转录因子调控植物萜类化合物生物合成研究进展
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摘要
植物三萜酸等萜类化合物具有抗炎、抗氧化、抑制肿瘤细胞增殖等生物活性,在医药、化妆品、食品等等领域应用广泛,但萜类化合物的生物合成调控机制尚未明确。本文重点综述近年来植物萜类化合物生物合成相关转录因子和调控机制的研究进展,为进一步阐明萜类代谢的转录调控网络提供参考。
Plants terpenoids, such as triterpenes, which have efficacy on anti-inflammatory, anti-oxidation,tumor cell proliferation-resistant and so on, were widely used in medicine, cosmetics and processed food.However, the molecular mechanisms through which the compounds were produced were still unclear. This article reviewed the identifications of key critical transcription factors activate/repress the terpene biosynthesis. At the end, prospects were drawn on measures which would promote the construction of gene transcription network in plant terpene biosynthesis.
Plants terpenoids, such as triterpenes, which have efficacy on anti-inflammatory, anti-oxidation,tumor cell proliferation-resistant and so on, were widely used in medicine, cosmetics and processed food.However, the molecular mechanisms through which the compounds were produced were still unclear. This article reviewed the identifications of key critical transcription factors activate/repress the terpene biosynthesis. At the end, prospects were drawn on measures which would promote the construction of gene transcription network in plant terpene biosynthesis.
引文
刘晓芬,李方,殷学仁,等.2013.花青苷生物合成转录调控研究进展[J].园艺学报,40(11):2295-2306.(Liu X F,Li F,Yin X R,et al.2013.Recent advances in the transcriptional regulation of anthocyanin biosynthesis[J].Acta Horticulturae Sinica,40(11):2295-2306.)
Arendt P,Miettinen K,Pollier J,et al.2017.An endoplasmic reticulum-engineered yeast platform for overproduction of triterpenoids[J].Metabolic Engineering,40:165-175.
Butelli E,Licciardello C,Zhang Y,et al.2012.Retrotransposons control fruit-specific,cold-dependent accumulation of anthocyanins in blood oranges[J].Plant Cell,24(3):1242-1255.
Cardenas,Sonawane P,Pollier J,et al.2016.GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway[J].Nature Communications,7:10654.
Chuang Y C,Hung Y C,Tsai W C,et al.2018.PbbHLH4 regulates floral monoterpene biosynthesis in Phalaenopsis orchids[J].Journal of Experimental Botany,69(18):4363-4377.
Ding K,Pei T,Bai Z,et al.2017.SmMYB36,a novel R2R3-MYB transcription factor,enhances tanshinone accumulation and decreases phenolic acid content in Salvia Miltiorrhiza hairy roots[J].Scientific Reports,7(1):5104.
Espley R V,Brendolise C,Chagne D,et al.2009.Multiple repeats of a promoter segment causes transcription factor autoregulation in red apples[J].Plant Cell,21(1):168-183.
Field B,Fiston-Lavier A,Kemen A,et al.2011.Formation of plant metabolic gene clusters within dynamic chromosomal regions[J].Proceedings of the National Academy of Sciences of the USA,108(38):16116-16121.
Field B,Osbourn A E.2008.Metabolic diversification-Independent assembly of operon-like gene clusters in different plants[J].Science,320(5875):543-547.
Fricke J,Hillebrand A,Twyman R M,et al.2013.Abscisic acid-dependent regulation of small rubber particle protein gene expression in Taraxacum brevicorniculatum is mediated by TbbZIP1[J].Plant and Cell Physiology,54(4):448-464.
Fu X,Kong W,Peng G,et al.2012.Plastid structure and carotenogenic gene expression in red-and white-fleshed loquat(Eriobotrya japonica)fruits[J].Journal of Experimental Botany,63(1):341-354.
Ghosh S.2017.Triterpene structural diversification by plant Cytochrome P450 enzymes[J].Frontiers in Plant Science,8:1886.
