健脾祛湿方联合咪唑斯汀治疗脾虚湿蕴证亚急性湿疹临床观察
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摘要
目的:亚急性湿疹属于湿疹的一个阶段,多数研究认为,亚急性湿疹是急性湿疹和慢性湿疹病情转换的过渡症状。目前,湿疹在皮肤科较为常见,秋冬好发,占门诊就诊病人总数的10%-15%,也是治愈率较低的一类疾病。中医治疗根据患者的临床表现进行细致的辨证分型,根据症型的不同,使用不同的方剂针对性治疗,对患者的临床症状的改善显著,尤其具有复发率低,不良反应小等优点。虽然中医治疗远期疗效明显,但是近期显效缓慢,不利于增强患者就诊的信心和依从性;现代医学研究多将湿疹归为过敏性疾病,根据病因重点使用抗组胺药物及糖皮质激素类药物内服及外用对症治疗,近期效果明显,但治愈率低,且复发率较高。根据中西医单独治疗的利弊,结合各种文献报道及历代名老中医研究的精华,本课题根据张志礼老先生的方剂加减,自拟健脾祛湿方联合抗阻按药物咪唑斯汀缓释片治疗亚急性湿疹,系统观察其治疗脾虚湿蕴症型亚急性湿疹患者的临床疗效并探讨其机理,旨在寻找一个新的中西医结合治疗方法,增加痊愈率,降低复发机率。
研究方法:将符合纳入标准的100例患者随机分入联合用药组、对照组,各观察50例。其中联合用药组给予健脾祛湿方(组方:薏仁黄柏白术炒扁豆枳壳茵陈苦参白鲜皮黄芩泽泻徐长卿。方法:每日一剂,煎水500ml,分2次口服)及咪唑斯汀缓释片(10mg,每天一次,睡前半小时口服);对照组仅给予咪唑斯汀缓释片口服。两组均连续用药28天评定疗效,对于部分痊愈的患者进行痊愈后一月和三月随访,观测二组治疗前后皮损总积分的变化,瘙痒情况以及复发率和不良反应的比较。
研究结果:健脾祛湿方联合咪唑斯汀缓释片和单用咪唑斯汀缓释片均能缓解患者症状,治疗28天后总有效率分别达96%及84%,治愈率及痊愈后一月随访,三月随访结果经统计学计算得出均为p＜0.05,有明显差异,联合用药组治愈率及复发率低于对照组。对两组患者进行不良反应追踪,显示联合用药组患者有1例出现胃部不适,不良反应发生率2%。对照组患者有7例嗜睡,1例口干,1例乏力,2例胃部烧灼感、恶心、头晕、3例头疼,不良反应发生率14%,经统计学显示,p＜0.05,有差异,联合用药组不良反应发生率低于对照组.
结论:健脾祛湿方联合咪唑斯汀缓释片及单用咪唑斯汀缓释片缓释片均可改善脾虚湿蕴证亚急性湿疹患者临床症状,患者治疗前后的症状积分均有所下降,但健脾祛湿方联合咪唑斯汀缓释片对脾虚湿蕴证患者临床症状的改善优于单用咪唑斯汀缓释片治疗,且副作用小于单用咪唑斯汀缓释片,治疗痊愈后1月、3月随访,联合用药组的复发率远低于对照组,故说明联合用药效果优于单一用药。
Objective:Subacute eczema belongs to a subtype of eczema,most research thinks that subacute eczema is an acute eczema and chronic illness conversion between eczema symptoms.Eczema is a common disease of dermatology,the outpatient service of 10-15%total patients with low rate.Traditional medical treats with meticulous syndrome according to the clinical manifestations of patients and different shows of the proprietary with clinical symptoms improved significantly,especially low recurrence rate and small the adverse reaction.Although long-term efficacy is obvious,recent power is lowly,which is bad for the patient's confidence and compliance. Modern medical thinks that eczema is an allergic disease and uses antihistamines and corticosteroids drugs orally and topical symptomatic treatment according to eczema cause,which is low curing rate and high relapse.According to the advantage and disadvantage of single treatment,combining various reports in the literature and the essence of the old Chinese studies,this study create an own strengthening spleen and dehumidification potion combining antihistamine Mizolastine Sustained release tablets cure subacute eczema according to the potion of ZhangZhiLi with system observation clinical curative effect in order to find an effective treatment method.
