肉桂叶化学成分及药理作用研究进展
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摘要
肉桂叶为樟科樟属植物肉桂(Cinnamomum cassia Presl)的叶,是肉桂种植加工产业中常见的副产物之一。肉桂叶是工业上通过水蒸气蒸馏法提取肉桂油的原料,提取残渣通常仅作为锅炉燃料处理,其中含有丰富的天然活性成分没有得到充分利用,造成资源浪费和环境污染。本文综述了肉桂叶化学成分、提取方法及药理作用的研究进展,以期为肉桂叶的综合利用提供参考。
Cinnamomum cassia leaves,the leaves of Cinnamomum cassia( Cinnamomum camphoraceae Presl),are common by-product in the Cinnamon planting and processing industry. They are raw materials for extracting cinnamon oil by steam distillation in industry. Extraction residue,which contains rich natural active ingredients,is not fully utilized and often only treated as boiler fuel,causing resource-wasting and environmental pollution. The chemical constituents,extraction methods and pharmacological activities of Cinnamomum cassia leaves were reviewed in order to provide reference for the comprehensive utilization of Cinnamomum cassia leaves.
Cinnamomum cassia leaves,the leaves of Cinnamomum cassia( Cinnamomum camphoraceae Presl),are common by-product in the Cinnamon planting and processing industry. They are raw materials for extracting cinnamon oil by steam distillation in industry. Extraction residue,which contains rich natural active ingredients,is not fully utilized and often only treated as boiler fuel,causing resource-wasting and environmental pollution. The chemical constituents,extraction methods and pharmacological activities of Cinnamomum cassia leaves were reviewed in order to provide reference for the comprehensive utilization of Cinnamomum cassia leaves.
引文
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[3]李艳,苗明三.肉桂的化学、药理及应用特点[J].中医学报,2015,30(9):1335-1337.
[4]郭虹,林观样.肉桂叶挥发性成分分析[J].浙江中医药大学学报,2009,33(6):883-884.
[5]黄丽涛,杨向宏,许育佳,等.肉桂的研究进展[J].大众科技,2018,20(1):77-79.
[6]邓淑蓉,潘宇政.肉桂主要化学成分及药理作用研究概况[J].现代中西医结合杂志,2018,27(4):448-451.
[7]欧阳少林,罗志华,周小卿,等.樟属植物化学型研究概况[J].中国实验方剂学杂志,2011,17(18):268-271.
[8]王琳琳,陈小鹏,韦小杰.广西桂枝桂叶挥发油化学成分分析[J].企业技术开发,2003(15):6-8.
[9]张浩,柴向华.肉桂叶精油水蒸气提取工艺及甄别技术的研究[J].广东工业大学学报,2017,34(4):27-30,40.
[10]朱羽尧,钱骅,张琪瑶,等.肉桂不同植物部位精油成分分析及抑菌活性研究[J].中国野生植物资源,2014,33(6):1-5.
[11]刘红星,孙振军,黄初升,等.桂皮、桂枝、桂叶挥发油的化学成分比较分析[J].食品研究与开发,2010,31(12):144-147.
[12]刘红星,林森,黄初升,等.肉桂三个不同部位提取肉桂油的化学成分比较分析[J].中国调味品,2011,36(4):102-104,110.
[13]孙振军.桂皮、桂枝、桂叶油提取工艺、化学成分及其乙醇提取物的抗氧化活性研究[D].南宁:广西师范学院,2010.
[14]卫向南.水扩散蒸馏提取肉桂叶有效成分的研究[D].南宁:广西大学,2014.
[15] Chang C T,Chang W L,Hsu J C,et al. Chemical composition and tyrosinase inhibitory activity of Cinnamomum cassia essential oil[J].Botanical Studies,2013,54(10):1-7.
[16] Wang R,Wang R J,Yang B. Extraction of essential oils from five cinnamon leaves and identification of their volatile compound compositions[J]. Innovative Food Science and Emerging Technologies,2009,10(2):289-292.
[17]卫向南,李伟光,刘雄民,等.肉桂叶水扩散蒸馏提取肉桂油的研究[J].应用化工,2014,43(6):1047-1049.
[18]张清华.四种海南芳香药物的超临界萃取工艺及GC-MS分析研究[D].北京:中国协和医科大学,2010.
[19]周蕾.肉桂叶化学成分及免疫调节活性研究[D].武汉:华中科技大学,2016.
[20]曾俊芬.肉桂皮及叶化学成分和生物活性研究[D].武汉:华中科技大学,2014.
[21]曾俊芬,朱虎成,周忠泉.肉桂皮及叶中木脂素类化学成分的研究[J].中国药师,2017,20(5):781-784.
[22]向丽,张贵君,赵保胜,等.肉桂不同部位及其挥发油的红外光谱宏观表征[J].中国实验方剂学杂志,2017,23(8):57-61.
[23]李军集,周丽珠,陈海燕,等.紫外分光光度法检测桂叶、桂叶渣总黄酮研究[J].应用化工,2015,44(5):970-971,975.
