鼻炎3号治疗鼻渊胆腑郁热证的临床研究
摘要
目的：观察鼻炎3号治疗鼻渊胆腑郁热证的临床疗效。
方法：将60例门诊鼻渊胆腑郁热证患者,采用非盲法进行随机对照平行试验。用鼻炎3号(试验组)治疗30例,并与鼻渊通窍颗粒(对照组)治疗的30例进行比较,以7天为1个疗程,持续观察2个疗程。2周后,比较两组的临床疗效,从而判定鼻炎3号治疗鼻渊胆腑郁热证的临床疗效。
结果：试验组与对照组均可以有效改善患者的鼻塞、脓涕、头痛、鼻甲肿大、鼻黏膜红肿等症状；试验组和对照组总有效率分别为93.33%和80.00%,两组疗效经检验,P>0.05,无统计学意义,尚不能认为两组疗效不同。
结论：鼻炎3号治疗鼻渊胆腑郁热证有较好的临床疗效。
Objective:To investigate the clinical effect of the Rhinitis III on treating rhinosinusitis(stagnated heat of gallbladder type).
Methods:We selected 60 rhinosinusitis(stagnated heat of gallbladder type)out-patients as testing objects,which was divided into two groups at random.30 patients were set to be the treatment group and treated by the Rhinitis III, the other patients were set to be control group and treated by the Bi Yuan Tong Qiao pill. Stipulated one week one period of treatment and treated these patients two weeks continuously. Two weeks later, we compared the clinical effect of the two groups, and estimated the therapeutic effect of the Rhinitis III on treating rhinosinusitis(stagnated heat of gallbladder type).
Results:The symptoms of the treatment group patients were improved more effectively than those of the control group in nasal congestion, nasal discharge, headache and so on. The total effective rate of the treatment group and the control group were 93.33% and 80.00%, the comparison between the two groups showed little difference (P>0.05).
Conclusion:The Rhinitis III have effective clinical effect on treating rhinosinusitis(stagnated heat of gallbladder type).
方法：将60例门诊鼻渊胆腑郁热证患者,采用非盲法进行随机对照平行试验。用鼻炎3号(试验组)治疗30例,并与鼻渊通窍颗粒(对照组)治疗的30例进行比较,以7天为1个疗程,持续观察2个疗程。2周后,比较两组的临床疗效,从而判定鼻炎3号治疗鼻渊胆腑郁热证的临床疗效。
结果：试验组与对照组均可以有效改善患者的鼻塞、脓涕、头痛、鼻甲肿大、鼻黏膜红肿等症状；试验组和对照组总有效率分别为93.33%和80.00%,两组疗效经检验,P>0.05,无统计学意义,尚不能认为两组疗效不同。
结论：鼻炎3号治疗鼻渊胆腑郁热证有较好的临床疗效。
Objective:To investigate the clinical effect of the Rhinitis III on treating rhinosinusitis(stagnated heat of gallbladder type).
Methods:We selected 60 rhinosinusitis(stagnated heat of gallbladder type)out-patients as testing objects,which was divided into two groups at random.30 patients were set to be the treatment group and treated by the Rhinitis III, the other patients were set to be control group and treated by the Bi Yuan Tong Qiao pill. Stipulated one week one period of treatment and treated these patients two weeks continuously. Two weeks later, we compared the clinical effect of the two groups, and estimated the therapeutic effect of the Rhinitis III on treating rhinosinusitis(stagnated heat of gallbladder type).
Results:The symptoms of the treatment group patients were improved more effectively than those of the control group in nasal congestion, nasal discharge, headache and so on. The total effective rate of the treatment group and the control group were 93.33% and 80.00%, the comparison between the two groups showed little difference (P>0.05).
Conclusion:The Rhinitis III have effective clinical effect on treating rhinosinusitis(stagnated heat of gallbladder type).
引文
1.Dubreuil C, Gehanno P, Goldstein F, et al. Treatment of acute maxillary sinusitis in adult outpatients:comparison of a five versus ten day-course of cefuroxime axetil. Med Mal Infect 2001;31:70-78.
2.Benninger MS, Sedory Holzer SE, Lau J. Diagnosis and treatment of uncomplicated acute bacterial rhinosinusitis:summary of the Agency for Health Care Policy and Research evidence-based report. Otolaryngol Head Neck Surg2000,122:1-7. Search date 1998; primary sources Medline and bibliographies or retrieved articles.
3.刘丽庭.现代鼻科学[M].中国中医药出版社,2005：106.