Research methods:100 patients with criteria were randomized into a treatment group and a control group,each observation of 50 cases. The treatment group was given strengthening spleen and dehumidification potion(component:Chinese Pearl Barley, philodendrons,Largehead AtractylodesRhizome,stir-fried kidney、beansBitter orange、absinthe、radix sophorae flavescentis、dittany、radix scutellariae、rhizoma alismatis、radix cynanchi paniculati.Taking method:fired water 500ml,250ml po bid)and mizolastine Sustained release tablets(1 table po qd,before to sleep);Control group was given mizolastine only.Both groups continuous administration 28 days and interviewed the patients of certain healing effect after one and three months.The two groups were observed before and after the treatment of skin,integral syndrome,and the recurrence rate and adverse reaction.
Research results:Using strengthening spleen and dehumidification potion combining antihistamine Mizolastine Sustained release tablets and singly use Mizolastine to improve symptoms for patients,the total effective is 96%and 84% respectively.After recovering from one and three months follow-up results were obtained by statistically calculated p＜0.05,with obvious difference between the treatment group and control group in recurrence.Chinese traditional medicine group appeared one patient stomach,and adverse reaction rate is 2%.Combined treatment group appeared two cases of patients,one somnolence dry mouth and one weakness,and adverse reaction rate 8%.The statistics shows that p＜0.05.
Conclusion:strengthening spleen and dehumidification potion combining antihistamine Mizolastine Sustained release tablets and single treatment can improve the clinical symptoms of spleen syndrome subacute eczema,signs of patients before and after treatment were dropped,but strengthening spleen and dehumidification potion combining antihistamine Mizolastine Sustained release tablets for the patients to improved clinical symptoms than single with acute and less side effect than single miaowthiazoleo treatment after recovering from January,3 months of follow-up,the recurrence rate of treatment group is far less than control group according to the random interview afer one and three months,which shows that combination therapy effect is better than the single use therapy.
研究方法:将符合纳入标准的100例患者随机分入联合用药组、对照组,各观察50例。其中联合用药组给予健脾祛湿方(组方:薏仁黄柏白术炒扁豆枳壳茵陈苦参白鲜皮黄芩泽泻徐长卿。方法:每日一剂,煎水500ml,分2次口服)及咪唑斯汀缓释片(10mg,每天一次,睡前半小时口服);对照组仅给予咪唑斯汀缓释片口服。两组均连续用药28天评定疗效,对于部分痊愈的患者进行痊愈后一月和三月随访,观测二组治疗前后皮损总积分的变化,瘙痒情况以及复发率和不良反应的比较。
研究结果:健脾祛湿方联合咪唑斯汀缓释片和单用咪唑斯汀缓释片均能缓解患者症状,治疗28天后总有效率分别达96%及84%,治愈率及痊愈后一月随访,三月随访结果经统计学计算得出均为p＜0.05,有明显差异,联合用药组治愈率及复发率低于对照组。对两组患者进行不良反应追踪,显示联合用药组患者有1例出现胃部不适,不良反应发生率2%。对照组患者有7例嗜睡,1例口干,1例乏力,2例胃部烧灼感、恶心、头晕、3例头疼,不良反应发生率14%,经统计学显示,p＜0.05,有差异,联合用药组不良反应发生率低于对照组.
结论:健脾祛湿方联合咪唑斯汀缓释片及单用咪唑斯汀缓释片缓释片均可改善脾虚湿蕴证亚急性湿疹患者临床症状,患者治疗前后的症状积分均有所下降,但健脾祛湿方联合咪唑斯汀缓释片对脾虚湿蕴证患者临床症状的改善优于单用咪唑斯汀缓释片治疗,且副作用小于单用咪唑斯汀缓释片,治疗痊愈后1月、3月随访,联合用药组的复发率远低于对照组,故说明联合用药效果优于单一用药。
Objective:Subacute eczema belongs to a subtype of eczema,most research thinks that subacute eczema is an acute eczema and chronic illness conversion between eczema symptoms.Eczema is a common disease of dermatology,the outpatient service of 10-15%total patients with low rate.Traditional medical treats with meticulous syndrome according to the clinical manifestations of patients and different shows of the proprietary with clinical symptoms improved significantly,especially low recurrence rate and small the adverse reaction.Although long-term efficacy is obvious,recent power is lowly,which is bad for the patient's confidence and compliance. Modern medical thinks that eczema is an allergic disease and uses antihistamines and corticosteroids drugs orally and topical symptomatic treatment according to eczema cause,which is low curing rate and high relapse.According to the advantage and disadvantage of single treatment,combining various reports in the literature and the essence of the old Chinese studies,this study create an own strengthening spleen and dehumidification potion combining antihistamine Mizolastine Sustained release tablets cure subacute eczema according to the potion of ZhangZhiLi with system observation clinical curative effect in order to find an effective treatment method.