Hamel L P,Benchabane M,Nicole M C,et al.2011.Stress-responsive mitogen-activated protein kinases interact with the EAR motif of a poplar zinc finger protein and mediate its degradation through the 26S proteasome[J].Plant Physiology,157(3):1379-1393.
Hong G J,Xue X Y,Mao Y B,et al.2012.Arabidopsis MYC2interacts with DELLA proteins in regulating sesquiterpene synthase gene expression[J].Plant Cell,24(6):2635-2648.
Jiang W,Fu X,Pan Q,et al.2016.Overexpression of AaWRKY1 leads to an enhanced content of artemisinin in Artemisia annua[J].Biomed Research International,2016(4):1-9.
King A J,Brown G D,Gilday A D,et al.2014.Production of bioactive diterpenoids in the euphorbiaceae depends on evolutionarily conserved gene clusters[J].Plant Cell,26(8):3286-3298.
Krokida A,Delis C,Geisler K,et al.2013.A metabolic gene cluster in Lotus japonicus discloses novel enzyme functions and products in triterpene biosynthesis[J].New Phytologist,200(3):675-690.
Kumar S,Hahn F M,Baidoo E,et al.2012.Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts[J].Metabolic Engineering,14(1):19-28.
Lercher M J,Hurst L D,Pál C.2004.The evolutionary dynamics of eukaryotic gene order[J].Nature Reviews Genetics,5(4):299-310.
Li C Y,Leopold A L,Sander G W,et al.2015.CrBPF1 overexpression alters transcript levels of terpenoid indole alkaloid biosynthetic and regulatory genes[J].Frontiers in Plant Science,6:818.
Li X,Fan S,Hu W,et al.2017.Two cassava basic leucine zipper(bZIP)transcription factors(MebZIP3 and Meb ZIP5)confer disease resistance against cassava bacterial blight[J].Frontiers in Plant Science,8:2110.
Liu D,Ren W,Cui L,et al.2011.Enhanced accumulation of catharanthine and vindoline in Catharanthus roseus hairy roots by overexpression of transcriptional factor ORCA2[J].African Journal of Biotechnology,10(17):3260-3268.
Liu J,Gao F,Ren J,et al.2017.A novel AP2/ERF transcription factor CR1 regulates the accumulation of Vindoline and Serpentine in Catharanthus roseus[J].Frontiers in Plant Science,8:2082.
Lv Z,Wang S,Zhang F,et al.2016.Overexpression of a novel NAC Domain-Containing transcription factor gene(AaNAC1)enhances the content of artemisinin and increases tolerance to drought and botrytis cinerea in Artemisia annua[J].Plant and Cell Physiology,57(9):1961-1971.
Matias-Hernandez L,Jiang W,Yang K,et al.2017.Aa MYB1and its orthologue AtMYB61 affect terpene metabolism and trichome development in Artemisia annua and Arabidopsis thaliana[J].Plant Journal,90(3):520-534.
Matsuba Y,Zi J,Jones A D,et al.2015.Biosynthesis of the diterpenoid lycosantalonol via nerylneryl diphosphate in Solanum lycopersicum[J].PLoS One,10(3):e01193023.
Mertens J,Pollier J,Vanden B R,et al.2016.The bHLH transcription factors TSAR1 and TSAR2 regulate triterpene saponin biosynthesis in Medicago truncatula[J].Plant Physiology,170(1):194-210.
Miettinen K,Inigo S,Kreft L,et al.2018.The TriForC database:A comprehensive up-to-date resource of plant triterpene biosynthesis[J].Nucleic Acids Research,46(D1):D586-D594.
Menke F,Champion A,Kijne J,et al.1999.A novel jasmonate-and elicitor-responsive element in the periwinkle secondary metabolite biosynthetic gene Str interacts with a jasmonate-and elicitor-inducible AP2-domain transcription factor,ORCA2[J].The EMBO Journal,18(16):4455-4463.
