微量营养素与脂肪对动物基因表达的调控作用
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- 英文论文题名：Effect of Trace Nutrients and Fat on Manipulation of Animal Gene Expression
- 论文作者：王杰 ; 刁其玉 ; 张乃锋
- 英文论文作者：WANG Jie ; DIAO Qi-yu ; ZHANG Nai-feng ; Feed Research Institute ; Chinese Academy of Agricultural Sciences ; Key Laboratory of Feed Biotechnology of Ministry of Agriculture
- 年：2016
- 作者机构：中国农业科学院饲料研究所农业部生物技术重点实验室;
- 论文关键词：微量营养素 ; 脂肪 ; 基因表达 ; 调控机制
- 英文论文关键词：trace nutrients ; fat ; gene expression ; regulation mechanism
- 会议召开时间：2016-11-04
- 会议录名称：中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会论文集
- 语种：中文
- 分类号：S816
- 学会代码：ZGXJ
- 会议名称：中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会
- 会议地点：中国山东青岛
- 主办单位：中国畜牧兽医学会动物微生态学分会
- 学会名称：中国畜牧兽医学会
- 页数：5
- 文件大小：474k
- 原文格式：O
- 会议级别：全国
摘要
微量营养素与脂肪作为动物新陈代谢重要的营养物质种类,只有满足生长发育的营养需要,动物才能平稳的进行各项生命活动。更重要的是它们还作为基因表达的调控物,可以在多途径、多水平对动物基因表达进行调控。动物日粮中营养素含量和类型都会影响动物基因表达,进而导致动物机体的代谢途径和效率发生改变,最终影响到动物的营养需求和生产性能。近年来,随着分子生物技术发展,营养素对动物基因表达的调控作用及其机制逐渐被揭示出来,新的研究发现纷纷涌现。本综述针对微量营养素与脂肪对动物基因表达的调控作用研究进展进行综述,旨在为更准确、更合理地确定动物对营养素的需要量提供理论依据。此外,本综述还对营养素调控基因表达的研究与应用前景作了展望。
Trace nutrients and fat,as important nutrients for animal metabolism,are vital for the growth and development of animals.Importantly,they can regulate the expression of gene in different ways and levels.The alteration of animal gene expression can affect the animal's nutritional requirements and growth performance by changing the nutrient metabolic pathway and efficiency.With the development of animal nutrition and molecular biology,the mechanism of nutrients regulating the gene expression is gradually revealed.In this paper,the effects of trace nutrients and fat regulating the gene expression were reviewed aiming to provide a theoretical basis for the determining of animal nutrients requirement more accurately and scientifically.In addition,the application prospects of nutrients regulating gene expression were also discussed.
Trace nutrients and fat,as important nutrients for animal metabolism,are vital for the growth and development of animals.Importantly,they can regulate the expression of gene in different ways and levels.The alteration of animal gene expression can affect the animal's nutritional requirements and growth performance by changing the nutrient metabolic pathway and efficiency.With the development of animal nutrition and molecular biology,the mechanism of nutrients regulating the gene expression is gradually revealed.In this paper,the effects of trace nutrients and fat regulating the gene expression were reviewed aiming to provide a theoretical basis for the determining of animal nutrients requirement more accurately and scientifically.In addition,the application prospects of nutrients regulating gene expression were also discussed.
引文
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[7]朱中胜,李吕木,唐倩.蛋氨酸及其螯合物对动物基因表达的调控[J].饲料工业,2014(23):26-29.
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[10]林忠荔,江明锋,任洪辉.牛乳蛋白合成的分子调控机制[J].中国畜牧兽医,2014(05):158-162.
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[12]李喜艳,王加启,魏宏阳,等.MTT比色法检测赖氨酸、蛋氨酸对体外培养的奶牛乳腺上皮细胞增殖的影响.生物技术通报,2010,3:144.
[13]Liu X F,Li M,Li Q Z,et al.Stat5a increases lactation of dairy cow mammary gland epithelial cells cultured in vitro[J].In Vitro Cellular&Developmental Biology-Animal,2012,48(9):554-561.
[14]张克英,陈代文.类胰岛素生长因子及其营养调控[J].中国畜牧杂志,2002(6):42-44.
[15]荣风梅,谭兴智.日粮添加蛋氨酸对生长肉兔肝脏中IGF-I mRNA表达量的影响[J].中国动物检疫,2010,27(9):39-41.
[16]Del Vesco A P,Gasparino E,Oliveira Neto A R,et al.Dietary methionine effects on IGF-1 and GHR mRNA expression in broilers[J].Genetics and Molecular Research,2013,12(4):6414-6423.
[2]Ibanez A J,Peinado-Onsurbe J,Sanchez E,et al.Lipoprotein lipase(LPL)is highly expressed and active in the ovary of European sea bass(Dicentrarchus labrax L.),during gonadal development[J].Comparative Biochemistry and Physiology Part A:Molecular&Integrative Physiology,2008,150(3):347-354.
[3]吕丹娜,许丽.营养物质对基因表达的调控作用[J].中国畜牧兽医,2006(07):14-17.
[4]Semenza G L.Transcriptional regulation of gene expression:mechanisms and path physiology[J].Human Mutation,1994,3(3):180-199.
[5]Freedman L P,Luisi B P.On the mechanism of DNA binding by nuclear hormone receptors:a structural and functional perspective[J].Journal of Cell Biochemistry,1993,1(2):140-150.
[6]韩春晓,苗翠.蛋氨酸的功能及代谢吸收过程[J].现代畜牧兽医,2013(09):75-80.
[7]朱中胜,李吕木,唐倩.蛋氨酸及其螯合物对动物基因表达的调控[J].饲料工业,2014(23):26-29.
[8]夏芳.蛋氨酸缺乏对泌乳奶山羊乳蛋白合成影响机制研究[D].泰安:山东农业大学,2014.
[9]王佳丽,高学军,李庆章,等.蛋氨酸对体外培养奶牛乳腺上皮细胞泌乳能力的影响[J].乳业科学与技术,2012(01):8-10.
[10]林忠荔,江明锋,任洪辉.牛乳蛋白合成的分子调控机制[J].中国畜牧兽医,2014(05):158-162.
[11]Mercier J C,Vilott J L.Structure and function of milk protein genes[J].J Dairy Sci,1993,76:3079-3098.
[12]李喜艳,王加启,魏宏阳,等.MTT比色法检测赖氨酸、蛋氨酸对体外培养的奶牛乳腺上皮细胞增殖的影响.生物技术通报,2010,3:144.
[13]Liu X F,Li M,Li Q Z,et al.Stat5a increases lactation of dairy cow mammary gland epithelial cells cultured in vitro[J].In Vitro Cellular&Developmental Biology-Animal,2012,48(9):554-561.
[14]张克英,陈代文.类胰岛素生长因子及其营养调控[J].中国畜牧杂志,2002(6):42-44.
[15]荣风梅,谭兴智.日粮添加蛋氨酸对生长肉兔肝脏中IGF-I mRNA表达量的影响[J].中国动物检疫,2010,27(9):39-41.
[16]Del Vesco A P,Gasparino E,Oliveira Neto A R,et al.Dietary methionine effects on IGF-1 and GHR mRNA expression in broilers[J].Genetics and Molecular Research,2013,12(4):6414-6423.