体检时联合检测血清胱抑素C和同型半胱氨酸对早期发现糖尿病肾病的意义
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- 论文作者：王晓蓉 ; 杜向阳
- 年：2016
- 作者机构：上海市电力医院;上海外服门诊部;
- 论文关键词：血清胱抑素C ; 同型半胱氨酸 ; 糖尿病 ; 早期肾损伤 ; 健康体检
- 英文论文关键词：Serum Cystatin c ; homocysteine ; diabetes ; early renal injury health examination
- 会议召开时间：2016-11-25
- 会议录名称：湖南中医药大学学报2016/专集：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会论文集
- 语种：中文
- 分类号：R587.2;R692.9
- 学会代码：HNZY
- 会议名称：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会
- 会议地点：中国广东珠海
- 主办单位：国际数字医学会、Digital Chinese Medicine
- 学会名称：湖南中医药大学期刊杂志社
- 页数：2
- 文件大小：1822k
- 原文格式：D
- 会议级别：全国
摘要
目的分析探讨体检时联合检测血清胱抑素C(Cy CS)和同型半胱氨酸(HCY)对早期发现糖尿病肾损伤的临床意义。方法在2000例来院体检者中选择200例健康对照人群与200例糖尿病(DM)与30例糖尿病肾病(DN)的Cy CS与HCY的数据进行比较。使用两点终点法对体检者Cy CS进行测定;使用循环酶法对体检者HCY进行测定。同时使用酶法对体检者的尿素氮(BUN)和血清肌酐(Cr)值进行测定,并分析其结果差异。结果 DM组的Cy CS与HCY的水平显著高于健康体检人群(P<0.05),而DN组升高得更为显著,差异具有统计学意义(P<0.01)。结论对体检人群实施Cy CS和HCY的检验和测定,能够提高发现糖尿病早期肾损害的敏感性,真正体现出体检的早发现、早诊断、早治疗的临床意义。
Objective Analysis of physical examination combined with serum Cystatin c(Cy CS) and homocysteine(HCY) on the clinical significance of early detection of diabetic kidneydamage. Methods In 2000 hospital Checkup, select 200 healthy control subjects and 200 cases of diabetes mellitus(DM) and 30 cases of diabetic nephropathy(DN) Cy CS HCY data werecompared. Checkup Cy CS by using two point Terminal approach determination determination of the enzymatic cycling approach is used HCY to medical. Using enzymatic approach for examinationof blood urea nitrogen(BUN) and creatinine(Cr) values for the determination and analysis of its outcomings. Results DM group Cy CS and HCY levels significantly higher than those of the healthycrowd(P<0.05), while DN groups increased much more significant difference statistically significant(P<0.01). Conclusions Cy CS and HCY test imposed on the population of determination andcan improve the sensitivity of early renal damage in diabetes, really reflect examination of early detection, early diagnosis and treatment of clinical significance.
Objective Analysis of physical examination combined with serum Cystatin c(Cy CS) and homocysteine(HCY) on the clinical significance of early detection of diabetic kidneydamage. Methods In 2000 hospital Checkup, select 200 healthy control subjects and 200 cases of diabetes mellitus(DM) and 30 cases of diabetic nephropathy(DN) Cy CS HCY data werecompared. Checkup Cy CS by using two point Terminal approach determination determination of the enzymatic cycling approach is used HCY to medical. Using enzymatic approach for examinationof blood urea nitrogen(BUN) and creatinine(Cr) values for the determination and analysis of its outcomings. Results DM group Cy CS and HCY levels significantly higher than those of the healthycrowd(P<0.05), while DN groups increased much more significant difference statistically significant(P<0.01). Conclusions Cy CS and HCY test imposed on the population of determination andcan improve the sensitivity of early renal damage in diabetes, really reflect examination of early detection, early diagnosis and treatment of clinical significance.
引文
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[8]刘军须,张敬各,王树人,等.同型半胱氨酸对内皮细胞一氧化氮合成酶活力及基因表达的影响[J].华西药学杂志,2007,,2(5):508-511
[2]姜芳.血清胱抑素C和尿微量白蛋白联合检测对糖尿病早期肾损伤诊断价值[J].中国卫生标准管理,2014,5(3):5-6.
[3]杨忠臣.联合检测血清胱抑素C、糖化血红蛋白和尿微量尿白蛋白/肌酐在2型糖尿病早期肾损伤诊断价值[J].实验与检验医学,2013,31(3):261-262.
[4]Mussap M,Plebani M.Biochem istry and clinical role of human cys 2tation C[J].Crit Rev Clin Lab Sci.2004,41(5):467-550.
[5]张淑兰,王铭超.胱抑素C的临床应用及进展[J].国外医学.临床生物化学与检验学分册,2002,23(5):271–272
[6]Hillenbrand R,H Hillenbrand A,Liewald F,et al.Hyperhomocysteinemia and recuurent carotid stenosis[J].BMC Cardiocasc Disord,2008,8:1-2
[7]Ozemen B,Ozemen D,Turgan N,et al.Association between homocystieinemia and real function in patients with type 2 diabetes mellitus[J].Ann Clin Kab Sci,2002,32:29-286
[8]刘军须,张敬各,王树人,等.同型半胱氨酸对内皮细胞一氧化氮合成酶活力及基因表达的影响[J].华西药学杂志,2007,,2(5):508-511