来曲唑与尿促性素对多囊卵巢综合征不孕患者排卵质量的影响
|
摘要
目的:探讨来曲唑与尿促性素对多囊卵巢综合征不孕患者排卵质量的影响。方法:选取2016年4月—2018年1月我院收治的96例多囊卵巢综合征不孕患者,按随机数字表法分为两组,各48例。对照组采用来曲唑(2.5 mg,bid)治疗,试验组在此基础上联合尿促性素(75 IU,qd)治疗,比较两组子宫内膜厚度、成熟卵泡数、妊娠结局及不良反应发生情况。结果:试验组子宫内膜厚度、成熟卵泡数较对照组高,差异有统计学意义(P <0.05);试验组排卵率、临床妊娠率较对照组高,差异有统计学意义(P <0.05);两组早期流产率、多胎妊娠率、不良反应发生率比较,差异无统计学意义(P> 0.05)。结论:来曲唑联合尿促性素可促进多囊卵巢综合征不孕患者卵泡发育,提升排卵率、妊娠率,改善妊娠结局,且安全性较高。
Objective:To investigate the effect of letrozole and menotropins on ovulation quality in infertile patients with polycystic ovary syndrome. Methods:96 infertile patients with polycystic ovary syndrome admitted to our hospital from April 2016 to January 2018 were selected and randomly divided into two groups, 48 cases each.The patients in the control group were treated with letrozole(2.5 mg, bid), and the patients in the experimental group were treated with menotropins(75 IU, qd). The endometrial thickness, mature follicle number, pregnancy outcomes and adverse reactions were compared between the two groups. Results:The endometrial thickness and the number of mature follicles in the experimental group were higher than those in the control group, and the differences were statistically significant(P<0.05). The ovulation rate and clinical pregnancy rate in the experimental group were higher than those in the control group, and the differences were statistically signi?cant(P<0.05). There were no statistically significant differences in early abortion rate, multiple pregnancy rate and adverse reaction incidence between the two groups(P>0.05). Conclusion:Letrozole combined with menotropins can promote follicular development in the infertile patients with polycystic ovary syndrome, increase ovulation rate and pregnancy rate and improve pregnancy outcomes, and has higher safety.
Objective:To investigate the effect of letrozole and menotropins on ovulation quality in infertile patients with polycystic ovary syndrome. Methods:96 infertile patients with polycystic ovary syndrome admitted to our hospital from April 2016 to January 2018 were selected and randomly divided into two groups, 48 cases each.The patients in the control group were treated with letrozole(2.5 mg, bid), and the patients in the experimental group were treated with menotropins(75 IU, qd). The endometrial thickness, mature follicle number, pregnancy outcomes and adverse reactions were compared between the two groups. Results:The endometrial thickness and the number of mature follicles in the experimental group were higher than those in the control group, and the differences were statistically significant(P<0.05). The ovulation rate and clinical pregnancy rate in the experimental group were higher than those in the control group, and the differences were statistically signi?cant(P<0.05). There were no statistically significant differences in early abortion rate, multiple pregnancy rate and adverse reaction incidence between the two groups(P>0.05). Conclusion:Letrozole combined with menotropins can promote follicular development in the infertile patients with polycystic ovary syndrome, increase ovulation rate and pregnancy rate and improve pregnancy outcomes, and has higher safety.
引文
[1]黄凤,周全,毛巧玲,等.多囊卵巢综合征患者不良妊娠结局研究现状[J].中国医师杂志,2018,20(5):793-796.
[2]唐亭亭,阳翎,禹虹,等.不同促排卵方案治疗多囊卵巢综合征的疗效分析[J].医学临床研究,2017,34(2):402-404.
[3]黎少琴.人绝经期促性腺激素联合来曲唑对多囊卵巢综合征不孕症患者子宫内膜厚度及妊娠结局的影响[J].中国合理用药探索,2018,15(9):22-24.
[4]吴允.吡格列酮联合枸橼酸氯米芬治疗多囊卵巢综合征不孕患者的疗效分析[J].中国合理用药探索,2017,14(12):32-34,37.
[5]中华医学会妇产科学分会内分泌学组.多囊卵巢综合征的诊断和治疗专家共识[J].中华妇产科杂志,2008,43(7):553-555.
[6]孙立兰,叶青,陈艳娥.来曲唑改善多囊卵巢综合征不孕患者激素水平和排卵情况的疗效分析[J].中国性科学,201625(7):121-123.
[7]王仕丽,陈涛,刘跃辉,等.克罗米芬联合尿促性素对多囊卵巢综合症患者促排卵效果及其对妊娠的影响研究[J].药学与临床研究,2015,23(4):383-387.
[8]王燕,王春莲,员相冰,等.来曲唑与尿促性素在多囊卵巢综合征不孕患者促排卵中的应用[J].医学研究杂志,201746(8):160-163.
[2]唐亭亭,阳翎,禹虹,等.不同促排卵方案治疗多囊卵巢综合征的疗效分析[J].医学临床研究,2017,34(2):402-404.
[3]黎少琴.人绝经期促性腺激素联合来曲唑对多囊卵巢综合征不孕症患者子宫内膜厚度及妊娠结局的影响[J].中国合理用药探索,2018,15(9):22-24.
[4]吴允.吡格列酮联合枸橼酸氯米芬治疗多囊卵巢综合征不孕患者的疗效分析[J].中国合理用药探索,2017,14(12):32-34,37.
[5]中华医学会妇产科学分会内分泌学组.多囊卵巢综合征的诊断和治疗专家共识[J].中华妇产科杂志,2008,43(7):553-555.
[6]孙立兰,叶青,陈艳娥.来曲唑改善多囊卵巢综合征不孕患者激素水平和排卵情况的疗效分析[J].中国性科学,201625(7):121-123.
[7]王仕丽,陈涛,刘跃辉,等.克罗米芬联合尿促性素对多囊卵巢综合症患者促排卵效果及其对妊娠的影响研究[J].药学与临床研究,2015,23(4):383-387.
[8]王燕,王春莲,员相冰,等.来曲唑与尿促性素在多囊卵巢综合征不孕患者促排卵中的应用[J].医学研究杂志,201746(8):160-163.