FRD宫颈上皮组织染色技术在阳春地区宫颈癌前病变筛查中的应用
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摘要
目的:探讨叶酸受体介导的宫颈特殊染色法(FRD)宫颈上皮组织染色技术在阳春地区宫颈癌前病变筛查中的应用。方法:选取广东省阳春地区30～60岁的女性1 000例进行以人群为基础的宫颈癌筛查。均给予RFD检查和液基薄层细胞学(TCT)检查,并以阴道镜检查诊断结果作为金标准,比较RFD、TCT筛查宫颈癌前病变的效能,计算诊断符合度、敏感性、特异性。结果:阴道镜检查为宫颈正常或炎症875例、CINⅠ64例、CINⅡ36例、CINⅢ23例、宫颈癌2例,FRD检查阳性67例(6.70%)、阴性933例(93.30%),TCT检查阳性220例(22.00%)、阴性78例(78.00%),FRD宫颈癌前病变的诊断符合率高于TCT检查(x~2=95.230,P=0.000);FRD筛查宫颈癌前病变的敏感性、特异性均高于TCT检查,比较差异均有统计学意义(P<0.05)。结论:FRD宫颈上皮组织染色技术应用在阳春地区宫颈癌前病变中诊断符合率、敏感性和特异性极高,且是一种准确、快速、便捷、经济的一种检测方法,值得在临床上广泛推广。
Objective:To explore the application of folate receptor mediated cervical special staining(FRD)in cervical precancerous lesion screening in Yangchun area.Method:A population-based screening for cervical cancer was conducted in 1 000 women aged 30 to 60 years old in Yangchun,Guangdong Province.RFD and liquid-based thin-layer cytology(TCT)were performed,and the diagnostic results of colposcopy were used as the gold standard.The efficacy of RFD and TCT in screening cervical precancerous lesions was compared,the diagnostic accuracy,sensitivity and specificity were calculated.Result:Colposcopic examination included 875 cases of cervical normal or inflammation,64 cases of CIN Ⅰ,36 cases of CIN Ⅱ,23 cases of CIN Ⅲ and 2 cases of cervical cancer.FRD was positive in 67 cases(6.70%)and negative in 933 cases(93.30%),TCT was positive in 220 cases(22.00%)and negative in 78 cases(78.00%),the diagnostic coincidence rate of FRD for cervical precancerous lesions was higher than that of TCT( x~2=95.230,P=0.000).The sensitivity and specificity of FRD in screening cervical precancerous lesions were higher than those of TCT,the differences were statistically significant(P<0.05).Conclusion:The application of FRD cervical epithelial tissue staining technology in Yangchun area has high diagnostic accuracy,sensitivity and specificity,and it is an accurate,fast,convenient and economical detection method.It is worth of popularizing widely in clinic.
Objective:To explore the application of folate receptor mediated cervical special staining(FRD)in cervical precancerous lesion screening in Yangchun area.Method:A population-based screening for cervical cancer was conducted in 1 000 women aged 30 to 60 years old in Yangchun,Guangdong Province.RFD and liquid-based thin-layer cytology(TCT)were performed,and the diagnostic results of colposcopy were used as the gold standard.The efficacy of RFD and TCT in screening cervical precancerous lesions was compared,the diagnostic accuracy,sensitivity and specificity were calculated.Result:Colposcopic examination included 875 cases of cervical normal or inflammation,64 cases of CIN Ⅰ,36 cases of CIN Ⅱ,23 cases of CIN Ⅲ and 2 cases of cervical cancer.FRD was positive in 67 cases(6.70%)and negative in 933 cases(93.30%),TCT was positive in 220 cases(22.00%)and negative in 78 cases(78.00%),the diagnostic coincidence rate of FRD for cervical precancerous lesions was higher than that of TCT( x~2=95.230,P=0.000).The sensitivity and specificity of FRD in screening cervical precancerous lesions were higher than those of TCT,the differences were statistically significant(P<0.05).Conclusion:The application of FRD cervical epithelial tissue staining technology in Yangchun area has high diagnostic accuracy,sensitivity and specificity,and it is an accurate,fast,convenient and economical detection method.It is worth of popularizing widely in clinic.
引文
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[4]彭奕琼,林钻娣,刘永珠,等.叶酸受体介导的宫颈特殊染色法筛查宫颈病变临床研究[J].深圳中西医结合杂志,2017,27(20):17-18.
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[6]李开颜,蔡海莹,沈慧敏.FRD上皮组织特殊染色液筛查宫颈病变的应用研究[J].基因组学与应用生物学,2016,35(7):1584-1588.
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[10]Xu H H,Wang K,Feng X J,et al.Prevalence of human papillomavirus genotypes and relative risk of cervical cancer in China:a systematic review and meta-analysis[J].Oncotarget,2018,9(20):15386-15397.
[11]张春花,吴玲,杨慧,等.叶酸受体介导的宫颈上皮组织特殊染色在宫颈癌筛查中的应用[J].江苏医药,2017,43(8):570-572.
[12]穆成柱,韩兰芳,方建平,等.高危型人乳头状瘤病毒检测联合细胞学检查在宫颈病变筛查中的应用[J].中国药物与临床,2016,16(7):1073-1074.