Research methods:100 patients with criteria were randomized into a treatment group and a control group,each observation of 50 cases. The treatment group was given strengthening spleen and dehumidification potion(component:Chinese Pearl Barley, philodendrons,Largehead AtractylodesRhizome,stir-fried kidney、beansBitter orange、absinthe、radix sophorae flavescentis、dittany、radix scutellariae、rhizoma alismatis、radix cynanchi paniculati.Taking method:fired water 500ml,250ml po bid)and mizolastine Sustained release tablets(1 table po qd,before to sleep);Control group was given mizolastine only.Both groups continuous administration 28 days and interviewed the patients of certain healing effect after one and three months.The two groups were observed before and after the treatment of skin,integral syndrome,and the recurrence rate and adverse reaction.
Research results:Using strengthening spleen and dehumidification potion combining antihistamine Mizolastine Sustained release tablets and singly use Mizolastine to improve symptoms for patients,the total effective is 96%and 84% respectively.After recovering from one and three months follow-up results were obtained by statistically calculated p＜0.05,with obvious difference between the treatment group and control group in recurrence.Chinese traditional medicine group appeared one patient stomach,and adverse reaction rate is 2%.Combined treatment group appeared two cases of patients,one somnolence dry mouth and one weakness,and adverse reaction rate 8%.The statistics shows that p＜0.05.
Conclusion:strengthening spleen and dehumidification potion combining antihistamine Mizolastine Sustained release tablets and single treatment can improve the clinical symptoms of spleen syndrome subacute eczema,signs of patients before and after treatment were dropped,but strengthening spleen and dehumidification potion combining antihistamine Mizolastine Sustained release tablets for the patients to improved clinical symptoms than single with acute and less side effect than single miaowthiazoleo treatment after recovering from January,3 months of follow-up,the recurrence rate of treatment group is far less than control group according to the random interview afer one and three months,which shows that combination therapy effect is better than the single use therapy.
引文
[1]国家中医药管理局.中华人民共和国中医药行业标准·中医皮肤科病证诊断疗效标准.1995年1月1日实施.
[2]赵辨.临床皮肤病学,南京:江苏科学技术出版社,1993,第2版:512.
[3]朱仁康.中医外科学,北京:人民卫生出版社,1987,第1版:724-727.
[4].Oranje Ap,ven meure T.Scoring severity of atopic dermatitis using scorad in:dyall -smith D,eds Dermatology at the millennium.New YORK:Parthenon Publishing Group Inc,1999.477-480
[5]Bahmer FA,Schafer J,Schafer HJ.Quantification Of the extent and the severrity of atopic dermatitis:the ADASI score.ARCH Dermatol,1991,127:1239-1240
[6]Kunz B,Oranje AP,Labreze L,et al.Clinical validtion and guidelines for the SCORAD index:consensus report of the EuropeanTas Force on Atopic Dermatitis,Dermatology,1997,195:10-9
[7].Berth-Jones J.Six area,six sign atopic dermatitis(SASSAD)severity score:a simple system for monitoring disease activity in atopic dermatitis.Br J Dermatol,1996,135 Supple 48:25-30
[8]毕武艳.湿疹的病机及防治探讨.辽宁中医杂志,2003;30(2):129-130
[9]赵丽平.中医辨证联合用药组湿疹86例.中国中医药信息杂志,2000;17(7):66
[10]康景华.中医药联合用药组急性湿疹36例.新中医,2001;33(9):61
[11]米要和.辨证联合用药组慢性湿疹40例.实用中医药杂志,2002;18(3):17
[12]黄英姿.马绍尧教授联合用药组湿疹经验.四川中医.2002;20(12):2-3.
[13]阎景东,王玉玺.王玉玺教授.联合用药组湿疹的经验.中医药信息.2005;22(3):43.
[14]尹东辉,李晖.李月玺.联合用药组湿疹临床经验.中国医药学报.2003;18(8):509-510
[15]刘铭锐.湿疹的中西医结合分型及联合用药组研究.兰州医学院学报1987;(1):38
[16]郭继华,张皖敏.自拟湿疹方为主联合用药组急性湿疹85例分析[J].安徽中医临床杂志,2002,11(1):24-25.
[17]陈希明.除湿胃苓汤加减联合用药组亚急性湿疹临床观察[J].中国皮肤性病学杂志,1999,13(4):236-237.
