内皮微颗粒与血管疾病的相关性研究进展
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摘要
心血管疾病是一系列高发病率、高死亡率的常见病,是危害中老年人健康的一大杀手。内皮微颗粒是在内皮细胞活化、凋亡时所释放的一组微粒,由磷酯酰丝氨酸和不同的表面蛋白组成,不同的刺激会引起不同性质的内皮微颗粒释放,因此具有不同的生物功能。内皮损伤是动脉粥样硬化病变的始动因素,在血管性疾病中起着重要作用。内皮微颗粒可较灵敏地反映内皮功能紊乱,对血管性疾病的早期评估有较好的预测作用。
Cardiovascular disease is a series of common diseases with high morbidity and high mortality rate,and it is a major killer that harms the health of middle-aged and elderly people.Endothelial microparticles are a group of microparticles released by activation or apoptosis of endothelial cells.They are composed of phosphatidylserine and different surface proteins.Different stimuli can cause the release of different properties endothelial microparticles which have different biological functions.Endothelial injury is the initiating factor of atherosclerotic lesions and plays an important role in vascular diseases.Endothelial microparticles can respond more sensitively to endothelial dysfunction and have a better predictive effect on the early assessment of vascular diseases.
Cardiovascular disease is a series of common diseases with high morbidity and high mortality rate,and it is a major killer that harms the health of middle-aged and elderly people.Endothelial microparticles are a group of microparticles released by activation or apoptosis of endothelial cells.They are composed of phosphatidylserine and different surface proteins.Different stimuli can cause the release of different properties endothelial microparticles which have different biological functions.Endothelial injury is the initiating factor of atherosclerotic lesions and plays an important role in vascular diseases.Endothelial microparticles can respond more sensitively to endothelial dysfunction and have a better predictive effect on the early assessment of vascular diseases.
引文
[1]李强,郭壮波,伍光颖,等.阿托伐他汀对急性心肌梗死大鼠内皮微颗粒及心肌细胞凋亡的影响[J].中国病理生理杂志,2015,31(2):359-363,373.
[2]Boulanger CM,Scoazec A,Ebrahimian T,et al.Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction[J].Circulation,2001,104(22):2649.
[3]Hugel B,Martinez C,Kunzelmann C,et al.Membrane microparticles:two sides of the coin[J].Physiology,2005,20(1):22-27.
[4]Chen J,Chen S,Chen Y,et al.Circulating endothelial progenitor cells and cellular membrane microparticles in db/db diabetic mouse:possible implications in cerebral ischemic damage[J].Am J Physiol Endocrinol Metab,2011,301(1):E62-E71.
[5]Wu ZH,Ji CL,Li H,et al.Membrane microparticles and diseases[J].Eur Rev Med Pharmacol Sci,2013,17(18):2420-2427.
[6]Martinez MC,Tualchalot S,Leonetti D,et al.Microparticles:targets and tools in cardiovascular disease[J].Trends Pharmacol Sci,2011,32(11):659-665.
[7]夏金盈,华奇峰,李莹.内皮微颗粒与冠心病[J].中国动脉硬化杂志,2011,19(2):160-164.
[8]Priou P,Gaqnadoux F,Tesse A,et al.Endothelial dysfunction and circulating micropaticles from patients with obstructive sleep apnea[J].Am J Pathol,2010,177(2):974-983.
[9]Lacroix R,Plawinski L,Robert S,et al.Leukocyte-and endothelial-derived microparticles:a circulating source for fibrinolysis[J].Haematologica,2012,97(12):1864-872.
[10]Wang JG,Aikawa E,Aikawa M.Leukocyte-derived microparticles as pro-inflammatory mediators in atherosclerosis[J].J Am Coll Cardiol,2013,62(16):1442-1445.
[11]Burger D,Touyz RM.Cellular biomarkers of endothelial health:microparticles,endothelial progenitor cells,and circulating endothelial cells[J].J Am Soc Hypertens,2012,6(2):85-99.
