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腹主动脉瘤腔内修复术后形态学研究
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摘要
目的:回顾性观察腹主动脉瘤(Abdominal Aortic Aneurysm AAA)腔内修复(endovascular repair EVR)术后瘤体直径变化、近端瘤颈直径变化、支架型血管主体向远端移位,并分析影响因素。
     方法:对45例有完整术前计算机断层扫描(Computed tomography CT)资料并接受EVR,且6个月以上的定期(术后1、3、6、12月及以后每年)增强CT随访的AAAs患者进行回顾分析。通过CT观察术后瘤体直径变化、近端瘤颈直径变化及支架型血管主体向远端移位,分别以5mm、2mm和5mm为有变化,不足5mm和2mm时为无变化,并分析与支架型血管相关和与病人相关的的影响因素。经CT检查内漏发生情况。
     结果:平均随访时间34.5±24.8个月(9~100个月)。
     (1)平均术前瘤体直径51.9±9.7mm(30~82mm),术后瘤体直径47.9±13.2mm(26.2~78.8mm),平均瘤体直径变化-4.0±8.3mm(-23.8~11mm)。瘤体直径增加15.6%,增加10mm以上4.5%;瘤体直径减小40%;瘤体直径不变44.5%。术中Ⅰ型内漏8例(17.8%),Ⅱ型内漏12例(26.7%)。术后24个月瘤体减少5mm及以上发生率为37.6%,31个月为53.4%,96个月时89.7%。
     (2)平均术前瘤颈直径为21.54±2.3mm;术后一月瘤颈22.444±2.36mm,最近一次瘤颈直径24.04±2.82mm。瘤颈增71.1%。所选支架较术前瘤颈增大百分比(oversizing percentage OP)18.94±6.10%。瘤颈直径大于支架标定型号6.7%。16个月无瘤颈扩张率为97.4%,24个月时无瘤颈扩张率为68.6%,36个月无瘤颈扩张为39.3%,96个月时无瘤颈扩张率为3.3%(2例)。
     (3)移位率22%,平均距离7.04±1.32mm(0~9.5mm),无移位10mm以上者,没有因为移位需要进行二次治疗者。28个月时无移位率为87.5%,66个月时无移位率为64.2%,82个月时无移位率为32.1%,96个月时无移位率为16%。
     结论:
     (1)术中内漏对术后瘤体变化影响不明显。术后持续性Ⅱ型漏、迟发和再发Ⅰ型漏可能促进瘤体增加。
     (2)OP值越大,术后一个月瘤颈扩张越多。
     (3)支架型血管的移位与中远期瘤颈扩张有相互促进作用。
     (4)跨肾动脉固定对术后移位发生率减低有关
Objective:To review the diameter change in Abdominal Aortic Aneurysm(AAA), aneurysm neck diameter change and device migration after endovascular repair (EVR)of AAA and analyze the factors related to these changes.
     Methods:The completely preoperative CT of forty-five patients with AAAs who underwent EVR and followed up longer than 6 months at regular intervals were reviewed retrospectively.The follow-up program was contrast-enhanced CT at 1, 3,6,12 months and annually thereafter.The diameter change in AAA,aneurysm neck diameter change and device migration were reviewed respectively,and 5mm, 2mm,5mm were defined as a significant change correspondingly.No changes was defined as less than 5mm and 2mm.The patient-related and stent-graft-related factors were analyzed.The status of endoleak was detected by CT.
     Results:The average follow-up interval was 34.5±24.8 months(range, 9~100mon).
     (1)Aneurysm sac diameter changed from 51.9±9.7mm(range,30~82mm) preoperatively to 47.9±13.2mm(26.2~78.8mm)postoperatively(P<.05).The mean diameter change was -4.0±8.3mm(-23.8~11mm).The expansion of sac diameter was detected in 15.6%and 4.5%when over-5mm and over-10mm respectively.The decrease of sac diameter was detected in 40%when more than 5mm.The sac diameter had kept stable was detected in 44.5%.There were 20 patients with endoleak intraoperation.Eight of these were type-1 endoleaks and twelve were type-2 endoleaks.The incidence of over-5mm decrease was 37.6%, 53.4%and 89.7%at 24,31 and 96months postoperatively respectively. (2)The mean proximal neck diameter was 21.5±2.3mm,22.44±2.36mm and 24.0±2.82mm at the preoperative,one month after operative and the latest follow-up.The increase of proximal neck diameter was detected in 71.1%.The oversizing percentage(OP)was 18.9±6.10%.The incidence of proximal neck over-sizing stent-graft in diameter was detected in 6.7%.The incidence of no dilation at proximal neck diameter was 97.4%,68.6%,39.3%and 3.3%(2 cases) at 16,24,36 and 96 months postoperatively respectively.
     (3)The stent-graft migration was detected in 22%,and was 7.0±1.32mm in average(range,0~9.5mm).There were not cases which the migration oversized 10mm,and no reintervine was necessary.The incidence of no migration was 87.5%,64.2%,32.1%and 16%at 28,66,82 and 96 months postoperatively respectively.
     Conclusions:
     (1)The intra-procedure endoleak has not significant effect on the change of AAA diameter.The persistent typeⅡendoleak,late and recurrent typeⅠendoleak may influence the expansion of AAA positively.
     (2)The more oversizing percentage,the more dilation the proximal neck.
     (3)The stent-graft migration and the dilation the proximal neck of median and long term follow-up might have effect on each other.
     (4)The suprarenal aortic stent-grafts might have decrease the frequency of migration
引文
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