[24]张玉姣,方岩雄,杨祖金,等.水蒸气蒸馏提取桂叶精油中组分的分布规律[J].精细化工,2014,31(1):50-53.
[25]邹勇芳,黄锁义,李卫彬,等.肉桂植物总黄酮的超声波提取工艺研究[J].食品研究与开发,2008(4):20-23.
[26]张笮晦,邓家刚,黄静,等.微生物法提取桂叶精油的组分研究[J].应用化工,2017,46(1):109-112.
[27] Duan J,Zhao Y. Antimicrobial efficiency of essential oil and freezethaw treatments against Escherichia coli O157:H7 and Salmonella enterica Ser. Enteritidis in strawberry juice[J]. Journal of Food Science,2009,74(3):131-137.
[28] Jeong E J,Lee N K,Oh J,et al. Inhibitory effect of cinnamon essential oils on selected cheese-contaminating fungi(Penicillium spp.)during the cheese-ripening process[J]. Food Science and Biotechnology,2014,23(4):1193-1198.
[29] Jasenka'Cosi'c,Karolina Vrande(c i'c,Jelena Po2ti'c,et al. In vitro antifungal activity of essential oils on growth of phytopathogenic fungi[J]. Agriculture,2010,16(2):25-28.
[30] Ayala-Zavala J F,Silva-Espinoza B A,Cruz-Valenzuela M R,et al.Pectin-cinnamon leaf oil coatings add antioxidant and antibacterial properties to fresh-cut peach[J]. Flavour and Fragrance Journal,2013,28(1):39-45.
[31] Melgarejo-Flores B G,Ortega-Ramírez L A,Silva-Espinoza B A,et al. Antifungal protection and antioxidant enhancement of table grapes treated with emulsions,vapors,and coatings of cinnamon leaf oil[J].Postharvest Biology and Technology,2013,86:321-328.
[32]王旭林,王萍,侯玉龙,等.肉桂醛对肝癌HepG2细胞p21和CDK4蛋白的影响[J].实用肿瘤杂志,2016,31(4):344-348.
[33]郑晓文,陈一强,孔晋亮,等.肉桂醛通过Hedgehog信号通路影响人肺腺癌A549细胞的E-cadherin、MMP-9的表达[J].中国免疫学杂志,2014,30(6):768-773,778.
[34]宋晓兵.肉桂醛对肺癌细胞A549具有体外抑制作用[J].中国卫生标准管理,2014,5(6):30-32.
[35]王跃新,邢继强,张晓波,等.肉桂醛抗人宫颈癌相关机制的研究[J].中国微生态学杂志,2011,23(6):516-518,524.
[36] Marta Sánchez-Rubio,Amaury Taboada-Rodríguez,Rita Cava-Roda,et al. Combined use of thermo-ultrasound and cinnamon leaf essential oil to inactivate Saccharomyces cerevisiae in natural orange and pomegranate juices[J]. LWT-Food Science and Technology,2016,73:140-146.
[37] Perczak Adam, Ju's Krzysztof, Marchwińska Katarzyna, et al.Degradation of zearalenone by essential oils under in vitro conditions[J]. Frontiers in microbiology,2016,7:1224.
[38] Veal L. The potential effectiveness of essential oils as a treatment for headlice,Pediculus humanus capitis[J]. Complementary Therapies in Nursing and Midwifery,1996,2(4):97-101.
[2]侯小涛,郝二伟,秦健峰,等.肉桂的化学成分、药理作用及质量标志物(Q-marker)的预测分析[J].中草药,2018,49(1):20-34.
[3]李艳,苗明三.肉桂的化学、药理及应用特点[J].中医学报,2015,30(9):1335-1337.
[4]郭虹,林观样.肉桂叶挥发性成分分析[J].浙江中医药大学学报,2009,33(6):883-884.
[5]黄丽涛,杨向宏,许育佳,等.肉桂的研究进展[J].大众科技,2018,20(1):77-79.
[6]邓淑蓉,潘宇政.肉桂主要化学成分及药理作用研究概况[J].现代中西医结合杂志,2018,27(4):448-451.
[7]欧阳少林,罗志华,周小卿,等.樟属植物化学型研究概况[J].中国实验方剂学杂志,2011,17(18):268-271.
[8]王琳琳,陈小鹏,韦小杰.广西桂枝桂叶挥发油化学成分分析[J].企业技术开发,2003(15):6-8.
[9]张浩,柴向华.肉桂叶精油水蒸气提取工艺及甄别技术的研究[J].广东工业大学学报,2017,34(4):27-30,40.
[10]朱羽尧,钱骅,张琪瑶,等.肉桂不同植物部位精油成分分析及抑菌活性研究[J].中国野生植物资源,2014,33(6):1-5.
[11]刘红星,孙振军,黄初升,等.桂皮、桂枝、桂叶挥发油的化学成分比较分析[J].食品研究与开发,2010,31(12):144-147.
[12]刘红星,林森,黄初升,等.肉桂三个不同部位提取肉桂油的化学成分比较分析[J].中国调味品,2011,36(4):102-104,110.
