某院住院患者质子泵抑制剂临床预防性使用情况分析
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- 英文论文题名：Analysis of clinical preventive use of proton pump inhibitors in a hospital
- 论文作者：陈秋红 ; 周妍 ; 张云琛 ; 费燕
- 英文论文作者：CHEN Qiu-hong ; ZHOU Yan ; ZHANG Yun-chen ; FEI Yan ; Department of Pulmonary ; No.175 Hospital of PLA/The Affiliated Southeast Hospital of Xiamen University ; Wenzhou Medical University ; College of Pharmacy
- 年：2016
- 作者机构：解放军第175医院/厦门大学附属东南医院药学科;温州医科大学药学系;
- 论文关键词：质子泵抑制剂 ; 住院患者 ; 预防性使用 ; 分析
- 英文论文关键词：Proton pump inhibitors ; hospitalized patients ; preventive use ; analysis
- 会议召开时间：2016-09-27
- 会议录名称：中国药学会第十三届青年药学科研成果交流会论文集
- 语种：中文
- 分类号：R975
- 学会代码：YYWS
- 会议名称：中国药学会第十三届青年药学科研成果交流会
- 会议地点：中国江西南昌
- 主办单位：中国药学会
- 学会名称：中国药学会
- 页数：5
- 文件大小：334k
- 原文格式：O
- 会议级别：全国
摘要
目的:调查分析住院患者质子泵抑制剂(PPIs)临床预防性使用情况,为临床合理用药及规范化管理提供参考。方法:通过医院信息化管理系统,随机抽取某三甲医院2013年1月至2015年12月期间使用质子泵抑制剂的住院患者674份,在剔除治疗性用药的基础上,以该院PPIs临床预防性使用管理规定为点评依据,回顾性调查分析PPIs预防性用药的情况。结果:406份使用PPIs预防性用药的住院医嘱中,预防性使用不合理共176份(占52.38%),不合理主要表现在无用药指征、遴选药品不适宜、用药时间过长、用法用量不适宜,占比分别为77.27%,12.5%,7.95%,2.27%。结论:该院质子泵抑制剂的预防性使用存在不合理现象,须加强规范化管理。
Objective To investigate the clinical preventive use of proton pump inhibitors(PPIs) in inpatients,and to provide reference for clinical rational drug use and standardized management.Methods Through the hospital information management system,using randomly selected from a tertiary hospital in January 2013 to 2015 December proton pump inhibitors 674 hospitalized patients,the treatment medication based on excluding,to the hospital PPIs clinical preventive use management regulations comment on,the retrospective investigation and analysis of PPIs preventive medication use.Results 406 PPIs are used to prevent use of inpatient prescriptions,prevention of irrational use of a total of 176(52.38%),unreasonable mainly on useless medicine refers to the syndrome,selection of drugs is not suitable,medication for a long time,usage and dosage is not suitable,accounted for 77.27%,respectively,12.5%and 7.95%and 2.27%.Conclusion the preventive use of proton pump inhibitors in the hospital is not reasonable,so it is necessary to strengthen the standardized management.
Objective To investigate the clinical preventive use of proton pump inhibitors(PPIs) in inpatients,and to provide reference for clinical rational drug use and standardized management.Methods Through the hospital information management system,using randomly selected from a tertiary hospital in January 2013 to 2015 December proton pump inhibitors 674 hospitalized patients,the treatment medication based on excluding,to the hospital PPIs clinical preventive use management regulations comment on,the retrospective investigation and analysis of PPIs preventive medication use.Results 406 PPIs are used to prevent use of inpatient prescriptions,prevention of irrational use of a total of 176(52.38%),unreasonable mainly on useless medicine refers to the syndrome,selection of drugs is not suitable,medication for a long time,usage and dosage is not suitable,accounted for 77.27%,respectively,12.5%and 7.95%and 2.27%.Conclusion the preventive use of proton pump inhibitors in the hospital is not reasonable,so it is necessary to strengthen the standardized management.
引文
[1]黄立新.某院质子泵抑制剂使用情况分析[J].中国当代医药,2015,22(11):147-149.
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[3]朱雅艳,华俊彦,华延焱,等.注射用质子泵抑制剂临床合理用药评价[J].浙江中西医结合杂志,2013,23(12):1036-1037.