[18]栾天庆.中医药联合用药组亚急性湿疹临床观察现代中西医结合杂志,2008;17(33) 5168-5169
[19]任少杰.二黄茯苓汤联合用药组亚急性湿疹临床观察.中医药临床杂志,2008:20(4):392-393
[21]Gu stafsson D,Sjoberg O,Fouca rd T.Sen sitiza tion tofood and a irbo rne a llergen s in child ten w ith a top icderm a titis fo llow ed up to 7 yea rs of age[J].Ped ia trA llergy Im m unol,2003,14(6):44824521
[22]Leyden JJ,Marples RR,Kligrman AM.Staphylcoccus aureus in the lesinons of atopic dermatitis[J].Br J Dermatol,1974;90(5):525-530
[23].袁伟,真菌感染在过敏性皮炎发病机制中的作用,贵州医药,2005;29(3):211-212
[24]张学军,刘维达,何春涤主编.现代皮肤病学进展.北京:人民卫生出版社,2001.
[25]吴志华主编.皮肤性病学.广州科技出版社,1997.
[26].吴志华.现代皮肤性病学.广东人民出版社,2000;106-109
[27]赵辨.临床皮肤病学.江苏科学技术出版社,2001.604-605
[28]olesen AB.Role of theea rlye nvironment of express ionofatopied ermatiti.J Am read Dermatol 2001,45(lSuppl):537-540
[29]叶冬青.皮肤病流行病学.人民卫生出版社,2001;356-358
[30]袁茵,郑苏容,张炜.慢性湿疹患者心理防御方式测查分析.成都医药,2003;12(6)344-345
[31]陈文琦,张美华,毕志刚,等.金黄色葡萄球菌超抗原与特应性皮炎及湿疹的初步探讨.临床皮肤科杂志,2005;34(8):507-509.
[32]弓娟琴,林麟,郝飞,等.湿疹和特应性皮炎皮损处细菌定植情况及药物联合联合用药组的分析.中华皮肤科杂志,2004;34(9):515-518.
[33]Bunikowski R,M ielke M,Skarabis H,el al.Prevalence and role of serum IgE antibodies to the Staphylococcus aureus-de-rived superantigens SEA and SEB in children with atopic der -matitis [J].JAllergy Clin Immunol,1999,103(1 Pt 1):119-124.
[34]万芹.莫匹罗星软膏和醋酸地塞米松乳膏联合外用联合用药组亚急性湿疹疗效观察 医学临床研究,2008;25(1)168-169
[35]杨玲等.慢性湿疹皮损中糖皮质激素受体-α(表达下调.中国麻风皮肤病杂志,2008;4(2):102-103
[36]Sudo K,Nagai K,Yanada N.Inhibitory effects of mizolastine on 5-lipoxygenase EJ].Jpan Pharmacol Ther,1998;26(Sup-p1):155-157.
[37]付萌,樊平中,廖文俊等.咪唑斯汀抗炎活性的动物实验研究.临床皮肤科杂志,2003;32(Ⅱ):635-637.
[38]陈妍,郭在培.咪唑斯汀抑制小鼠变应性接触性皮炎机制的研究.中华皮肤科杂志,2004;37(6):344-346.
[39]王懿娜,方红,周宗立等.咪唑斯汀对致敏小鼠脾淋巴细胞释放LTB4和IL-5的抑制作用.中国皮肤性病学杂志,2005;19(3):138-140
[40]Prous.JR.Treatment of upper respiratory tract disorders.In: The year' s Drug news Therapeutic Targets[M].1995 Edition,Prous Science Pub-lishers,Barcelona,1995.141
[41]LevierJ.Anti -anaphylaetie activity of the Novel Selective Histamine H1 Receptor Antagonist Mizolastine in the Rodent[J].A rzneim-forsch/Drug Res,1995,45(1):5
[42]李慧忠,刘翔等.咪唑斯汀缓解50例皮炎湿疹患者临床症状的疗效评价.中国医院药学杂志:2007,27(2):229-300
[43]周萌,韦斌.咪唑斯汀联合用药组皮炎湿疹类皮肤病临床观察.现代中西医结合杂志,2006;15(19):2622-2623
[44]支玉香,张宏誉.抗组胺药对认知功能的影响.中国新药杂志,2003;12(10):807-809
[45]乔刚.咪唑斯汀联合用药组慢性荨麻疹有效性和安全性评估[J].国外医学·皮肤性病学分册,2001,27(3):180
[46]Yap YG,Camm AJ.The currentcardiac safety situations with anti -histamines[J].Clin Ellergy,1999,29(Supp1).15
[47]CarayolN,etal.Allergy[J].2002,57(11):1067
[48]车月玺,湿疹冲剂联合用药组急性程疹90例,宁中医杂志,1996;23(4):167
[49]殷金珠.中药苦参对I型变态反应的实验研究[J].中草药,1985;(6):44.
