不同浓度阿托品制剂治疗屈光不正疗效及安全性比较观察
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摘要
目的研究屈光不正患者应用不同浓度阿托品治疗的临床效果和安全性。方法 150例屈光不正患者作为研究对象,按照随机数字表分为实验甲组、实验乙组和对照组,各50例。实验甲组患者接受高浓度(0.1%)阿托品治疗,实验乙组患者接受低浓度(0.01%)阿托品治疗,对照组患者不接受任何药物治疗,对比三组患者治疗效果(对照组同期观察视力情况),以及实验甲组与实验乙组不良反应发生情况。结果实验甲组患者总有效率92%明显高于实验乙组的72%及对照组的0,且实验乙组患者总有效率明显高于对照组,差异均具有统计学意义(P<0.05)。实验乙组不良反应发生率4%明显低于实验甲组的18%,差异具有统计学意义(P<0.05)。结论高、低浓度阿托品对于治疗屈光不正都有效果,高浓度阿托品的治疗效果比低浓度阿托品的治疗效果更为显著,但低浓度阿托品治疗安全性更高。
Objective To study the clinical effect and safety of different concentrations of atropine preparations in the treatment of ametropia patients. Methods A total of 150 ametropia patients as study subjects were divided by random number table into experimental group A, experimental group B and control group, with 50 cases in each group. The experimental group A received high concentration(0.1%) atropine, experimental group B received low concentration(0.01%) atropine, and control group received no drug therapy. The treatment effect(visual acuity of the control group was observed at the same time) in the three groups was compared, and the occurrence of adverse reactions between experimental group A and experimental group B. Results Experimental group A had obviously higher total effective rate as 92% than 72% in experimental group B and 0 in control group, and experimental group B had obviously higher total effective rate than the control group. Their difference was statistically significant(P<0.05). Experimental group B had obviously lower incidence of adverse reactions as 4% than 18% in experimental group A, and the difference was statistically significant(P<0.05). Conclusion High and low concentrations of atropine are effective in the treatment of refractive errors. High concentration of atropine is more effective than low concentration of atropine, but low concentration of atropine is safer than low concentration of atropine.
Objective To study the clinical effect and safety of different concentrations of atropine preparations in the treatment of ametropia patients. Methods A total of 150 ametropia patients as study subjects were divided by random number table into experimental group A, experimental group B and control group, with 50 cases in each group. The experimental group A received high concentration(0.1%) atropine, experimental group B received low concentration(0.01%) atropine, and control group received no drug therapy. The treatment effect(visual acuity of the control group was observed at the same time) in the three groups was compared, and the occurrence of adverse reactions between experimental group A and experimental group B. Results Experimental group A had obviously higher total effective rate as 92% than 72% in experimental group B and 0 in control group, and experimental group B had obviously higher total effective rate than the control group. Their difference was statistically significant(P<0.05). Experimental group B had obviously lower incidence of adverse reactions as 4% than 18% in experimental group A, and the difference was statistically significant(P<0.05). Conclusion High and low concentrations of atropine are effective in the treatment of refractive errors. High concentration of atropine is more effective than low concentration of atropine, but low concentration of atropine is safer than low concentration of atropine.
引文
[1]张晓瑾,周磊.不同浓度阿托品制剂治疗屈光不正患者的疗效及安全性.中国生化药物杂志, 2016, 36(11):106-108, 111.
[2]何梦梅,杜亚茹,刘晴雨,等.角膜塑形镜治疗我国青少年低中度近视患者短期效果评价.国际眼科杂志, 2016, 16(2):237-241.
[3]韩雯婷,徐蔚,荣翱.阿托品在儿童及青少年近视治疗中应用的研究进展.同济大学学报(医学版), 2016, 37(1):120-123.
[4]苏梦茹,马雅贞,黄君,等.阿托品联合综合疗法治疗青少年屈光不正的疗效及安全性分析.现代生物医学进展, 2017, 17(31):6091, 6120-6123.
[5]王长海.阿托品治疗儿童屈光不正的临床疗效观察.热带医学杂志, 2017(1):69-70.
[6]卞丹梅.不同浓度阿托品治疗青少年近视的疗效观察.健康之路, 2016(9):161.
[7]梁斗立,于雪冰,俞佳伟,等.不同浓度阿托品眼用凝胶间断使用延缓儿童近视发展的对比研究.中国斜视与小儿眼科杂志, 2013, 21(2):20-22.
[2]何梦梅,杜亚茹,刘晴雨,等.角膜塑形镜治疗我国青少年低中度近视患者短期效果评价.国际眼科杂志, 2016, 16(2):237-241.
[3]韩雯婷,徐蔚,荣翱.阿托品在儿童及青少年近视治疗中应用的研究进展.同济大学学报(医学版), 2016, 37(1):120-123.
[4]苏梦茹,马雅贞,黄君,等.阿托品联合综合疗法治疗青少年屈光不正的疗效及安全性分析.现代生物医学进展, 2017, 17(31):6091, 6120-6123.
[5]王长海.阿托品治疗儿童屈光不正的临床疗效观察.热带医学杂志, 2017(1):69-70.
[6]卞丹梅.不同浓度阿托品治疗青少年近视的疗效观察.健康之路, 2016(9):161.
[7]梁斗立,于雪冰,俞佳伟,等.不同浓度阿托品眼用凝胶间断使用延缓儿童近视发展的对比研究.中国斜视与小儿眼科杂志, 2013, 21(2):20-22.