多重乳液法制备维生素C微胶囊
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- 英文论文题名：Preparation of vitamin C microcapsules via multiple emulsion method
- 论文作者：胡静 ; 王宇轩 ; 王嘉敏 ; 范逸君
- 英文论文作者：Hu Jing ; Wang YuXuan ; Wang JiaMin ; Fan YiJun ; School of Perfumem and Aroma Technology ; Shang hai Institute of Technology
- 年：2016
- 作者机构：上海应用技术学院香料香精技术与工程学院;
- 论文关键词：多重乳液法 ; 壳聚糖 ; 维生素C ; 微胶囊
- 英文论文关键词：Multiple emulsion polymerization ; Chitosan ; Vitamin C ; Microcapsule
- 会议召开时间：2016-06-15
- 会议录名称：第十一届中国香料香精学术研讨会论文集
- 英文会议录名称：The Proceedings of the 11th Seminar on Fragrance and Flavor China
- 语种：中文
- 分类号：TQ466.3
- 学会代码：ZGXE
- 会议名称：第十一届中国香料香精学术研讨会
- 会议地点：中国上海
- 主办单位：中国香料香精化妆品工业协会
- 学会名称：中国香料香精化妆品工业协会
- 页数：8
- 文件大小：1623k
- 原文格式：O
- 会议级别：全国
摘要
本文以壳聚糖为壁材,维生素C溶液为芯材,采用多重乳液法制备维生素C微胶囊。考察了外层水相和内乳液的质量比,外相乳化剂tween20的用量,壳聚糖溶液的浓度和搅拌时间等因素对维生素C微胶囊微观形貌的影响。采用傅立叶变换红外光谱仪(FTIR)、热重分析仪(TGA)和紫外分光光度计对维生素C微胶囊的结构和性能进行表征。结果表明:当外层水相和内乳液的质量比为2:1;外相乳化剂tween-20用量为3%;壳聚糖溶液浓度为2%;搅拌时间为15min时,维生素C微胶囊的粒径为69-117μm,包覆率为5.248%。红外光谱证明壳聚糖已成功的包覆维生素C。紫外光谱结果表明维生素C微胶囊在水溶液和模拟胃液中均具有良好的缓释效果。
Vitamin C microcapsules were prepared through multiple emulsion method using chitosan as wall materials and Vitamin C solution as core materials.Several factors including the mass ratio between outer phase and inner emulsion;the amount of outer emulsifier;the concentration of chitosan solution and the mixing time were considered to investigate their influence on the microtopography of microcapsules.We use the fourier transform infrared spectrometer(FTIR),thermogravimetricanalysis(TGA) and ultraviolet spectroscopy to observe its constituents and performance.As a result,the mass ratio of inner and outer phases is 2:1;the amount of outer emulsifier is 3%;the concentration of chitosan solution is 2%;mixing time is 15 min.The particle diameter is 69-117μm.The coating rate is 5.248%.FTIR spectrum suggests the successful encapsulation of Vitamin C solution.Ultraviolet spectroscopy indicates good slow-release property of Vitamin C microcapsules in aqueous solution and simulated gastric fluid.
Vitamin C microcapsules were prepared through multiple emulsion method using chitosan as wall materials and Vitamin C solution as core materials.Several factors including the mass ratio between outer phase and inner emulsion;the amount of outer emulsifier;the concentration of chitosan solution and the mixing time were considered to investigate their influence on the microtopography of microcapsules.We use the fourier transform infrared spectrometer(FTIR),thermogravimetricanalysis(TGA) and ultraviolet spectroscopy to observe its constituents and performance.As a result,the mass ratio of inner and outer phases is 2:1;the amount of outer emulsifier is 3%;the concentration of chitosan solution is 2%;mixing time is 15 min.The particle diameter is 69-117μm.The coating rate is 5.248%.FTIR spectrum suggests the successful encapsulation of Vitamin C solution.Ultraviolet spectroscopy indicates good slow-release property of Vitamin C microcapsules in aqueous solution and simulated gastric fluid.
引文
[1]井乐刚,赵新淮.维生素C微胶囊的制备及应用的研究进展[J].化工进展,2006,25(11):1256-1260
[2]阎师杰,吴彩娥,寇晓虹等.核桃油微胶囊化工艺的研究[J].农业工程学报,2003,19(1):168-172
[3]Quintanar G D,Allemann E,Doelker E,et al.A mechanistic study of the formation of polymer nanopartles by the emulsification-diffusion technique[J].Pharma-ceutical Research,1998,15(7):1056-1062.
[4]蔡涛,王丹,宋志祥,余万能.微胶囊的制备技术及其国内应用进展[J].化学推进剂与高分子材料,2010,8(2):20-26.