[50]张志礼.中西医结合皮肤性病学.北京:人民卫生出版社,2000。424.
[51]陆朝华,曹劲松,凡华等.白鲜皮水提物改善迟发型变态反应性肝损伤的作用机理.中国药科大学学报,1999;30(3):212.
[52]苗明三.薏苡仁多糖对环磷酰胺致免疫抑制小鼠免疫功能的影响[J].中医药学报,2002;30(5):49.
[53]徐淑贞,修虹.薄层色谱法对观音健胃茶中黄芪、白术、陈皮的鉴别.海峡药学,1997;9(4):15-16.
[54]马允慰.白术对家兔离体肠管活动的影响.中成药研究,1982;12: 26-27.
[55]国家医药管理局中草药情报中心站植物药有效成分手册北京:人民卫生出版社,1986;725:1011-1012
[56]杨霓芝,黄春林.泌尿专科中医临床诊治.北京:人民卫生出版社,2000.275-309.
[57]冉先穗.中华药海 哈尔滨:哈尔滨出版社,1998:1588-1589.
[58]郑虎占,董泽宏,佘靖.中药现代研究与应用[M].第4册.北京:学苑出版社,1998;3022.
[59]侯艳宁,朱秀媛,程桂芳,等.黄芩甙的抗炎机理[J].药学学报,2000;35(3):161-164.
[60]江熟平.徐长卿及丹皮酚的应用与研究进展[J].中国中药杂志,1994;19(5):311.
[61]许青松,张红英,李迎军,等.徐长卿水煎剂抗炎及镇痛作用的研究时珍国医国药,2007;18(6):1047-1048.
[62]江苏新医学院.中药大辞典[M].上册.上海:上海科学技术出版社。1986,1462.
[63]周德文.术类的药理和药效.国外医药·植物药分册,1996,11(3):120-122.
[64]马瑞君,王钦,陈学林等.当归的研究进展.中草药,2002;33(3):280-282.
[65]刘圣,沈爱宗.土茯苓研究进展.中医药学报,1997;(5):54-56.
[66]石钺,石任兵,陆蕴如.我国药用金银花资源、化学成分及药理研究进展.中国药学杂志,1999;34(11):724-727.
[67]尹春萍,吴继洲.泽泻及其活性成分免疫调节作用研究进展.中草药,2001;32(12):1132-1133.
[68]李砥晖,林天慕,张秀荣等.黄芩化学成分研究进展.空军医高专学报.1999;21(4):231-233.
[1]涂彩霞,刘芳,李敬,等.复方茯苓汤联合用药组湿疹582例临床观察及实验研究[J].中国中西医结合皮肤性病学杂志,2002;1(1):13-15.
[2]郭继华,张皖敏.自拟湿疹方为主联合用药组急性湿疹85例分析[J]安徽中医临床杂志,2002;11(1):24-25.
[3]丁文,王玉玺湿疹汤加减联合用药组亚急性湿疹的疗效观察中医药学报2008年第36卷第3期Vol.36,No.3,2008 52-53
[4]朱霞等凉血消风散联合用药组亚急性湿疹60例临床观察.中医药导报,2005;11(9):33-34
[5]黄其清,除湿胃苓汤加减联合用药组亚急性湿疹26例临床观察.海南医学,2001;12(7):67-68
[6]商燕畦,雷翠云,中药离子喷雾联合用药组亚急性湿疹效果观察.护理学杂志,2005;5(20)10:(外科版)45-46
[7]张军弼.加味石兰草方联合用药组热盛型亚急性湿疹68例临床观察.四川中医,2005;23(12):87-88.
[8]栾天庆.中医药联合用药组亚急性湿疹临床观察.现代中西医结合杂志,2008;17(33):5168-5169
[9]施康能.银蛇汤为主联合用药组亚急性湿疹62例.江西中医药,2001;32(5):52-53.