[13]栗丽,胡桂英,吴宇丹,等.薄层液基细胞学联合HPV-DNA检测在粤东地区宫颈癌筛查中的临床价值[J].癌变·畸变·突变,2016,28(4):281-283.
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[15]陈昕,胡敏,徐珍珍,等.FRD特殊染色技术在宫颈疾病筛查中的结果分析[J].现代生物医学进展,2016,16(32):6269-6271.
[16]王霞.宫颈癌及癌前病变中的HPV-16整合人宿主基因组的发生情况及其在宫颈癌筛查中的应用[J].河北医学,2017,23(11):1768-1772.
[17]甘涛,柯国女,吴晓霞,等.宫颈特殊染色法应用于1652例宫颈病变筛查的结果分析[J].实用癌症杂志,2015,30(3):368-370.
[18]耿茹.液基薄层细胞学检查人乳头状瘤病毒检测及阴道镜活检在宫颈病变诊断中的应用价值[J].中国药物与临床,2016,16(7):1059-1061.
[19]夏作利,陈国荣,潘丹,等.HPV E6/E7联合液基细胞学检查在宫颈癌前病变筛查中的意义[J].实用医学杂志,2016,32(18):3053-3056.
[20]汤冠华.阴道镜对宫颈癌前病变的诊断价值[J].中国药物与临床,2014,14(9):1253-1255.
[2]陈凯英.叶酸受体介导的宫颈特殊染色法联合TCT/HPV在早期宫颈病变中的应用价值[J].中国妇幼健康研究,2014,25(5):828-831.
[3]张萍,陶瑞环,曹惠桃.叶酸受体介导的宫颈特殊染色法与TCT联合HPV在宫颈病变初筛中的对比研究[J].中国医药科学,2017,7(11):239-241.
[4]彭奕琼,林钻娣,刘永珠,等.叶酸受体介导的宫颈特殊染色法筛查宫颈病变临床研究[J].深圳中西医结合杂志,2017,27(20):17-18.
[5]王栾玲,廖咪妮.宫颈特殊染色法上皮组织染色技术用于宫颈癌前病变检测的临床价值[J].中国妇幼保健,2016,31(22):4724-4726.
[6]李开颜,蔡海莹,沈慧敏.FRD上皮组织特殊染色液筛查宫颈病变的应用研究[J].基因组学与应用生物学,2016,35(7):1584-1588.
[7]黄彩平,李日红,邓惠宜,等.FRD上皮组织特殊染色液在宫颈病变筛查中的应用[J].海南医学,2016,27(14):2260-2262.
[8]Shu T,Zhao D,Li B,et al.Prognostic evaluation of postoperative adjuvant therapy for operable cervical cancer:10 years’experience of National Cancer Center in China[J].Chin J Cancer Res,2017,29(6):510-520.
[9]王皓洁,王君,宋菁华,等.宫颈特殊染色法在宫颈病变筛查中价值的研究[J].中国妇幼保健,2016,31(4):835-837.
[10]Xu H H,Wang K,Feng X J,et al.Prevalence of human papillomavirus genotypes and relative risk of cervical cancer in China:a systematic review and meta-analysis[J].Oncotarget,2018,9(20):15386-15397.
[11]张春花,吴玲,杨慧,等.叶酸受体介导的宫颈上皮组织特殊染色在宫颈癌筛查中的应用[J].江苏医药,2017,43(8):570-572.
[12]穆成柱,韩兰芳,方建平,等.高危型人乳头状瘤病毒检测联合细胞学检查在宫颈病变筛查中的应用[J].中国药物与临床,2016,16(7):1073-1074.
[13]栗丽,胡桂英,吴宇丹,等.薄层液基细胞学联合HPV-DNA检测在粤东地区宫颈癌筛查中的临床价值[J].癌变·畸变·突变,2016,28(4):281-283.
[14]Siegel R L,Miller K D,Jemal A.Cancer statistics,2018[J].CACancer J Clin,2018,68(1):7-30.
[15]陈昕,胡敏,徐珍珍,等.FRD特殊染色技术在宫颈疾病筛查中的结果分析[J].现代生物医学进展,2016,16(32):6269-6271.
[16]王霞.宫颈癌及癌前病变中的HPV-16整合人宿主基因组的发生情况及其在宫颈癌筛查中的应用[J].河北医学,2017,23(11):1768-1772.
[17]甘涛,柯国女,吴晓霞,等.宫颈特殊染色法应用于1652例宫颈病变筛查的结果分析[J].实用癌症杂志,2015,30(3):368-370.
[18]耿茹.液基薄层细胞学检查人乳头状瘤病毒检测及阴道镜活检在宫颈病变诊断中的应用价值[J].中国药物与临床,2016,16(7):1059-1061.
[19]夏作利,陈国荣,潘丹,等.HPV E6/E7联合液基细胞学检查在宫颈癌前病变筛查中的意义[J].实用医学杂志,2016,32(18):3053-3056.
[20]汤冠华.阴道镜对宫颈癌前病变的诊断价值[J].中国药物与临床,2014,14(9):1253-1255.