细胞色素P450氧化还原酶在发育中的作用
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摘要
细胞色素P450氧化还原酶(POR)是一种电子供体,参与许多发育相关的内源性物质的代谢,从而影响机体的生长发育。本文就POR在发育相关内源性物质代谢中的作用以及POR缺陷导致的发育不良等方面进行综述。
Cytochrome P450 oxidoreductase(POR), an electron donor, was involved in the metabolism of many endogenous substances related to development, thereby affecting the growth and development of the organism. This review highlights the role of POR in development - related endogenous metabolism, as well as the dysplasia caused by POR deficiency.
Cytochrome P450 oxidoreductase(POR), an electron donor, was involved in the metabolism of many endogenous substances related to development, thereby affecting the growth and development of the organism. This review highlights the role of POR in development - related endogenous metabolism, as well as the dysplasia caused by POR deficiency.
引文
[1] Pandey AV, Fluck CE. NADPH P450 oxidoreduc-tase:structure, function, and pathology of diseases[J].Pharmacol Ther, 2013,138(2):229-254.
[2] Gong L, Zhang CM, Lv JF, et al. Polymorphisms in cytochrome P450 oxidoreductase and its effect on drug metabolism and efficacy[J]. Pharmacogenet Genomics,2017, 27(9):337-346.
[3] Fluck CE, Nicolo C, Pandey AV. Clinical, structural and functional implications of mutations and polymor-phisms in human NADPH P450 oxidoreductase[J].Fundam Clin Pharmacol, 2007, 21(4):399-410.
[4] Riddick DS, Ding X, Wolf CR, et al. NADPH-cyto-chrome P450 oxidoreductase:roles in physiology, phar-macology, and toxicology[J]. Drug Metab Dispos,2013, 41(1):12-23.
[5] Mu?ozsánchez J, Chánezcárdenas ME. A review on hemeoxygenase-2:focus on cellular protection and oxy-gen response[J]. Oxid Med Cell Longev, 2014, 2014(10):604981.
[6] Belter A, Skupinska M, Giel-Pietraszuk M, et al.Squalene monooxygenase-a target for hypercholester-olemic therapy[J]. Biological Chemistry, 2011, 392(12):1 053-1 075.
[7] Prabhu AV, Luu W, Li D, et al. DHCR7:A vital en-zyme switch between cholesterol and vitamin D produc-tion[J]. Prog Lipid Res, 2016,64:138-151.
[8] Storbeck KH, Swart AC, Goosen P, et al. Cyto-chrome b5:novel roles in steroidogenesis[J]. Mol Cell Endocrinol, 2013,371(1-2):87-99.
[9]刘文波,陈禹保,邢玉华.细胞色素P450基因多态性与药物代谢研究进展[J].中国生物工程杂志, 2016,36(12):104-110.Liu WB, Chen YB, Xing YH. Advances in research on genetic polymorphism of cytochrome P450 and drug metabolism[J]. China Biotechnology, 2016,36(12):104-110.
[10] Chen X, Pan LQ, Naranmandura H, et al. Influence of various polymorphic variants of cytochrome P450 oxido-reductase(POR)on drug metabolic activity of CYP3A4and CYP2B6[J]. PLoS One, 2012,7(6):e38495.
[11] Fan QW, Yu W, Gong JS, et al. Cholesterol-depen-dent modulation of dendrite outgrowth and microtubule stability in cultured neurons[J]. J Neurochem, 2002,80(1):178-190.
[12] Pfrieger FW, Ungerer N. Cholesterol metabolism in neurons and astrocytes[J]. Prog Lipid Res, 2011,50(4):357-371.
[13] Cooper MK, Wassif CA, Krakowiak PA, et al. A de-fective response to Hedgehog signaling in disorders of cholesterol biosynthesis[J]. Nat Genet, 2003,33(4):508-513.
[14] Ingham PW, McMahon AP. Hedgehog signaling in an-imal development:paradigms and principles[J]. Genes Dev, 2001,15(23):3 059-3 087.
[15] Xiao X, Tang JJ, Peng C, et al. Cholesterol modifica-tion of smoothened is required for hedgehog signaling[J]. Mol Cell, 2017,66(1):154-162. e110.
[16] McMillin M, DeMorrow S. Effects of bile acids on neu-rological function and disease[J]. Faseb J, 2016,30(11):3 658-3 668.
[17]唐俊英.胆汁酸在动物营养中的应用[J].养殖技术顾问, 2011,(9):47-47.Tang JY. Application of Bile Acid in Animal Nutrition[J]. Technical Advisor for Animal Husbandry, 2011,(9):47-47.
[18] Cheng X, Zhang Y, Klaassen CD. Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in in-creased bile acids in serum[J]. J Pharmacol Exp Ther,2014,351(1):105-113.
