ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8~+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy
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- 英文论文题名：ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8~+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy
- 论文作者：Li Chunyang ; Li Weiyun ; Xiao Jun ; Jiao Shaozhuo ; Teng Fei ; Xue Shengjie ; Zhang Chi ; Sheng Chun ; Leng Qibin ; Rudd Christopher E ; Wei Bin ; Wang Hongyan
- 英文论文作者：Li Chunyang ; Li Weiyun ; Xiao Jun ; Jiao Shaozhuo ; Teng Fei ; Xue Shengjie ; Zhang Chi ; Sheng Chun ; Leng Qibin ; Rudd Christopher E ; Wei Bin ; Wang Hongyan ; Institute of Biochemistry and Cell Biology ; Shanghai Institutes for Biological Sciences ; Chinese Academy of Sciences ; Shanghai Normal University ; Institute Pasteur of Shanghai ; Chinese Academy of Sciences ; Cambridge Institute of Medical Research ; Wuhan Institute of Virology ; Chinese Academy of Sciences
- 年：2016
- 作者机构：Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences;Shanghai Normal University;Institute Pasteur of Shanghai, Chinese Academy of Sciences;Cambridge Institute of Medical Research;Wuhan Institute of Virology, Chinese Academy of Sciences;
- 英文论文关键词：ADAP/SKAP55 ; Anti‐Tumor Immunotherapy ; Cs A ; CTL Cytotoxicity ; PD‐1
- 会议召开时间：2016-11-04
- 会议录名称：第十一届全国免疫学学术大会分会场交流报告集
- 英文会议录名称：Proceedings of 2016 CSI Congress on Immunology
- 语种：英文
- 分类号：R730.51
- 学会代码：IGMD
- 会议名称：第十一届全国免疫学学术大会
- 会议地点：中国安徽合肥
- 主办单位：中国免疫学会
- 学会名称：中国免疫学会
- 页数：1
- 文件大小：254k
- 原文格式：D
- 会议级别：全国
摘要
<正>PD‐1 negatively regulates CD8+cytotoxic T lymphocytes(CTL)cytotoxicity and anti‐tumor immunity.However,it is not fully understood how PD‐1 expression on CD8+CTL is regulated during anti‐tumor immunotherapy.In this study,we have identified that the ADAP‐SKAP55 signaling module reduced CD8+CTL cytotoxicity and enhanced
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