain in a rat model[J].Canadian Respirat J,2017,2017:8530352
10 Meuth SG,Budde T,Kanyshkova T,et al.Contribution of TWIK-related acid-sensitive K channel 1(TASK1) and TASK3 channels to the control of activity modes in thalamocortical neurons[J].J Neurosci,2003,23(16):6460-6469
11 Conway KE,Cotten JF.Covalent modification of a volatile anesthetic regulatory site activates TASK-3 (KCNK9) tandem-pore potassium channels[J].Mol Pharmacol,2012,81(3):393-400
12 张成,王菁,王广发,等.钾离子通道TASK-1、TASK-3在大鼠脑干的表达与睡眠呼吸暂停的关系[J].中华医学杂志,2007,87 (41):2929-2931
13 Buehler PK,Bleiler D,Tegtmeier I,et al.Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice[J].Respir Physiol Neurobiol,2017,244:17-25
14 Bayliss DA,Barhanin J,Gestreau C,et al.The role of pH-sensitive TASK channels in central respiratory chemoreception[J].Pflugers Arch,2015,467(5):917-929
15 Schmidt C,Wiedmann F,Voigt N,et al.Upregulation of K(2P)3.1 K+ current causes action potential shortening in patients with chronic atrial fibrillation[J].Circulation,2015,132(2):82-92
16 Harleton E,Besana A,Chandra P,et al.TASK-1 current is inhibited by phosphorylation during human and canine chronic atrial fibrillation[J].Am J Physiol Heart Circ Physiol,2015,308(2):H126-H134
17 Lambert M,Boet A,Rucker-Martin C,et al.Loss of KCNK3 is a hallmark of RV hypertrophy/dysfunction associated with pulmonary hypertension[J].Cardiovasc Res,2018,114(6):880-893
18 Kiper AK,Rinné S,Rolfes C,et al.Kv1.5 blockers preferentially inhibit TASK-1 channels:TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?[J].Pflugers Arch,2015,467(5):1081-1090
19 Bandulik S,Tauber P,Lalli E,et al.Two-pore domain potassium channels in the adrenal cortex[J].Pflugers Arch,2015,467(5):1027-1042
20 Li HJ,Li NF,Wang MH,et al.Clinical analysis of 224 patients with hypertension and normokalemic primary aldosteronism[J].Chin J hypertens,2012,20(4):363-367
21 Guagliardo NA,Yao J,Hu C,et al.TASK-3 channel deletion in mice recapituates low renin essential hypertension[J].Hypertension,2012,59 (5):999-1005
22 E Hachmane MF,Rees KA,Veale EL,et al.Enhancement of TWIK-related acid-sensitive potassium channel 3 (TASK3) two-pore domain potassium channel activity by tumor necrosis factor α[J].J Biol Chem,2014,289 (3):1388-1401
23 Leithner K,Hirschmugl B,Li Y,et al.TASK-1 Regulates apoptosis and proliferation in a subset of non-small cell lung cancers[J].PLoS One,2016,11(6):e0157453
24 Sun H,Luo L,Lal B,et al.A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis[J].Nat Commun,2016,7:10339
2 Shinoda K,Luijten IH,Hasegawa Y,et al.Genetic and functional characterization of clonally derived adult human brown adipocytes[J].Nat Med,2015,21(4):389-394
3 Buckler KJ.TASK channels in arterial chemoreceptors and their role in oxygen and acid sensing[J].Pflugers Arch,2015,467(5):1013-1025
4 Ma L,Roman-Campos D,Austin ED,et al.A novel channelopathy in pulmonary arterial hypertension[J].N Engl J Med,2013,369(4):351-361
5 Liang B,Soka M,Christensen AH,et al.Genetic variation in the two-pore domain potassium channel,TASK-1,may contribute to an atrial substrate for arrhythmogenesis[J].J Mol Cell Cardiol,2014,67:69-76
6 Graham JM Jr,Zadeh N,Kelley M,et al.KCNK9 imprinting syndrome-further delineation of a possible treatable disorder[J].Am J Med Genet A,2016,170 (10):2632-2637
7 Meuth SG,Kleinschnitz C,Broicher T,et al.The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice[J].Neurobiol Dis,2009,33(1):1-11
8 Ehling P,Bittner S,Bobak N,et al.Two pore domain potassium channels in cerebral ischemia:a focus on K2P9.1 (TASK3,KCNK9)[J].Exp Transl Stroke Med,2013,5(1):3
9 Na B,Zhang H,Wang G,et al.The effect of mechanical ventilation on TASK-1 expression in the brain in a rat model[J].Canadian Respirat J,2017,2017:8530352
10 Meuth SG,Budde T,Kanyshkova T,et al.Contribution of TWIK-related acid-sensitive K channel 1(TASK1) and TASK3 channels to the control of activity modes in thalamocortical neurons[J].J Neurosci,2003,23(16):6460-6469
11 Conway KE,Cotten JF.Covalent modification of a volatile anesthetic regulatory site activates TASK-3 (KCNK9) tandem-pore potassium channels[J].Mol Pharmacol,2012,81(3):393-400
12 张成,王菁,王广发,等.钾离子通道TASK-1、TASK-3在大鼠脑干的表达与睡眠呼吸暂停的关系[J].中华医学杂志,2007,87 (41):2929-2931
13 Buehler PK,Bleiler D,Tegtmeier I,et al.Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice[J].Respir Physiol Neurobiol,2017,244:17-25
14 Bayliss DA,Barhanin J,Gestreau C,et al.The role of pH-sensitive TASK channels in central respiratory chemoreception[J].Pflugers Arch,2015,467(5):917-929
15 Schmidt C,Wiedmann F,Voigt N,et al.Upregulation of K(2P)3.1 K+ current causes action potential shortening in patients with chronic atrial fibrillation[J].Circulation,2015,132(2):82-92
16 Harleton E,Besana A,Chandra P,et al.TASK-1 current is inhibited by phosphorylation during human and canine chronic atrial fibrillation[J].Am J Physiol Heart Circ Physiol,2015,308(2):H126-H134
17 Lambert M,Boet A,Rucker-Martin C,et al.Loss of KCNK3 is a hallmark of RV hypertrophy/dysfunction associated with pulmonary hypertension[J].Cardiovasc Res,2018,114(6):880-893
18 Kiper AK,Rinné S,Rolfes C,et al.Kv1.5 blockers preferentially inhibit TASK-1 channels:TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?[J].Pflugers Arch,2015,467(5):1081-1090
19 Bandulik S,Tauber P,Lalli E,et al.Two-pore domain potassium channels in the adrenal cortex[J].Pflugers Arch,2015,467(5):1027-1042
20 Li HJ,Li NF,Wang MH,et al.Clinical analysis of 224 patients with hypertension and normokalemic primary aldosteronism[J].Chin J hypertens,2012,20(4):363-367
21 Guagliardo NA,Yao J,Hu C,et al.TASK-3 channel deletion in mice recapituates low renin essential hypertension[J].Hypertension,2012,59 (5):999-1005
22 E Hachmane MF,Rees KA,Veale EL,et al.Enhancement of TWIK-related acid-sensitive potassium channel 3 (TASK3) two-pore domain potassium channel activity by tumor necrosis factor α[J].J Biol Chem,2014,289 (3):1388-1401
23 Leithner K,Hirschmugl B,Li Y,et al.TASK-1 Regulates apoptosis and proliferation in a subset of non-small cell lung cancers[J].PLoS One,2016,11(6):e0157453
24 Sun H,Luo L,Lal B,et al.A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis[J].Nat Commun,2016,7:10339