Miyamoto K,Matsumoto T,Okada A,et al.2014.Identification of target genes of the bZIP transcription factor OsT-GAP1,whose overexpression causes elicitor-induced hyperaccumulation of diterpenoid phytoalexins in rice cells[J].PLoS One,9(8):e105823.
Miyamoto K,Nishizawa Y,Minami E,et al.2015.Overexpression of the bZIP transcription factor OsbZIP79 suppresses the production of diterpenoid phytoalexin in rice cells[J].Journal of Plant Physiology,173:19-27.
Naoumkina M A,Modolo L V,Huhman D V,et al.2010.Genomic and coexpression analyses predict multiple genes involved in triterpene saponin biosynthesis in Medicago truncatula[J].Plant Cell,22(3):850-866.
Nieuwenhuizen N J,Chen X,Wang M Y,et al.2015.Natural variation in monoterpene synthesis in kiwifruit:Transcriptional regulation of terpene synthases by NAC and ETHYLENE-INSENSITIVE3-Like transcription factors[J].Plant Physiology,167(4):1243-1258.
Okada A,Okada K,Miyamoto K,et al.2009.OsTGAP1,a b ZIP transcription factor,coordinately regulates the inductive production of diterpenoid phytoalexins in rice[J].Journal of Biological Chemistry,284(39):26510-26518.
Pandey N,Pandey-Rai S.2015.Deciphering UV-B-induced variation in DNA methylation pattern and its influence on regulation of DBR2 expression in Artemisia annua L.[J].Planta,242(4):869-879.
Patra B,Pattanaik S,Schluttenhofer C,et al.2018.A network of jasmonate-responsive bHLH factors modulate monoterpenoid indole alkaloid biosynthesis in Catharanthus roseus[J].New Phytologist,217(4):1566-1581.
Paul P,Singh S,Patra B,et al.2016.A differentially regulated AP2/ERF transcription factor gene cluster acts downstream of a MAP kinase cascade to modulate terpenoid indole alkaloid biosynthesis in Catharanthus roseus[J].New Phytologist,213(3):1107-1123.
Pauw B,Hilliou F A,Martin V S,et al.2004.Zinc finger proteins act as transcriptional repressors of alkaloid biosynthesis genes in Catharanthus roseus[J].Journal of Biological Chemistry,279(51):52940-52948.
Plasencia A,Soler M,Dupas A,et al.2016.Eucalyptus hairy roots,a fast,efficient and versatile tool to explore function and expression of genes involved in wood formation[J].Plant Biotechnology Journal,14(6):1381-1393.
Qi X,Bakht S,Leggett M,et al.2004.A gene cluster for secondary metabolism in oat:Implications for the evolution of metabolic diversity in plants[J].Proceedings of the National Academy of Sciences of the USA,101(21):8233-8238.
Raina S,Wankhede D,Jaggi M,et al.2012.CrMPK3,a mitogen activated protein kinase from Catharanthus roseus and its possible role in stress induced biosynthesis of monoterpenoid indole alkaloids[J].BMC Plant Biology,12(1):134.
Reddy V A,Wang Q,Dhar N,et al.2017.Spearmint R2R3-MYB transcription factor MsMYB negatively regulates monoterpene production and suppresses the expression of geranyl diphosphate synthase large subunit(MsGPPS.LSU)[J].Plant Biotechnology Journal,15(9):1105-1119.
Shang Y,Ma Y,Zhou Y,et al.2014.Biosynthesis,regulation,and domestication of bitterness in cucumber[J].Science,346(6213):1084-1088.
Shi M,Zhou W,Zhang J,et al.2016.Methyl jasmonate induction of tanshinone biosynthesis in Salvia miltiorrhiza hairy roots is mediated by JASMONATE ZIM-DO-MAIN repressor proteins[J].Scientific Reports,6:20919.
Shimura K,Okada A,Okada K,et al.2007.Identification of a biosynthetic gene cluster in rice for momilactones[J].Journal of Biological Chemistry,282(47):34013-34018.