[13]孙振军.桂皮、桂枝、桂叶油提取工艺、化学成分及其乙醇提取物的抗氧化活性研究[D].南宁:广西师范学院,2010.
[14]卫向南.水扩散蒸馏提取肉桂叶有效成分的研究[D].南宁:广西大学,2014.
[15] Chang C T,Chang W L,Hsu J C,et al. Chemical composition and tyrosinase inhibitory activity of Cinnamomum cassia essential oil[J].Botanical Studies,2013,54(10):1-7.
[16] Wang R,Wang R J,Yang B. Extraction of essential oils from five cinnamon leaves and identification of their volatile compound compositions[J]. Innovative Food Science and Emerging Technologies,2009,10(2):289-292.
[17]卫向南,李伟光,刘雄民,等.肉桂叶水扩散蒸馏提取肉桂油的研究[J].应用化工,2014,43(6):1047-1049.
[18]张清华.四种海南芳香药物的超临界萃取工艺及GC-MS分析研究[D].北京:中国协和医科大学,2010.
[19]周蕾.肉桂叶化学成分及免疫调节活性研究[D].武汉:华中科技大学,2016.
[20]曾俊芬.肉桂皮及叶化学成分和生物活性研究[D].武汉:华中科技大学,2014.
[21]曾俊芬,朱虎成,周忠泉.肉桂皮及叶中木脂素类化学成分的研究[J].中国药师,2017,20(5):781-784.
[22]向丽,张贵君,赵保胜,等.肉桂不同部位及其挥发油的红外光谱宏观表征[J].中国实验方剂学杂志,2017,23(8):57-61.
[23]李军集,周丽珠,陈海燕,等.紫外分光光度法检测桂叶、桂叶渣总黄酮研究[J].应用化工,2015,44(5):970-971,975.
[24]张玉姣,方岩雄,杨祖金,等.水蒸气蒸馏提取桂叶精油中组分的分布规律[J].精细化工,2014,31(1):50-53.
[25]邹勇芳,黄锁义,李卫彬,等.肉桂植物总黄酮的超声波提取工艺研究[J].食品研究与开发,2008(4):20-23.
[26]张笮晦,邓家刚,黄静,等.微生物法提取桂叶精油的组分研究[J].应用化工,2017,46(1):109-112.
[27] Duan J,Zhao Y. Antimicrobial efficiency of essential oil and freezethaw treatments against Escherichia coli O157:H7 and Salmonella enterica Ser. Enteritidis in strawberry juice[J]. Journal of Food Science,2009,74(3):131-137.
[28] Jeong E J,Lee N K,Oh J,et al. Inhibitory effect of cinnamon essential oils on selected cheese-contaminating fungi(Penicillium spp.)during the cheese-ripening process[J]. Food Science and Biotechnology,2014,23(4):1193-1198.
[29] Jasenka'Cosi'c,Karolina Vrande(c i'c,Jelena Po2ti'c,et al. In vitro antifungal activity of essential oils on growth of phytopathogenic fungi[J]. Agriculture,2010,16(2):25-28.
[30] Ayala-Zavala J F,Silva-Espinoza B A,Cruz-Valenzuela M R,et al.Pectin-cinnamon leaf oil coatings add antioxidant and antibacterial properties to fresh-cut peach[J]. Flavour and Fragrance Journal,2013,28(1):39-45.
[31] Melgarejo-Flores B G,Ortega-Ramírez L A,Silva-Espinoza B A,et al. Antifungal protection and antioxidant enhancement of table grapes treated with emulsions,vapors,and coatings of cinnamon leaf oil[J].Postharvest Biology and Technology,2013,86:321-328.
[32]王旭林,王萍,侯玉龙,等.肉桂醛对肝癌HepG2细胞p21和CDK4蛋白的影响[J].实用肿瘤杂志,2016,31(4):344-348.
[33]郑晓文,陈一强,孔晋亮,等.肉桂醛通过Hedgehog信号通路影响人肺腺癌A549细胞的E-cadherin、MMP-9的表达[J].中国免疫学杂志,2014,30(6):768-773,778.
[34]宋晓兵.肉桂醛对肺癌细胞A549具有体外抑制作用[J].中国卫生标准管理,2014,5(6):30-32.
[35]王跃新,邢继强,张晓波,等.肉桂醛抗人宫颈癌相关机制的研究[J].中国微生态学杂志,2011,23(6):516-518,524.
[36] Marta Sánchez-Rubio,Amaury Taboada-Rodríguez,Rita Cava-Roda,et al. Combined use of thermo-ultrasound and cinnamon leaf essential oil to inactivate Saccharomyces cerevisiae in natural orange and pomegranate juices[J]. LWT-Food Science and Technology,2016,73:140-146.
[37] Perczak Adam, Ju's Krzysztof, Marchwińska Katarzyna, et al.Degradation of zearalenone by essential oils under in vitro conditions[J]. Frontiers in microbiology,2016,7:1224.
[38] Veal L. The potential effectiveness of essential oils as a treatment for headlice,Pediculus humanus capitis[J]. Complementary Therapies in Nursing and Midwifery,1996,2(4):97-101.