宫腔粘连分离术联合中药补肾化瘀法治疗人流术后宫腔粘连的临床观察
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摘要
目的：通过临床研究,观察宫腔粘连分离术联合中药补肾化瘀法对人流术后宫腔粘连的疗效,评价中医药治疗对该病的疗效,并对其作用机理进行初步探讨。
方法：选择人流术后宫腔粘连患者40例,随机分为两组,治疗组20例,行宫腔粘连分离术后给予补肾活血中药口服；对照组20例,行宫腔粘连分离术后给予克龄蒙口服,治疗3个月经周期。观察两组患者疗效、IUA程度的改善情况及对血清E2、FSH、血液流变学的影响。
结果：治疗组经治疗临床总有效率达95%,对照组为80%,治疗组总体疗效优于对照组(P<0.05)。两组患者经治疗中医证候均明显改善(P<0.05),治疗组总有效率达90%,对照组为75%,两组中医证候疗效比较有显著性差异(P<0.05)。治疗组经治疗中医主症总有效率均在80.00%以上,其中经期、经量、月经色质总有效率分别为84.21%、95.00%、94.73%,明显高于对照组(P<0.05)。两组患者经治疗后IUA程度均减轻(P<0.05),但两者无显著性差异(P>0.05)。两组患者经治疗后E2水平明显上升,FSH下降,较疗前均有显著性差异(P<0.05),治疗组和对照组之间无显著性差异(P>0.05)。两组患者经治疗后血液流变学有改善,全血高切、全血低切均较疗前下降(P<0.05),且治疗组优于对照组(P<0.05)。
结论：宫腔粘连分离术联合中药补肾化瘀法治疗人流术后宫腔粘连所致月经过少、闭经疗效好,机理可能与调节机体免疫失衡,改善血液高凝状态,防止IUA再形成有关。
Objective:Clinical research, observation of transcervical resection of adhesions combined with BuShenHuaYuFang in treating intrauterine adhesion caused by induced abortion, evaluation of the efficacy of medical treatment of the disease and its mechanism were discussed.
Methods:The flow of 40 patients with intrauterine adhesion caused by induced abortion were randomly divided into two groups, treatment group 20 cases, were treated with BuShenHuaYuFang after transcervical resection of adhesions; the control group 20 cases, were treated with Climen after transcervical resection of adhesions for three menstrual cycles. To observe treatment efficacy, IUA degree of improvement,affection on sex hormone and hemorheology.
Results:The treatment group were treated and total effective rate was 95%,80% in the control group, the overall effect of the treatment group than the control group (P<0.05). The symptoms of two groups were obviously improved (P<0.05), total effective rate of treatment group was 90%,75% in the control group, two groups of Chinese medicine syndromes were significantly different (P<0.05). Chinese medicine treatment group main symptoms after treatment in the 80.00% total effective rate of more than one menstrual period, by volume, color quality of the total effective period were 84.21%,95.00%,94.73%, significantly higher (P<0.05). Two groups after treatment were to reduce the degree IUA(P<0.05), but there was no significant difference (P>0.05). Two groups after treatment significantly increased the level of E2, FSH decreased, compared with before treatment were significantly different (P<0.05), treatment group and control group had no significant difference (P>0.05).Two groups after treatment to improve blood rheology, blood high shear, low shear whole blood compared with pre-treatment decreased (P<0.05), and the treatment group than the control group (P<0.05)
Conclusion:Transcervical resection of adhesions combined with BuShenHuaYuFang in treating intrauterine adhesion caused by induced abortion,which effect was significant.The mechanism may be achieved through correcting unbanlanced immunity,improving the blood high viscosity,preventing the reformulation of IUA.
方法：选择人流术后宫腔粘连患者40例,随机分为两组,治疗组20例,行宫腔粘连分离术后给予补肾活血中药口服；对照组20例,行宫腔粘连分离术后给予克龄蒙口服,治疗3个月经周期。观察两组患者疗效、IUA程度的改善情况及对血清E2、FSH、血液流变学的影响。
结果：治疗组经治疗临床总有效率达95%,对照组为80%,治疗组总体疗效优于对照组(P<0.05)。两组患者经治疗中医证候均明显改善(P<0.05),治疗组总有效率达90%,对照组为75%,两组中医证候疗效比较有显著性差异(P<0.05)。治疗组经治疗中医主症总有效率均在80.00%以上,其中经期、经量、月经色质总有效率分别为84.21%、95.00%、94.73%,明显高于对照组(P<0.05)。两组患者经治疗后IUA程度均减轻(P<0.05),但两者无显著性差异(P>0.05)。两组患者经治疗后E2水平明显上升,FSH下降,较疗前均有显著性差异(P<0.05),治疗组和对照组之间无显著性差异(P>0.05)。两组患者经治疗后血液流变学有改善,全血高切、全血低切均较疗前下降(P<0.05),且治疗组优于对照组(P<0.05)。
结论：宫腔粘连分离术联合中药补肾化瘀法治疗人流术后宫腔粘连所致月经过少、闭经疗效好,机理可能与调节机体免疫失衡,改善血液高凝状态,防止IUA再形成有关。
Objective:Clinical research, observation of transcervical resection of adhesions combined with BuShenHuaYuFang in treating intrauterine adhesion caused by induced abortion, evaluation of the efficacy of medical treatment of the disease and its mechanism were discussed.