[10]高子平,艾儒棣,郝平生.蛇黄膏外治亚急性湿疹60例近期疗效观察.中国中医药信息杂志,2007;14(3):57
[11]苏惜香,李森真,蔡怿等.中西药结合联合用药组接触性皮炎,急性、亚急性湿疹的疗效观察.中国医药导报,2008;5(2):143-144
[12]陈晓红.咪唑斯汀与复方硝酸益康唑乳膏联合联合用药组皮炎湿疹类皮肤病的疗效观察[J].临床皮肤科杂志,2004;33(5):319-320
[13]刘波,王晓敏,周玉芳 复方甘草酸苷联合葡萄糖酸钙联合用药组皮炎湿疹的疗效观察.中国皮肤性病学杂志,2008;22(1):63-64
[14]孙瑞 派瑞松联合用药组皮炎湿疹50例疗效观察.中国冶金工业医学 杂志,2006;23(3):351-352
[15]万芹,莫匹罗星软膏和醋酸地塞米松乳膏联合外用联合用药组亚急性湿疹疗效观察.医学临床研究,2008;25(1):168-169
[16]王妍 卤米松乳膏联合用药组湿疹120例疗效观察.中国冶金工业医学杂志,2006;23(3):352-353
[17]高宜云,许月.清如意金黄散合尤卓尔联合用药组亚急性湿疹120例.浙江中医杂志
[18]梁颖,杨新建,王雷.盐酸多塞平乳膏联合用药组亚急性湿疹60例,中华今日医学杂志,2004;4(3).
[2]赵辨.临床皮肤病学,南京:江苏科学技术出版社,1993,第2版:512.
[3]朱仁康.中医外科学,北京:人民卫生出版社,1987,第1版:724-727.
[4].Oranje Ap,ven meure T.Scoring severity of atopic dermatitis using scorad in:dyall -smith D,eds Dermatology at the millennium.New YORK:Parthenon Publishing Group Inc,1999.477-480
[5]Bahmer FA,Schafer J,Schafer HJ.Quantification Of the extent and the severrity of atopic dermatitis:the ADASI score.ARCH Dermatol,1991,127:1239-1240
[6]Kunz B,Oranje AP,Labreze L,et al.Clinical validtion and guidelines for the SCORAD index:consensus report of the EuropeanTas Force on Atopic Dermatitis,Dermatology,1997,195:10-9
[7].Berth-Jones J.Six area,six sign atopic dermatitis(SASSAD)severity score:a simple system for monitoring disease activity in atopic dermatitis.Br J Dermatol,1996,135 Supple 48:25-30
[8]毕武艳.湿疹的病机及防治探讨.辽宁中医杂志,2003;30(2):129-130
[9]赵丽平.中医辨证联合用药组湿疹86例.中国中医药信息杂志,2000;17(7):66
[10]康景华.中医药联合用药组急性湿疹36例.新中医,2001;33(9):61
[11]米要和.辨证联合用药组慢性湿疹40例.实用中医药杂志,2002;18(3):17
[12]黄英姿.马绍尧教授联合用药组湿疹经验.四川中医.2002;20(12):2-3.
[13]阎景东,王玉玺.王玉玺教授.联合用药组湿疹的经验.中医药信息.2005;22(3):43.
[14]尹东辉,李晖.李月玺.联合用药组湿疹临床经验.中国医药学报.2003;18(8):509-510
[15]刘铭锐.湿疹的中西医结合分型及联合用药组研究.兰州医学院学报1987;(1):38
[16]郭继华,张皖敏.自拟湿疹方为主联合用药组急性湿疹85例分析[J].安徽中医临床杂志,2002,11(1):24-25.
[17]陈希明.除湿胃苓汤加减联合用药组亚急性湿疹临床观察[J].中国皮肤性病学杂志,1999,13(4):236-237.
[18]栾天庆.中医药联合用药组亚急性湿疹临床观察现代中西医结合杂志,2008;17(33) 5168-5169
[19]任少杰.二黄茯苓汤联合用药组亚急性湿疹临床观察.中医药临床杂志,2008:20(4):392-393
[21]Gu stafsson D,Sjoberg O,Fouca rd T.Sen sitiza tion tofood and a irbo rne a llergen s in child ten w ith a top icderm a titis fo llow ed up to 7 yea rs of age[J].Ped ia trA llergy Im m unol,2003,14(6):44824521
[22]Leyden JJ,Marples RR,Kligrman AM.Staphylcoccus aureus in the lesinons of atopic dermatitis[J].Br J Dermatol,1974;90(5):525-530
[23].袁伟,真菌感染在过敏性皮炎发病机制中的作用,贵州医药,2005;29(3):211-212
[24]张学军,刘维达,何春涤主编.现代皮肤病学进展.北京:人民卫生出版社,2001.
[25]吴志华主编.皮肤性病学.广州科技出版社,1997.