Siberil Y,Benhamron S,Memelink J,et al.2001.Catharanthus roseus G-box binding factors 1 and 2 act as repressors of strictosidine synthase gene expression in cell cultures[J].Plant Molecular Biology,45(4):477-488.
Sui X,Singh S K,Patra B,et al.2018.Cross-family transcription factor interaction between MYC2 and GBFs modulates terpenoid indole alkaloid biosynthesis[J].Journal of Experimental Botany,69(18):4267-4281.
Sun T,Yuan H,Cao H,et al.2018.Carotenoid metabolism in plants:The role of plastids[J].Molecular Plant,11(1):58-74.
Suttipanta N,Pattanaik S,Kulshrestha M,et al.2011.The transcription factor CrWRKY1 positively regulates the terpenoid indole alkaloid biosynthesis in Catharanthus roseus[J].Plant Physiology,157(4):2081-2093.
Tamura K,Yoshida K,Hiraoka Y,et al.2018.The basic HelixLoop-Helix transcription factor GubHLH3 positively regulates soyasaponin biosynthetic genes in Glycyrrhiza uralensis[J].Plant and Cell Physiology,59(4):778-796.
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Butelli E,Licciardello C,Zhang Y,et al.2012.Retrotransposons control fruit-specific,cold-dependent accumulation of anthocyanins in blood oranges[J].Plant Cell,24(3):1242-1255.
Cardenas,Sonawane P,Pollier J,et al.2016.GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway[J].Nature Communications,7:10654.
Chuang Y C,Hung Y C,Tsai W C,et al.2018.PbbHLH4 regulates floral monoterpene biosynthesis in Phalaenopsis orchids[J].Journal of Experimental Botany,69(18):4363-4377.
Ding K,Pei T,Bai Z,et al.2017.SmMYB36,a novel R2R3-MYB transcription factor,enhances tanshinone accumulation and decreases phenolic acid content in Salvia Miltiorrhiza hairy roots[J].Scientific Reports,7(1):5104.
Espley R V,Brendolise C,Chagne D,et al.2009.Multiple repeats of a promoter segment causes transcription factor autoregulation in red apples[J].Plant Cell,21(1):168-183.
Field B,Fiston-Lavier A,Kemen A,et al.2011.Formation of plant metabolic gene clusters within dynamic chromosomal regions[J].Proceedings of the National Academy of Sciences of the USA,108(38):16116-16121.
Field B,Osbourn A E.2008.Metabolic diversification-Independent assembly of operon-like gene clusters in different plants[J].Science,320(5875):543-547.
Fricke J,Hillebrand A,Twyman R M,et al.2013.Abscisic acid-dependent regulation of small rubber particle protein gene expression in Taraxacum brevicorniculatum is mediated by TbbZIP1[J].Plant and Cell Physiology,54(4):448-464.
Fu X,Kong W,Peng G,et al.2012.Plastid structure and carotenogenic gene expression in red-and white-fleshed loquat(Eriobotrya japonica)fruits[J].Journal of Experimental Botany,63(1):341-354.
Ghosh S.2017.Triterpene structural diversification by plant Cytochrome P450 enzymes[J].Frontiers in Plant Science,8:1886.
Hamel L P,Benchabane M,Nicole M C,et al.2011.Stress-responsive mitogen-activated protein kinases interact with the EAR motif of a poplar zinc finger protein and mediate its degradation through the 26S proteasome[J].Plant Physiology,157(3):1379-1393.
Hong G J,Xue X Y,Mao Y B,et al.2012.Arabidopsis MYC2interacts with DELLA proteins in regulating sesquiterpene synthase gene expression[J].Plant Cell,24(6):2635-2648.
Jiang W,Fu X,Pan Q,et al.2016.Overexpression of AaWRKY1 leads to an enhanced content of artemisinin in Artemisia annua[J].Biomed Research International,2016(4):1-9.