Methods:The flow of 40 patients with intrauterine adhesion caused by induced abortion were randomly divided into two groups, treatment group 20 cases, were treated with BuShenHuaYuFang after transcervical resection of adhesions; the control group 20 cases, were treated with Climen after transcervical resection of adhesions for three menstrual cycles. To observe treatment efficacy, IUA degree of improvement,affection on sex hormone and hemorheology.
Results:The treatment group were treated and total effective rate was 95%,80% in the control group, the overall effect of the treatment group than the control group (P<0.05). The symptoms of two groups were obviously improved (P<0.05), total effective rate of treatment group was 90%,75% in the control group, two groups of Chinese medicine syndromes were significantly different (P<0.05). Chinese medicine treatment group main symptoms after treatment in the 80.00% total effective rate of more than one menstrual period, by volume, color quality of the total effective period were 84.21%,95.00%,94.73%, significantly higher (P<0.05). Two groups after treatment were to reduce the degree IUA(P<0.05), but there was no significant difference (P>0.05). Two groups after treatment significantly increased the level of E2, FSH decreased, compared with before treatment were significantly different (P<0.05), treatment group and control group had no significant difference (P>0.05).Two groups after treatment to improve blood rheology, blood high shear, low shear whole blood compared with pre-treatment decreased (P<0.05), and the treatment group than the control group (P<0.05)
Conclusion:Transcervical resection of adhesions combined with BuShenHuaYuFang in treating intrauterine adhesion caused by induced abortion,which effect was significant.The mechanism may be achieved through correcting unbanlanced immunity,improving the blood high viscosity,preventing the reformulation of IUA.
引文
[1]王雨蕊,卓毅.加减滋水清肝饮治疗人工流产术后月经过少40例[J].现代中西医结合杂志,2008,17(7)：1044.
[2]盛立珍.人工流产术后闭经的分型辨治体会[J].湖北中医学报,2000,20(1)：70.
[3]哈孝贤.漫谈宫腔粘连及中医的治疗[J].开卷有益(求医问药),2003, (10)：40-41.
[4]叶青,高进军,郭瑞华.活血补肾法加宫腔镜分离术治疗宫腔粘连所致月经过少、继发性闭经、继发性不孕57例临床观察[J].中医杂志,2007,46(9)：806-808.
[5]闵静红.从肾虚血瘀论治人流后闭经的体会[J].中国厂矿医学,2001,14(6)：504-505.
[6]袁萍,蒋荣超.补肾益血汤治疗人流术后月经量少58例[J].中国中医急症,2005,(9)：861.
[7]张淑敏,宋恩芬.中医药疗法治疗人流术后闭经36例[J].北京中医药大学学报,2000,23(6)：65-66.
[8]张华.中西医结合治疗人流术后闭经的临床探讨[J].中华中西医杂志,2007,8(3)：232-234.
[9]伊书红,武水斗,朱青霞.中药治疗人流术后闭经18例[J].河南中医药学刊,2000,15(5)：63-64.
[10]王雪敏,王芝敏.人流术后闭经的辩证治疗[J].河南中医,2001,21(4)：12-13.
[11]丁吉丽.桃红四物汤加减治疗轻中度宫腔粘连48例[J].山东中医杂志,2009,28(7)：470-471.
[12]朱秋玲,曾加益.黑逍遥散加味治疗人流术后闭经21例[J].湖北中医杂志,1999,21(10)：468.
[13]吴心芳,齐玉珍.逍遥丸合六味地黄丸治疗月经过少临床分析[J].河北中医,2000,22(1)：57.
[14]赵敏,彩拉.益肾化瘀法治疗人工流产后闭经12例[J].内蒙古中医药,2003,22(4)：43.
[15]王东红,佟庆.通闭汤治疗人流术后闭经30例临床总结[J].北京中医,2001, (2)：34.
[16]陈靓芬.归肾活血调经汤治疗人工流产术后月经过少疗效观察[D].广州中医药大学,2006.