[26].吴志华.现代皮肤性病学.广东人民出版社,2000;106-109
[27]赵辨.临床皮肤病学.江苏科学技术出版社,2001.604-605
[28]olesen AB.Role of theea rlye nvironment of express ionofatopied ermatiti.J Am read Dermatol 2001,45(lSuppl):537-540
[29]叶冬青.皮肤病流行病学.人民卫生出版社,2001;356-358
[30]袁茵,郑苏容,张炜.慢性湿疹患者心理防御方式测查分析.成都医药,2003;12(6)344-345
[31]陈文琦,张美华,毕志刚,等.金黄色葡萄球菌超抗原与特应性皮炎及湿疹的初步探讨.临床皮肤科杂志,2005;34(8):507-509.
[32]弓娟琴,林麟,郝飞,等.湿疹和特应性皮炎皮损处细菌定植情况及药物联合联合用药组的分析.中华皮肤科杂志,2004;34(9):515-518.
[33]Bunikowski R,M ielke M,Skarabis H,el al.Prevalence and role of serum IgE antibodies to the Staphylococcus aureus-de-rived superantigens SEA and SEB in children with atopic der -matitis [J].JAllergy Clin Immunol,1999,103(1 Pt 1):119-124.
[34]万芹.莫匹罗星软膏和醋酸地塞米松乳膏联合外用联合用药组亚急性湿疹疗效观察 医学临床研究,2008;25(1)168-169
[35]杨玲等.慢性湿疹皮损中糖皮质激素受体-α(表达下调.中国麻风皮肤病杂志,2008;4(2):102-103
[36]Sudo K,Nagai K,Yanada N.Inhibitory effects of mizolastine on 5-lipoxygenase EJ].Jpan Pharmacol Ther,1998;26(Sup-p1):155-157.
[37]付萌,樊平中,廖文俊等.咪唑斯汀抗炎活性的动物实验研究.临床皮肤科杂志,2003;32(Ⅱ):635-637.
[38]陈妍,郭在培.咪唑斯汀抑制小鼠变应性接触性皮炎机制的研究.中华皮肤科杂志,2004;37(6):344-346.
[39]王懿娜,方红,周宗立等.咪唑斯汀对致敏小鼠脾淋巴细胞释放LTB4和IL-5的抑制作用.中国皮肤性病学杂志,2005;19(3):138-140
[40]Prous.JR.Treatment of upper respiratory tract disorders.In: The year' s Drug news Therapeutic Targets[M].1995 Edition,Prous Science Pub-lishers,Barcelona,1995.141
[41]LevierJ.Anti -anaphylaetie activity of the Novel Selective Histamine H1 Receptor Antagonist Mizolastine in the Rodent[J].A rzneim-forsch/Drug Res,1995,45(1):5
[42]李慧忠,刘翔等.咪唑斯汀缓解50例皮炎湿疹患者临床症状的疗效评价.中国医院药学杂志:2007,27(2):229-300
[43]周萌,韦斌.咪唑斯汀联合用药组皮炎湿疹类皮肤病临床观察.现代中西医结合杂志,2006;15(19):2622-2623
[44]支玉香,张宏誉.抗组胺药对认知功能的影响.中国新药杂志,2003;12(10):807-809
[45]乔刚.咪唑斯汀联合用药组慢性荨麻疹有效性和安全性评估[J].国外医学·皮肤性病学分册,2001,27(3):180
[46]Yap YG,Camm AJ.The currentcardiac safety situations with anti -histamines[J].Clin Ellergy,1999,29(Supp1).15
[47]CarayolN,etal.Allergy[J].2002,57(11):1067
[48]车月玺,湿疹冲剂联合用药组急性程疹90例,宁中医杂志,1996;23(4):167
[49]殷金珠.中药苦参对I型变态反应的实验研究[J].中草药,1985;(6):44.
[50]张志礼.中西医结合皮肤性病学.北京:人民卫生出版社,2000。424.
[51]陆朝华,曹劲松,凡华等.白鲜皮水提物改善迟发型变态反应性肝损伤的作用机理.中国药科大学学报,1999;30(3):212.
[52]苗明三.薏苡仁多糖对环磷酰胺致免疫抑制小鼠免疫功能的影响[J].中医药学报,2002;30(5):49.
[53]徐淑贞,修虹.薄层色谱法对观音健胃茶中黄芪、白术、陈皮的鉴别.海峡药学,1997;9(4):15-16.
[54]马允慰.白术对家兔离体肠管活动的影响.中成药研究,1982;12: 26-27.
[55]国家医药管理局中草药情报中心站植物药有效成分手册北京:人民卫生出版社,1986;725:1011-1012
[56]杨霓芝,黄春林.泌尿专科中医临床诊治.北京:人民卫生出版社,2000.275-309.