[5]李书国,薛文通,李雪梅等.乙基纤维素微胶囊化Vc工艺参数及其活性保护的研究[J].食品工业科技,2005,26(5):143-148.
[6]刘丽仙,蒋丽刚,申奉受,吴依娜.维生素C包裹技术的研究进展[J].香料香精化妆品,2015,(6):56-61.
[7]Lee J B,Ahn J,Lee J,et al.L-ascorbic acid microencapsulated with polyacylglycerol monostearate for milk fortification[J].Biosci.Biotechnol.Biochem,2004,68(3):495-500.
[8]Uddin M S,Hawlader M N A,Zhu H J.Microencapsulation of ascorbic acid:effect of process variable on product characteristics[J].J.Microencapsulation,2001,18(2):199-209.
[9]李刚,孟宪刚,康燕莉.维生素C微胶囊化包埋工艺研究[J].应用化工,2013,42(3):404-409.
[10]刘亚文,曹光群,陈婷婷.维生素C脂质体的制备研究[J].大豆科学,2007,26(2):270-272.
[11]赵华,董银卯,何聪芬等.维生素C脂质体的制备与研究[J].香料香精化妆品,2006,(6)3:17-20.
[12]Cui J H,Goh J S,Park S Y,et al.Preparation and physical characterization of alginate microparticles using air atomization method[J].Drug Development and Industrial Pharmacy.2001,27(4):309-319.
[13]李书国,薛文通,李雪梅,等.乙基纤维素微胶囊化Vc工艺参数及其活性保护的研究[J].食品工业科技,2005,26(5):143-148.
[14]Trindade M A,Grosso R F.The stability of ascorbic acid microencapsulated in granules of ricestarch and in gum Arabic[J].Journal of Microencapsulation,2000,17(2):169-176.
[15]Naveed Akhtar,Mahmood Ahmad,Haji M.Shoaib Khan,Jawad Akram,Gulfishan,Ahmad Mahmood,Muhammad Uzair.Formulation and characterization of a multiple emulsion containing 1%L-ascorbic acid[J].Bull.Chem.Soc.Ethiop.2010,24(1):1-10.
[2]阎师杰,吴彩娥,寇晓虹等.核桃油微胶囊化工艺的研究[J].农业工程学报,2003,19(1):168-172
[3]Quintanar G D,Allemann E,Doelker E,et al.A mechanistic study of the formation of polymer nanopartles by the emulsification-diffusion technique[J].Pharma-ceutical Research,1998,15(7):1056-1062.
[4]蔡涛,王丹,宋志祥,余万能.微胶囊的制备技术及其国内应用进展[J].化学推进剂与高分子材料,2010,8(2):20-26.
[5]李书国,薛文通,李雪梅等.乙基纤维素微胶囊化Vc工艺参数及其活性保护的研究[J].食品工业科技,2005,26(5):143-148.
[6]刘丽仙,蒋丽刚,申奉受,吴依娜.维生素C包裹技术的研究进展[J].香料香精化妆品,2015,(6):56-61.
[7]Lee J B,Ahn J,Lee J,et al.L-ascorbic acid microencapsulated with polyacylglycerol monostearate for milk fortification[J].Biosci.Biotechnol.Biochem,2004,68(3):495-500.
[8]Uddin M S,Hawlader M N A,Zhu H J.Microencapsulation of ascorbic acid:effect of process variable on product characteristics[J].J.Microencapsulation,2001,18(2):199-209.
[9]李刚,孟宪刚,康燕莉.维生素C微胶囊化包埋工艺研究[J].应用化工,2013,42(3):404-409.
[10]刘亚文,曹光群,陈婷婷.维生素C脂质体的制备研究[J].大豆科学,2007,26(2):270-272.
[11]赵华,董银卯,何聪芬等.维生素C脂质体的制备与研究[J].香料香精化妆品,2006,(6)3:17-20.
[12]Cui J H,Goh J S,Park S Y,et al.Preparation and physical characterization of alginate microparticles using air atomization method[J].Drug Development and Industrial Pharmacy.2001,27(4):309-319.
[13]李书国,薛文通,李雪梅,等.乙基纤维素微胶囊化Vc工艺参数及其活性保护的研究[J].食品工业科技,2005,26(5):143-148.
[14]Trindade M A,Grosso R F.The stability of ascorbic acid microencapsulated in granules of ricestarch and in gum Arabic[J].Journal of Microencapsulation,2000,17(2):169-176.
[15]Naveed Akhtar,Mahmood Ahmad,Haji M.Shoaib Khan,Jawad Akram,Gulfishan,Ahmad Mahmood,Muhammad Uzair.Formulation and characterization of a multiple emulsion containing 1%L-ascorbic acid[J].Bull.Chem.Soc.Ethiop.2010,24(1):1-10.