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膳食血糖负荷与糖尿病关系的队列研究
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摘要
目的:探讨广州社区中老年人群膳食血糖负荷(GL)与糖尿病发病的关系。方法:研究对象为同时参与我院2011年和2013年2型糖尿病流行病学调查、且资料完整的40-79岁广州社区居民,剔除2011年已诊断糖尿病的人群,研究对象共799人。采用非条件logistic回归模型研究GL与糖尿病的关系。结果:截止2013年,发生糖尿病57人,累计发生率7.1%。研究对象按GL四分位分组,各组糖尿病发病风险分别为1.00,2.55,3.01(95%CI,1.12-8.09),3.78(95%CI,1.43-9.99),趋势检验P<0.01。结论:膳食GL可能是影响我国中老年人群糖尿病发病的重要膳食因素,降低膳食GL对于预防我国中老年人糖尿病可能具有一定作用。
OBJECTIVE:To investigate the association between dietary glycemic load(GL) and diabetes mellitus incidence among middle-aged and elderly adults in Guangzhou,China.METHODS:Study population were Guangzhou community residents,who had twice participated in epidemiological investigations of type 2 diabetes mellitus which were conducted in Sun Yat-Sen memorial hospital in 2011 and 2013,aged 40-79 years,and were not newly or previously diagnosed as diabetes mellitus in 2011.Non-conditional logistic regression was used to investigate association between dietary GL and diabetes mellitus.RESULTS:During 2011-2013,57 cases were diagnosed diabetes mellitus and the cumulative rate was 7.1%.Participants were categorized into 4 groups according to quartiles of energy-adjusted GL.The multivariable-adjusted odds ratios across quartiles of energy-adjusted GL was 1.00,2.55,3.01(95%CI,1.12-8.09),3.78(95%CI,1.43-9.99)(P for trend<0.01).CONCLUSION:Among middleaged and elderly people in Guangzhou,China,dietary GL may be one of the most important dietary factors affecting the incidence of diabetes mellitus.Reducing dietary GL might be helpful for the prevention of diabetes.
引文
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