[57]冉先穗.中华药海 哈尔滨:哈尔滨出版社,1998:1588-1589.
[58]郑虎占,董泽宏,佘靖.中药现代研究与应用[M].第4册.北京:学苑出版社,1998;3022.
[59]侯艳宁,朱秀媛,程桂芳,等.黄芩甙的抗炎机理[J].药学学报,2000;35(3):161-164.
[60]江熟平.徐长卿及丹皮酚的应用与研究进展[J].中国中药杂志,1994;19(5):311.
[61]许青松,张红英,李迎军,等.徐长卿水煎剂抗炎及镇痛作用的研究时珍国医国药,2007;18(6):1047-1048.
[62]江苏新医学院.中药大辞典[M].上册.上海:上海科学技术出版社。1986,1462.
[63]周德文.术类的药理和药效.国外医药·植物药分册,1996,11(3):120-122.
[64]马瑞君,王钦,陈学林等.当归的研究进展.中草药,2002;33(3):280-282.
[65]刘圣,沈爱宗.土茯苓研究进展.中医药学报,1997;(5):54-56.
[66]石钺,石任兵,陆蕴如.我国药用金银花资源、化学成分及药理研究进展.中国药学杂志,1999;34(11):724-727.
[67]尹春萍,吴继洲.泽泻及其活性成分免疫调节作用研究进展.中草药,2001;32(12):1132-1133.
[68]李砥晖,林天慕,张秀荣等.黄芩化学成分研究进展.空军医高专学报.1999;21(4):231-233.
[1]涂彩霞,刘芳,李敬,等.复方茯苓汤联合用药组湿疹582例临床观察及实验研究[J].中国中西医结合皮肤性病学杂志,2002;1(1):13-15.
[2]郭继华,张皖敏.自拟湿疹方为主联合用药组急性湿疹85例分析[J]安徽中医临床杂志,2002;11(1):24-25.
[3]丁文,王玉玺湿疹汤加减联合用药组亚急性湿疹的疗效观察中医药学报2008年第36卷第3期Vol.36,No.3,2008 52-53
[4]朱霞等凉血消风散联合用药组亚急性湿疹60例临床观察.中医药导报,2005;11(9):33-34
[5]黄其清,除湿胃苓汤加减联合用药组亚急性湿疹26例临床观察.海南医学,2001;12(7):67-68
[6]商燕畦,雷翠云,中药离子喷雾联合用药组亚急性湿疹效果观察.护理学杂志,2005;5(20)10:(外科版)45-46
[7]张军弼.加味石兰草方联合用药组热盛型亚急性湿疹68例临床观察.四川中医,2005;23(12):87-88.
[8]栾天庆.中医药联合用药组亚急性湿疹临床观察.现代中西医结合杂志,2008;17(33):5168-5169
[9]施康能.银蛇汤为主联合用药组亚急性湿疹62例.江西中医药,2001;32(5):52-53.
[10]高子平,艾儒棣,郝平生.蛇黄膏外治亚急性湿疹60例近期疗效观察.中国中医药信息杂志,2007;14(3):57
[11]苏惜香,李森真,蔡怿等.中西药结合联合用药组接触性皮炎,急性、亚急性湿疹的疗效观察.中国医药导报,2008;5(2):143-144
[12]陈晓红.咪唑斯汀与复方硝酸益康唑乳膏联合联合用药组皮炎湿疹类皮肤病的疗效观察[J].临床皮肤科杂志,2004;33(5):319-320
[13]刘波,王晓敏,周玉芳 复方甘草酸苷联合葡萄糖酸钙联合用药组皮炎湿疹的疗效观察.中国皮肤性病学杂志,2008;22(1):63-64
[14]孙瑞 派瑞松联合用药组皮炎湿疹50例疗效观察.中国冶金工业医学 杂志,2006;23(3):351-352
[15]万芹,莫匹罗星软膏和醋酸地塞米松乳膏联合外用联合用药组亚急性湿疹疗效观察.医学临床研究,2008;25(1):168-169
[16]王妍 卤米松乳膏联合用药组湿疹120例疗效观察.中国冶金工业医学杂志,2006;23(3):352-353
[17]高宜云,许月.清如意金黄散合尤卓尔联合用药组亚急性湿疹120例.浙江中医杂志
[18]梁颖,杨新建,王雷.盐酸多塞平乳膏联合用药组亚急性湿疹60例,中华今日医学杂志,2004;4(3).