[17]袁萍,蒋荣超,翁双燕,等.补肾调经颗粒治疗人工流产手术后月经过少临床观察[J].中国中医急症,2007,16(6)：671-678.
[18]王璇.补肾活血汤治疗创伤性闭经的临床观察[J].湖北中医杂志,2002,24(12)：28-29.
[19]贾金英,贾可夫.中西医结合治疗宫腔粘连56例[J].陕西中医,1999,20(12)：537.
[20]鲁献斌,王臻.中西医结合治疗人工流产后闭经48例[J].河南中医,2002,22(5)：78.
[21]梁玉杰.中西医结合治疗人工流产术后闭经18例[J].中国医药指南,2008,6(24)：234-235.
[22]王长华.中西医综合治疗宫腔粘连43例分析[J].江西中医药,2004,35(261)：43.
[23]肖利敏,腾万里.中西医结合治疗人工流产术后闭经的19例体会[J].中华现代妇产科学杂志,2008,5(1)：53-54.
[24]刘新军.中西医结合治疗人流术后闭经35例[J].国医论坛,2004,19(6)：41-42.
[25]曹泽毅.中华妇产科学[M].北京：人民卫生出版社.1999：2188-2202.
[26]廖松柏,胡燕,鞠躬,等.二仙汤对18月龄雌性大鼠下丘脑-垂体-卵巢轴功能的调节[J].山东中医学院学报,1996,20(6)：396-398.
[27]余运初.补肾中药对下丘脑-垂体-卵巢促黄体功能的影响[C].中国中西医结合研究会.中西医结合研究学术论文汇编·妇产科专著.1983：161.
[28]刘涓.补肾活血助孕汤对卵泡发育及子宫内膜的影响[J].中国中医药信息杂志,2006,13(10)：14-16.
[29]魏美娟,俞瑾.补肾药对雄激素致无排卵大鼠垂体及卵巢的形态学变化观察[J].中国中西医结合杂志,1993,13(3)：164-167.
[30]梁建宁.阴道细胞学观察补肾药对月经失调病的疗效[J].江苏中医,1993,11(3)：34-35.
[31]李丽,孙维峰.中药补肾活血法治疗青春期多囊卵巢综合症的临床研究[J].广州中医药大学学报,2009,26(3)：221-224.
[32]李伟莉,许秀秀,龙子江,等.补肾化瘀方对药流后雌孕激素的影响及调经作用的实验研究[J].中医药临床杂志.2007,19(2)：128-130.
[33]陈秋梅,张树成,贺斌,等.调经孕育方药对人子宫内膜体外培养细胞生长发育及诱导间质细胞退魔化的血清药理学研究[J].中国中医基础医学杂志,2004,10(12)：11-13.
[34]蒋彦,刘复权.卵巢内调节因子与PCOS[J].国外医学妇幼保健分册,2003,14(2)：104-107.
[35]李桂玲,归绥联.补肾中药对雄激素致不孕大鼠胰岛素样生长因子-1及胰岛素样生长因子-1受体的影响[J].中国中西医结合杂志,2000,20(9)：677-678.
[36]唐旭,葛春晓.宫腔粘连诊治的研究进展[J].中国微创外科杂志,2005,5(10)：935-837.
[37]韩字研,胡勤仪,郭绍清.人工流产后子宫粘连的发病率调查[J].实用妇产科杂志,1992,8：309.
[38]葛春晓.宫腔镜诊治宫腔粘连的评价[J].实用妇产科杂志,2005,21(7)：394-397.
[39]Pace S, Stentella P, Catania R, et al. Endoscopic treatment of intrauterine adhesion[J]. Clin Exp Obstet Gynecol,2003,30 (1) : 26-28.
[40]Preutthipan S, LinasmitaV. Aprospective comparative study between hysterosalpingography and hysteroscopy in the detection of intrauterine pathology in patients with infertility[J]. Obstet Gynaecol Res, 2003,29:33-37.
[41]Nawroth F, Foth D, Schmidt T. Minihysteroscopy as routine diagnostic procedure in women with primary infertility[J]. Am Assoc Gynecol LaParosc,2003,10:396-398.
[42]刘春梅.宫腔粘连综合征62例临床分析[J].中国医刊,2007,42(3)：40-42.
[43]孔繁英,于楠,贾世美,等.吸宫刮宫术后子宫粘连16例分析[J].中国计划生育学杂志,1998,(33)：34-35.
[44]Friedler S, Margalioth EJ, Kafka L, et al. Incidence of post-abortion intrauterine adhesions evaluated by hysteroscopy aprospective study[J]. Hum peprod,1993,8:442-444.