[19] Kalaany NY, Mangelsdorf DJ. LXRS and FXR:the yin and yang of cholesterol and fat metabolism[J]. Annu Rev Physiol, 2006,68:159-191.
[20] Ross SA, McCaffery PJ, Drager UC, et al. Retinoids in embryonal development[J]. Physiol Rev, 2000, 80(3):1 021-1 054.
[21]齐焰,谢院生.视黄酸的结构、代谢、受体及其与器官发育的关系[J].中华肾病研究电子杂志, 2015,4(5):257-260.Qi Y, Xie YS. The structure,metabolism,receptors of retinoic acid and its relationship with organ development[J]. Chinese Journal of Kidney Disease Investigation:Electronic Edition, 2015,4(5):257-260.
[22] Janesick A, Wu SC, Blumberg B. Retinoic acid signal-ing and neuronal differentiation[J]. Cell Mol Life Sci,2015,72(8):1 559-1 576.
[23] Niederreither K, Subbarayan V, Dolle P, et al. Embry-onic retinoic acid synthesis is essential for early mouse post-implantation development[J]. Nat Genet, 1999,21(4):444-448.
[24] Gu J, Weng Y, Zhang QY, et al. Liver-specific dele-tion of the NADPH-cytochrome P450 reductase gene:impact on plasma cholesterol homeostasis and the func-tion and regulation of microsomal cytochrome P450 and heme oxygenase[J]. J Biol Chem, 2003, 278(28):25 895-25 901.
[25] Shen AL, O′Leary KA, Kasper CB. Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxi-doreductase[J]. J Biol Chem, 2002, 277(8):6 536-6 541.
[26] Krone N, Dhir V, Ivison HE, et al. Congenital adrenal hyperplasia and P450 oxidoreductase deficiency[J]. Clin Endocrinol(Oxf), 2007,66(2):162-172.
[27]宋璐璐,蒋玲.先天性肾上腺皮质增生症和细胞色素P450氧化还原酶缺陷[J].国际儿科学杂志, 2009,36(6):646-649.Song LL, Jiang L. Congenital adrenal hyperplasia and cytochrome P450 oxidative reductase deficiency[J]. In-ternational Journal of Pediatrics, 2009,36(6):646-649.
[28] Khadilkar KS, Jagtap V, Lila A, et al. Cytochrome P450 oxidoreductase deficiency:Novel cause of ambigu-ity with primary amenorrhea[J]. Indian J Endocrinol Metab, 2017,21(2):360-362.
[29]邱明芳.细胞色素P450氧化还原酶缺陷和先天性肾上腺皮质增生症[J].中国社区医师, 2015,31(21):6-7.Qiu MF. Cytochrome P450 oxidoreductase defects and congenital adrenal hyperplasia[J]. Chinese Community Doctors, 2015,31(21):6-7.
[2] Gong L, Zhang CM, Lv JF, et al. Polymorphisms in cytochrome P450 oxidoreductase and its effect on drug metabolism and efficacy[J]. Pharmacogenet Genomics,2017, 27(9):337-346.
[3] Fluck CE, Nicolo C, Pandey AV. Clinical, structural and functional implications of mutations and polymor-phisms in human NADPH P450 oxidoreductase[J].Fundam Clin Pharmacol, 2007, 21(4):399-410.
[4] Riddick DS, Ding X, Wolf CR, et al. NADPH-cyto-chrome P450 oxidoreductase:roles in physiology, phar-macology, and toxicology[J]. Drug Metab Dispos,2013, 41(1):12-23.
[5] Mu?ozsánchez J, Chánezcárdenas ME. A review on hemeoxygenase-2:focus on cellular protection and oxy-gen response[J]. Oxid Med Cell Longev, 2014, 2014(10):604981.
[6] Belter A, Skupinska M, Giel-Pietraszuk M, et al.Squalene monooxygenase-a target for hypercholester-olemic therapy[J]. Biological Chemistry, 2011, 392(12):1 053-1 075.
[7] Prabhu AV, Luu W, Li D, et al. DHCR7:A vital en-zyme switch between cholesterol and vitamin D produc-tion[J]. Prog Lipid Res, 2016,64:138-151.
[8] Storbeck KH, Swart AC, Goosen P, et al. Cyto-chrome b5:novel roles in steroidogenesis[J]. Mol Cell Endocrinol, 2013,371(1-2):87-99.
[9]刘文波,陈禹保,邢玉华.细胞色素P450基因多态性与药物代谢研究进展[J].中国生物工程杂志, 2016,36(12):104-110.Liu WB, Chen YB, Xing YH. Advances in research on genetic polymorphism of cytochrome P450 and drug metabolism[J]. China Biotechnology, 2016,36(12):104-110.