4.王士贞.中医耳鼻咽喉科学[M].中国中医药出版社,2005：130-133.
5.杨上善.黄帝内经太素[M].肖延平校正.人民卫生出版社,1965：520.
6.明·张介宾.景岳全书[M].上海科学技术出版社,1959：458.
7.明·吴坤.医方考[M].张宽等整理.人民卫生出版社,2007：214.
8.明·李时珍.本草纲目[M].中医古籍出版社,1994：123.
9.明·高武纂集.针灸聚英[M].黄龙祥整理.北京：人民卫生出版社,2006：343.
10.明·李挺.医学入门[M].北京：中国中医药出版社,1995：456.
11.清·吴谦.医宗金鉴[M].北京：人民卫生出版社,1998：176.
12.宋·赵括.圣济总录[M].人民卫生出版社,1987：283.
13.宋·严用和.济生方·鼻门[M].湖州医学院整理.人民卫生出版社,1980：234.
14.陈士铎.辩证录[M].北京：人民卫生出版社,1965：376.
15.明·万全.万氏秘传片玉心书[M].湖北人民出版社,1981：164.
16.明·陈实功.外科正宗[M].上海科学技术出版社,1989：225.
17.清·高秉钧.疡科心得集[M].中国中医药出版社,2000：386.
18.明·江瓘.名医类案[M].人民卫生出版社,2005：154.
19.金·刘完素.宣明论方[M].中国中医药出版社,2007：467.
20.元·朱震亨.丹溪心法[M].山东科学技术出版社,1985：287.
21.明·杨继洲.针灸大成[M].人民卫生出版社,2006：321.
22.明·王肯堂.证治准绳[M].人民卫生出版社,2001：567.
23.清·沈金鳌.杂病源流犀烛[M].田思胜整理.人民卫生出版社,2006：624.
24.单书健,陈子华.古今名医临证金鉴·五官科卷[M].中国中医药出版社,1999：354.
25.王英,郭喜军.针药并用治疗急性鼻窦炎48例[J].陕西中医,2002,23(6)：539.
26.薛愧玲.综合疗法治疗鼻渊35例临床观察[J].中医临床研究,2010,02(19)：67.
27.刘颖等.从玄府学说论鼻渊发病的重要机制[A].全国中医耳鼻喉学术传承与研究学术研讨会论文集[C],2009,40-43.
28.刘敏,张大铮,张勤修.“内外双毒”在鼻-鼻窦炎形成中的意义[J].中医药导报,2011,17(1)：13-14.
29.何兴伟,谢强.通督升阳法论治鼻渊病理论探讨[J].中国中医基础医学杂志,2010,16(1)：29-30.
30.李莉,刘艳丽,熊大经.熊大经教授治疗鼻窦炎经验谈[J].四川中医,2004,22(3)：4-5.
31.王子英.畅窦汤治疗鼻渊实热证96例疗效观察[J].山东中医杂志,2007,26(3)：165.
32.梁晓阳.鼻渊舒口服液联合超短波治疗急性鼻窦炎临床观察[J].中医药学刊,2006,24(6)：1156-1157.
33.汪吉宝,孔维佳,黄选兆.实用耳鼻咽喉头颈外科学[M].人民卫生出版社,2008.
34. Kennedy DW. International conference on sinus terminology, staging, therapy. Ann Otol Rhinol Laryngol 1995;104:10.
35.江满杰等.南京城区儿童慢性鼻-鼻窦炎流行病学调查[J].医学研究生学报,2006,19(7)：613-615.
36.Saltini C,Amicosante M.Beryllium disease, AM J Med Sci.2001,321;89-98.
37.Brook I.Bacteriology of acute and chronic frontal sinusitis. Arch Otolaryngoi Head Neck Surg,2002,128:583-585.
38.Brook I. Microbiology of acute and chronic maxillary sinusitis associated with an odontogenic origin.Laryngoscope,2005,115:823-825.
39.Brook I.Bacteriology of acute and chronic sphenoid sinusitis.Ann OtolRhinol Laryngol,2002,111:1002-1004.
40.Sinus.Allergy Health Partnership Antimicrobial treatment guidelines for acute bacterial rhin.inusitis 2004.
41.Nayak A S, Settipane G A, Pedinoff A, Nasonex Sinusitis Group et al Effective dose range of mometasone furoate nasal spray in the treatment of acute rhinosinusitis. Ann Allergy Asthma Immunol 2002.