[45]Al-Inany H. Intrauterine adhesions an update[J]. Acta Obstet Gynecol Scand,2001,80:986-993.
[46]Scenker JG, Mmargalioth EJ. Intrauterine adhesions an updated appraisal[J]. Fertil Steril,1982,37(5): 593-609.
[47]刘芳,宋静慧,宋建东.宫腔镜诊治宫腔粘连综合征35例临床分析[J].内蒙古医学杂志,2008,40(7)：821-824.
[48]Etterap, Mussetr, Lamberta, et al. Tarumaticuterinesynechiae:aeommoneuase of menstrual insuffieiency, sterility, adbortion[J]. Am Jobsett Gyneeol,1956,71:368-375.
[49]Polishuk WZ. Endometrialergeneartionanddahesionfinration[J].5ArfMedJ,1975,49:440-442.
[50]成九梅,靳琳,夏恩兰.雌孕激素受体及转化生长因子β1在宫腔粘连发病机制中的作用[J].中国实用妇科与产科杂志,2005,21(9)：539-541.
[51]李刚,申爱荣.宫腔粘连子宫内膜中tPA PAI-1变化的研究[J].医药论坛杂志,2008,29(5)：1-2.
[52]王素梅,申爱荣.IGF-1、IGF-IR在宫腔粘连患者内膜中的表达研究[J].中国妇产科临床杂志,2009,10(2)：146-147.
[53]李盛蒲.子宫输卵管造影对宫腔粘连的诊断价值(附70例报告)[J].中国现代医学杂志,2003,13(5)：97-99.
[54]夏恩兰.妇科内镜学[M].北京：人民卫生出版社,2001：104-107.
[55]常才.经阴道超声诊断学[M].上海：上海科学技术出版社,1986：72.
[56]Fedele L, Bianchi S, Dorta M, et al. Intrauterine adhesion:detection with transvaginal US[J]. Radiology, 1996,199:757-759.
[57]杨志伟,周世英,杨太珠.经阴道超声诊断子宫腔内粘连的价值[J].中华超声影响学杂志,2001,10(3)：163-165.
[58]March CM. Intrauterine adhesions[J]. Obstet Gynecol Clin North Am,1995,22 (3):491-505.
[59]Valle RF, Sciarra JJ. Intrauterine adhesions:ysterescopic diagnosis, lassification, treatment and repoductive outcome[J]. Obstet Gynecol,1988,58:1459-1470.
[60]Wamsteker K, De Block S. Diagnostic hysteroscopy:technique and documentation. In:Sutton C, Diamond M, eds. Endoscopic surgery for gynecologists. London:WB Saunders,1998:511-524.
[61]The American Fertility Society classifications of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, Mcullerian anomalies and intrauterine adhesions[J]. Fertil, Steril,1988,49:944-955.
[62]左越.Ⅲ度以上宫腔粘连宫腔镜分离术后宫腔再粘连的预防[J].中国基层医药,2006,13(8)：1265-1266.
[63]葛春晓,裴德恩,左怀之.宫腔镜手术为主治疗重度宫腔粘连27例临床研究[J].中国微创外科杂志,2004,4(1)：53-54.
[64]易丹妮,姚书忠.宫腔电切镜治疗宫腔粘连32例临床分析[J].中国微创外科杂志,2005,5(6)：481-482.
[65]成九梅,靳琳,夏恩兰,等.B超和(或)腹腔镜监护下宫腔镜诊治宫腔粘连108例分析[J].中国微创外科杂志,2004,4(1)：55-58.
[66]徐爱娣,陈敏,汪清,等.宫腔镜下Nd:YAG激光手术治疗宫腔粘连[J].中国激光医学杂志,2000,9(2)：77-79.
[67]郑备红,陈文祯,张小燕,等.水囊扩宫分离宫腔粘连16例临床观察[J].海峡预防医学杂志,2004, 10(1)：79-80.
[68]肖中苏,康焕初,贺梅欢.气囊扩张分离宫颈宫腔粘连的疗效观察[J].湖南医学,2001,18(4)：295-296.
[69]PreutthiPan S, Linasmila V. Reproductive outcome fellowing hysteroscopic lysis of intrauterine adhesion:a result of 65 cases at ramathibodi hospital [J]. Med Assoe Thai,2000,83:42-46.
[70]田秦杰,温秀艳,陈蓉.戊酸雌二醇用于宫腔镜术后防止宫腔粘连的疗效观察[J].中国妇幼保健,2006,21(12)：1708-1709.
[71]南方,陈春华,王兰兰.宫腔镜术后宫腔持续放置球囊导尿管治疗宫腔粘连20例分析[J].医学新知杂志,2003,13(1)：52.