[12]González-Quintero VH,Smarkusky LP,Jiménez JJ,et al.Elevated plasma endothelial microparticles:preeclampsia versus gestational hypertension[J].Am JObstet Gynecol,2004,191(4):1418-1424.
[13]Wang JM,Su C,Wang Y,et al.Elevated circulating endothelial microparticles and brachial-ankle pulse wave velocity in well-controlled hypertensive patients[J].J Human Hypertens,2009,23(5):307.
[14]权晓慧,张春艳,王聪霞,等.CD31+/CD42b-、CD144+内皮微颗粒水平与颈动脉内膜中层厚度的关系[J].西安交通大学学报(医学版),2016,37(3):327-330.
[15]权晓慧,王聪霞,李毓杰,等.内皮微颗粒CD31+/CD42b-水平、颈动脉内膜中层厚度与冠状动脉病变程度的相关性[J].中国老年学,2016,36(11):2650-2652.
[16]Rautou PE,Leroyer AS,Ramkhelawon B,et al.Microparticles from human atherosclerotic plaques promote endothelial ICAM-1-dependent monocyte adhesion and transendothelial migrationnovelty and significance[J].Circ Res,2011,108(3):335-343.
[17]Lee SK,Yang SH,Kwon I,et al.Role of tumour necrosis factor receptor-1 and nuclear factor-κB in production of TNF-α-induced pro-inflammatory microparticles in endothelial cells[J].Thromb Haemost,2014,112(3):580-588.
[18]Boulanger CM,Scoazec A,Ebrahimian T,et al.Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction[J].Circulation,2001,104(22):2649.
[19]Hao P,Fu K,Wang SP,et al.Expression of profilin-1 in endothelial cells of rats with acute myocardial infarction[J].Eur Rev Med Pharmacol Sci,2017,21(6):1318.
[20]彭瑞君,黄铮.急性心肌梗死血管狭窄程度与内皮微颗粒及炎性因子的相关性研究[J].中国临床研究,2017,30(3):330-332.
[21]Burger D,Turner M,Xiao F,et al.High glucose increases the formation and pro-oxidative activity of endothelial microparticles[J].Diabetologia,2017,60(9):1791-1800.
[22]Jansen F,Zietzer A,Stumpf T,et al.Endothelial microparticle-promoted inhibition of vascular remodeling is abrogated under hyperglycaemic conditions[J].J Mol Cell Cardiol,2017,112(9):91-94.
[23]Jung KH,Chu K,Lee ST,et al.Risk of macrovascular complications in type 2diabetes mellitus:endothelial microparticle profiles[J].Cerebrovasc Dis,2011,31(5):485-493.
[24]Koga H,Sugiyama S,Kugiyama K,et al.Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease[J].J Am Coll Cardiol,2005,45(10):1622.
[25]Esposito K,Ciotola M,Schisano B,et al.Endothelial microparticles correlate with endothelial dysfunction in obese women[J].J Clin Endocrinol Metab,2006,91(9):3676-3679.
[26]胡帅帅,仉红刚.高血压内皮微颗粒产生的机制和病理生理学作用[J].中国病理生理杂志,2013,29(8):1525-1529.
[2]Boulanger CM,Scoazec A,Ebrahimian T,et al.Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction[J].Circulation,2001,104(22):2649.
[3]Hugel B,Martinez C,Kunzelmann C,et al.Membrane microparticles:two sides of the coin[J].Physiology,2005,20(1):22-27.
[4]Chen J,Chen S,Chen Y,et al.Circulating endothelial progenitor cells and cellular membrane microparticles in db/db diabetic mouse:possible implications in cerebral ischemic damage[J].Am J Physiol Endocrinol Metab,2011,301(1):E62-E71.
[5]Wu ZH,Ji CL,Li H,et al.Membrane microparticles and diseases[J].Eur Rev Med Pharmacol Sci,2013,17(18):2420-2427.
[6]Martinez MC,Tualchalot S,Leonetti D,et al.Microparticles:targets and tools in cardiovascular disease[J].Trends Pharmacol Sci,2011,32(11):659-665.
[7]夏金盈,华奇峰,李莹.内皮微颗粒与冠心病[J].中国动脉硬化杂志,2011,19(2):160-164.
