Yellow and white tongue coating color may reflect contrary inflammatory status via serum interleukin-17α level
详细信息 查看官网全文
- 英文论文题名：Yellow and white tongue coating color may reflect contrary inflammatory status via serum interleukin-17α level
- 论文作者：Zhang Junfeng ; Liwei Zhang ; Juan Wu ; Bin Lu ; Wei Dong ; Yajun Chen ; Yaping Yang ; Shujuan Tong ; Zhen Zhan ; Ruiping Wang
- 英文论文作者：Zhang Junfeng ; Liwei Zhang ; Juan Wu ; Bin Lu ; Wei Dong ; Yajun Chen ; Yaping Yang ; Shujuan Tong ; Zhen Zhan ; Ruiping Wang ; Discipline of Chinese and Western Integrative Medicine ; Nanjing University of Chinese Medicine ; Department of Oncology ; Yangzhong People's Hospital ; Department of Clinical Laboratory ; First Affiliated Hospital of Nanjing University of Chinese Medicine ; Department of Oncology ; First Affiliated Hospital of Nanjing University of Chinese Medicine
- 年：2016
- 作者机构：Discipline of Chinese and Western Integrative Medicine,Nanjing University of Chinese Medicine;Department of Oncology,Yangzhong People's Hospital;Department of Clinical Laboratory,First Affiliated Hospital of Nanjing University of Chinese Medicine;Department of Oncology,First Affiliated Hospital of Nanjing University of Chinese Medicine;
- 英文论文关键词：Gastric cancer ; tongue coating color ; inflammation ; cytokines
- 会议召开时间：2016-11-04
- 会议录名称：第十一届全国免疫学学术大会摘要汇编
- 英文会议录名称：Abstracts of 2016 CSI Congress on Immunology
- 语种：英文
- 分类号：R241
- 学会代码：IGMD
- 会议名称：第十一届全国免疫学学术大会
- 会议地点：中国安徽合肥
- 主办单位：中国免疫学会
- 学会名称：中国免疫学会
- 页数：1
- 文件大小：352k
- 原文格式：D
- 会议级别：全国
摘要
Tongue coating is an important diagnostic indicator in traditional Chinese medicine(TCM). A typical white or yellow tongue indicate external/Cold ZHENG and internal/Heat ZHENG, respectively, which are closely related to different inflammatory stimuli that lead to the development of digestive system diseases. The aim of this study was to test the hypothesis that coating color is dictated by inflammatory cytokines. A hospital-based case-control study included 142 patients with gastric cancer(GC) and 98 healthy controls, whose coating color and texture of each individual were recorded. An electrochemiluminescence assay was used to measure serum levels of 20 inflammatory cytokines. The results showed that a yellow tongue coating correlated with higher serum interleukin-17α(IL-17α) levels in both GC patients(Z=2.612, P=0.009) and controls(Z=2.279, P=0.023), with receiver operating characteristics(ROC) curve cutoff values of 6.033 pg/ml and 3.507 pg/ml, respectively. Correlation network analysis showed that there were identical 11 pairs of negatively correlated cytokines in the GC patients and controls, respectively. Accordingly, these results suggest that the yellow and white tongue coating may reflect contrary inflammatory status via different serum interleukin-17α levels in both GC patients and controls.
Tongue coating is an important diagnostic indicator in traditional Chinese medicine(TCM). A typical white or yellow tongue indicate external/Cold ZHENG and internal/Heat ZHENG, respectively, which are closely related to different inflammatory stimuli that lead to the development of digestive system diseases. The aim of this study was to test the hypothesis that coating color is dictated by inflammatory cytokines. A hospital-based case-control study included 142 patients with gastric cancer(GC) and 98 healthy controls, whose coating color and texture of each individual were recorded. An electrochemiluminescence assay was used to measure serum levels of 20 inflammatory cytokines. The results showed that a yellow tongue coating correlated with higher serum interleukin-17α(IL-17α) levels in both GC patients(Z=2.612, P=0.009) and controls(Z=2.279, P=0.023), with receiver operating characteristics(ROC) curve cutoff values of 6.033 pg/ml and 3.507 pg/ml, respectively. Correlation network analysis showed that there were identical 11 pairs of negatively correlated cytokines in the GC patients and controls, respectively. Accordingly, these results suggest that the yellow and white tongue coating may reflect contrary inflammatory status via different serum interleukin-17α levels in both GC patients and controls.
Tongue coating is an important diagnostic indicator in traditional Chinese medicine(TCM). A typical white or yellow tongue indicate external/Cold ZHENG and internal/Heat ZHENG, respectively, which are closely related to different inflammatory stimuli that lead to the development of digestive system diseases. The aim of this study was to test the hypothesis that coating color is dictated by inflammatory cytokines. A hospital-based case-control study included 142 patients with gastric cancer(GC) and 98 healthy controls, whose coating color and texture of each individual were recorded. An electrochemiluminescence assay was used to measure serum levels of 20 inflammatory cytokines. The results showed that a yellow tongue coating correlated with higher serum interleukin-17α(IL-17α) levels in both GC patients(Z=2.612, P=0.009) and controls(Z=2.279, P=0.023), with receiver operating characteristics(ROC) curve cutoff values of 6.033 pg/ml and 3.507 pg/ml, respectively. Correlation network analysis showed that there were identical 11 pairs of negatively correlated cytokines in the GC patients and controls, respectively. Accordingly, these results suggest that the yellow and white tongue coating may reflect contrary inflammatory status via different serum interleukin-17α levels in both GC patients and controls.
引文