[72]陈红,石圣洪.中药川、怀牛膝对小鼠微循环及大鼠血液流变学的影响[J].中国微循环,1988,2(3)： 182.
[73]李乾五,葛玲,李生正,等.川牛膝提取物抗生育作用的实验研究[J].西安医科大学学报,1990,1(1)：27.
[74]Chen H, Liu YP. The elementary anti-tumor research of Gyathula officiralis kuan polysacclaride[J]. J Chengda Onw TCM,2001,24 (1):49-50.
[75]夏泉,张平,李绍平,等.当归的药理作用研究进展[J].时珍国医国药,2004,15(3)：164-166.
[76]王芳,李东.当归的化学及药理研究进展[J].中国药房,2003,14(10)：630-631.
[77]陈坤华,方军,匡兴伟,等.覆盆子水提取液对大鼠下丘脑-垂体-性腺轴功能的作用[J].中国中药杂志,1996,21(9)：560-562.
[78]蔡永敏,任玉让,王黎,等.最新中药药理与临床应用[J].北京：华夏出版社,1999,1：429-433.
[79]张连富,吉宏武,任顺成.药食兼用资源与生物活性成分[M].北京：化学工业出版社,2005：286-287.
[80]杨珺,邹全明,王东昕.鳖甲超微细粉免疫调节功能实验研究[J].食品科学,2000,21(3)：40-42.
[81]法京,王明艳,贾敏,等.鳖甲龟板的抗突变效应[J].中国海洋药物,1996, (2)：27-29.
[82]刘超,王静,杨军.赤芍总苷活血化瘀作用的研究[J].中药材,2000,23(9)：557-560：
[83]徐红梅,刘青云.赤芍总苷对大鼠血液流变学的影响[J].中国中医药信息杂志,2002,9(11)：17-19.
[84]郭兰忠.现代实用中药学[M].北京：人民卫生出版社,1999：352.
[85]马清钧,王淑玲.临床实用中药学[M].南昌：江西科学技术出版社,2002：348-349.
[86]孙洁民.丹参、桑葚子、四物汤对免疫功能影响的实验研究[J].中医药研究,1991, (3)：50.
[87]黄南龙,张碧玉.简述黄芪的药理作用与临床应用[J].海峡药学,2009,21(1)：137-139.
[88]龙启才,邱建波.威灵仙、秦艽、桑寄生醇提物体外对淋巴细胞和环氧酶的影响[J].中药药理与临床,2004,20(4)：26-27.
[89]徐家庆,杨锋,沈翔.三味活血化瘀中药对小鼠NK, LAK细胞活性的影响[J].上海免疫学杂志,1996,16(3)：141.
[90]张铁军,苏雅,赵益桂.中药三棱的药源调查及其活血作用的研究[J].中草药,1991,22(6)： 272.
[91]党春兰,辛小南.三棱对家兔血液流变学的影响[J].河南医科大学学报,1996,31(3)：31.
[92]卜长武,王东荣,郭文来,等.莪术对小白鼠免疫功能的影响[J].中国中医药信息杂志,1997,4(2)：29.
[93]苗明三.薏苡仁多糖对环磷酰胺致免疫抑制小鼠免疫功能的影响[J].中医药学报,2002,30(5)：49.
[94]蒋岩,尹建豪,孙晓媛,等.夏枯草对动物脾腺、脾脏和肾上腺的影响[J].甘肃医药,1988,7(4)：4.
[95]周震.蒲公英药理研究与临床应用[J].光明中医,2009,24(9)：1801-1802.
[2]盛立珍.人工流产术后闭经的分型辨治体会[J].湖北中医学报,2000,20(1)：70.
[3]哈孝贤.漫谈宫腔粘连及中医的治疗[J].开卷有益(求医问药),2003, (10)：40-41.
[4]叶青,高进军,郭瑞华.活血补肾法加宫腔镜分离术治疗宫腔粘连所致月经过少、继发性闭经、继发性不孕57例临床观察[J].中医杂志,2007,46(9)：806-808.
[5]闵静红.从肾虚血瘀论治人流后闭经的体会[J].中国厂矿医学,2001,14(6)：504-505.
[6]袁萍,蒋荣超.补肾益血汤治疗人流术后月经量少58例[J].中国中医急症,2005,(9)：861.
[7]张淑敏,宋恩芬.中医药疗法治疗人流术后闭经36例[J].北京中医药大学学报,2000,23(6)：65-66.
[8]张华.中西医结合治疗人流术后闭经的临床探讨[J].中华中西医杂志,2007,8(3)：232-234.