King A J,Brown G D,Gilday A D,et al.2014.Production of bioactive diterpenoids in the euphorbiaceae depends on evolutionarily conserved gene clusters[J].Plant Cell,26(8):3286-3298.
Krokida A,Delis C,Geisler K,et al.2013.A metabolic gene cluster in Lotus japonicus discloses novel enzyme functions and products in triterpene biosynthesis[J].New Phytologist,200(3):675-690.
Kumar S,Hahn F M,Baidoo E,et al.2012.Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts[J].Metabolic Engineering,14(1):19-28.
Lercher M J,Hurst L D,Pál C.2004.The evolutionary dynamics of eukaryotic gene order[J].Nature Reviews Genetics,5(4):299-310.
Li C Y,Leopold A L,Sander G W,et al.2015.CrBPF1 overexpression alters transcript levels of terpenoid indole alkaloid biosynthetic and regulatory genes[J].Frontiers in Plant Science,6:818.
Li X,Fan S,Hu W,et al.2017.Two cassava basic leucine zipper(bZIP)transcription factors(MebZIP3 and Meb ZIP5)confer disease resistance against cassava bacterial blight[J].Frontiers in Plant Science,8:2110.
Liu D,Ren W,Cui L,et al.2011.Enhanced accumulation of catharanthine and vindoline in Catharanthus roseus hairy roots by overexpression of transcriptional factor ORCA2[J].African Journal of Biotechnology,10(17):3260-3268.
Liu J,Gao F,Ren J,et al.2017.A novel AP2/ERF transcription factor CR1 regulates the accumulation of Vindoline and Serpentine in Catharanthus roseus[J].Frontiers in Plant Science,8:2082.
Lv Z,Wang S,Zhang F,et al.2016.Overexpression of a novel NAC Domain-Containing transcription factor gene(AaNAC1)enhances the content of artemisinin and increases tolerance to drought and botrytis cinerea in Artemisia annua[J].Plant and Cell Physiology,57(9):1961-1971.
Matias-Hernandez L,Jiang W,Yang K,et al.2017.Aa MYB1and its orthologue AtMYB61 affect terpene metabolism and trichome development in Artemisia annua and Arabidopsis thaliana[J].Plant Journal,90(3):520-534.
Matsuba Y,Zi J,Jones A D,et al.2015.Biosynthesis of the diterpenoid lycosantalonol via nerylneryl diphosphate in Solanum lycopersicum[J].PLoS One,10(3):e01193023.
Mertens J,Pollier J,Vanden B R,et al.2016.The bHLH transcription factors TSAR1 and TSAR2 regulate triterpene saponin biosynthesis in Medicago truncatula[J].Plant Physiology,170(1):194-210.
Miettinen K,Inigo S,Kreft L,et al.2018.The TriForC database:A comprehensive up-to-date resource of plant triterpene biosynthesis[J].Nucleic Acids Research,46(D1):D586-D594.
Menke F,Champion A,Kijne J,et al.1999.A novel jasmonate-and elicitor-responsive element in the periwinkle secondary metabolite biosynthetic gene Str interacts with a jasmonate-and elicitor-inducible AP2-domain transcription factor,ORCA2[J].The EMBO Journal,18(16):4455-4463.
Miyamoto K,Matsumoto T,Okada A,et al.2014.Identification of target genes of the bZIP transcription factor OsT-GAP1,whose overexpression causes elicitor-induced hyperaccumulation of diterpenoid phytoalexins in rice cells[J].PLoS One,9(8):e105823.
Miyamoto K,Nishizawa Y,Minami E,et al.2015.Overexpression of the bZIP transcription factor OsbZIP79 suppresses the production of diterpenoid phytoalexin in rice cells[J].Journal of Plant Physiology,173:19-27.
Naoumkina M A,Modolo L V,Huhman D V,et al.2010.Genomic and coexpression analyses predict multiple genes involved in triterpene saponin biosynthesis in Medicago truncatula[J].Plant Cell,22(3):850-866.