[10] Chen X, Pan LQ, Naranmandura H, et al. Influence of various polymorphic variants of cytochrome P450 oxido-reductase(POR)on drug metabolic activity of CYP3A4and CYP2B6[J]. PLoS One, 2012,7(6):e38495.
[11] Fan QW, Yu W, Gong JS, et al. Cholesterol-depen-dent modulation of dendrite outgrowth and microtubule stability in cultured neurons[J]. J Neurochem, 2002,80(1):178-190.
[12] Pfrieger FW, Ungerer N. Cholesterol metabolism in neurons and astrocytes[J]. Prog Lipid Res, 2011,50(4):357-371.
[13] Cooper MK, Wassif CA, Krakowiak PA, et al. A de-fective response to Hedgehog signaling in disorders of cholesterol biosynthesis[J]. Nat Genet, 2003,33(4):508-513.
[14] Ingham PW, McMahon AP. Hedgehog signaling in an-imal development:paradigms and principles[J]. Genes Dev, 2001,15(23):3 059-3 087.
[15] Xiao X, Tang JJ, Peng C, et al. Cholesterol modifica-tion of smoothened is required for hedgehog signaling[J]. Mol Cell, 2017,66(1):154-162. e110.
[16] McMillin M, DeMorrow S. Effects of bile acids on neu-rological function and disease[J]. Faseb J, 2016,30(11):3 658-3 668.
[17]唐俊英.胆汁酸在动物营养中的应用[J].养殖技术顾问, 2011,(9):47-47.Tang JY. Application of Bile Acid in Animal Nutrition[J]. Technical Advisor for Animal Husbandry, 2011,(9):47-47.
[18] Cheng X, Zhang Y, Klaassen CD. Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in in-creased bile acids in serum[J]. J Pharmacol Exp Ther,2014,351(1):105-113.
[19] Kalaany NY, Mangelsdorf DJ. LXRS and FXR:the yin and yang of cholesterol and fat metabolism[J]. Annu Rev Physiol, 2006,68:159-191.
[20] Ross SA, McCaffery PJ, Drager UC, et al. Retinoids in embryonal development[J]. Physiol Rev, 2000, 80(3):1 021-1 054.
[21]齐焰,谢院生.视黄酸的结构、代谢、受体及其与器官发育的关系[J].中华肾病研究电子杂志, 2015,4(5):257-260.Qi Y, Xie YS. The structure,metabolism,receptors of retinoic acid and its relationship with organ development[J]. Chinese Journal of Kidney Disease Investigation:Electronic Edition, 2015,4(5):257-260.
[22] Janesick A, Wu SC, Blumberg B. Retinoic acid signal-ing and neuronal differentiation[J]. Cell Mol Life Sci,2015,72(8):1 559-1 576.
[23] Niederreither K, Subbarayan V, Dolle P, et al. Embry-onic retinoic acid synthesis is essential for early mouse post-implantation development[J]. Nat Genet, 1999,21(4):444-448.
[24] Gu J, Weng Y, Zhang QY, et al. Liver-specific dele-tion of the NADPH-cytochrome P450 reductase gene:impact on plasma cholesterol homeostasis and the func-tion and regulation of microsomal cytochrome P450 and heme oxygenase[J]. J Biol Chem, 2003, 278(28):25 895-25 901.
[25] Shen AL, O′Leary KA, Kasper CB. Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxi-doreductase[J]. J Biol Chem, 2002, 277(8):6 536-6 541.
[26] Krone N, Dhir V, Ivison HE, et al. Congenital adrenal hyperplasia and P450 oxidoreductase deficiency[J]. Clin Endocrinol(Oxf), 2007,66(2):162-172.
[27]宋璐璐,蒋玲.先天性肾上腺皮质增生症和细胞色素P450氧化还原酶缺陷[J].国际儿科学杂志, 2009,36(6):646-649.Song LL, Jiang L. Congenital adrenal hyperplasia and cytochrome P450 oxidative reductase deficiency[J]. In-ternational Journal of Pediatrics, 2009,36(6):646-649.
[28] Khadilkar KS, Jagtap V, Lila A, et al. Cytochrome P450 oxidoreductase deficiency:Novel cause of ambigu-ity with primary amenorrhea[J]. Indian J Endocrinol Metab, 2017,21(2):360-362.
[29]邱明芳.细胞色素P450氧化还原酶缺陷和先天性肾上腺皮质增生症[J].中国社区医师, 2015,31(21):6-7.Qiu MF. Cytochrome P450 oxidoreductase defects and congenital adrenal hyperplasia[J]. Chinese Community Doctors, 2015,31(21):6-7.