[9]伊书红,武水斗,朱青霞.中药治疗人流术后闭经18例[J].河南中医药学刊,2000,15(5)：63-64.
[10]王雪敏,王芝敏.人流术后闭经的辩证治疗[J].河南中医,2001,21(4)：12-13.
[11]丁吉丽.桃红四物汤加减治疗轻中度宫腔粘连48例[J].山东中医杂志,2009,28(7)：470-471.
[12]朱秋玲,曾加益.黑逍遥散加味治疗人流术后闭经21例[J].湖北中医杂志,1999,21(10)：468.
[13]吴心芳,齐玉珍.逍遥丸合六味地黄丸治疗月经过少临床分析[J].河北中医,2000,22(1)：57.
[14]赵敏,彩拉.益肾化瘀法治疗人工流产后闭经12例[J].内蒙古中医药,2003,22(4)：43.
[15]王东红,佟庆.通闭汤治疗人流术后闭经30例临床总结[J].北京中医,2001, (2)：34.
[16]陈靓芬.归肾活血调经汤治疗人工流产术后月经过少疗效观察[D].广州中医药大学,2006.
[17]袁萍,蒋荣超,翁双燕,等.补肾调经颗粒治疗人工流产手术后月经过少临床观察[J].中国中医急症,2007,16(6)：671-678.
[18]王璇.补肾活血汤治疗创伤性闭经的临床观察[J].湖北中医杂志,2002,24(12)：28-29.
[19]贾金英,贾可夫.中西医结合治疗宫腔粘连56例[J].陕西中医,1999,20(12)：537.
[20]鲁献斌,王臻.中西医结合治疗人工流产后闭经48例[J].河南中医,2002,22(5)：78.
[21]梁玉杰.中西医结合治疗人工流产术后闭经18例[J].中国医药指南,2008,6(24)：234-235.
[22]王长华.中西医综合治疗宫腔粘连43例分析[J].江西中医药,2004,35(261)：43.
[23]肖利敏,腾万里.中西医结合治疗人工流产术后闭经的19例体会[J].中华现代妇产科学杂志,2008,5(1)：53-54.
[24]刘新军.中西医结合治疗人流术后闭经35例[J].国医论坛,2004,19(6)：41-42.
[25]曹泽毅.中华妇产科学[M].北京：人民卫生出版社.1999：2188-2202.
[26]廖松柏,胡燕,鞠躬,等.二仙汤对18月龄雌性大鼠下丘脑-垂体-卵巢轴功能的调节[J].山东中医学院学报,1996,20(6)：396-398.
[27]余运初.补肾中药对下丘脑-垂体-卵巢促黄体功能的影响[C].中国中西医结合研究会.中西医结合研究学术论文汇编·妇产科专著.1983：161.
[28]刘涓.补肾活血助孕汤对卵泡发育及子宫内膜的影响[J].中国中医药信息杂志,2006,13(10)：14-16.
[29]魏美娟,俞瑾.补肾药对雄激素致无排卵大鼠垂体及卵巢的形态学变化观察[J].中国中西医结合杂志,1993,13(3)：164-167.
[30]梁建宁.阴道细胞学观察补肾药对月经失调病的疗效[J].江苏中医,1993,11(3)：34-35.
[31]李丽,孙维峰.中药补肾活血法治疗青春期多囊卵巢综合症的临床研究[J].广州中医药大学学报,2009,26(3)：221-224.
[32]李伟莉,许秀秀,龙子江,等.补肾化瘀方对药流后雌孕激素的影响及调经作用的实验研究[J].中医药临床杂志.2007,19(2)：128-130.
[33]陈秋梅,张树成,贺斌,等.调经孕育方药对人子宫内膜体外培养细胞生长发育及诱导间质细胞退魔化的血清药理学研究[J].中国中医基础医学杂志,2004,10(12)：11-13.
[34]蒋彦,刘复权.卵巢内调节因子与PCOS[J].国外医学妇幼保健分册,2003,14(2)：104-107.
[35]李桂玲,归绥联.补肾中药对雄激素致不孕大鼠胰岛素样生长因子-1及胰岛素样生长因子-1受体的影响[J].中国中西医结合杂志,2000,20(9)：677-678.
[36]唐旭,葛春晓.宫腔粘连诊治的研究进展[J].中国微创外科杂志,2005,5(10)：935-837.
[37]韩字研,胡勤仪,郭绍清.人工流产后子宫粘连的发病率调查[J].实用妇产科杂志,1992,8：309.
[38]葛春晓.宫腔镜诊治宫腔粘连的评价[J].实用妇产科杂志,2005,21(7)：394-397.