Nieuwenhuizen N J,Chen X,Wang M Y,et al.2015.Natural variation in monoterpene synthesis in kiwifruit:Transcriptional regulation of terpene synthases by NAC and ETHYLENE-INSENSITIVE3-Like transcription factors[J].Plant Physiology,167(4):1243-1258.
Okada A,Okada K,Miyamoto K,et al.2009.OsTGAP1,a b ZIP transcription factor,coordinately regulates the inductive production of diterpenoid phytoalexins in rice[J].Journal of Biological Chemistry,284(39):26510-26518.
Pandey N,Pandey-Rai S.2015.Deciphering UV-B-induced variation in DNA methylation pattern and its influence on regulation of DBR2 expression in Artemisia annua L.[J].Planta,242(4):869-879.
Patra B,Pattanaik S,Schluttenhofer C,et al.2018.A network of jasmonate-responsive bHLH factors modulate monoterpenoid indole alkaloid biosynthesis in Catharanthus roseus[J].New Phytologist,217(4):1566-1581.
Paul P,Singh S,Patra B,et al.2016.A differentially regulated AP2/ERF transcription factor gene cluster acts downstream of a MAP kinase cascade to modulate terpenoid indole alkaloid biosynthesis in Catharanthus roseus[J].New Phytologist,213(3):1107-1123.
Pauw B,Hilliou F A,Martin V S,et al.2004.Zinc finger proteins act as transcriptional repressors of alkaloid biosynthesis genes in Catharanthus roseus[J].Journal of Biological Chemistry,279(51):52940-52948.
Plasencia A,Soler M,Dupas A,et al.2016.Eucalyptus hairy roots,a fast,efficient and versatile tool to explore function and expression of genes involved in wood formation[J].Plant Biotechnology Journal,14(6):1381-1393.
Qi X,Bakht S,Leggett M,et al.2004.A gene cluster for secondary metabolism in oat:Implications for the evolution of metabolic diversity in plants[J].Proceedings of the National Academy of Sciences of the USA,101(21):8233-8238.
Raina S,Wankhede D,Jaggi M,et al.2012.CrMPK3,a mitogen activated protein kinase from Catharanthus roseus and its possible role in stress induced biosynthesis of monoterpenoid indole alkaloids[J].BMC Plant Biology,12(1):134.
Reddy V A,Wang Q,Dhar N,et al.2017.Spearmint R2R3-MYB transcription factor MsMYB negatively regulates monoterpene production and suppresses the expression of geranyl diphosphate synthase large subunit(MsGPPS.LSU)[J].Plant Biotechnology Journal,15(9):1105-1119.
Shang Y,Ma Y,Zhou Y,et al.2014.Biosynthesis,regulation,and domestication of bitterness in cucumber[J].Science,346(6213):1084-1088.
Shi M,Zhou W,Zhang J,et al.2016.Methyl jasmonate induction of tanshinone biosynthesis in Salvia miltiorrhiza hairy roots is mediated by JASMONATE ZIM-DO-MAIN repressor proteins[J].Scientific Reports,6:20919.
Shimura K,Okada A,Okada K,et al.2007.Identification of a biosynthetic gene cluster in rice for momilactones[J].Journal of Biological Chemistry,282(47):34013-34018.
Siberil Y,Benhamron S,Memelink J,et al.2001.Catharanthus roseus G-box binding factors 1 and 2 act as repressors of strictosidine synthase gene expression in cell cultures[J].Plant Molecular Biology,45(4):477-488.
Sui X,Singh S K,Patra B,et al.2018.Cross-family transcription factor interaction between MYC2 and GBFs modulates terpenoid indole alkaloid biosynthesis[J].Journal of Experimental Botany,69(18):4267-4281.
Sun T,Yuan H,Cao H,et al.2018.Carotenoid metabolism in plants:The role of plastids[J].Molecular Plant,11(1):58-74.
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