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[5]彭瑞光.奥美拉唑与CYP2C19基因多态性及其药物相互作用.泸州医学院学报,2010,33(6):718-720.
[6]郭丰,张宝娣,谢丹青.奥美拉唑药物相互作用分析.中国现代药物应用,2011,5(4):79.
[7]中国医院协会药事管理专业委员会.质子泵抑制剂临床应用的药学监护[M].人民卫生出版社,2013,6-128.
[8]朱雅艳,华俊彦,华延焱,等.注射用质子泵抑制剂I临床合理用药评价[J].浙江中西医结合杂志,2013,23(12):1036-1037.
[9]Graziani G,Badalamenti S,Como G,et al.Calcium and phosphate plasma levels in dialysis patients after dietary Ca-Poverload.Role of gastric acid secretion[J].Nephron,2002,91(3):474-479.
[10]李雪莲,周力.长期应用质子泵抑制剂对老年男性消化性溃疡患者骨密度的影响[J].贵阳医学院学报,2011,36(5):528-529.
[11]中华医学杂志编辑委员会.应激性溃疡防治建议[J].中华医学杂志,2002,82(14):1000-1001.
[12]陈新谦,金有豫,汤光.新编药物学[M].17版.北京:人民卫生出版社,2011:469-471.
[13]Eom CS,Jeon CY,Lim JW,et al.Use of acid-suppressive drugs and risk of pneumonia:a systematic review and meta-analysis[J].CMAJ,2011,183(3):310-319.
[14]李荣富,李欣,吴姗珊,等.长期使用质子泵抑制剂对肠道菌群的影响[J].临床荟萃,2011,26(22):1940-1943.
[15]Haruma K,ITO M.Review article clinical significance of mucosal-protective agents Acid inflammation carcinogenesis and rebam ipide[J].Aliment Pharmacol Ther,2003,18(Suppl 1):153-159.
[2]《中国国家处方集》编委会.消化系统疾病用药[M].中国国家处方集(化学药品与生物制品卷),北京:人民军医出版社,2010:144.
[3]朱雅艳,华俊彦,华延焱,等.注射用质子泵抑制剂临床合理用药评价[J].浙江中西医结合杂志,2013,23(12):1036-1037.
[4]许国铭,钟杰.质子泵抑制剂-基础与临床[M].上海:上海科技教育出版社,2004:40-46.
[5]彭瑞光.奥美拉唑与CYP2C19基因多态性及其药物相互作用.泸州医学院学报,2010,33(6):718-720.
[6]郭丰,张宝娣,谢丹青.奥美拉唑药物相互作用分析.中国现代药物应用,2011,5(4):79.
[7]中国医院协会药事管理专业委员会.质子泵抑制剂临床应用的药学监护[M].人民卫生出版社,2013,6-128.
[8]朱雅艳,华俊彦,华延焱,等.注射用质子泵抑制剂I临床合理用药评价[J].浙江中西医结合杂志,2013,23(12):1036-1037.
[9]Graziani G,Badalamenti S,Como G,et al.Calcium and phosphate plasma levels in dialysis patients after dietary Ca-Poverload.Role of gastric acid secretion[J].Nephron,2002,91(3):474-479.
[10]李雪莲,周力.长期应用质子泵抑制剂对老年男性消化性溃疡患者骨密度的影响[J].贵阳医学院学报,2011,36(5):528-529.
[11]中华医学杂志编辑委员会.应激性溃疡防治建议[J].中华医学杂志,2002,82(14):1000-1001.
[12]陈新谦,金有豫,汤光.新编药物学[M].17版.北京:人民卫生出版社,2011:469-471.
[13]Eom CS,Jeon CY,Lim JW,et al.Use of acid-suppressive drugs and risk of pneumonia:a systematic review and meta-analysis[J].CMAJ,2011,183(3):310-319.
[14]李荣富,李欣,吴姗珊,等.长期使用质子泵抑制剂对肠道菌群的影响[J].临床荟萃,2011,26(22):1940-1943.
[15]Haruma K,ITO M.Review article clinical significance of mucosal-protective agents Acid inflammation carcinogenesis and rebam ipide[J].Aliment Pharmacol Ther,2003,18(Suppl 1):153-159.