[39]Pace S, Stentella P, Catania R, et al. Endoscopic treatment of intrauterine adhesion[J]. Clin Exp Obstet Gynecol,2003,30 (1) : 26-28.
[40]Preutthipan S, LinasmitaV. Aprospective comparative study between hysterosalpingography and hysteroscopy in the detection of intrauterine pathology in patients with infertility[J]. Obstet Gynaecol Res, 2003,29:33-37.
[41]Nawroth F, Foth D, Schmidt T. Minihysteroscopy as routine diagnostic procedure in women with primary infertility[J]. Am Assoc Gynecol LaParosc,2003,10:396-398.
[42]刘春梅.宫腔粘连综合征62例临床分析[J].中国医刊,2007,42(3)：40-42.
[43]孔繁英,于楠,贾世美,等.吸宫刮宫术后子宫粘连16例分析[J].中国计划生育学杂志,1998,(33)：34-35.
[44]Friedler S, Margalioth EJ, Kafka L, et al. Incidence of post-abortion intrauterine adhesions evaluated by hysteroscopy aprospective study[J]. Hum peprod,1993,8:442-444.
[45]Al-Inany H. Intrauterine adhesions an update[J]. Acta Obstet Gynecol Scand,2001,80:986-993.
[46]Scenker JG, Mmargalioth EJ. Intrauterine adhesions an updated appraisal[J]. Fertil Steril,1982,37(5): 593-609.
[47]刘芳,宋静慧,宋建东.宫腔镜诊治宫腔粘连综合征35例临床分析[J].内蒙古医学杂志,2008,40(7)：821-824.
[48]Etterap, Mussetr, Lamberta, et al. Tarumaticuterinesynechiae:aeommoneuase of menstrual insuffieiency, sterility, adbortion[J]. Am Jobsett Gyneeol,1956,71:368-375.
[49]Polishuk WZ. Endometrialergeneartionanddahesionfinration[J].5ArfMedJ,1975,49:440-442.
[50]成九梅,靳琳,夏恩兰.雌孕激素受体及转化生长因子β1在宫腔粘连发病机制中的作用[J].中国实用妇科与产科杂志,2005,21(9)：539-541.
[51]李刚,申爱荣.宫腔粘连子宫内膜中tPA PAI-1变化的研究[J].医药论坛杂志,2008,29(5)：1-2.
[52]王素梅,申爱荣.IGF-1、IGF-IR在宫腔粘连患者内膜中的表达研究[J].中国妇产科临床杂志,2009,10(2)：146-147.
[53]李盛蒲.子宫输卵管造影对宫腔粘连的诊断价值(附70例报告)[J].中国现代医学杂志,2003,13(5)：97-99.
[54]夏恩兰.妇科内镜学[M].北京：人民卫生出版社,2001：104-107.
[55]常才.经阴道超声诊断学[M].上海：上海科学技术出版社,1986：72.
[56]Fedele L, Bianchi S, Dorta M, et al. Intrauterine adhesion:detection with transvaginal US[J]. Radiology, 1996,199:757-759.
[57]杨志伟,周世英,杨太珠.经阴道超声诊断子宫腔内粘连的价值[J].中华超声影响学杂志,2001,10(3)：163-165.
[58]March CM. Intrauterine adhesions[J]. Obstet Gynecol Clin North Am,1995,22 (3):491-505.
[59]Valle RF, Sciarra JJ. Intrauterine adhesions:ysterescopic diagnosis, lassification, treatment and repoductive outcome[J]. Obstet Gynecol,1988,58:1459-1470.
[60]Wamsteker K, De Block S. Diagnostic hysteroscopy:technique and documentation. In:Sutton C, Diamond M, eds. Endoscopic surgery for gynecologists. London:WB Saunders,1998:511-524.
[61]The American Fertility Society classifications of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, Mcullerian anomalies and intrauterine adhesions[J]. Fertil, Steril,1988,49:944-955.
[62]左越.Ⅲ度以上宫腔粘连宫腔镜分离术后宫腔再粘连的预防[J].中国基层医药,2006,13(8)：1265-1266.
[63]葛春晓,裴德恩,左怀之.宫腔镜手术为主治疗重度宫腔粘连27例临床研究[J].中国微创外科杂志,2004,4(1)：53-54.
[64]易丹妮,姚书忠.宫腔电切镜治疗宫腔粘连32例临床分析[J].中国微创外科杂志,2005,5(6)：481-482.
[65]成九梅,靳琳,夏恩兰,等.B超和(或)腹腔镜监护下宫腔镜诊治宫腔粘连108例分析[J].中国微创外科杂志,2004,4(1)：55-58.