42.严道南,张连山.仙璐贝滴剂治疗急性鼻窦炎的疗效与安全性[J].中国新药杂志,2004,13(3)：269-272.
43.金香子,徐明.龙胆草提取物抗炎、镇痛、耐缺氧及抗疲劳作用的研究[J].时珍国医国药,2005,16(9)：842-843.
44.金·张元素.医学启源[M].中国中医药出版社,2007：422.
45.李琰.柴胡药理作用的研究进展[J].河北医学.2010,16(5)：633-635.
46.宋扬文,陈忻.中药黄芩药理作用的研究进展[J].中国中医药科技,2010,17(4)：375-377.
47.何开家,张涵庆.白芷化学成分及其药理研究进展[J].现代中药研究与实践,2008,22(3)：59-62.
48.朱雄伟,杨晋凯.辛夷成分及其药理应用研究综述[J].海峡药学.2002,14(5)：5-7.
49.巩聿清,武玉锦.鱼腥草的临床药理研究进展[J].中国药业,2005,14(3)：73-74.
50.刘萍.桔梗的现代研究进展[J].中国药物应用与监测,2008,5(2)：48-50.
51.苏新国,宓穗卿.苍耳子药用研究进展苏新国[J].中药新药与临床药理,2006,17(1)：69-72.
52.董梅娟,倪艳.连翘药理活性及其物质基础的研究概况[J].山西中医,2009,25(4)：56-57.
53.张清华,张玲.菊花化学成分及药理作用的研究进展[J].食品与药品,2007,9(2)：60-63.
54.赵栋,丁青.败酱草的研究进展[J].中医药导报,2009,15(10)：76-78.
55.官月平,张波.甘草有效成分的药理作用研究进展[J].天然产物研究与开发,2006,18(2)：343-37.
56.田勇泉.耳鼻咽喉头颈外科学[M].人民卫生出版社,2008：81-84.
57.戴慎.中医病症诊疗标准与方剂选用[M].人民卫生出版社,2001：124.
58.郑筱萸.中药新药临床研究指导原则[M]中国医药科技出版社,2002：324-327.
2.Benninger MS, Sedory Holzer SE, Lau J. Diagnosis and treatment of uncomplicated acute bacterial rhinosinusitis:summary of the Agency for Health Care Policy and Research evidence-based report. Otolaryngol Head Neck Surg2000,122:1-7. Search date 1998; primary sources Medline and bibliographies or retrieved articles.
3.刘丽庭.现代鼻科学[M].中国中医药出版社,2005：106.
4.王士贞.中医耳鼻咽喉科学[M].中国中医药出版社,2005：130-133.
5.杨上善.黄帝内经太素[M].肖延平校正.人民卫生出版社,1965：520.
6.明·张介宾.景岳全书[M].上海科学技术出版社,1959：458.
7.明·吴坤.医方考[M].张宽等整理.人民卫生出版社,2007：214.
8.明·李时珍.本草纲目[M].中医古籍出版社,1994：123.
9.明·高武纂集.针灸聚英[M].黄龙祥整理.北京：人民卫生出版社,2006：343.
10.明·李挺.医学入门[M].北京：中国中医药出版社,1995：456.
11.清·吴谦.医宗金鉴[M].北京：人民卫生出版社,1998：176.
12.宋·赵括.圣济总录[M].人民卫生出版社,1987：283.
13.宋·严用和.济生方·鼻门[M].湖州医学院整理.人民卫生出版社,1980：234.
14.陈士铎.辩证录[M].北京：人民卫生出版社,1965：376.
15.明·万全.万氏秘传片玉心书[M].湖北人民出版社,1981：164.
16.明·陈实功.外科正宗[M].上海科学技术出版社,1989：225.
17.清·高秉钧.疡科心得集[M].中国中医药出版社,2000：386.
18.明·江瓘.名医类案[M].人民卫生出版社,2005：154.
19.金·刘完素.宣明论方[M].中国中医药出版社,2007：467.
20.元·朱震亨.丹溪心法[M].山东科学技术出版社,1985：287.
21.明·杨继洲.针灸大成[M].人民卫生出版社,2006：321.
22.明·王肯堂.证治准绳[M].人民卫生出版社,2001：567.
23.清·沈金鳌.杂病源流犀烛[M].田思胜整理.人民卫生出版社,2006：624.
24.单书健,陈子华.古今名医临证金鉴·五官科卷[M].中国中医药出版社,1999：354.
25.王英,郭喜军.针药并用治疗急性鼻窦炎48例[J].陕西中医,2002,23(6)：539.