[8]Priou P,Gaqnadoux F,Tesse A,et al.Endothelial dysfunction and circulating micropaticles from patients with obstructive sleep apnea[J].Am J Pathol,2010,177(2):974-983.
[9]Lacroix R,Plawinski L,Robert S,et al.Leukocyte-and endothelial-derived microparticles:a circulating source for fibrinolysis[J].Haematologica,2012,97(12):1864-872.
[10]Wang JG,Aikawa E,Aikawa M.Leukocyte-derived microparticles as pro-inflammatory mediators in atherosclerosis[J].J Am Coll Cardiol,2013,62(16):1442-1445.
[11]Burger D,Touyz RM.Cellular biomarkers of endothelial health:microparticles,endothelial progenitor cells,and circulating endothelial cells[J].J Am Soc Hypertens,2012,6(2):85-99.
[12]González-Quintero VH,Smarkusky LP,Jiménez JJ,et al.Elevated plasma endothelial microparticles:preeclampsia versus gestational hypertension[J].Am JObstet Gynecol,2004,191(4):1418-1424.
[13]Wang JM,Su C,Wang Y,et al.Elevated circulating endothelial microparticles and brachial-ankle pulse wave velocity in well-controlled hypertensive patients[J].J Human Hypertens,2009,23(5):307.
[14]权晓慧,张春艳,王聪霞,等.CD31+/CD42b-、CD144+内皮微颗粒水平与颈动脉内膜中层厚度的关系[J].西安交通大学学报(医学版),2016,37(3):327-330.
[15]权晓慧,王聪霞,李毓杰,等.内皮微颗粒CD31+/CD42b-水平、颈动脉内膜中层厚度与冠状动脉病变程度的相关性[J].中国老年学,2016,36(11):2650-2652.
[16]Rautou PE,Leroyer AS,Ramkhelawon B,et al.Microparticles from human atherosclerotic plaques promote endothelial ICAM-1-dependent monocyte adhesion and transendothelial migrationnovelty and significance[J].Circ Res,2011,108(3):335-343.
[17]Lee SK,Yang SH,Kwon I,et al.Role of tumour necrosis factor receptor-1 and nuclear factor-κB in production of TNF-α-induced pro-inflammatory microparticles in endothelial cells[J].Thromb Haemost,2014,112(3):580-588.
[18]Boulanger CM,Scoazec A,Ebrahimian T,et al.Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction[J].Circulation,2001,104(22):2649.
[19]Hao P,Fu K,Wang SP,et al.Expression of profilin-1 in endothelial cells of rats with acute myocardial infarction[J].Eur Rev Med Pharmacol Sci,2017,21(6):1318.
[20]彭瑞君,黄铮.急性心肌梗死血管狭窄程度与内皮微颗粒及炎性因子的相关性研究[J].中国临床研究,2017,30(3):330-332.
[21]Burger D,Turner M,Xiao F,et al.High glucose increases the formation and pro-oxidative activity of endothelial microparticles[J].Diabetologia,2017,60(9):1791-1800.
[22]Jansen F,Zietzer A,Stumpf T,et al.Endothelial microparticle-promoted inhibition of vascular remodeling is abrogated under hyperglycaemic conditions[J].J Mol Cell Cardiol,2017,112(9):91-94.
[23]Jung KH,Chu K,Lee ST,et al.Risk of macrovascular complications in type 2diabetes mellitus:endothelial microparticle profiles[J].Cerebrovasc Dis,2011,31(5):485-493.
[24]Koga H,Sugiyama S,Kugiyama K,et al.Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease[J].J Am Coll Cardiol,2005,45(10):1622.
[25]Esposito K,Ciotola M,Schisano B,et al.Endothelial microparticles correlate with endothelial dysfunction in obese women[J].J Clin Endocrinol Metab,2006,91(9):3676-3679.
[26]胡帅帅,仉红刚.高血压内皮微颗粒产生的机制和病理生理学作用[J].中国病理生理杂志,2013,29(8):1525-1529.