[66]徐爱娣,陈敏,汪清,等.宫腔镜下Nd:YAG激光手术治疗宫腔粘连[J].中国激光医学杂志,2000,9(2)：77-79.
[67]郑备红,陈文祯,张小燕,等.水囊扩宫分离宫腔粘连16例临床观察[J].海峡预防医学杂志,2004, 10(1)：79-80.
[68]肖中苏,康焕初,贺梅欢.气囊扩张分离宫颈宫腔粘连的疗效观察[J].湖南医学,2001,18(4)：295-296.
[69]PreutthiPan S, Linasmila V. Reproductive outcome fellowing hysteroscopic lysis of intrauterine adhesion:a result of 65 cases at ramathibodi hospital [J]. Med Assoe Thai,2000,83:42-46.
[70]田秦杰,温秀艳,陈蓉.戊酸雌二醇用于宫腔镜术后防止宫腔粘连的疗效观察[J].中国妇幼保健,2006,21(12)：1708-1709.
[71]南方,陈春华,王兰兰.宫腔镜术后宫腔持续放置球囊导尿管治疗宫腔粘连20例分析[J].医学新知杂志,2003,13(1)：52.
[72]陈红,石圣洪.中药川、怀牛膝对小鼠微循环及大鼠血液流变学的影响[J].中国微循环,1988,2(3)： 182.
[73]李乾五,葛玲,李生正,等.川牛膝提取物抗生育作用的实验研究[J].西安医科大学学报,1990,1(1)：27.
[74]Chen H, Liu YP. The elementary anti-tumor research of Gyathula officiralis kuan polysacclaride[J]. J Chengda Onw TCM,2001,24 (1):49-50.
[75]夏泉,张平,李绍平,等.当归的药理作用研究进展[J].时珍国医国药,2004,15(3)：164-166.
[76]王芳,李东.当归的化学及药理研究进展[J].中国药房,2003,14(10)：630-631.
[77]陈坤华,方军,匡兴伟,等.覆盆子水提取液对大鼠下丘脑-垂体-性腺轴功能的作用[J].中国中药杂志,1996,21(9)：560-562.
[78]蔡永敏,任玉让,王黎,等.最新中药药理与临床应用[J].北京：华夏出版社,1999,1：429-433.
[79]张连富,吉宏武,任顺成.药食兼用资源与生物活性成分[M].北京：化学工业出版社,2005：286-287.
[80]杨珺,邹全明,王东昕.鳖甲超微细粉免疫调节功能实验研究[J].食品科学,2000,21(3)：40-42.
[81]法京,王明艳,贾敏,等.鳖甲龟板的抗突变效应[J].中国海洋药物,1996, (2)：27-29.
[82]刘超,王静,杨军.赤芍总苷活血化瘀作用的研究[J].中药材,2000,23(9)：557-560：
[83]徐红梅,刘青云.赤芍总苷对大鼠血液流变学的影响[J].中国中医药信息杂志,2002,9(11)：17-19.
[84]郭兰忠.现代实用中药学[M].北京：人民卫生出版社,1999：352.
[85]马清钧,王淑玲.临床实用中药学[M].南昌：江西科学技术出版社,2002：348-349.
[86]孙洁民.丹参、桑葚子、四物汤对免疫功能影响的实验研究[J].中医药研究,1991, (3)：50.
[87]黄南龙,张碧玉.简述黄芪的药理作用与临床应用[J].海峡药学,2009,21(1)：137-139.
[88]龙启才,邱建波.威灵仙、秦艽、桑寄生醇提物体外对淋巴细胞和环氧酶的影响[J].中药药理与临床,2004,20(4)：26-27.
[89]徐家庆,杨锋,沈翔.三味活血化瘀中药对小鼠NK, LAK细胞活性的影响[J].上海免疫学杂志,1996,16(3)：141.
[90]张铁军,苏雅,赵益桂.中药三棱的药源调查及其活血作用的研究[J].中草药,1991,22(6)： 272.
[91]党春兰,辛小南.三棱对家兔血液流变学的影响[J].河南医科大学学报,1996,31(3)：31.
[92]卜长武,王东荣,郭文来,等.莪术对小白鼠免疫功能的影响[J].中国中医药信息杂志,1997,4(2)：29.
[93]苗明三.薏苡仁多糖对环磷酰胺致免疫抑制小鼠免疫功能的影响[J].中医药学报,2002,30(5)：49.
[94]蒋岩,尹建豪,孙晓媛,等.夏枯草对动物脾腺、脾脏和肾上腺的影响[J].甘肃医药,1988,7(4)：4.
[95]周震.蒲公英药理研究与临床应用[J].光明中医,2009,24(9)：1801-1802.