薄膜表面微图案化及其尺寸对薄膜抗细菌粘附能力的影响
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- 英文论文题名：Bacteria Adhesion on Micro-patterned Polydimethylsiloxane Surfaces
- 论文作者：陆乃彦 ; 张薇 ; 周鹏
- 英文论文作者：Naiyan Lu ; Wei Zhang ; Peng Zhou ; State Key Laboratory of Food Science and Technology ; Jiangnan University
- 年：2016
- 作者机构：江南大学食品科学与技术国家重点实验室;
- 论文关键词：电子束曝光 ; 表面拓扑结构 ; 微米图案 ; 抗细菌粘附
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十一分会：胶体与界面化学
- 语种：中文
- 分类号：TB383.2
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十一分会 ; 胶体与界面化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：202k
- 原文格式：D
- 会议级别：全国
摘要
在医疗器材、食品加工等领域,材料表面的细菌粘附常引起植入性感染或食品腐败,有时甚至会引发疾病,而控制细菌在材料表面的初始粘附能够减少这些安全隐患。本文通过电子束刻蚀和纳米翻刻技术,在材料表面引入三种不同形状的微米级表面拓扑结构,尺寸大小从0.5μm到4μm,并将其与大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌等三种不同尺寸的常见致病菌共同培养。结果表明在材料表面引入拓扑结能够有效抑制细菌粘附,并且细菌尺寸与拓扑结构尺寸之间的差异是其抑制细菌粘附效果的重要影响因素。另外,材料表面的疏水程度也对其抑制细菌粘附能力有影响。
Bacteria adhesion on surfaces often occurs in medical and food applications,and causes implanted infections,food spoilage and human illness.The control of the initial adhesion to materials is very important to avoid safety and health problems.Compared with chemical antibacterial methods,micro-patterned topography has shown a great potential application on inhibiting the bacteria adhesion owing to their nontoxic property.In this study,we fabricated 3 different micro-patterned polydimethylsiloxane films with various pattern sizes from 0.5 to 4μm.Three model strains(Escherichia coli BL21,Staphylococcus aureus 6538 and Pseudomonas aeruginosa ATCC 9027)were used to demonstrate the anti-adhesive of the films by quantitatively exploring the amount of these strains.The results showed that the introduction of micro-pattern topography could reduce the attachment of these 3 strains.The difference between the pattern size and the bacteria size was crucial to the amount of bacteria adhered on the surfaces for different strains.Hydrophobicity of thesurface could also influence the anti-adhesive property of the surfaces.
Bacteria adhesion on surfaces often occurs in medical and food applications,and causes implanted infections,food spoilage and human illness.The control of the initial adhesion to materials is very important to avoid safety and health problems.Compared with chemical antibacterial methods,micro-patterned topography has shown a great potential application on inhibiting the bacteria adhesion owing to their nontoxic property.In this study,we fabricated 3 different micro-patterned polydimethylsiloxane films with various pattern sizes from 0.5 to 4μm.Three model strains(Escherichia coli BL21,Staphylococcus aureus 6538 and Pseudomonas aeruginosa ATCC 9027)were used to demonstrate the anti-adhesive of the films by quantitatively exploring the amount of these strains.The results showed that the introduction of micro-pattern topography could reduce the attachment of these 3 strains.The difference between the pattern size and the bacteria size was crucial to the amount of bacteria adhered on the surfaces for different strains.Hydrophobicity of thesurface could also influence the anti-adhesive property of the surfaces.
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