26.薛愧玲.综合疗法治疗鼻渊35例临床观察[J].中医临床研究,2010,02(19)：67.
27.刘颖等.从玄府学说论鼻渊发病的重要机制[A].全国中医耳鼻喉学术传承与研究学术研讨会论文集[C],2009,40-43.
28.刘敏,张大铮,张勤修.“内外双毒”在鼻-鼻窦炎形成中的意义[J].中医药导报,2011,17(1)：13-14.
29.何兴伟,谢强.通督升阳法论治鼻渊病理论探讨[J].中国中医基础医学杂志,2010,16(1)：29-30.
30.李莉,刘艳丽,熊大经.熊大经教授治疗鼻窦炎经验谈[J].四川中医,2004,22(3)：4-5.
31.王子英.畅窦汤治疗鼻渊实热证96例疗效观察[J].山东中医杂志,2007,26(3)：165.
32.梁晓阳.鼻渊舒口服液联合超短波治疗急性鼻窦炎临床观察[J].中医药学刊,2006,24(6)：1156-1157.
33.汪吉宝,孔维佳,黄选兆.实用耳鼻咽喉头颈外科学[M].人民卫生出版社,2008.
34. Kennedy DW. International conference on sinus terminology, staging, therapy. Ann Otol Rhinol Laryngol 1995;104:10.
35.江满杰等.南京城区儿童慢性鼻-鼻窦炎流行病学调查[J].医学研究生学报,2006,19(7)：613-615.
36.Saltini C,Amicosante M.Beryllium disease, AM J Med Sci.2001,321;89-98.
37.Brook I.Bacteriology of acute and chronic frontal sinusitis. Arch Otolaryngoi Head Neck Surg,2002,128:583-585.
38.Brook I. Microbiology of acute and chronic maxillary sinusitis associated with an odontogenic origin.Laryngoscope,2005,115:823-825.
39.Brook I.Bacteriology of acute and chronic sphenoid sinusitis.Ann OtolRhinol Laryngol,2002,111:1002-1004.
40.Sinus.Allergy Health Partnership Antimicrobial treatment guidelines for acute bacterial rhin.inusitis 2004.
41.Nayak A S, Settipane G A, Pedinoff A, Nasonex Sinusitis Group et al Effective dose range of mometasone furoate nasal spray in the treatment of acute rhinosinusitis. Ann Allergy Asthma Immunol 2002.
42.严道南,张连山.仙璐贝滴剂治疗急性鼻窦炎的疗效与安全性[J].中国新药杂志,2004,13(3)：269-272.
43.金香子,徐明.龙胆草提取物抗炎、镇痛、耐缺氧及抗疲劳作用的研究[J].时珍国医国药,2005,16(9)：842-843.
44.金·张元素.医学启源[M].中国中医药出版社,2007：422.
45.李琰.柴胡药理作用的研究进展[J].河北医学.2010,16(5)：633-635.
46.宋扬文,陈忻.中药黄芩药理作用的研究进展[J].中国中医药科技,2010,17(4)：375-377.
47.何开家,张涵庆.白芷化学成分及其药理研究进展[J].现代中药研究与实践,2008,22(3)：59-62.
48.朱雄伟,杨晋凯.辛夷成分及其药理应用研究综述[J].海峡药学.2002,14(5)：5-7.
49.巩聿清,武玉锦.鱼腥草的临床药理研究进展[J].中国药业,2005,14(3)：73-74.
50.刘萍.桔梗的现代研究进展[J].中国药物应用与监测,2008,5(2)：48-50.
51.苏新国,宓穗卿.苍耳子药用研究进展苏新国[J].中药新药与临床药理,2006,17(1)：69-72.
52.董梅娟,倪艳.连翘药理活性及其物质基础的研究概况[J].山西中医,2009,25(4)：56-57.
53.张清华,张玲.菊花化学成分及药理作用的研究进展[J].食品与药品,2007,9(2)：60-63.
54.赵栋,丁青.败酱草的研究进展[J].中医药导报,2009,15(10)：76-78.
55.官月平,张波.甘草有效成分的药理作用研究进展[J].天然产物研究与开发,2006,18(2)：343-37.
56.田勇泉.耳鼻咽喉头颈外科学[M].人民卫生出版社,2008：81-84.
57.戴慎.中医病症诊疗标准与方剂选用[M].人民卫生出版社,2001：124.
58.郑筱萸.中药新药临床研究指导原则[M]中国医药科技出版社,2002：324-327.